New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (1334 views)
Biochemical Journal, 2012 Apr 1; 443: 231-240.
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Paper type: Journal Article,
Impact factor: 4.779, 5-year impact factor: 4.95
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84858326728&partnerID=40&md5=faa27d1fb46c92fdd0ce041ebc1b452d
Keywords: Janus Kinase Signal Transducer And Activator Of Transcription Pathway (jak Stat Pathway), Kinase Inhibitory Region (kir), Mimetic Peptide, Peptide Library, Suppressor Of Cytokine Signalling 1 (socs1), Gamma Interferon, Interferon Regulatory Factor 1, Stat1 Protein, Suppressor Of Cytokine Signaling 1, Amino Acid Sequence, Article, Binding Affinity, Catalysis, Controlled Study, Enzyme Activation, Enzyme Activity, Enzyme Stability, Human, Human Cell, Keratinocyte, Normal Human, Priority Journal, Protein Analysis, Protein Binding, Protein Function, Protein Interaction, Protein Phosphorylation, Protein Structure, Protein Synthesis, Signal Transduction, Competitive, Catalytic Domain, Cultured, Circular Dichroism, Drug Evaluation, Preclinical, Drug Stability, Models, Molecular, Molecular Sequence Data, Secondary, Tertiary, Stat1 Transcription Factor, Suppressor Of Cytokine Signaling Proteins,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging - IBB-CNR, Via Mezzocannone 16, 80134, Naples, Italy
Laboratory of Experimental Immunology, Istituto Dermopatico dell'Immacolata, Via Monti di Creta 104, 00167 Rome, Italy
Department of Biological Sciences, School of Biotechnological Sciences, University Federico II, Via Mezzocannone 16, 80134, Naples, Italy
References:
Ihle, J.N., Witthuhn, B.A., Quelle, F.W., Yamamoto, K., Silvennoinen, O., Signaling through the hematopoietic cytokine receptors (1995) Annu. Rev. Immunol., 13, pp. 369-39
Sasaki, A., Yasukawa, H., Suzuki, A., Kamizono, S., Syoda, T., Kinjyo, I., Sasaki, M., Yoshimura, A., Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain (1999) Genes to Cells, 4 (6), pp. 339-351. , DOI 10.1046/j.1365-2443.1999.00263.x
Alexander, W.S., Suppressors of cytokine signalling (SOCS) in the immune system (2002) Nat. Rev. Immunol., 2, pp. 410-416
Alexander, W.S., Hilton, D.J., The role of Suppressors of Cytokine Signaling (SOCS) proteins in regulation of the immune response (2004) Annual Review of Immunology, 22, pp. 503-529. , DOI 10.1146/annurev.immunol.22.091003.090312
Ilangumaran, S., Ramanathan, S., Rottapel, R., Regulation of the immune system by SOCS family adaptor proteins (2004) Seminars in Immunology, 16 (6), pp. 351-365. , DOI 10.1016/j.smim.2004.08.015, PII S104453230400048X, Adaptors in Immune Regulation
Darnell Jr., J.E., Kerr, I.M., Stark, G.R., Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins (1994) Science, 264 (5164), pp. 1415-1421
Platanias, L.C., Mechanisms of type-I- And type-II-interferon-mediated signalling (2005) Nat. Rev. Immunol., 5, pp. 375-386
Shuai, K., Liu, B., Regulation of JAK-STAT signalling in the immune system (2003) Nature Reviews Immunology, 3 (11), pp. 900-911
Wormald, S., Hilton, D.J., Inhibitors of Cytokine Signal Transduction (2004) Journal of Biological Chemistry, 279 (2), pp. 821-824. , DOI 10.1074/jbc.R300030200
Gregorieff, A., Pyronnet, S., Sonenberg, N., Veillette, A., Regulation of SOCS-1 expression by translational repression (2000) Journal of Biological Chemistry, 275 (28), pp. 21596-21604. , DOI 10.1074/jbc.M910087199
Larsen, L., Ropke, C., Suppressors of cytokine signalling: SOCS (2002) APMIS, 110 (12), pp. 833-844. , DOI 10.1034/j.1600-0463.2002.1101201.x
Endo, T.A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Yoshimura, A., A new protein containing an SH2 domain that inhibits JAK kinases (1997) Nature, 387 (6636), pp. 921-924. , DOI 10.1038/43213
Federici, M., Giustizieri, M.L., Scarponi, C., Girolomoni, G., Albanesi, C., Impaired IFN-γ-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1 (2002) Journal of Immunology, 169 (1), pp. 434-442
Ungureanu, D., Saharinen, P., Junttila, I., Hilton, D.J., Silvennoinen, O., Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1 (2002) Molecular and Cellular Biology, 22 (10), pp. 3316-3326. , DOI 10.1128/MCB.22.10.3316-3326.2002
