The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0, 5-year impact factor: 0
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84899507056&partnerID=40&md5=1a5c63137254d5091ee5597590b626fe
Keywords: Charged Particles, Compensation (personnel), Societies And Institutions, Telescopes, European Organization For Nuclear Researches, Experimental Apparatus, Extensive Air Showers, High School, Multi-Gap Resistive Plate Chambers, Muon Telescope, Temporal Resolution, Tracking Detectors, Cosmic Rays, Cholecystokinin, Dota, Gastrin, Tumour, 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid, Cholecystokinin B Receptor, Gastrin Receptor, Indium 111, Animal Cell, Autoradiography, Binding Affinity, Binding Site, Cancer Tissue, Comparative Study, Controlled Study, Dissociation Constant, Human, Human Cell, Human Tissue, In Vitro Study, Nonhuman, Protein Binding, Protein Localization, Protein Stability, Protein Transport, Receptor Affinity, Receptor Binding, Thyroid Medullary Carcinoma, Tissue Section, Amino Acid Sequence, Cell Line, Cooperative Behavior, Heterocyclic Compounds, 1-Ring, Indium Radioisotopes, Inhibitory Concentration 50, Molecular Sequence Data, Peptides,
Affiliations:
*** IBB - CNR ***
INFN, Department of Physics, University of Bologna, Italy
Centro Studi E Ricerche E. Fermi, Museo Storico della Fisica, Rome, Italy
INFN, Laboratori Nazionali di Frascati, Italy
World Laboratory, Lausanne, Switzerland
CERN Geneva, Switzerland
AF Medicina Nucleare, Istituto Nazionale Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
CIRPeB, Università Federico II, Naples, Italy
Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia
Molecular Radiopharmacy, Institute of Radioisotopes-Radiodiagnostic Products, National Center for Scientific Research Demokritos, Athens, Greece
Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and the London Queen Mary's School of Medicine and Dentistry, London, United Kingdom
University of Berne, Berne, Switzerland
CIRPeB, Universit Federico II, Naples, Italy
References:
Progetto, La scienza nelle scuole (2005) EEE Extreme Energy Events, , http://www.centrofermi.it/eee, Antonino Zichichi, Italian Physical Societ
Antolini, R., The EEE project (2005) 29th ICRC Proceedings, 8, p. 279. , Pune
Akindinov, A.N., (2000) Nucl. Instr. and Meth., A456, p. 16
Antolini, R., (2007) Nuclear Physics, B165, p. 333. , Proc. Suppl
An, S., (2007) Proceedings of the VCI2007 Conference, , Vienna, to be published on Nucl. Instr. and Meth. A
Abbrescia, M., Multigap resistive plate chambers for EAS study in the EEE project (2007) 30th ICRC, , these Proceedings
Anghinolfi, A., (2004) Nucl. Instr. and Meth., A533, p. 183
Abbrescia, M., (2007) Proceedings of the RICAP07 Conference, , Rome, to be published on Nucl. Instr. and Meth. A
Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocrine Reviews, 24 (4), pp. 389-427. , DOI 10.1210/er.2002-000
Reubi, J.C., Schaer, J.-C., Waser, B., Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Research, 57 (7), pp. 1377-1386
Roman, S., Mehta, P., Sosa, J.A., Medullary thyroid cancer: Early detection and novel treatments (2009) Curr Opin Oncol, 21, pp. 5-10
Behe, M., Becker, W., Gotthardt, M., Angerstein, C., Behr, T.M., Improved kinetic stability of DTPA-DGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: Preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives (2003) European Journal of Nuclear Medicine and Molecular Imaging, 30 (8), pp. 1140-1146. , DOI 10.1007/s00259-003-1178-1
Behr, T.M., Behe, M., Becker, W., Diagnostic applications of radiolabeled peptides in nuclear endocrinology (1999) Quarterly Journal of Nuclear Medicine, 43 (3), pp. 268-280
Good, S., Walter, M.A., Waser, B., Wang, X., Müller-Brand, J., Béhé, M.P., Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours (2008) Eur J Nucl Med Mol Imaging, 35, pp. 1868-1877. , doi:10.1007/s00259-008-0803-4
