Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials (394 views)
Diseases Of The Esophagus, 2012 Feb; 142(5): 130-136.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 2.057, 5-year impact factor: 2.005
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857113777&partnerID=40&md5=97910941a8218bdc62cf539ac71b35cb
Keywords: Esophageal Cancer, Pooled Analysis, Preoperative Chemoradiotherapy, Cetuximab, Cisplatin, Fluorouracil, Folinic Acid, Oxaliplatin, Paclitaxel, Adult, Article, Cancer Combination Chemotherapy, Cancer Radiotherapy, Cancer Survival, Clinical Effectiveness, Continuous Infusion, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Female, Histopathology, Human, Human Tissue, Major Clinical Study, Multiple Cycle Treatment, Outcome Assessment, Overall Survival, Phase 2 Clinical Trial, Preoperative Treatment, Priority Journal, Radiation Dose, Treatment Response, Antineoplastic Combined Chemotherapy Protocols, Esophageal Neoplasms, Middle Aged, Preoperative Period, Remission Induction, Survival Analysis, Treatment Outcome, Forced Vital Capacity, Letter, Mortality, Reference Value, Risk Assessment, Risk Factor, Total Lung Capacity,
Affiliations:
*** IBB - CNR ***
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi - A. Lanzara', Second University of Naples School of Medicine, Italy
Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi - A. Lanzara', Second University of Naples School of Medicine, Italy
Division of Radiotherapy, Federico II University of Naples School of Medicine, Naples, Italy
Division of General Surgery, Federico II University of Naples School of Medicine, Naples, Italy
Unit of Respiratory Pathophysiology, Universit Campus Biomedico, Via Alvaro del Portillo, 200, 00128 Rome, Italy
Alberto Sordi Foundation, Rome, Italy
Department of Epidemiology, Roma E. Health Authority, Rome, Italy
Fondazione San Raffaele, Cittadella della Carit, Taranto, Italy
References:
Parkin, D. M., Bray, F. I., Devesa, S. S., Cancer burden in the year 2000. The global picture (2001) Eur J Cancer, 37 (8 SUPPL.), pp. 64-6
Associazione Italiana Oncologia Medica (AIOM). Tumori dell'Esofago: linee guida. Available from URL: Ries, L. A. G., Melbert, D., Krapcho, M., (2008) SEER Cancer Statistics Review, 1975-2005, , Bethesda, MD: National Cancer Institute, Available from URL:, based on November 2007 SEER data submission, posted to the SEER web site
Siewert, J. R., Stein, H. J., Feith, M., Bruecher, B. L., Bartels, H., Fink, U., Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1, 000 consecutive resections at a single center in the Western world (2001) Ann Surg, 234, pp. 360-369
Walsh, T. N., Noonan, N., Hollywood, D., Kelly, A., Keeling, N., Hennessy, T. P., A comparison of multimodal therapy and surgery for adenocarcinoma (1996) N Engl J Med, 335, pp. 462-467
Tepper, J., Krasna, M. J., Niedzwiecki, D., Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer. CALGB 9781 (2008) J Clin Oncol, 26, pp. 1086-1092
Urschel, J. D., Vasan, H., A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer (2003) Am J Surg, 185, pp. 538-543
Fiorica, F., Camm, C., Venturi, A., A preoperative chemotherapy and radiotherapy in patients with esophageal carcinoma: a meta-analysis (2004) Gut, 53, pp. 925-930
Gebsky, V., Burmeister, B., Smithers, B. M., Foo, K., Zalcberg, J., Simes, J., Survival benefit from neoadjuvant chemoradiotherapy or chemotherapy in esophageal carcinoma: a meta-analysis (2007) Lancet Oncol, 8, pp. 226-234
Graham, A. J., Scrive, F. M., Ghali, A., Defining the optimal treatment of locally advanced esophageal cancer: a systematic review and decision analysis (2007) Ann Thorac Surg, 83, pp. 1257-1264
Lv, J., Cao, X. F., Zhu, B., Tao, L., Wang, D. D., Effect of neoadjuvant chemoradiotherapy on prognosis and surgery for esophageal carcinoma (2009) World J Gastroenterol, 15, pp. 4962-4968
Berger, A. C., Farma, J., Scott, W. J., Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival (2005) J Clin Oncol, 23, pp. 4330-4337
Le Prise, E., Etienne, P. L., Meunier, B., A randomized study of chemotherapy, radiation therapy, and surgery versus surgery for localized squamous cell carcinoma of the esophagus (1994) Cancer, 73, pp. 1779-1784