Alexander, W.S., Starr, R., Fenner, J.E., Scott, C.L., Handman, E., Sprigg, N.S., Corbin, J.E., Hilton, D.J., SOCS1 is a critical inhibitor of interferon γ signaling and prevents the potentially fatal neonatal actions of this cytokine (1999) Cell, 98 (5), pp. 597-608. , DOI 10.1016/S0092-8674(00)80047-1
Brysha, M., Zhang, J.G., Bertolino, P., Corbin, J.E., Alexander, W.S., Nicola, N.A., Hilton, D.J., Starr, R., Suppressor of cytokine signaling-1 attenuates the duration of interferon γ signal transduction in vitro and in vivo (2001) J. Biol. Chem., 276, pp. 22086-22089
Marine, J.-C., Topham, D.J., McKay, C., Wang, D., Parganas, E., Stravopodis, D., Yoshimura, A., Ihle, J.N., SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality (1999) Cell, 98 (5), pp. 609-616. , DOI 10.1016/S0092-8674(00)80048-3
Noon-Song, E.N., Ahmed, C.M., Dabelic, R., Canton, J., Johnson, H.M., Controlling nuclear JAKs and STATs for specific gene activation by IFNγ (2011) Biochem. Biophys. Res. Commun., 410, p. 648
Solomon, M., Flodstrom-Tullberg, M., Sarvetnick, N., β-Cell specific expression of suppressor of cytokine signaling-1 (SOCS-1) delays islet allograft rejection by down-regulating interferon regulatory factor-1 (IRF-1) signaling (2011) Transplant Immunol., 24, pp. 181-188
Yoshimura, A., Ohkubo, T., Kiguchi, T., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Hara, T., Miyajima, A., A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors (1995) EMBO J., 14, pp. 2816-2826
Nicholson, S.E., De Souza, D., Fabri, L.J., Corbin, J., Willson, T.A., Zhang, J.-G., Silva, A., Baca, M., Suppressor of cytokine signaling-3 preferentially binds to the SHP-2- binding site on the shared cytokine receptor subunit gp130 (2000) Proceedings of the National Academy of Sciences of the United States of America, 97 (12), pp. 6493-6498. , DOI 10.1073/pnas.100135197
Yasukawa, H., Misawa, H., Sakamoto, H., Masuhara, M., Sasaki, A., Wakioka, T., Ohtsuka, S., Yoshimura, A., The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop (1999) EMBO Journal, 18 (5), pp. 1309-1320
Giordanetto, F., Kroemer, R.T., A three-dimensional model of suppressor of cytokine signalling 1 (SOCS-1) (2003) Protein Engineering, 16 (2), pp. 115-124
Flowers, L.O., Subramaniam, P.S., Johnson, H.M., A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells (2005) Oncogene, 24 (12), pp. 2114-2120. , DOI 10.1038/sj.onc.1208437
Flowers, L.O., Johnson, H.M., Mujtaba, M.G., Ellis, M.R., Haider, S.M.I., Subramaniam, P.S., Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function (2004) Journal of Immunology, 172 (12), pp. 7510-7518
Waiboci, L.W., Ahmed, C.M., Mujtaba, M.G., Flowers, L.O., Martin, J.P., Haider, M.I., Johnson, H.M., Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: Implications for the development of a SOCS-1 antagonist (2007) Journal of Immunology, 178 (8), pp. 5058-5068
Madonna, S., Scarponi, C., Sestito, R., Pallotta, S., Cavani, A., Albanesi, C., The IFN-γ-dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic keratinocytes (2011) J. Immunol., 185, pp. 2467-2481
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Scognamiglio, P.L., Doti, N., Grieco, P., Pedone, C., Ruvo, M., Marasco, D., Discovery of small peptide antagonists of PED/PEA15-D4α interaction from simplified combinatorial libraries (2011) Chem. Biol. Drug Des., 77, pp. 319-327
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Hiemstra, H.S., Schloot, N.C., Van Veelen, P.A., Willemen, S.J.M., Franken, K.L.M.C., Van Rood, J.J., De Vries, R.R.P., Roep, B.O., Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (7), pp. 3988-3991. , DOI 10.1073/pnas.071050898
Chang, C.-Y., Norris, J.D., Gron, H., Paige, L.A., Hamilton, P.T., Kenan, D.J., Fowlkes, D., McDonnell, D.P., Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: Discovery of peptide antagonists of estrogen receptors α and β (1999) Molecular and Cellular Biology, 19 (12), pp. 8226-8239
Northrop, J.P., Nguyen, D., Piplani, S., Olivan, S.E., Kwan, S.T.-S., Go, N.F., Hart, C.P., Schatz, P.J., Selection of estrogen receptor β- and Thyroid hormone receptor β-specific coactivator-mimetic peptides using recombinant peptide libraries (2000) Molecular Endocrinology, 14 (5), pp. 605-622. , DOI 10.1210/me.14.5.605
