New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries (1826 views)
Biochemical Journal, 2012 Apr 1; 443: 231-240.
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Paper type: Journal Article,
Impact factor: 4.779, 5-year impact factor: 4.95
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84858326728&partnerID=40&md5=faa27d1fb46c92fdd0ce041ebc1b452d
Keywords: Janus Kinase Signal Transducer And Activator Of Transcription Pathway (jak Stat Pathway), Kinase Inhibitory Region (kir), Mimetic Peptide, Peptide Library, Suppressor Of Cytokine Signalling 1 (socs1), Gamma Interferon, Interferon Regulatory Factor 1, Stat1 Protein, Suppressor Of Cytokine Signaling 1, Amino Acid Sequence, Article, Binding Affinity, Catalysis, Controlled Study, Enzyme Activation, Enzyme Activity, Enzyme Stability, Human, Human Cell, Keratinocyte, Normal Human, Priority Journal, Protein Analysis, Protein Binding, Protein Function, Protein Interaction, Protein Phosphorylation, Protein Structure, Protein Synthesis, Signal Transduction, Competitive, Catalytic Domain, Cultured, Circular Dichroism, Drug Evaluation, Preclinical, Drug Stability, Models, Molecular, Molecular Sequence Data, Secondary, Tertiary, Stat1 Transcription Factor, Suppressor Of Cytokine Signaling Proteins,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging - IBB-CNR, Via Mezzocannone 16, 80134, Naples, Italy
Laboratory of Experimental Immunology, Istituto Dermopatico dell'Immacolata, Via Monti di Creta 104, 00167 Rome, Italy
Department of Biological Sciences, School of Biotechnological Sciences, University Federico II, Via Mezzocannone 16, 80134, Naples, Italy
References:
Not available.
Biochemical Journal, 2012 Apr 1; 443: 231-240.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.779, 5-year impact factor: 4.95
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84858326728&partnerID=40&md5=faa27d1fb46c92fdd0ce041ebc1b452d
Keywords: Janus Kinase Signal Transducer And Activator Of Transcription Pathway (jak Stat Pathway), Kinase Inhibitory Region (kir), Mimetic Peptide, Peptide Library, Suppressor Of Cytokine Signalling 1 (socs1), Gamma Interferon, Interferon Regulatory Factor 1, Stat1 Protein, Suppressor Of Cytokine Signaling 1, Amino Acid Sequence, Article, Binding Affinity, Catalysis, Controlled Study, Enzyme Activation, Enzyme Activity, Enzyme Stability, Human, Human Cell, Keratinocyte, Normal Human, Priority Journal, Protein Analysis, Protein Binding, Protein Function, Protein Interaction, Protein Phosphorylation, Protein Structure, Protein Synthesis, Signal Transduction, Competitive, Catalytic Domain, Cultured, Circular Dichroism, Drug Evaluation, Preclinical, Drug Stability, Models, Molecular, Molecular Sequence Data, Secondary, Tertiary, Stat1 Transcription Factor, Suppressor Of Cytokine Signaling Proteins,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging - IBB-CNR, Via Mezzocannone 16, 80134, Naples, Italy
Laboratory of Experimental Immunology, Istituto Dermopatico dell'Immacolata, Via Monti di Creta 104, 00167 Rome, Italy
Department of Biological Sciences, School of Biotechnological Sciences, University Federico II, Via Mezzocannone 16, 80134, Naples, Italy
References:
Not available.
New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries
SOCS (suppressor of cytokine signalling) proteins are negative-feedback regulators of the JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathway. Their expression levels are low under physiological conditions, but they are up-regulated in response to cytokine stimulation in many immune and inflammatory processes. Overexpression of SOCS I in keratinocyte clones abrogates the IFN gamma (interferon gamma)-induced expression of many pro-inflammatory genes and the release of related chemokines by blocking the JAK/STAT pathway. SOCS1 inhibits JAK2 kinase activity by binding the catalytic site of JAK2, with its KIR (kinase-inhibitory region) acting as a pseudo-substrate of the enzyme. In the present study, we screened a focused combinatorial peptide library of KIR to identify new peptides able to mimic its function with an improved affinity towards the JAK2 catalytic site. Using an alanine-scanning method, KIR residues that are crucial for the interaction with JAK2 were unveiled. In this way, the KIR sequence was restricted to a shorter segment and 'non-essential' residues were replaced by different amino acids following a simplified combinatorial approach. We selected a new unnatural sequence able to bind to JAK2 with K-d values in the nanomolar range. This peptide was tested in human keratinocyte cultures and reduced the phosphorylation of STAT1 and the expression levels of IRF-1 (interferon regulatory factor-1).
SOCS (suppressor of cytokine signalling) proteins are negative-feedback regulators of the JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathway. Their expression levels are low under physiological conditions, but they are up-regulated in response to cytokine stimulation in many immune and inflammatory processes. Overexpression of SOCS I in keratinocyte clones abrogates the IFN gamma (interferon gamma)-induced expression of many pro-inflammatory genes and the release of related chemokines by blocking the JAK/STAT pathway. SOCS1 inhibits JAK2 kinase activity by binding the catalytic site of JAK2, with its KIR (kinase-inhibitory region) acting as a pseudo-substrate of the enzyme. In the present study, we screened a focused combinatorial peptide library of KIR to identify new peptides able to mimic its function with an improved affinity towards the JAK2 catalytic site. Using an alanine-scanning method, KIR residues that are crucial for the interaction with JAK2 were unveiled. In this way, the KIR sequence was restricted to a shorter segment and 'non-essential' residues were replaced by different amino acids following a simplified combinatorial approach. We selected a new unnatural sequence able to bind to JAK2 with K-d values in the nanomolar range. This peptide was tested in human keratinocyte cultures and reduced the phosphorylation of STAT1 and the expression levels of IRF-1 (interferon regulatory factor-1).
New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries
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New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries
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* Structure-Activity Relationship Investigations of Novel Constrained Chimeric Peptidomimetics of SOCS3 Protein Targeting JAK2 (491 views)
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View Export to BibTeX Export to EndNote
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* Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics (496 views)
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Impact Factor: 5.572
View Export to BibTeX Export to EndNote
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Impact Factor: 5.307
View Export to BibTeX Export to EndNote
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Impact Factor: 3.929
View Export to BibTeX Export to EndNote
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Impact Factor: 2.579
View Export to BibTeX Export to EndNote
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Impact Factor: 5.16
View Export to BibTeX Export to EndNote
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Impact Factor: 1.99
View Export to BibTeX Export to EndNote
Capasso D, Di Gaetano S, Celentano V, Diana D, Festa L, Di Stasi R, De Rosa L, Fattorusso R, D'Andrea LD
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Mol Biosyst (ISSN: 1742-206x), 2017 Jul 25; 13(8): 1619-1629.
Impact Factor: 2.759
View Export to BibTeX Export to EndNote
La Manna S, Scognamiglio PL, Di Natale C, Leone M, Mercurio FA, Malfitano AM, Cianfarani F, Madonna S, Caravella S, Albanesi C, Novellino E, Marasco D
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Impact Factor: 3.188
View Export to BibTeX Export to EndNote
D’andrea LD, De Rosa L, Vigliotti C, Cataldi M
* VEGF mimetic peptides: potential applications in central nervous system therapeutics (669 views)
New Horizons In Translational Medicine, 2017; 233: 225-225.
Impact Factor: 0
View Export to BibTeX Export to EndNote
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* Neuroprotective Effect of VEGF-Mimetic Peptide QK in Experimental Brain Ischemia Induced in Rat by Middle Cerebral Artery Occlusion (481 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic), 2015 Sep 16; 6(9): 1517-1525.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Zhou JS, Sandomenico A, Burton O, Oettgen HC, Ruvo M
* An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis (1157 views)
Molecular Biosystems (ISSN: 1742-206x), 2013 Nov; 9(11): 2853-2859.
Impact Factor: 3.183
View Export to BibTeX Export to EndNote
Causa F, Della Moglie R, Iaccino E, Mimmi S, Marasco D, Scognamiglio PL, Battista E, Palmieri C, Cosenza C, Sanguigno L, Quinto I, Scala G, Netti PA
* Evolutionary screening and adsorption behavior of engineered M13 bacteriophage and derived dodecapeptide for selective decoration of gold interfaces (713 views)
J Colloid Interface Sci (ISSN: 0021-9797, 1095-7103electronic, 0021-9797linking), 2013 Jan 1; 389(1): 220-229.
Impact Factor: 1.646
View Export to BibTeX Export to EndNote
Carotenuto A, Cipolletta E, Gomez-Monterrey I, Sala M, Vernieri E, Limatola A, Bertamino A, Musella S, Sorriento D, Grieco P, Trimarco B, Novellino E, Iaccarino G, Campiglia P
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Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013; 69: 384-392.
Impact Factor: 3.432
View Export to BibTeX Export to EndNote
Finetti F, Basile A, Capasso D, Di Gaetano S, Di Stasi R, Pascale M, Turco CM, Ziche M, Morbidelli L, D'Andrea LD
* Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (868 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Impact Factor: 4.576
View Export to BibTeX Export to EndNote
Riccio A, Cubellis MV
* Gain of function in CDKN1C (714 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
View Export to BibTeX Export to EndNote
Sandomenico A, Russo A, Palmieri G, Bergamo P, Gogliettino M, Falcigno L, Ruvo M
* Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation (949 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2012 Mar 8; 55(5): 2102-2111.
Impact Factor: 5.614
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (837 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
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Sandomenico A, Monti SM, Palumbo R, Ruvo M
* A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells (1324 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Sep; 17(9): 604-609.
Impact Factor: 1.799
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Madonna S, Scarponi C, Sestito R, Doti N, Carbone T, Nasorri F, Marasco D, Cavani A, Albanesi C
* Mimetic peptides of suppressor of cytokine signaling (SOCS)1 impair inflammatory responses of epidermal keratinocytes in vitro and in a mouse skin model of allergic contact dermatitis (632 views)
Journal Of Investigative Dermatology (ISSN: 0022-202x), 2011 Sep; 131: N/D-N/D.
Impact Factor: 6.314
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (946 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (1166 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (1058 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (1234 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Sarmientos P, Morelli G, Alberghina L, Colangelo A, Martegani E, Vitagliano L, Papa M, Tornesello AL
* Synthesis and in vitro and in vivo characterization of NGF mimetic peptides (598 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* The unusual helix stability of a VEGF mimetic peptide (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E
* A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (990 views)
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Impact Factor: 7.452
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (662 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Bianco MR, Cirillo G, Cavaliere C, Colangelo AM, Vitagliano L, Morelli G, Sarmientos P, Martegani E, Alberghina L, Papa M
* A new Nerve Growth Factor (NGF)-mimetic peptide reduces gliosis and is active on neuropathic pain in rats (515 views)
Neuron Glia Biology (ISSN: 1740-925x), 2007; 2: N/D-N/D.
Impact Factor: 6.636
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De Luca S, Saviano M, Della Moglie R, Digilio G, Bracco C, Aloj L, Tarallo L, Pedone C, Morelli G
* Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor (734 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2006 Sep; 1(9): 997-1006.
Impact Factor: 3.046
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (821 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* Erratum: A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (ChemBioChem (2005) 6 (1242-1253)) (552 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005; 20(4): 1307-1307.
Impact Factor: 3.94
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (1085 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Fassina G, Ruvo M, Palombo G, Verdoliva A, Marino M
* Novel ligands for the affinity-chromatographic purification of antibodies (1876 views)
J Biochem Biophys Methods (ISSN: 0165-022x, 0165-022xlinking), 2001 Oct 30; 49(1-3): 481-490.
Impact Factor: 1.218
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34 Records (30 excluding Abstracts).
Total impact factor: 169.245 (152.987 excluding Abstracts).
Total 5 year impact factor: 161.197 (147.972 excluding Abstracts).
Total impact factor: 169.245 (152.987 excluding Abstracts).
Total 5 year impact factor: 161.197 (147.972 excluding Abstracts).
1826 views. Last view on Friday 18 April 2025, 8:28:09
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