Aloj, L., Caraco, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-b receptor imaging (2004) Journal of Nuclear Medicine, 45 (3), pp. 485-494. , http://jnm.snmjournals.org/cgi/reprint/45/3/485
Reubi, J.C., Waser, B., Schaer, J.C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M.A., Bugaj, J.E., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) European Journal of Nuclear Medicine, 25 (5), pp. 481-490. , DOI 10.1007/s002590050247
Von Guggenberg, E., Sallegger, W., Helbok, A., Ocak, M., King, R., Mather, S.J., Cyclic minigastrin analogues for gastrin receptor scintigraphy with technetium-99m: Preclinical evaluation (2009) J Med Chem, 52, pp. 4786-4793. , doi:10.1021/jm900400w
Roosenburg, S., Laverman, P., Joosten, L., Eek, A., Oyen, W.J., De Jong, M., Stabilized (111)In-labeled sCCK8 analogues for targeting CCK2-receptor positive tumors: Synthesis and evaluation (2010) Bioconjug Chem, 21, pp. 663-670. , doi:10.1021/bc900465y
Mather, S.J., McKenzie, A.J., Sosabowski, J.K., Morris, T.M., Ellison, D., Watson, S.A., Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy (2007) Journal of Nuclear Medicine, 48 (4), pp. 615-622. , http://jnm.snmjournals.org/cgi/reprint/48/4/615, DOI 10.2967/jnumed.106.037085
Sosabowski, J.K., Matzow, T., Foster, J.M., Finucane, C., Ellison, D., Watson, S.A., Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide (2009) J Nucl Med, 50, pp. 2082-2089. , doi:10.2967/jnumed.109.064808
Nock, B.A., Maina, T., Behe, M., Nikolopoulou, A., Gotthardt, M., Schmitt, J.S., Behr, T.M., Macke, H.R., CCK-2/gastrin receptor-targeted tumor imaging with 99mTc- labeled minigastrin analogs (2005) Journal of Nuclear Medicine, 46 (10), pp. 1727-1736
Fröberg, A.C., De Jong, M., Nock, B.A., Breeman, W.A., Erion, J.L., Maina, T., Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1265-1272. , doi:10.1007/s00259-009-1098-9
Béhé, M., Behr, T.M., Cholecystokinin-B (CCK-B)/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies (2002) Biopolymers, 66, pp. 399-418. , doi:10.1002/bip.10356
Behe, M., Kluge, G., Becker, W., Gotthardt, M., Behr, T.M., Use of polyglutamic acids to reduce uptake of radiometal-labeled minigastrin in the kidneys (2005) Journal of Nuclear Medicine, 46 (6), pp. 1012-1015
Laverman, P., Roosenburg, S., Gotthardt, M., Park, J., Oyen, W.J., De Jong, M., Targeting of a CCK 2) receptor splice variant with 111)In-labelled cholecystokinin-8 (CCK8) and (111)In-labelled minigastrin (2008) Eur J Nucl Med Mol Imaging, 35, pp. 386-392. , doi:10.1007/s00259-007-0604-1
Ocak, M., Helbok, A., Rangger, C., Peitl, P.K., Nock, B., Morelli, G., Comparison of biological stability and metabolism of CCK2-receptor targeting peptides, a collaborative project under COST BM0607 (2011) Eur J Nucl Med Mol Imaging, , in press
Sosabowski, J.K., Finucane, C., Foster, J.M., Ellison, D., Burnet, J., Laverman, P., (2011) Comparison of 111In-Labelled CCK2-Receptor Targeting Peptides using NanoSPECT/CT imaging, , Submitted for publication
Giragossian, C., Mierke, D.F., Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor (2002) Biochemistry, 41 (14), pp. 4560-4566. , DOI 10.1021/bi0160009
D'Andrea, L.D., Testa, I., Panico, M., Di Stasi, R., Caracó, C., Tarallo, L., In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with 99mTc-tricarbonyl (2008) Biopolymers, 90, pp. 707-712. , doi:10.1002/bip.21041
Tornesello, A.L., Aurilio, M., Accardo, A., Tarallo, L., Barbieri, A., Arra, C., Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (2011) J Pept Sci, 17, pp. 405-412. , doi:10.1002/psc.1327
Marsouvanidis, P.J., Tatsi, A., Nock, B.A., Krenning, E.P., Maina, T., De Jong, M., [111In] Sargastrin, a Gastrin I-based radioligand targeting CCK2-R-positive tumors in vivo (2009) Eur J Nucl Med Mol Imaging, 36, pp. S259
Kolenc-Peitl, P., Mansi, R., Tamma, M.L., Gmeiner-Stopar, T., Sollner-Dolenc, M., Waser, B., Highly improved metabolic stability and pharmacokinetics of indium-111-DOTA-gastrin conjugates for targeting of the gastrin receptor (2011) J Med Chem, , In press
Reubi, J. C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocrine Reviews, 24 (4), pp. 389-427. , DOI 10. 1210/er. 2002-000
Reubi, J. C., Schaer, J. -C., Waser, B., Cholecystokinin (CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Research, 57 (7), pp. 1377-1386
Behr, T. M., Behe, M., Becker, W., Diagnostic applications of radiolabeled peptides in nuclear endocrinology (1999) Quarterly Journal of Nuclear Medicine, 43 (3), pp. 268-280
Reubi, J. C., Waser, B., Schaer, J. C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M. A., Bugaj, J. E., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) European Journal of Nuclear Medicine, 25 (5), pp. 481-490. , DOI 10. 1007/s002590050247
Mather, S. J., McKenzie, A. J., Sosabowski, J. K., Morris, T. M., Ellison, D., Watson, S. A., Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy (2007) Journal of Nuclear Medicine, 48 (4), pp. 615-622. , http: //jnm. snmjournals. org/cgi/reprint/48/4/615, DOI 10. 2967/jnumed. 106. 037085
Nock, B. A., Maina, T., Behe, M., Nikolopoulou, A., Gotthardt, M., Schmitt, J. S., Behr, T. M., Macke, H. R., CCK-2/gastrin receptor-targeted tumor imaging with 99mTc- labeled minigastrin analogs (2005) Journal of Nuclear Medicine, 46 (10), pp. 1727-1736
Fr berg, A. C., De Jong, M., Nock, B. A., Breeman, W. A., Erion, J. L., Maina, T., Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1265-1272. , doi: 10. 1007/s00259-009-1098-9
B h, M., Behr, T. M., Cholecystokinin-B (CCK-B) /gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies (2002) Biopolymers, 66, pp. 399-418. , doi: 10. 1002/bip. 10356
Sosabowski, J. K., Finucane, C., Foster, J. M., Ellison, D., Burnet, J., Laverman, P., (2011) Comparison of 111In-Labelled CCK2-Receptor Targeting Peptides using NanoSPECT/CT imaging, , Submitted for publication
D'Andrea, L. D., Testa, I., Panico, M., Di Stasi, R., Carac, C., Tarallo, L., In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with 99mTc-tricarbonyl (2008) Biopolymers, 90, pp. 707-712. , doi: 10. 1002/bip. 21041
Tornesello, A. L., Aurilio, M., Accardo, A., Tarallo, L., Barbieri, A., Arra, C., Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (2011) J Pept Sci, 17, pp. 405-412. , doi: 10. 1002/psc. 1327
Marsouvanidis, P. J., Tatsi, A., Nock, B. A., Krenning, E. P., Maina, T., De Jong, M., [111In] Sargastrin, a Gastrin I-based radioligand targeting CCK2-R-positive tumors in vivo (2009) Eur J Nucl Med Mol Imaging, 36, pp. S259
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0, 5-year impact factor: 0
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84899507056&partnerID=40&md5=1a5c63137254d5091ee5597590b626fe
Keywords: Charged Particles, Compensation (personnel), Societies And Institutions, Telescopes, European Organization For Nuclear Researches, Experimental Apparatus, Extensive Air Showers, High School, Multi-Gap Resistive Plate Chambers, Muon Telescope, Temporal Resolution, Tracking Detectors, Cosmic Rays, Cholecystokinin, Dota, Gastrin, Tumour, 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid, Cholecystokinin B Receptor, Gastrin Receptor, Indium 111, Animal Cell, Autoradiography, Binding Affinity, Binding Site, Cancer Tissue, Comparative Study, Controlled Study, Dissociation Constant, Human, Human Cell, Human Tissue, In Vitro Study, Nonhuman, Protein Binding, Protein Localization, Protein Stability, Protein Transport, Receptor Affinity, Receptor Binding, Thyroid Medullary Carcinoma, Tissue Section, Amino Acid Sequence, Cell Line, Cooperative Behavior, Heterocyclic Compounds, 1-Ring, Indium Radioisotopes, Inhibitory Concentration 50, Molecular Sequence Data, Peptides,
Affiliations:
*** IBB - CNR ***
INFN, Department of Physics, University of Bologna, Italy
Centro Studi E Ricerche E. Fermi, Museo Storico della Fisica, Rome, Italy
INFN, Laboratori Nazionali di Frascati, Italy
World Laboratory, Lausanne, Switzerland
CERN Geneva, Switzerland
