HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents (870 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.373, 5-year impact factor: 6.889
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79960065049&partnerID=40&md5=12e3e2f10e8021ad1d67de4df0692e7d
Keywords: Atm, Dna Repair, Hmga, Actin, Atm Protein, High Mobility Group A Protein, High Mobility Group A1 Protein, High Mobility Group A2 Protein, Protein P21, Unclassified Drug, Vinculin, Animal Cell, Article, Atm Gene, Cancer Relapse, Cancer Resistance, Cell Stress, Cell Transformation, Controlled Study, Dna Damage, Embryo, Enzyme Induction, Gene Expression, Genotoxicity, Human, Human Cell, Mouse, Nonhuman, Positive Feedback, Priority Journal, Prognosis, Promoter Region, Protein Expression, Protein Family, Transcription Initiation, Cell Cycle Proteins, Cell Line, Dna-Binding Proteins, Gene Expression Regulation, Neoplastic, Hmga Proteins, Mutagens, Phosphorylation, Genetic, Protein-Serine-Threonine Kinases, Tumor Suppressor Proteins, Ataxia Telangiectasia,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia Ed Oncologia Sperimentale Del CNR, Università Degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy
Istituto di Biostrutture e Bioimmagini Del CNR, Naples, Italy
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH, United States
NOGEC (Naples Oncogenomic Center), CEINGE Biotecnologie Avanzate, Via Comunale Margherita, Naples, Italy
References:
Bakkenist, C.J., Kastan, M.B., DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation (2003) Nature, 421 (6922), pp. 499-506. , DOI 10.1038/nature0136
Berkovich, E., Ginsberg, D., ATM is a target for positive regulation by E2F-1 (2003) Oncogene, 22 (2), pp. 161-167. , DOI 10.1038/sj.onc.1206144
Berlingieri, M.T., Pierantoni, G.M., Giancotti, V., Santoro, M., Fusco, A., Thyroid cell transformation requires the expression of the HMGA1 proteins (2002) Oncogene, 21 (19), pp. 2971-2980. , DOI 10.1038/sj/onc/1205368
Canman, C.E., Lim, D.-S., Cimprich, K.A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Siliciano, J.D., Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 (1998) Science, 281 (5383), pp. 1677-1679. , DOI 10.1126/science.281.5383.1677
Chiappetta, G., Avantaggiato, V., Visconti, R., Fedele, M., Battista, S., Trapasso, F., Merciai, B.M., Fusco, A., High level expression of the HMGI (Y) gene during embryonic development (1996) Oncogene, 13 (11), pp. 2439-2446
Crescenzi, E., Palumbo, G., De Boer, J., Brady, H.J.M., Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy (2008) Clinical Cancer Research, 14 (6), pp. 1877-1887. , http://clincancerres.aacrjournals.org/cgi/reprint/14/6/1877, DOI 10.1158/1078-0432.CCR-07-4298
D'Adda Di Fagagna, F., Living on a break: Cellular senescence as a DNA-damage response (2008) Nature Reviews Cancer, 8 (7), pp. 512-522. , DOI 10.1038/nrc2440, PII NRC2440
Fedele, M., Fusco, A., HMGA and cancer (2010) Biochim Biophys Acta, 1799, pp. 48-54
Fedele, M., Pierantoni, G.M., Berlingieri, M.T., Battista, S., Baldassarre, G., Munshi, N., Dentice, M., Fusco, A., Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells (2001) Cancer Research, 61 (11), pp. 4583-4590
Fedele, M., Visone, R., De Martino, I., Troncone, G., Palmieri, D., Battista, S., Ciarmiello, A., Fusco, A., HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity (2006) Cancer Cell, 9 (6), pp. 459-471. , DOI 10.1016/j.ccr.2006.04.024, PII S1535610806001474
Fusco, A., Fedele, M., Roles of HMGA proteins in cancer (2007) Nature Reviews Cancer, 7 (12), pp. 899-910. , DOI 10.1038/nrc2271, PII NRC2271
Gueven, N., Keating, K., Fukao, T., Loeffler, H., Kondo, N., Rodemann, H.P., Lavin, M.F., Site-directed mutagenesis of the ATM promoter: Consequences for response to proliferation and ionizing radiation (2003) Genes Chromosomes and Cancer, 38 (2), pp. 157-167. , DOI 10.1002/gcc.10261
Hickson, I., Zhao, Y., Richardson, C.J., Green, S.J., Martin, N.M.B., Orr, A.I., Reaper, P.M., Smith, G.C.M., Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM (2004) Cancer Research, 64 (24), pp. 9152-9159. , DOI 10.1158/0008-5472.CAN-04-2727