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Burke, M.D., Berger, E.M., Schreiber, S.L., Generating Diverse Skeletons of Small Molecules Combinatorially (2003) Science, 302 (5645), pp. 613-618. , DOI 10.1126/science.1089946
Burke, M.D., Khan, S.A., Triggered enzymatic degradation of a water-soluble polymer solution using a novel inhibitor (2000) Biomacromolecules, 1, pp. 688-695
Geysen, H.M., Rodda, S.J., Mason, T.J., A priori delineation of a peptide which mimics a discontinuous antigenic determinant (1986) Molecular Immunology, 23 (7), pp. 709-715. , DOI 10.1016/0161-5890(86)90081-7
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Bos, J.D., De Korte, J., Effects of etanercept on quality of life, fatigue, and depression in psoriasis (2006) Lancet, 367 (9504), pp. 6-7. , DOI 10.1016/S0140-6736(05)67818-X, PII S014067360567818X
Dalpke, A., Heeg, K., Bartz, H., Baetz, A., Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins (2008) Immunobiology, 213 (3-4), pp. 225-235. , DOI 10.1016/j.imbio.2007.10.008, PII S0171298507001295
Yoshimura, A., Naka, T., Kubo, M., SOCS proteins, cytokine signalling and immune regulation (2007) Nature Reviews Immunology, 7 (6), pp. 454-465. , DOI 10.1038/nri2093, PII NRI2093
Babon, J.J., Sabo, J.K., Zhang, J.G., Nicola, N.A., Norton, R.S., The SOCS box encodes a hierarchy of affinities for Cullin5: Implications for ubiquitin ligase formation and cytokine signalling suppression (2009) J. Mol. Biol., 387, pp. 162-174
Kubo, M., Hanada, T., Yoshimura, A., Suppressors of cytokine signaling and immunity (2003) Nature Immunology, 4 (12), pp. 1169-1176. , DOI 10.1038/ni1012
Lacronique, V., Boureux, A., Della, V.V., Poirel, H., Tran, Q.C., Mauchauffe, M., Berthou, C., Bernard, O.A., A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia (1997) Science, 278 (5341), pp. 1309-1312. , DOI 10.1126/science.278.5341.1309
Ihle, J. N., Witthuhn, B. A., Quelle, F. W., Yamamoto, K., Silvennoinen, O., Signaling through the hematopoietic cytokine receptors (1995) Annu. Rev. Immunol., 13, pp. 369-39
Alexander, W. S., Suppressors of cytokine signalling (SOCS) in the immune system (2002) Nat. Rev. Immunol., 2, pp. 410-416
Alexander, W. S., Hilton, D. J., The role of Suppressors of Cytokine Signaling (SOCS) proteins in regulation of the immune response (2004) Annual Review of Immunology, 22, pp. 503-529. , DOI 10. 1146/annurev. immunol. 22. 091003. 090312
Darnell Jr., J. E., Kerr, I. M., Stark, G. R., Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins (1994) Science, 264 (5164), pp. 1415-1421
Platanias, L. C., Mechanisms of type-I- And type-II-interferon-mediated signalling (2005) Nat. Rev. Immunol., 5, pp. 375-386
Endo, T. A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Yoshimura, A., A new protein containing an SH2 domain that inhibits JAK kinases (1997) Nature, 387 (6636), pp. 921-924. , DOI 10. 1038/43213
Marine, J. -C., Topham, D. J., McKay, C., Wang, D., Parganas, E., Stravopodis, D., Yoshimura, A., Ihle, J. N., SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality (1999) Cell, 98 (5), pp. 609-616. , DOI 10. 1016/S0092-8674 (00) 80048-3
Noon-Song, E. N., Ahmed, C. M., Dabelic, R., Canton, J., Johnson, H. M., Controlling nuclear JAKs and STATs for specific gene activation by IFN (2011) Biochem. Biophys. Res. Commun., 410, p. 648
Nicholson, S. E., De Souza, D., Fabri, L. J., Corbin, J., Willson, T. A., Zhang, J. -G., Silva, A., Baca, M., Suppressor of cytokine signaling-3 preferentially binds to the SHP-2- binding site on the shared cytokine receptor subunit gp130 (2000) Proceedings of the National Academy of Sciences of the United States of America, 97 (12), pp. 6493-6498. , DOI 10. 1073/pnas. 100135197
Flowers, L. O., Subramaniam, P. S., Johnson, H. M., A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells (2005) Oncogene, 24 (12), pp. 2114-2120. , DOI 10. 1038/sj. onc. 1208437
Flowers, L. O., Johnson, H. M., Mujtaba, M. G., Ellis, M. R., Haider, S. M. I., Subramaniam, P. S., Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function (2004) Journal of Immunology, 172 (12), pp. 7510-7518
Waiboci, L. W., Ahmed, C. M., Mujtaba, M. G., Flowers, L. O., Martin, J. P., Haider, M. I., Johnson, H. M., Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: Implications for the development of a SOCS-1 antagonist (2007) Journal of Immunology, 178 (8), pp. 5058-5068
Scognamiglio, P. L., Doti, N., Grieco, P., Pedone, C., Ruvo, M., Marasco, D., Discovery of small peptide antagonists of PED/PEA15-D4 interaction from simplified combinatorial libraries (2011) Chem. Biol. Drug Des., 77, pp. 319-327
Hiemstra, H. S., Van Veelen, P. A., Schloot, N. C., Geluk, A., Van Meijgaarden, K. E., Willemen, S. J. M., Leunissen, J. A. M., Drijfhout, J. W., Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries (1998) Journal of Immunology, 161 (8), pp. 4078-4082
Hiemstra, H. S., Schloot, N. C., Van Veelen, P. A., Willemen, S. J. M., Franken, K. L. M. C., Van Rood, J. J., De Vries, R. R. P., Roep, B. O., Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (7), pp. 3988-3991. , DOI 10. 1073/pnas. 071050898
Chang, C. -Y., Norris, J. D., Gron, H., Paige, L. A., Hamilton, P. T., Kenan, D. J., Fowlkes, D., McDonnell, D. P., Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: Discovery of peptide antagonists of estrogen receptors and (1999) Molecular and Cellular Biology, 19 (12), pp. 8226-8239
Northrop, J. P., Nguyen, D., Piplani, S., Olivan, S. E., Kwan, S. T. -S., Go, N. F., Hart, C. P., Schatz, P. J., Selection of estrogen receptor - and Thyroid hormone receptor -specific coactivator-mimetic peptides using recombinant peptide libraries (2000) Molecular Endocrinology, 14 (5), pp. 605-622. , DOI 10. 1210/me. 14. 5. 605
Burke, M. D., Berger, E. M., Schreiber, S. L., Generating Diverse Skeletons of Small Molecules Combinatorially (2003) Science, 302 (5645), pp. 613-618. , DOI 10. 1126/science. 1089946
Burke, M. D., Khan, S. A., Triggered enzymatic degradation of a water-soluble polymer solution using a novel inhibitor (2000) Biomacromolecules, 1, pp. 688-695
Geysen, H. M., Rodda, S. J., Mason, T. J., A priori delineation of a peptide which mimics a discontinuous antigenic determinant (1986) Molecular Immunology, 23 (7), pp. 709-715. , DOI 10. 1016/0161-5890 (86) 90081-7
Bos, J. D., De Korte, J., Effects of etanercept on quality of life, fatigue, and depression in psoriasis (2006) Lancet, 367 (9504), pp. 6-7. , DOI 10. 1016/S0140-6736 (05) 67818-X, PII S014067360567818X
Babon, J. J., Sabo, J. K., Zhang, J. G., Nicola, N. A., Norton, R. S., The SOCS box encodes a hierarchy of affinities for Cullin5: Implications for ubiquitin ligase formation and cytokine signalling suppression (2009) J. Mol. Biol., 387, pp. 162-174
Biochemical Journal, 2012 Apr 1; 443: 231-240.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.779, 5-year impact factor: 4.95
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84858326728&partnerID=40&md5=faa27d1fb46c92fdd0ce041ebc1b452d
Keywords: Janus Kinase Signal Transducer And Activator Of Transcription Pathway (jak Stat Pathway), Kinase Inhibitory Region (kir), Mimetic Peptide, Peptide Library, Suppressor Of Cytokine Signalling 1 (socs1), Gamma Interferon, Interferon Regulatory Factor 1, Stat1 Protein, Suppressor Of Cytokine Signaling 1, Amino Acid Sequence, Article, Binding Affinity, Catalysis, Controlled Study, Enzyme Activation, Enzyme Activity, Enzyme Stability, Human, Human Cell, Keratinocyte, Normal Human, Priority Journal, Protein Analysis, Protein Binding, Protein Function, Protein Interaction, Protein Phosphorylation, Protein Structure, Protein Synthesis, Signal Transduction, Competitive, Catalytic Domain, Cultured, Circular Dichroism, Drug Evaluation, Preclinical, Drug Stability, Models, Molecular, Molecular Sequence Data, Secondary, Tertiary, Stat1 Transcription Factor, Suppressor Of Cytokine Signaling Proteins,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging - IBB-CNR, Via Mezzocannone 16, 80134, Naples, Italy
Laboratory of Experimental Immunology, Istituto Dermopatico dell'Immacolata, Via Monti di Creta 104, 00167 Rome, Italy
Department of Biological Sciences, School of Biotechnological Sciences, University Federico II, Via Mezzocannone 16, 80134, Naples, Italy
References:
Ihle, J.N., Witthuhn, B.A., Quelle, F.W., Yamamoto, K., Silvennoinen, O., Signaling through the hematopoietic cytokine receptors (1995) Annu. Rev. Immunol., 13, pp. 369-39
Sasaki, A., Yasukawa, H., Suzuki, A., Kamizono, S., Syoda, T., Kinjyo, I., Sasaki, M., Yoshimura, A., Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain (1999) Genes to Cells, 4 (6), pp. 339-351. , DOI 10.1046/j.1365-2443.1999.00263.x
Alexander, W.S., Suppressors of cytokine signalling (SOCS) in the immune system (2002) Nat. Rev. Immunol., 2, pp. 410-416
Alexander, W.S., Hilton, D.J., The role of Suppressors of Cytokine Signaling (SOCS) proteins in regulation of the immune response (2004) Annual Review of Immunology, 22, pp. 503-529. , DOI 10.1146/annurev.immunol.22.091003.090312
Ilangumaran, S., Ramanathan, S., Rottapel, R., Regulation of the immune system by SOCS family adaptor proteins (2004) Seminars in Immunology, 16 (6), pp. 351-365. , DOI 10.1016/j.smim.2004.08.015, PII S104453230400048X, Adaptors in Immune Regulation
Darnell Jr., J.E., Kerr, I.M., Stark, G.R., Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins (1994) Science, 264 (5164), pp. 1415-1421
Platanias, L.C., Mechanisms of type-I- And type-II-interferon-mediated signalling (2005) Nat. Rev. Immunol., 5, pp. 375-386
Shuai, K., Liu, B., Regulation of JAK-STAT signalling in the immune system (2003) Nature Reviews Immunology, 3 (11), pp. 900-911
Wormald, S., Hilton, D.J., Inhibitors of Cytokine Signal Transduction (2004) Journal of Biological Chemistry, 279 (2), pp. 821-824. , DOI 10.1074/jbc.R300030200
Gregorieff, A., Pyronnet, S., Sonenberg, N., Veillette, A., Regulation of SOCS-1 expression by translational repression (2000) Journal of Biological Chemistry, 275 (28), pp. 21596-21604. , DOI 10.1074/jbc.M910087199
Larsen, L., Ropke, C., Suppressors of cytokine signalling: SOCS (2002) APMIS, 110 (12), pp. 833-844. , DOI 10.1034/j.1600-0463.2002.1101201.x
Endo, T.A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Yoshimura, A., A new protein containing an SH2 domain that inhibits JAK kinases (1997) Nature, 387 (6636), pp. 921-924. , DOI 10.1038/43213
Federici, M., Giustizieri, M.L., Scarponi, C., Girolomoni, G., Albanesi, C., Impaired IFN-γ-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1 (2002) Journal of Immunology, 169 (1), pp. 434-442
Ungureanu, D., Saharinen, P., Junttila, I., Hilton, D.J., Silvennoinen, O., Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1 (2002) Molecular and Cellular Biology, 22 (10), pp. 3316-3326. , DOI 10.1128/MCB.22.10.3316-3326.2002
Alexander, W.S., Starr, R., Fenner, J.E., Scott, C.L., Handman, E., Sprigg, N.S., Corbin, J.E., Hilton, D.J., SOCS1 is a critical inhibitor of interferon γ signaling and prevents the potentially fatal neonatal actions of this cytokine (1999) Cell, 98 (5), pp. 597-608. , DOI 10.1016/S0092-8674(00)80047-1
Brysha, M., Zhang, J.G., Bertolino, P., Corbin, J.E., Alexander, W.S., Nicola, N.A., Hilton, D.J., Starr, R., Suppressor of cytokine signaling-1 attenuates the duration of interferon γ signal transduction in vitro and in vivo (2001) J. Biol. Chem., 276, pp. 22086-22089
Marine, J.-C., Topham, D.J., McKay, C., Wang, D., Parganas, E., Stravopodis, D., Yoshimura, A., Ihle, J.N., SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality (1999) Cell, 98 (5), pp. 609-616. , DOI 10.1016/S0092-8674(00)80048-3
Noon-Song, E.N., Ahmed, C.M., Dabelic, R., Canton, J., Johnson, H.M., Controlling nuclear JAKs and STATs for specific gene activation by IFNγ (2011) Biochem. Biophys. Res. Commun., 410, p. 648
Solomon, M., Flodstrom-Tullberg, M., Sarvetnick, N., β-Cell specific expression of suppressor of cytokine signaling-1 (SOCS-1) delays islet allograft rejection by down-regulating interferon regulatory factor-1 (IRF-1) signaling (2011) Transplant Immunol., 24, pp. 181-188
Yoshimura, A., Ohkubo, T., Kiguchi, T., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Hara, T., Miyajima, A., A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors (1995) EMBO J., 14, pp. 2816-2826
Nicholson, S.E., De Souza, D., Fabri, L.J., Corbin, J., Willson, T.A., Zhang, J.-G., Silva, A., Baca, M., Suppressor of cytokine signaling-3 preferentially binds to the SHP-2- binding site on the shared cytokine receptor subunit gp130 (2000) Proceedings of the National Academy of Sciences of the United States of America, 97 (12), pp. 6493-6498. , DOI 10.1073/pnas.100135197
Yasukawa, H., Misawa, H., Sakamoto, H., Masuhara, M., Sasaki, A., Wakioka, T., Ohtsuka, S., Yoshimura, A., The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop (1999) EMBO Journal, 18 (5), pp. 1309-1320
Giordanetto, F., Kroemer, R.T., A three-dimensional model of suppressor of cytokine signalling 1 (SOCS-1) (2003) Protein Engineering, 16 (2), pp. 115-124
Flowers, L.O., Subramaniam, P.S., Johnson, H.M., A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells (2005) Oncogene, 24 (12), pp. 2114-2120. , DOI 10.1038/sj.onc.1208437
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Flowers, L. O., Johnson, H. M., Mujtaba, M. G., Ellis, M. R., Haider, S. M. I., Subramaniam, P. S., Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function (2004) Journal of Immunology, 172 (12), pp. 7510-7518
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Hiemstra, H. S., Van Veelen, P. A., Schloot, N. C., Geluk, A., Van Meijgaarden, K. E., Willemen, S. J. M., Leunissen, J. A. M., Drijfhout, J. W., Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries (1998) Journal of Immunology, 161 (8), pp. 4078-4082
Hiemstra, H. S., Schloot, N. C., Van Veelen, P. A., Willemen, S. J. M., Franken, K. L. M. C., Van Rood, J. J., De Vries, R. R. P., Roep, B. O., Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (7), pp. 3988-3991. , DOI 10. 1073/pnas. 071050898
Chang, C. -Y., Norris, J. D., Gron, H., Paige, L. A., Hamilton, P. T., Kenan, D. J., Fowlkes, D., McDonnell, D. P., Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: Discovery of peptide antagonists of estrogen receptors and (1999) Molecular and Cellular Biology, 19 (12), pp. 8226-8239
Northrop, J. P., Nguyen, D., Piplani, S., Olivan, S. E., Kwan, S. T. -S., Go, N. F., Hart, C. P., Schatz, P. J., Selection of estrogen receptor - and Thyroid hormone receptor -specific coactivator-mimetic peptides using recombinant peptide libraries (2000) Molecular Endocrinology, 14 (5), pp. 605-622. , DOI 10. 1210/me. 14. 5. 605
Burke, M. D., Berger, E. M., Schreiber, S. L., Generating Diverse Skeletons of Small Molecules Combinatorially (2003) Science, 302 (5645), pp. 613-618. , DOI 10. 1126/science. 1089946
Burke, M. D., Khan, S. A., Triggered enzymatic degradation of a water-soluble polymer solution using a novel inhibitor (2000) Biomacromolecules, 1, pp. 688-695
Geysen, H. M., Rodda, S. J., Mason, T. J., A priori delineation of a peptide which mimics a discontinuous antigenic determinant (1986) Molecular Immunology, 23 (7), pp. 709-715. , DOI 10. 1016/0161-5890 (86) 90081-7
Bos, J. D., De Korte, J., Effects of etanercept on quality of life, fatigue, and depression in psoriasis (2006) Lancet, 367 (9504), pp. 6-7. , DOI 10. 1016/S0140-6736 (05) 67818-X, PII S014067360567818X
Babon, J. J., Sabo, J. K., Zhang, J. G., Nicola, N. A., Norton, R. S., The SOCS box encodes a hierarchy of affinities for Cullin5: Implications for ubiquitin ligase formation and cytokine signalling suppression (2009) J. Mol. Biol., 387, pp. 162-174
New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries
SOCS (suppressor of cytokine signalling) proteins are negative-feedback regulators of the JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathway. Their expression levels are low under physiological conditions, but they are up-regulated in response to cytokine stimulation in many immune and inflammatory processes. Overexpression of SOCS I in keratinocyte clones abrogates the IFN gamma (interferon gamma)-induced expression of many pro-inflammatory genes and the release of related chemokines by blocking the JAK/STAT pathway. SOCS1 inhibits JAK2 kinase activity by binding the catalytic site of JAK2, with its KIR (kinase-inhibitory region) acting as a pseudo-substrate of the enzyme. In the present study, we screened a focused combinatorial peptide library of KIR to identify new peptides able to mimic its function with an improved affinity towards the JAK2 catalytic site. Using an alanine-scanning method, KIR residues that are crucial for the interaction with JAK2 were unveiled. In this way, the KIR sequence was restricted to a shorter segment and 'non-essential' residues were replaced by different amino acids following a simplified combinatorial approach. We selected a new unnatural sequence able to bind to JAK2 with K-d values in the nanomolar range. This peptide was tested in human keratinocyte cultures and reduced the phosphorylation of STAT1 and the expression levels of IRF-1 (interferon regulatory factor-1).
SOCS (suppressor of cytokine signalling) proteins are negative-feedback regulators of the JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathway. Their expression levels are low under physiological conditions, but they are up-regulated in response to cytokine stimulation in many immune and inflammatory processes. Overexpression of SOCS I in keratinocyte clones abrogates the IFN gamma (interferon gamma)-induced expression of many pro-inflammatory genes and the release of related chemokines by blocking the JAK/STAT pathway. SOCS1 inhibits JAK2 kinase activity by binding the catalytic site of JAK2, with its KIR (kinase-inhibitory region) acting as a pseudo-substrate of the enzyme. In the present study, we screened a focused combinatorial peptide library of KIR to identify new peptides able to mimic its function with an improved affinity towards the JAK2 catalytic site. Using an alanine-scanning method, KIR residues that are crucial for the interaction with JAK2 were unveiled. In this way, the KIR sequence was restricted to a shorter segment and 'non-essential' residues were replaced by different amino acids following a simplified combinatorial approach. We selected a new unnatural sequence able to bind to JAK2 with K-d values in the nanomolar range. This peptide was tested in human keratinocyte cultures and reduced the phosphorylation of STAT1 and the expression levels of IRF-1 (interferon regulatory factor-1).
New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries
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New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries
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De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (421 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Impact Factor: 3.046
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (501 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* Erratum: A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (ChemBioChem (2005) 6 (1242-1253)) (265 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005; 20(4): 1307-1307.
Impact Factor: 3.94
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Fassina G, Ruvo M, Palombo G, Verdoliva A, Marino M
* Novel ligands for the affinity-chromatographic purification of antibodies (1313 views)
J Biochem Biophys Methods (ISSN: 0165-022x, 0165-022xlinking), 2001 Oct 30; 49(1-3): 481-490.
Impact Factor: 1.218
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* Structure-Activity Relationship Investigations of Novel Constrained Chimeric Peptidomimetics of SOCS3 Protein Targeting JAK2 (13 views)
Pharmaceuticals (ISSN: 1424-8247linking), 2022 Apr 9; 15(4): N/D-N/D.
Impact Factor: 5.68
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La Manna S, Lopez-sanz L, Bernal S, Fortuna S, Mercurio FA, Leone M, Gomez-guerrero C, Marasco D
* Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics (23 views)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2021 Oct 5; 221: 113547-113547.
Impact Factor: 5.572
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De Rosa L, Diana D, Di Stasi R, Romanelli A, Sciacca MF, Milardi D, Isernia C, Fattorusso R, D'Andrea LD
* Probing the helical stability in a VEGF-mimetic peptide (25 views)
Bioorganic Chemistry, 2021; 16: N/D-N/D.
Impact Factor: 5.307
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Mercurio FA, Di Natale C, Pirone L, Marasco D, Calce E, Vincenzi M, Pedone EM, De Luca S, Leone M
* Design and analysis of EphA2-SAM peptide ligands: A multi-disciplinary screening approach (229 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2019 Mar; 84: 434-443.
Impact Factor: 3.929
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Satriano C, Munzone A, Cucci LM, Giacomelli C, Trincavelli ML, Martini C, Rizzarelli E, La Mendola D
* Angiogenin-mimetic peptide functionalised gold nanoparticles for cancer therapy applications (185 views)
Microchemical Journal (ISSN: 0026-265x), 2018; 136: 157-163.
Impact Factor: 2.579
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Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (338 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(44): 11461-11466.
Impact Factor: 5.16
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La Manna S, Lopez-sanz L, Leone M, Brandi P, Scognamiglio PL, Morelli G, Novellino E, Gomez-guerrero C, Marasco D
* Structure-activity studies of peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling (412 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2017 Nov 20; N/D: N/D-N/D.
Impact Factor: 1.99
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Capasso D, Di Gaetano S, Celentano V, Diana D, Festa L, Di Stasi R, De Rosa L, Fattorusso R, D'Andrea LD
* Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein (564 views)
Mol Biosyst (ISSN: 1742-206x), 2017 Jul 25; 13(8): 1619-1629.