AF Medicina Nucleare, Istituto Nazionale Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
CIRPeB, Università Federico II, Naples, Italy
Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia
Molecular Radiopharmacy, Institute of Radioisotopes-Radiodiagnostic Products, National Center for Scientific Research Demokritos, Athens, Greece
Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and the London Queen Mary's School of Medicine and Dentistry, London, United Kingdom
University of Berne, Berne, Switzerland
CIRPeB, Universit Federico II, Naples, Italy
References:
Progetto, La scienza nelle scuole (2005) EEE Extreme Energy Events, , http://www.centrofermi.it/eee, Antonino Zichichi, Italian Physical Societ
Antolini, R., The EEE project (2005) 29th ICRC Proceedings, 8, p. 279. , Pune
Akindinov, A.N., (2000) Nucl. Instr. and Meth., A456, p. 16
Antolini, R., (2007) Nuclear Physics, B165, p. 333. , Proc. Suppl
An, S., (2007) Proceedings of the VCI2007 Conference, , Vienna, to be published on Nucl. Instr. and Meth. A
Abbrescia, M., Multigap resistive plate chambers for EAS study in the EEE project (2007) 30th ICRC, , these Proceedings
Anghinolfi, A., (2004) Nucl. Instr. and Meth., A533, p. 183
Abbrescia, M., (2007) Proceedings of the RICAP07 Conference, , Rome, to be published on Nucl. Instr. and Meth. A
Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocrine Reviews, 24 (4), pp. 389-427. , DOI 10.1210/er.2002-000
Reubi, J.C., Schaer, J.-C., Waser, B., Cholecystokinin (CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Research, 57 (7), pp. 1377-1386
Roman, S., Mehta, P., Sosa, J.A., Medullary thyroid cancer: Early detection and novel treatments (2009) Curr Opin Oncol, 21, pp. 5-10
Behe, M., Becker, W., Gotthardt, M., Angerstein, C., Behr, T.M., Improved kinetic stability of DTPA-DGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: Preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives (2003) European Journal of Nuclear Medicine and Molecular Imaging, 30 (8), pp. 1140-1146. , DOI 10.1007/s00259-003-1178-1
Behr, T.M., Behe, M., Becker, W., Diagnostic applications of radiolabeled peptides in nuclear endocrinology (1999) Quarterly Journal of Nuclear Medicine, 43 (3), pp. 268-280
Good, S., Walter, M.A., Waser, B., Wang, X., Müller-Brand, J., Béhé, M.P., Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours (2008) Eur J Nucl Med Mol Imaging, 35, pp. 1868-1877. , doi:10.1007/s00259-008-0803-4
Aloj, L., Caraco, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-b receptor imaging (2004) Journal of Nuclear Medicine, 45 (3), pp. 485-494. , http://jnm.snmjournals.org/cgi/reprint/45/3/485
Reubi, J.C., Waser, B., Schaer, J.C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M.A., Bugaj, J.E., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) European Journal of Nuclear Medicine, 25 (5), pp. 481-490. , DOI 10.1007/s002590050247
Von Guggenberg, E., Sallegger, W., Helbok, A., Ocak, M., King, R., Mather, S.J., Cyclic minigastrin analogues for gastrin receptor scintigraphy with technetium-99m: Preclinical evaluation (2009) J Med Chem, 52, pp. 4786-4793. , doi:10.1021/jm900400w
Roosenburg, S., Laverman, P., Joosten, L., Eek, A., Oyen, W.J., De Jong, M., Stabilized (111)In-labeled sCCK8 analogues for targeting CCK2-receptor positive tumors: Synthesis and evaluation (2010) Bioconjug Chem, 21, pp. 663-670. , doi:10.1021/bc900465y
Mather, S.J., McKenzie, A.J., Sosabowski, J.K., Morris, T.M., Ellison, D., Watson, S.A., Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy (2007) Journal of Nuclear Medicine, 48 (4), pp. 615-622. , http://jnm.snmjournals.org/cgi/reprint/48/4/615, DOI 10.2967/jnumed.106.037085
Sosabowski, J.K., Matzow, T., Foster, J.M., Finucane, C., Ellison, D., Watson, S.A., Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide (2009) J Nucl Med, 50, pp. 2082-2089. , doi:10.2967/jnumed.109.064808