Jackson, S.P., The DNA-damage response: New molecular insights and new approaches to cancer therapy (2009) Biochem Soc Trans, 37, pp. 483-494
Johnson, K.R., Lehn, D.A., Reeves, R., Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y (1989) Molecular and Cellular Biology, 9 (5), pp. 2114-2123
Kuhne, M., Riballo, E., Rief, N., Rothkamm, K., Jeggo, P.A., Lobrich, M., Double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity (2004) Cancer Research, 64 (2), pp. 500-508. , DOI 10.1158/0008-5472.CAN-03-2384
Lavin, M.F., Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer (2008) Nat Rev Mol Cell Biol, 9, pp. 759-769
Lavin, M.F., Kozlov, S., ATM activation and DNA damage response (2007) Cell Cycle, 6 (8), pp. 931-942. , http://www.landesbioscience.com/journals/cc/article/lavinCC6-8.pdf
Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method (2001) Methods, 25 (4), pp. 402-408. , DOI 10.1006/meth.2001.1262
Hoyos, J.M., Fedele, M., Battista, S., Pentimalli, F., Kruhoffer, M., Arra, C., Orntoft, T.F., Fusco, A., Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: Tissue specificity of the HMGA1-dependent gene regulation (2004) Cancer Research, 64 (16), pp. 5728-5735. , DOI 10.1158/0008-5472.CAN-04-1410
Meyn, M.S., Strasfeld, L., Allen, C., Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiecta-sia (1994) Int J Radiat Biol, 66, pp. S141-S149
Nagpal, S., Ghosn, C., Disepio, D., Molina, Y., Sutter, M., Klein, E.S., Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor (1999) J Biol Chem, 274, pp. 22563-22568
Narita, M., Narita, M., Krizhanovsky, V., Nunez, S., Chicas, A., Hearn, S.A., Myers, M.P., Lowe, S.W., A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation (2006) Cell, 126 (3), pp. 503-514. , DOI 10.1016/j.cell.2006.05.052, PII S0092867406009135
O'Neill, T., Dwyer, A.J., Ziv, Y., Chan, D.W., Lees-Miller, S.P., Abraham, R.H., Lai, J.H., Rathbun, G.A., Utilization of oriented peptide libraries to identify substrate motifs selected by ATM (2000) Journal of Biological Chemistry, 275 (30), pp. 22719-22727. , DOI 10.1074/jbc.M001002200
Parrinello, S., Samper, E., Krtolica, A., Goldstein, J., Melov, S., Campisi, J., Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts (2003) Nature Cell Biology, 5 (8), pp. 741-747. , DOI 10.1038/ncb1024
Pentimalli, F., Palmieri, D., Pacelli, R., Garbi, C., Cesari, R., Martin, E., HMGA1 protein is a novel target of the ATM kinase (2008) Eur J Cancer, 44, pp. 2668-2679
Pierantoni, G.M., Fedele, M., Pentimalli, F., Benvenuto, G., Pero, R., Viglietto, G., Santoro, M., Fusco, A., High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth (2001) Oncogene, 20 (43), pp. 6132-6141. , DOI 10.1038/sj.onc.1204635
Pierantoni, G.M., Rinaldo, C., Esposito, F., Mottolese, M., Soddu, S., Fusco, A., High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity (2006) Cell Death Differ, 5, pp. 2045-2048
Reeves, R., Adair, J.E., Role of high mobility group (HMG) chromatin proteins in DNA repair (2005) DNA Repair, 4 (8), pp. 926-938. , DOI 10.1016/j.dnarep.2005.04.010, PII S1568786405000935
Reeves, R., Nissen, M.S., The A.T-DNA-binding domain of mammalian high mobility group i chromosomal proteins. A novel peptide motif for recognizing DNA structure (1990) J Biol Chem, 265, pp. 8573-8582
Sarkaria, J.N., Busby, E.C., Tibbetts, R.S., Roos, P., Taya, Y., Karnitz, L.M., Abraham, R.T., Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine (1999) Cancer Research, 59 (17), pp. 4375-4382
Sarkaria, J.N., Eshleman, J.S., ATM as a target for novel radiosensitizers (2001) Seminars in Radiation Oncology, 11 (4), pp. 316-327
Sarkaria, J.N., Tibbetts, R.S., Busby, E.C., Kennedy, A.P., Hill, D.E., Abraham, R.T., Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin (1998) Cancer Research, 58 (19), pp. 4375-4382
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., A single ataxia telangiectasia gene with a product similar to PI-3 kinase (1995) Science, 268, pp. 1749-1753
Viale, A., De Franco, F., Orleth, A., Cambiaghi, V., Giuliani, V., Bossi, D., Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells (2009) Nature, 457, pp. 51-56