Bosset, J., Gignoux, M., Triboulet, J., Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus (1997) N Engl J Med, 337, pp. 161-167
Urba, S. G., Orringer, M. B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma (2001) J Clin Oncol, 19, pp. 305-313
Lee, J. L., Park, S. I., Kim, S. B., A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma (2004) Ann Oncol, 15, pp. 947-954
Burmeister, B. H., Smithers, B. M., Gebski, V., Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial (2005) Lancet Oncol, 6, pp. 659-668
Stahl, M., Stuschke, M., Lehmann, N., Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus (2005) J Clin Oncol, 23, pp. 2310-2317
Bedenne, L., Michel, P., Bouch, O., Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102 (2007) J Clin Oncol, 25, pp. 1160-1168
De Vita, F., Di Martino, N., Orditura, M., Preoperative chemoradiotherapy for squamous cell and adenocarcinoma of the esophagus: A phase II study (2002) Chest, 122, pp. 1302-1308
Orditura, M., Galizia, G., Napolitano, V., Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esophageal cancer (2010) Cancer Invest, 28, pp. 820-827
De Vita, F., Orditura, M., Martinelli, E., Neoadjuvant chemoradiation with FOLFOX 4 and Cetuximab in esophageal cancer: B152 phase II trial final results (2011) Br J Cancer, 104, pp. 427-432
Chan, Y. H., Biostatistics 203. Survival analysis (2004) Singapore Med J, 45, pp. 249-256
Mariette, C., Seitz, J. F., Mailard, E., Surgery alone versus chemoradiotherapy followed by surgery for localized esophageal cancer: analysis of a randomized controlled phase III trial FFCD 9901 (2010) J Clin Oncol, 28 (SUPPL.), pp. 15s. , abstract 4005)
Gaast, A. V., van Hagen, P., Hulshof, M., Effect of preoperative concurrent chemoradiotherapy on survival of patients with resectable esophageal or esophagogastric junction cancer: results from a multicenter randomized phase III study (2010) J Clin Oncol, 28 (SUPPL.), pp. 15s. , abstract 4004)
Geh, J. I., Crellin, A. M., Glynne-Jones, R., Preoperative (neoadjuvant) chemoradiotherapy in oesophageal cancer (2001) Br J Surg, 88, pp. 338-356
Rice, T. W., Rusch, V. W., Apperson-Hansen, C., Worldwide esophageal cancer collaboration (2009) Dis Esophagus, 22, pp. 1-8
Ruol, A., Castoro, C., Portale, G., Trends in management and prognosis for esophageal cancer surgery Twenty-five years of experience at a single institution (2009) Arch Surg, 144, pp. 247-254
Geh, J. I., Bond, S. J., Bentzen, S. M., Glynne-Jones, R., Systematic overview of preoperative (neoadjuvant) chemoradiation trials in oesophageal cancer: evidence of a radiation and chemotherapy dose-response (2006) Radiother Oncol, 78, pp. 236-244
Parkin, D.M., Bray, F.I., Devesa, S.S., Cancer burden in the year 2000. The global picture (2001) Eur J Cancer, 37 (8 SUPPL.), pp. 64-6
Siewert, J.R., Stein, H.J., Feith, M., Bruecher, B.L., Bartels, H., Fink, U., Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1,000 consecutive resections at a single center in the Western world (2001) Ann Surg, 234, pp. 360-369
Walsh, T.N., Noonan, N., Hollywood, D., Kelly, A., Keeling, N., Hennessy, T.P., A comparison of multimodal therapy and surgery for adenocarcinoma (1996) N Engl J Med, 335, pp. 462-467
Urschel, J.D., Vasan, H., A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer (2003) Am J Surg, 185, pp. 538-543
Fiorica, F., Cammà, C., Venturi, A., A preoperative chemotherapy and radiotherapy in patients with esophageal carcinoma: a meta-analysis (2004) Gut, 53, pp. 925-930
Graham, A.J., Scrive, F.M., Ghali, A., Defining the optimal treatment of locally advanced esophageal cancer: a systematic review and decision analysis (2007) Ann Thorac Surg, 83, pp. 1257-1264
Lv, J., Cao, X.F., Zhu, B., Tao, L., Wang, D.D., Effect of neoadjuvant chemoradiotherapy on prognosis and surgery for esophageal carcinoma (2009) World J Gastroenterol, 15, pp. 4962-4968
Berger, A.C., Farma, J., Scott, W.J., Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival (2005) J Clin Oncol, 23, pp. 4330-4337
Urba, S.G., Orringer, M.B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma (2001) J Clin Oncol, 19, pp. 305-313