Nock, B.A., Maina, T., Behe, M., Nikolopoulou, A., Gotthardt, M., Schmitt, J.S., Behr, T.M., Macke, H.R., CCK-2/gastrin receptor-targeted tumor imaging with 99mTc- labeled minigastrin analogs (2005) Journal of Nuclear Medicine, 46 (10), pp. 1727-1736
Fröberg, A.C., De Jong, M., Nock, B.A., Breeman, W.A., Erion, J.L., Maina, T., Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1265-1272. , doi:10.1007/s00259-009-1098-9
Béhé, M., Behr, T.M., Cholecystokinin-B (CCK-B)/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies (2002) Biopolymers, 66, pp. 399-418. , doi:10.1002/bip.10356
Behe, M., Kluge, G., Becker, W., Gotthardt, M., Behr, T.M., Use of polyglutamic acids to reduce uptake of radiometal-labeled minigastrin in the kidneys (2005) Journal of Nuclear Medicine, 46 (6), pp. 1012-1015
Laverman, P., Roosenburg, S., Gotthardt, M., Park, J., Oyen, W.J., De Jong, M., Targeting of a CCK 2) receptor splice variant with 111)In-labelled cholecystokinin-8 (CCK8) and (111)In-labelled minigastrin (2008) Eur J Nucl Med Mol Imaging, 35, pp. 386-392. , doi:10.1007/s00259-007-0604-1
Ocak, M., Helbok, A., Rangger, C., Peitl, P.K., Nock, B., Morelli, G., Comparison of biological stability and metabolism of CCK2-receptor targeting peptides, a collaborative project under COST BM0607 (2011) Eur J Nucl Med Mol Imaging, , in press
Sosabowski, J.K., Finucane, C., Foster, J.M., Ellison, D., Burnet, J., Laverman, P., (2011) Comparison of 111In-Labelled CCK2-Receptor Targeting Peptides using NanoSPECT/CT imaging, , Submitted for publication
Giragossian, C., Mierke, D.F., Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor (2002) Biochemistry, 41 (14), pp. 4560-4566. , DOI 10.1021/bi0160009
D'Andrea, L.D., Testa, I., Panico, M., Di Stasi, R., Caracó, C., Tarallo, L., In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with 99mTc-tricarbonyl (2008) Biopolymers, 90, pp. 707-712. , doi:10.1002/bip.21041
Tornesello, A.L., Aurilio, M., Accardo, A., Tarallo, L., Barbieri, A., Arra, C., Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (2011) J Pept Sci, 17, pp. 405-412. , doi:10.1002/psc.1327
Marsouvanidis, P.J., Tatsi, A., Nock, B.A., Krenning, E.P., Maina, T., De Jong, M., [111In] Sargastrin, a Gastrin I-based radioligand targeting CCK2-R-positive tumors in vivo (2009) Eur J Nucl Med Mol Imaging, 36, pp. S259
Kolenc-Peitl, P., Mansi, R., Tamma, M.L., Gmeiner-Stopar, T., Sollner-Dolenc, M., Waser, B., Highly improved metabolic stability and pharmacokinetics of indium-111-DOTA-gastrin conjugates for targeting of the gastrin receptor (2011) J Med Chem, , In press
Reubi, J. C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocrine Reviews, 24 (4), pp. 389-427. , DOI 10. 1210/er. 2002-000
Reubi, J. C., Schaer, J. -C., Waser, B., Cholecystokinin (CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Research, 57 (7), pp. 1377-1386
Behr, T. M., Behe, M., Becker, W., Diagnostic applications of radiolabeled peptides in nuclear endocrinology (1999) Quarterly Journal of Nuclear Medicine, 43 (3), pp. 268-280
Reubi, J. C., Waser, B., Schaer, J. C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M. A., Bugaj, J. E., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) European Journal of Nuclear Medicine, 25 (5), pp. 481-490. , DOI 10. 1007/s002590050247
Mather, S. J., McKenzie, A. J., Sosabowski, J. K., Morris, T. M., Ellison, D., Watson, S. A., Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy (2007) Journal of Nuclear Medicine, 48 (4), pp. 615-622. , http: //jnm. snmjournals. org/cgi/reprint/48/4/615, DOI 10. 2967/jnumed. 106. 037085
Nock, B. A., Maina, T., Behe, M., Nikolopoulou, A., Gotthardt, M., Schmitt, J. S., Behr, T. M., Macke, H. R., CCK-2/gastrin receptor-targeted tumor imaging with 99mTc- labeled minigastrin analogs (2005) Journal of Nuclear Medicine, 46 (10), pp. 1727-1736
Fr berg, A. C., De Jong, M., Nock, B. A., Breeman, W. A., Erion, J. L., Maina, T., Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma (2009) Eur J Nucl Med Mol Imaging, 36, pp. 1265-1272. , doi: 10. 1007/s00259-009-1098-9
B h, M., Behr, T. M., Cholecystokinin-B (CCK-B) /gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies (2002) Biopolymers, 66, pp. 399-418. , doi: 10. 1002/bip. 10356
Sosabowski, J. K., Finucane, C., Foster, J. M., Ellison, D., Burnet, J., Laverman, P., (2011) Comparison of 111In-Labelled CCK2-Receptor Targeting Peptides using NanoSPECT/CT imaging, , Submitted for publication
D'Andrea, L. D., Testa, I., Panico, M., Di Stasi, R., Carac, C., Tarallo, L., In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with 99mTc-tricarbonyl (2008) Biopolymers, 90, pp. 707-712. , doi: 10. 1002/bip. 21041
Tornesello, A. L., Aurilio, M., Accardo, A., Tarallo, L., Barbieri, A., Arra, C., Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (2011) J Pept Sci, 17, pp. 405-412. , doi: 10. 1002/psc. 1327
Marsouvanidis, P. J., Tatsi, A., Nock, B. A., Krenning, E. P., Maina, T., De Jong, M., [111In] Sargastrin, a Gastrin I-based radioligand targeting CCK2-R-positive tumors in vivo (2009) Eur J Nucl Med Mol Imaging, 36, pp. S259
The EEE project
The EEE (Extreme Energy Events) Project, conceived many years ago by its leader Antonino Zichichi [1], aims to study high-energy extensive air showers through the detection of the shower muon component by means of a network of tracking detectors, namely telescopes, installed in Italian High Schools. The Project is supported by the "Ministero dell'Istruzione, Universit̃A e Ricerca (MIUR)", "Museo Storico della Fisica e Centro Studi e Ricerche E. Fermi", "Istituto Nazionale di Fisica Nucleare (INFN)" and the European Organization for Nuclear Research (CERN). The single tracking telescope for a school is composed by 3 large (∼ 2 m2 each) Multi-gap Resistive Plate Chambers (MRPC). Using a very high precision particle detector based on MRPCs allows a very high accuracy direction reconstruction for energetic showers, together with a very good temporal resolution. In its first phase the telescopes are going to be installed in 23 High Schools located in seven pilot towns all over Italy. In the near future, as soon as new fundings will be provided, the network will be upgraded adding new High Schools and towns. The first muon telescopes have been installed in two schools nearby Rome and in one school nearby Bologna, and are successfully running. By the end of the year 2007, other telescopes will be installed. Here we present the experimental apparatus and its tasks.
The EEE (Extreme Energy Events) Project, conceived many years ago by its leader Antonino Zichichi [1], aims to study high-energy extensive air showers through the detection of the shower muon component by means of a network of tracking detectors, namely telescopes, installed in Italian High Schools. The Project is supported by the "Ministero dell'Istruzione, Universit̃A e Ricerca (MIUR)", "Museo Storico della Fisica e Centro Studi e Ricerche E. Fermi", "Istituto Nazionale di Fisica Nucleare (INFN)" and the European Organization for Nuclear Research (CERN). The single tracking telescope for a school is composed by 3 large (∼ 2 m2 each) Multi-gap Resistive Plate Chambers (MRPC). Using a very high precision particle detector based on MRPCs allows a very high accuracy direction reconstruction for energetic showers, together with a very good temporal resolution. In its first phase the telescopes are going to be installed in 23 High Schools located in seven pilot towns all over Italy. In the near future, as soon as new fundings will be provided, the network will be upgraded adding new High Schools and towns. The first muon telescopes have been installed in two schools nearby Rome and in one school nearby Bologna, and are successfully running. By the end of the year 2007, other telescopes will be installed. Here we present the experimental apparatus and its tasks.
The EEE project
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