Impact Factor: 2.759
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La Manna S, Scognamiglio PL, Di Natale C, Leone M, Mercurio FA, Malfitano AM, Cianfarani F, Madonna S, Caravella S, Albanesi C, Novellino E, Marasco D
* Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces (396 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2017 May 04; 138: 106-115.
Impact Factor: 3.188
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D’andrea LD, De Rosa L, Vigliotti C, Cataldi M
* VEGF mimetic peptides: potential applications in central nervous system therapeutics (487 views)
New Horizons In Translational Medicine, 2017; 233: 225-225.
Impact Factor: 0
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Pignataro G, Ziaco B, Tortiglione A, Gala R, Cuomo O, Vinciguerra A, Lapi D, Mastantuono T, Anzilotti S, D'Andrea LD, Pedone C, Di Renzo G, Annunziato L, Cataldi M
* Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion (286 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2015 Sep 16; 6(9): 1517-1525.
Impact Factor: 4.348
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Zhou JS, Sandomenico A, Burton O, Oettgen HC, Ruvo M
* An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis (502 views)
Molecular Biosystems (ISSN: 1742-206x), 2013 Nov; 9(11): 2853-2859.
Impact Factor: 3.183
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Causa F, Della Moglie R, Iaccino E, Mimmi S, Marasco D, Scognamiglio PL, Battista E, Palmieri C, Cosenza C, Sanguigno L, Quinto I, Scala G, Netti PA
* Evolutionary screening and adsorption behavior of engineered M13 bacteriophage and derived dodecapeptide for selective decoration of gold interfaces (415 views)
J Colloid Interface Sci (ISSN: 0021-9797, 1095-7103electronic, 0021-9797linking), 2013 Jan 1; 389(1): 220-229.
Impact Factor: 1.646
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Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
* Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors (575 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
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Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (607 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
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Riccio A, Cubellis MV
* Gain of function in CDKN1C (512 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
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Sandomenico A, Russo A, Palmieri G, Bergamo P, Gogliettino M, Falcigno L, Ruvo M
* Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation (521 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012 Mar 8; 55(5): 2102-2111.
Impact Factor: 5.614
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (476 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
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Sandomenico A, Monti SM, Palumbo R, Ruvo M
* A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells (696 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Sep; 17(9): 604-609.
Impact Factor: 1.799
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Madonna S, Scarponi C, Sestito R, Doti N, Carbone T, Nasorri F, Marasco D, Cavani A, Albanesi C
* Mimetic peptides of suppressor of cytokine signaling (SOCS)1 impair inflammatory responses of epidermal keratinocytes in vitro and in a mouse skin model of allergic contact dermatitis (399 views)
Journal Of Investigative Dermatology (ISSN: 0022-202x), 2011 Sep; 131: N/D-N/D.
Impact Factor: 6.314
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (532 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (775 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (615 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (937 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Sarmientos P, Morelli G, Alberghina L, Colangelo A, Martegani E, Vitagliano L, Papa M, Tornesello AL
* Synthesis and in vitro and in vivo characterization of NGF mimetic peptides (379 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* The unusual helix stability of a VEGF mimetic peptide (318 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E
* A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (658 views)
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Impact Factor: 7.452
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Bianco MR, Cirillo G, Cavaliere C, Colangelo AM, Vitagliano L, Morelli G, Sarmientos P, Martegani E, Alberghina L, Papa M
* A new Nerve Growth Factor (NGF)-mimetic peptide reduces gliosis and is active on neuropathic pain in rats (316 views)
Neuron Glia Biology (ISSN: 1740-925x), 2007; 2: N/D-N/D.
Impact Factor: 6.636
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De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (421 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Impact Factor: 3.046
View Export to BibTeX Export to EndNote
Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (501 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
View Export to BibTeX Export to EndNote
Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* Erratum: A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (ChemBioChem (2005) 6 (1242-1253)) (265 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005; 20(4): 1307-1307.
Impact Factor: 3.94
View Export to BibTeX Export to EndNote
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
View Export to BibTeX Export to EndNote
Fassina G, Ruvo M, Palombo G, Verdoliva A, Marino M
* Novel ligands for the affinity-chromatographic purification of antibodies (1313 views)
J Biochem Biophys Methods (ISSN: 0165-022x, 0165-022xlinking), 2001 Oct 30; 49(1-3): 481-490.
Impact Factor: 1.218
View Export to BibTeX Export to EndNote
34 Records (30 excluding Abstracts).
Total impact factor: 169.245 (152.987 excluding Abstracts).
Total 5 year impact factor: 161.197 (147.972 excluding Abstracts).
Total impact factor: 169.245 (152.987 excluding Abstracts).
Total 5 year impact factor: 161.197 (147.972 excluding Abstracts).
1334 views. Last view on Sunday 04 June 2023, 16:33:59
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