Lee, J.L., Park, S.I., Kim, S.B., A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma (2004) Ann Oncol, 15, pp. 947-954
Burmeister, B.H., Smithers, B.M., Gebski, V., Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial (2005) Lancet Oncol, 6, pp. 659-668
Chan, Y.H., Biostatistics 203. Survival analysis (2004) Singapore Med J, 45, pp. 249-256
Gaast, A.V., van Hagen, P., Hulshof, M., Effect of preoperative concurrent chemoradiotherapy on survival of patients with resectable esophageal or esophagogastric junction cancer: results from a multicenter randomized phase III study (2010) J Clin Oncol, 28 (SUPPL.), pp. 15s. , abstract 4004)
Geh, J.I., Crellin, A.M., Glynne-Jones, R., Preoperative (neoadjuvant) chemoradiotherapy in oesophageal cancer (2001) Br J Surg, 88, pp. 338-356
Rice, T.W., Rusch, V.W., Apperson-Hansen, C., Worldwide esophageal cancer collaboration (2009) Dis Esophagus, 22, pp. 1-8
Geh, J.I., Bond, S.J., Bentzen, S.M., Glynne-Jones, R., Systematic overview of preoperative (neoadjuvant) chemoradiation trials in oesophageal cancer: evidence of a radiation and chemotherapy dose-response (2006) Radiother Oncol, 78, pp. 236-244
Diseases Of The Esophagus, 2012 Feb; 142(5): 130-136.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 2.057, 5-year impact factor: 2.005
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857113777&partnerID=40&md5=97910941a8218bdc62cf539ac71b35cb
Keywords: Esophageal Cancer, Pooled Analysis, Preoperative Chemoradiotherapy, Cetuximab, Cisplatin, Fluorouracil, Folinic Acid, Oxaliplatin, Paclitaxel, Adult, Article, Cancer Combination Chemotherapy, Cancer Radiotherapy, Cancer Survival, Clinical Effectiveness, Continuous Infusion, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Female, Histopathology, Human, Human Tissue, Major Clinical Study, Multiple Cycle Treatment, Outcome Assessment, Overall Survival, Phase 2 Clinical Trial, Preoperative Treatment, Priority Journal, Radiation Dose, Treatment Response, Antineoplastic Combined Chemotherapy Protocols, Esophageal Neoplasms, Middle Aged, Preoperative Period, Remission Induction, Survival Analysis, Treatment Outcome, Forced Vital Capacity, Letter, Mortality, Reference Value, Risk Assessment, Risk Factor, Total Lung Capacity,
Affiliations:
*** IBB - CNR ***
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi - A. Lanzara', Second University of Naples School of Medicine, Italy
Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery 'F. Magrassi - A. Lanzara', Second University of Naples School of Medicine, Italy
Division of Radiotherapy, Federico II University of Naples School of Medicine, Naples, Italy
Division of General Surgery, Federico II University of Naples School of Medicine, Naples, Italy
Unit of Respiratory Pathophysiology, Universit Campus Biomedico, Via Alvaro del Portillo, 200, 00128 Rome, Italy
Alberto Sordi Foundation, Rome, Italy
Department of Epidemiology, Roma E. Health Authority, Rome, Italy
Fondazione San Raffaele, Cittadella della Carit, Taranto, Italy
References:
Parkin, D. M., Bray, F. I., Devesa, S. S., Cancer burden in the year 2000. The global picture (2001) Eur J Cancer, 37 (8 SUPPL.), pp. 64-6
Associazione Italiana Oncologia Medica (AIOM). Tumori dell'Esofago: linee guida. Available from URL: Ries, L. A. G., Melbert, D., Krapcho, M., (2008) SEER Cancer Statistics Review, 1975-2005, , Bethesda, MD: National Cancer Institute, Available from URL:, based on November 2007 SEER data submission, posted to the SEER web site
Siewert, J. R., Stein, H. J., Feith, M., Bruecher, B. L., Bartels, H., Fink, U., Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1, 000 consecutive resections at a single center in the Western world (2001) Ann Surg, 234, pp. 360-369
Walsh, T. N., Noonan, N., Hollywood, D., Kelly, A., Keeling, N., Hennessy, T. P., A comparison of multimodal therapy and surgery for adenocarcinoma (1996) N Engl J Med, 335, pp. 462-467
Tepper, J., Krasna, M. J., Niedzwiecki, D., Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer. CALGB 9781 (2008) J Clin Oncol, 26, pp. 1086-1092
Urschel, J. D., Vasan, H., A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer (2003) Am J Surg, 185, pp. 538-543
Fiorica, F., Camm, C., Venturi, A., A preoperative chemotherapy and radiotherapy in patients with esophageal carcinoma: a meta-analysis (2004) Gut, 53, pp. 925-930
Gebsky, V., Burmeister, B., Smithers, B. M., Foo, K., Zalcberg, J., Simes, J., Survival benefit from neoadjuvant chemoradiotherapy or chemotherapy in esophageal carcinoma: a meta-analysis (2007) Lancet Oncol, 8, pp. 226-234
Graham, A. J., Scrive, F. M., Ghali, A., Defining the optimal treatment of locally advanced esophageal cancer: a systematic review and decision analysis (2007) Ann Thorac Surg, 83, pp. 1257-1264
Lv, J., Cao, X. F., Zhu, B., Tao, L., Wang, D. D., Effect of neoadjuvant chemoradiotherapy on prognosis and surgery for esophageal carcinoma (2009) World J Gastroenterol, 15, pp. 4962-4968
Berger, A. C., Farma, J., Scott, W. J., Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival (2005) J Clin Oncol, 23, pp. 4330-4337
Le Prise, E., Etienne, P. L., Meunier, B., A randomized study of chemotherapy, radiation therapy, and surgery versus surgery for localized squamous cell carcinoma of the esophagus (1994) Cancer, 73, pp. 1779-1784
Bosset, J., Gignoux, M., Triboulet, J., Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus (1997) N Engl J Med, 337, pp. 161-167
Urba, S. G., Orringer, M. B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma (2001) J Clin Oncol, 19, pp. 305-313
Lee, J. L., Park, S. I., Kim, S. B., A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma (2004) Ann Oncol, 15, pp. 947-954
Burmeister, B. H., Smithers, B. M., Gebski, V., Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial (2005) Lancet Oncol, 6, pp. 659-668
Stahl, M., Stuschke, M., Lehmann, N., Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus (2005) J Clin Oncol, 23, pp. 2310-2317
Bedenne, L., Michel, P., Bouch, O., Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102 (2007) J Clin Oncol, 25, pp. 1160-1168
De Vita, F., Di Martino, N., Orditura, M., Preoperative chemoradiotherapy for squamous cell and adenocarcinoma of the esophagus: A phase II study (2002) Chest, 122, pp. 1302-1308
Orditura, M., Galizia, G., Napolitano, V., Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esophageal cancer (2010) Cancer Invest, 28, pp. 820-827
De Vita, F., Orditura, M., Martinelli, E., Neoadjuvant chemoradiation with FOLFOX 4 and Cetuximab in esophageal cancer: B152 phase II trial final results (2011) Br J Cancer, 104, pp. 427-432
Chan, Y. H., Biostatistics 203. Survival analysis (2004) Singapore Med J, 45, pp. 249-256
Mariette, C., Seitz, J. F., Mailard, E., Surgery alone versus chemoradiotherapy followed by surgery for localized esophageal cancer: analysis of a randomized controlled phase III trial FFCD 9901 (2010) J Clin Oncol, 28 (SUPPL.), pp. 15s. , abstract 4005)
Gaast, A. V., van Hagen, P., Hulshof, M., Effect of preoperative concurrent chemoradiotherapy on survival of patients with resectable esophageal or esophagogastric junction cancer: results from a multicenter randomized phase III study (2010) J Clin Oncol, 28 (SUPPL.), pp. 15s. , abstract 4004)
Geh, J. I., Crellin, A. M., Glynne-Jones, R., Preoperative (neoadjuvant) chemoradiotherapy in oesophageal cancer (2001) Br J Surg, 88, pp. 338-356
Rice, T. W., Rusch, V. W., Apperson-Hansen, C., Worldwide esophageal cancer collaboration (2009) Dis Esophagus, 22, pp. 1-8
Ruol, A., Castoro, C., Portale, G., Trends in management and prognosis for esophageal cancer surgery Twenty-five years of experience at a single institution (2009) Arch Surg, 144, pp. 247-254
Geh, J. I., Bond, S. J., Bentzen, S. M., Glynne-Jones, R., Systematic overview of preoperative (neoadjuvant) chemoradiation trials in oesophageal cancer: evidence of a radiation and chemotherapy dose-response (2006) Radiother Oncol, 78, pp. 236-244
Parkin, D.M., Bray, F.I., Devesa, S.S., Cancer burden in the year 2000. The global picture (2001) Eur J Cancer, 37 (8 SUPPL.), pp. 64-6
Siewert, J.R., Stein, H.J., Feith, M., Bruecher, B.L., Bartels, H., Fink, U., Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1,000 consecutive resections at a single center in the Western world (2001) Ann Surg, 234, pp. 360-369
Walsh, T.N., Noonan, N., Hollywood, D., Kelly, A., Keeling, N., Hennessy, T.P., A comparison of multimodal therapy and surgery for adenocarcinoma (1996) N Engl J Med, 335, pp. 462-467
Urschel, J.D., Vasan, H., A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer (2003) Am J Surg, 185, pp. 538-543
Fiorica, F., Cammà, C., Venturi, A., A preoperative chemotherapy and radiotherapy in patients with esophageal carcinoma: a meta-analysis (2004) Gut, 53, pp. 925-930
Graham, A.J., Scrive, F.M., Ghali, A., Defining the optimal treatment of locally advanced esophageal cancer: a systematic review and decision analysis (2007) Ann Thorac Surg, 83, pp. 1257-1264
Lv, J., Cao, X.F., Zhu, B., Tao, L., Wang, D.D., Effect of neoadjuvant chemoradiotherapy on prognosis and surgery for esophageal carcinoma (2009) World J Gastroenterol, 15, pp. 4962-4968
Berger, A.C., Farma, J., Scott, W.J., Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival (2005) J Clin Oncol, 23, pp. 4330-4337
Urba, S.G., Orringer, M.B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma (2001) J Clin Oncol, 19, pp. 305-313
Lee, J.L., Park, S.I., Kim, S.B., A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma (2004) Ann Oncol, 15, pp. 947-954
Burmeister, B.H., Smithers, B.M., Gebski, V., Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial (2005) Lancet Oncol, 6, pp. 659-668
Chan, Y.H., Biostatistics 203. Survival analysis (2004) Singapore Med J, 45, pp. 249-256
Gaast, A.V., van Hagen, P., Hulshof, M., Effect of preoperative concurrent chemoradiotherapy on survival of patients with resectable esophageal or esophagogastric junction cancer: results from a multicenter randomized phase III study (2010) J Clin Oncol, 28 (SUPPL.), pp. 15s. , abstract 4004)
Geh, J.I., Crellin, A.M., Glynne-Jones, R., Preoperative (neoadjuvant) chemoradiotherapy in oesophageal cancer (2001) Br J Surg, 88, pp. 338-356
Rice, T.W., Rusch, V.W., Apperson-Hansen, C., Worldwide esophageal cancer collaboration (2009) Dis Esophagus, 22, pp. 1-8
Geh, J.I., Bond, S.J., Bentzen, S.M., Glynne-Jones, R., Systematic overview of preoperative (neoadjuvant) chemoradiation trials in oesophageal cancer: evidence of a radiation and chemotherapy dose-response (2006) Radiother Oncol, 78, pp. 236-244
Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials
This pooled analysis was performed using individual patient data from three phase II trials that included on the whole 113 esophageal cancer treated preoperatively with chemoradiotherapy (CRT), in order to analyze the efficacy and survival outcomes according to the achievement of the pathologic complete response (pCR). Thirty-nine patients were treated with 5-fluorouracil/cisplatin and RT (40Gy), 33 patients received paclitaxel/cisplatin weekly during weeks 1-6 with and RT (46Gy), 41 patients were treated with induction bio-chemotherapy with cetuximab and FOLFOX-4 followed by concomitant cetuximab and RT of 50. 4Gy. One hundred and two out of 113 resected patients were included in the survival analysis. The median overall survival (OS) time for the whole population was 21. 5 months. The 12, 24, and 36 months OS rates were 85. 4, 45. 2, and 33%, respectively. The difference in survival probability between patients with pCR and patients with partial response or stable disease after treatment was significant (P= 0. 0002, hazard ratios = 0. 21, 95% CI 0. 18-0. 60). On multivariate analysis, the pathologic response and histology were the only covariates independently associated with OS (P= 0. 0157 and P= 0. 0212, respectively). In our series, complete responder patients had a significant longer survival probability after treatment when compared to patients with partial response or stable disease. 2011 the Authors. Journal compilation 2011, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus
This pooled analysis was performed using individual patient data from three phase II trials that included on the whole 113 esophageal cancer treated preoperatively with chemoradiotherapy (CRT), in order to analyze the efficacy and survival outcomes according to the achievement of the pathologic complete response (pCR). Thirty-nine patients were treated with 5-fluorouracil/cisplatin and RT (40Gy), 33 patients received paclitaxel/cisplatin weekly during weeks 1-6 with and RT (46Gy), 41 patients were treated with induction bio-chemotherapy with cetuximab and FOLFOX-4 followed by concomitant cetuximab and RT of 50. 4Gy. One hundred and two out of 113 resected patients were included in the survival analysis. The median overall survival (OS) time for the whole population was 21. 5 months. The 12, 24, and 36 months OS rates were 85. 4, 45. 2, and 33%, respectively. The difference in survival probability between patients with pCR and patients with partial response or stable disease after treatment was significant (P= 0. 0002, hazard ratios = 0. 21, 95% CI 0. 18-0. 60). On multivariate analysis, the pathologic response and histology were the only covariates independently associated with OS (P= 0. 0157 and P= 0. 0212, respectively). In our series, complete responder patients had a significant longer survival probability after treatment when compared to patients with partial response or stable disease. 2011 the Authors. Journal compilation 2011, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus
Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials
No results. |
Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials
Other filter: ([btitle,keywords] "Esophageal Cancer" O ...
Buonanno F, Conson M, De Almeida Ribeiro C, Oliviero C, Itta F, Liuzzi R, Pacelli R, Cella L, Clemente S
* Local tumor control and treatment related toxicity after plaque brachytherapy for uveal melanoma: A systematic review and a data pooled analysis (10 views)
Radiother Oncol (ISSN: 0167-8140linking), 2022 Jan; 166: 15-25.
Impact Factor: 6.28
View Export to BibTeX Export to EndNote
Bonaccorso C, Grasso G, Musso N, Barresi V, Condorelli DF, La Mendola D, Rizzarelli E
* Water soluble glucose derivative of thiocarbohydrazone acts as ionophore with cytotoxic effects on tumor cells (332 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 1873-3344electronic), 2018; 182: 92-102.
Impact Factor: 3.317
View Export to BibTeX Export to EndNote
D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (441 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
View Export to BibTeX Export to EndNote
Orditura M, Galizia G, Di Martino N, Ancona E, Castoro C, Pacelli R, Morgillo F, Rossetti S, Gambardella V, Farella A, Laterza MM, Ruol A, Fabozzi A, Napolitano V, Iovino F, Lieto E, Fei L, Conzo G, Ciardiello F, De Vita F
* Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study (1873 views)
Curr Oncol (ISSN: 1198-0052, 1718-7729electronic, 1198-0052linking), 2014 Jun; 21(3): 125-133.
Impact Factor: 1.785
View Export to BibTeX Export to EndNote
Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
* Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (351 views)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Impact Factor: 2.39
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (637 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
View Export to BibTeX Export to EndNote
Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (735 views)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
View Export to BibTeX Export to EndNote
Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (372 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Gustavsson T, Sarkar N, Banyasz A, Markovitsi D, Improta R
* Solvent effects on the steady-state absorption and fluorescence spectra of uracil, thymine and 5-fluorouracil (351 views)
Photochem Photobiol (ISSN: 0031-8655), 2007 May; 83(3): 595-599.
Impact Factor: 2.172
View Export to BibTeX Export to EndNote
Santoro F, Barone V, Gustavsson T, Improta R
* Solvent effect on the singlet excited-state lifetimes of nucleic acid bases: A computational study of 5-fluorouracil and uracil in acetonitrile and water (833 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Dec 20; 128(50): 16312-16322.
Impact Factor: 7.696
View Export to BibTeX Export to EndNote
Gustavsson T, Sarkar N, Lazzarotto E, Markovitsi D, Barone V, Improta R
* Solvent effect on the singlet excited-state dynamics of 5-fluorouracil in acetonitrile as compared with water (315 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2006 Jul 6; 110(26): 12843-12847.
Impact Factor: 4.115
View Export to BibTeX Export to EndNote
Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (585 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Gustavsson T, Banyasz A, Lazzarotto E, Markovitsi D, Scalmani G, Frisch MJ, Barone V, Improta R
* Singlet excited-state behavior of uracil and thymine in aqueous solution: A combined experimental and computational study of 11 uracil derivatives (484 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jan 18; 128(2): 607-619.
Impact Factor: 7.696
View Export to BibTeX Export to EndNote
d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (352 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
View Export to BibTeX Export to EndNote
Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (247 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
View Export to BibTeX Export to EndNote
* Local tumor control and treatment related toxicity after plaque brachytherapy for uveal melanoma: A systematic review and a data pooled analysis (10 views)
Radiother Oncol (ISSN: 0167-8140linking), 2022 Jan; 166: 15-25.
Impact Factor: 6.28
View Export to BibTeX Export to EndNote
Bonaccorso C, Grasso G, Musso N, Barresi V, Condorelli DF, La Mendola D, Rizzarelli E
* Water soluble glucose derivative of thiocarbohydrazone acts as ionophore with cytotoxic effects on tumor cells (332 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 1873-3344electronic), 2018; 182: 92-102.
Impact Factor: 3.317
View Export to BibTeX Export to EndNote
D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (441 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
View Export to BibTeX Export to EndNote
Orditura M, Galizia G, Di Martino N, Ancona E, Castoro C, Pacelli R, Morgillo F, Rossetti S, Gambardella V, Farella A, Laterza MM, Ruol A, Fabozzi A, Napolitano V, Iovino F, Lieto E, Fei L, Conzo G, Ciardiello F, De Vita F
* Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study (1873 views)
Curr Oncol (ISSN: 1198-0052, 1718-7729electronic, 1198-0052linking), 2014 Jun; 21(3): 125-133.
Impact Factor: 1.785
View Export to BibTeX Export to EndNote
Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
* Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (351 views)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Impact Factor: 2.39
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (637 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
View Export to BibTeX Export to EndNote
Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (735 views)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
View Export to BibTeX Export to EndNote
Storto G, Nicolai E, Salvatore M
* [18F]FDG-PET-CT for early monitoring of tumor response: When and why (372 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2009 Apr; 53(2): 167-180.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Gustavsson T, Sarkar N, Banyasz A, Markovitsi D, Improta R
* Solvent effects on the steady-state absorption and fluorescence spectra of uracil, thymine and 5-fluorouracil (351 views)
Photochem Photobiol (ISSN: 0031-8655), 2007 May; 83(3): 595-599.
Impact Factor: 2.172
View Export to BibTeX Export to EndNote
Santoro F, Barone V, Gustavsson T, Improta R
* Solvent effect on the singlet excited-state lifetimes of nucleic acid bases: A computational study of 5-fluorouracil and uracil in acetonitrile and water (833 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Dec 20; 128(50): 16312-16322.
Impact Factor: 7.696
View Export to BibTeX Export to EndNote
Gustavsson T, Sarkar N, Lazzarotto E, Markovitsi D, Barone V, Improta R
* Solvent effect on the singlet excited-state dynamics of 5-fluorouracil in acetonitrile as compared with water (315 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2006 Jul 6; 110(26): 12843-12847.
Impact Factor: 4.115
View Export to BibTeX Export to EndNote
Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (585 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Gustavsson T, Banyasz A, Lazzarotto E, Markovitsi D, Scalmani G, Frisch MJ, Barone V, Improta R
* Singlet excited-state behavior of uracil and thymine in aqueous solution: A combined experimental and computational study of 11 uracil derivatives (484 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jan 18; 128(2): 607-619.
Impact Factor: 7.696
View Export to BibTeX Export to EndNote
d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (352 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
View Export to BibTeX Export to EndNote
Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
* Rare diffuse peritoneal malignant neoplasms: CT findings in two cases (247 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2003 Nov; 28(6): 827-830.
Impact Factor: 0.996
View Export to BibTeX Export to EndNote
15 Records (15 excluding Abstracts).
Total impact factor: 61.249 (61.249 excluding Abstracts).
Total 5 year impact factor: 67.886 (67.886 excluding Abstracts).
Total impact factor: 61.249 (61.249 excluding Abstracts).
Total 5 year impact factor: 67.886 (67.886 excluding Abstracts).
394 views. Last view on Saturday 21 January 2023, 11:43:30
ibb.cnr.it
