Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (509 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
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Paper type: Journal Article, Review,
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Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79954479044&partnerID=40&md5=736a90e7eed662b18b9d9e9a0e8e3f83
Keywords: 7-14 Bombesin, Amphotericin B, Amphotericin B Lipid Complex, Chelating Agent, Cholecystokinin A Receptor, Cholecystokinin B Receptor, Cholecystokinin Octapeptide, Cyclophosphamide, Daunorubicin, Docetaxel, Doxorubicin, Gadolinium Diethylenetriamine Pentaacetic Acid, Gadolinium Pentetate, Gadoteridol, Liposome, Monomer, Nanoparticle, Naposome, Nuclear Magnetic Resonance Imaging Agent, Octroscan, Paclitaxel, Pentetreotide In 111, Peptide Derivative, Polysorbate 80, Unclassified Drug, Vincristine, Breast Cancer, Cardiotoxicity, Cell Proliferation, Drug Determination, Drug Dosage Form Comparison, Drug Efficacy, Drug Formulation, Drug Receptor Binding, Drug Safety, Encapsulation, Flow Cytometry, Gastrointestinal Symptom, Human, Hydrophobicity, Lung Metastasis, Lymphoma, Melanoma, Micelle, Molecular Weight, Nervous System Tumor, Neuroendocrine Tumor, Nonhuman, Particle Size, Priority Journal, Contrast Media, Drug Delivery Systems,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences and CIRPeB, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
References:
Not available.
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Review,
Impact factor: 0, 5-year impact factor: 0
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79954479044&partnerID=40&md5=736a90e7eed662b18b9d9e9a0e8e3f83
Keywords: 7-14 Bombesin, Amphotericin B, Amphotericin B Lipid Complex, Chelating Agent, Cholecystokinin A Receptor, Cholecystokinin B Receptor, Cholecystokinin Octapeptide, Cyclophosphamide, Daunorubicin, Docetaxel, Doxorubicin, Gadolinium Diethylenetriamine Pentaacetic Acid, Gadolinium Pentetate, Gadoteridol, Liposome, Monomer, Nanoparticle, Naposome, Nuclear Magnetic Resonance Imaging Agent, Octroscan, Paclitaxel, Pentetreotide In 111, Peptide Derivative, Polysorbate 80, Unclassified Drug, Vincristine, Breast Cancer, Cardiotoxicity, Cell Proliferation, Drug Determination, Drug Dosage Form Comparison, Drug Efficacy, Drug Formulation, Drug Receptor Binding, Drug Safety, Encapsulation, Flow Cytometry, Gastrointestinal Symptom, Human, Hydrophobicity, Lung Metastasis, Lymphoma, Melanoma, Micelle, Molecular Weight, Nervous System Tumor, Neuroendocrine Tumor, Nonhuman, Particle Size, Priority Journal, Contrast Media, Drug Delivery Systems,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences and CIRPeB, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
References:
Not available.
Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications
Modified supramolecular aggregates for selective delivery of contrast agents and/or drugs are examined with a focus on a new class of peptide-derivatized nanoparticles: naposomes. These nanoparticles are based on the co-aggregation of two different amphiphilic monomers that give aggregates of different shapes and sizes (micelles, vesicles and liposomes) with diameters ranging between 10 and 300 nm. Structural properties and in vitro and in vivo behaviors are discussed. For the high relaxitivity values (12-19 mM -1s -1) and to detect for the presence of a surface-exposed peptide, the new peptide-derived supramolecular aggregates are very promising candidates as target-selective MRI contrast agents. The efficiency of surface-exposed peptides in homing these nanovectors to a specific target introduces promising new opportunities for the development of diagnostic and therapeutic agents with high specificity toward the biological target and reduced toxic side effects on nontarget organs. © 2011 Future Science Ltd.
Modified supramolecular aggregates for selective delivery of contrast agents and/or drugs are examined with a focus on a new class of peptide-derivatized nanoparticles: naposomes. These nanoparticles are based on the co-aggregation of two different amphiphilic monomers that give aggregates of different shapes and sizes (micelles, vesicles and liposomes) with diameters ranging between 10 and 300 nm. Structural properties and in vitro and in vivo behaviors are discussed. For the high relaxitivity values (12-19 mM -1s -1) and to detect for the presence of a surface-exposed peptide, the new peptide-derived supramolecular aggregates are very promising candidates as target-selective MRI contrast agents. The efficiency of surface-exposed peptides in homing these nanovectors to a specific target introduces promising new opportunities for the development of diagnostic and therapeutic agents with high specificity toward the biological target and reduced toxic side effects on nontarget organs. © 2011 Future Science Ltd.
Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications
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Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 4.627
View Export to BibTeX Export to EndNote
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Impact Factor: 3.446
View Export to BibTeX Export to EndNote
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Impact Factor: 4.214
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (718 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
View Export to BibTeX Export to EndNote
De Luca S, Saviano M, Lassiani L, Yannakopoulou K, Stefanidou P, Aloj L, Morelli G, Varnavas A
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Impact Factor: 5.115
View Export to BibTeX Export to EndNote
De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (573 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (477 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (572 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (588 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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Morelli G, De Luca S, Tesauro D, Saviano M, Pedone C, Dolmella A, Visentin R, Mazzi U
* CCK8 peptide derivatized with diphenylphosphine for rhenium labelling: Synthesis and molecular mechanics calculations (451 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2002 Jul; 8(7): 373-381.
Impact Factor: 1.691
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De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (570 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
Impact Factor: 1.451
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30 Records (27 excluding Abstracts).
Total impact factor: 96.621 (83.964 excluding Abstracts).
Total 5 year impact factor: 97.161 (83.983 excluding Abstracts).
Total impact factor: 96.621 (83.964 excluding Abstracts).
Total 5 year impact factor: 97.161 (83.983 excluding Abstracts).
509 views. Last view on Tuesday 10 December 2024, 11:17:12
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