Wood, L.J., Maher, J.F., Bunton, T.E., Resar, L.M.S., The oncogenic properties of the HMG-I gene family (2000) Cancer Research, 60 (15), pp. 4256-4261
Xu, Y., Ashley, T., Brainerd, E.E., Bronson, R.T., Meyn, M.S., Baltimore, D., Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma (1996) Genes and Development, 10 (19), pp. 2411-2422
Xu, Y., Yang, E.M., Brugarolas, J., Jacks, T., Baltimore, D., Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm(-/-) mice (1998) Molecular and Cellular Biology, 18 (7), pp. 4385-4390
Zhou, X., Benson, K.F., Ashar, H.R., Chada, K., Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C (1995) Nature, 376, pp. 771-774
Bakkenist, C. J., Kastan, M. B., DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation (2003) Nature, 421 (6922), pp. 499-506. , DOI 10. 1038/nature0136
Berlingieri, M. T., Pierantoni, G. M., Giancotti, V., Santoro, M., Fusco, A., Thyroid cell transformation requires the expression of the HMGA1 proteins (2002) Oncogene, 21 (19), pp. 2971-2980. , DOI 10. 1038/sj/onc/1205368
Canman, C. E., Lim, D. -S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Siliciano, J. D., Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 (1998) Science, 281 (5383), pp. 1677-1679. , DOI 10. 1126/science. 281. 5383. 1677
Jackson, S. P., The DNA-damage response: New molecular insights and new approaches to cancer therapy (2009) Biochem Soc Trans, 37, pp. 483-494
Johnson, K. R., Lehn, D. A., Reeves, R., Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y (1989) Molecular and Cellular Biology, 9 (5), pp. 2114-2123
Lavin, M. F., Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer (2008) Nat Rev Mol Cell Biol, 9, pp. 759-769
Lavin, M. F., Kozlov, S., ATM activation and DNA damage response (2007) Cell Cycle, 6 (8), pp. 931-942. , http: //www. landesbioscience. com/journals/cc/article/lavinCC6-8. pdf
Livak, K. J., Schmittgen, T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2- CT method (2001) Methods, 25 (4), pp. 402-408. , DOI 10. 1006/meth. 2001. 1262
Hoyos, J. M., Fedele, M., Battista, S., Pentimalli, F., Kruhoffer, M., Arra, C., Orntoft, T. F., Fusco, A., Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: Tissue specificity of the HMGA1-dependent gene regulation (2004) Cancer Research, 64 (16), pp. 5728-5735. , DOI 10. 1158/0008-5472. CAN-04-1410
Meyn, M. S., Strasfeld, L., Allen, C., Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiecta-sia (1994) Int J Radiat Biol, 66, pp. S141-S149
Pierantoni, G. M., Fedele, M., Pentimalli, F., Benvenuto, G., Pero, R., Viglietto, G., Santoro, M., Fusco, A., High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth (2001) Oncogene, 20 (43), pp. 6132-6141. , DOI 10. 1038/sj. onc. 1204635
Sarkaria, J. N., Busby, E. C., Tibbetts, R. S., Roos, P., Taya, Y., Karnitz, L. M., Abraham, R. T., Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine (1999) Cancer Research, 59 (17), pp. 4375-4382
Sarkaria, J. N., Eshleman, J. S., ATM as a target for novel radiosensitizers (2001) Seminars in Radiation Oncology, 11 (4), pp. 316-327
Sarkaria, J. N., Tibbetts, R. S., Busby, E. C., Kennedy, A. P., Hill, D. E., Abraham, R. T., Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin (1998) Cancer Research, 58 (19), pp. 4375-4382
Wood, L. J., Maher, J. F., Bunton, T. E., Resar, L. M. S., The oncogenic properties of the HMG-I gene family (2000) Cancer Research, 60 (15), pp. 4256-4261
Xu, Y., Yang, E. M., Brugarolas, J., Jacks, T., Baltimore, D., Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm (-/-) mice (1998) Molecular and Cellular Biology, 18 (7), pp. 4385-4390
Oncogene (ISSN: 0950-9232, 1476-5594), 2011 Jul 7; 30(27): 3024-3035.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 6.373, 5-year impact factor: 6.889
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79960065049&partnerID=40&md5=12e3e2f10e8021ad1d67de4df0692e7d
Keywords: Atm, Dna Repair, Hmga, Actin, Atm Protein, High Mobility Group A Protein, High Mobility Group A1 Protein, High Mobility Group A2 Protein, Protein P21, Unclassified Drug, Vinculin, Animal Cell, Article, Atm Gene, Cancer Relapse, Cancer Resistance, Cell Stress, Cell Transformation, Controlled Study, Dna Damage, