HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents(870 views) Palmieri D, Valentino T, D'Angelo D, De Martino I, Postiglione I, Pacelli R, Croce CM, Fedele M, Fusco A
Keywords: Atm, Dna Repair, Hmga, Actin, Atm Protein, High Mobility Group A Protein, High Mobility Group A1 Protein, High Mobility Group A2 Protein, Protein P21, Unclassified Drug, Vinculin, Animal Cell, Article, Atm Gene, Cancer Relapse, Cancer Resistance, Cell Stress, Cell Transformation, Controlled Study, Dna Damage, Embryo, Enzyme Induction, Gene Expression, Genotoxicity, Human, Human Cell, Mouse, Nonhuman, Positive Feedback, Priority Journal, Prognosis, Promoter Region, Protein Expression, Protein Family, Transcription Initiation, Cell Cycle Proteins, Cell Line, Dna-Binding Proteins, Gene Expression Regulation, Neoplastic, Hmga Proteins, Mutagens, Phosphorylation, Genetic, Protein-Serine-Threonine Kinases, Tumor Suppressor Proteins, Ataxia Telangiectasia,
Affiliations: *** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia Ed Oncologia Sperimentale Del CNR, Università Degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy
Istituto di Biostrutture e Bioimmagini Del CNR, Naples, Italy
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH, United States
NOGEC (Naples Oncogenomic Center), CEINGE Biotecnologie Avanzate, Via Comunale Margherita, Naples, Italy
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Berlingieri, M. T., Pierantoni, G. M., Giancotti, V., Santoro, M., Fusco, A., Thyroid cell transformation requires the expression of the HMGA1 proteins (2002) Oncogene, 21 (19), pp. 2971-2980. , DOI 10. 1038/sj/onc/1205368
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Jackson, S. P., The DNA-damage response: New molecular insights and new approaches to cancer therapy (2009) Biochem Soc Trans, 37, pp. 483-494
Johnson, K. R., Lehn, D. A., Reeves, R., Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y (1989) Molecular and Cellular Biology, 9 (5), pp. 2114-2123
Lavin, M. F., Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer (2008) Nat Rev Mol Cell Biol, 9, pp. 759-769
Lavin, M. F., Kozlov, S., ATM activation and DNA damage response (2007) Cell Cycle, 6 (8), pp. 931-942. , http: //www. landesbioscience. com/journals/cc/article/lavinCC6-8. pdf
Livak, K. J., Schmittgen, T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2- CT method (2001) Methods, 25 (4), pp. 402-408. , DOI 10. 1006/meth. 2001. 1262
Hoyos, J. M., Fedele, M., Battista, S., Pentimalli, F., Kruhoffer, M., Arra, C., Orntoft, T. F., Fusco, A., Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: Tissue specificity of the HMGA1-dependent gene regulation (2004) Cancer Research, 64 (16), pp. 5728-5735. , DOI 10. 1158/0008-5472. CAN-04-1410
Meyn, M. S., Strasfeld, L., Allen, C., Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiecta-sia (1994) Int J Radiat Biol, 66, pp. S141-S149
Pierantoni, G. M., Fedele, M., Pentimalli, F., Benvenuto, G., Pero, R., Viglietto, G., Santoro, M., Fusco, A., High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth (2001) Oncogene, 20 (43), pp. 6132-6141. , DOI 10. 1038/sj. onc. 1204635
Sarkaria, J. N., Busby, E. C., Tibbetts, R. S., Roos, P., Taya, Y., Karnitz, L. M., Abraham, R. T., Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine (1999) Cancer Research, 59 (17), pp. 4375-4382
Sarkaria, J. N., Eshleman, J. S., ATM as a target for novel radiosensitizers (2001) Seminars in Radiation Oncology, 11 (4), pp. 316-327
Sarkaria, J. N., Tibbetts, R. S., Busby, E. C., Kennedy, A. P., Hill, D. E., Abraham, R. T., Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin (1998) Cancer Research, 58 (19), pp. 4375-4382
Wood, L. J., Maher, J. F., Bunton, T. E., Resar, L. M. S., The oncogenic properties of the HMG-I gene family (2000) Cancer Research, 60 (15), pp. 4256-4261
Xu, Y., Yang, E. M., Brugarolas, J., Jacks, T., Baltimore, D., Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm (-/-) mice (1998) Molecular and Cellular Biology, 18 (7), pp. 4385-4390
HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents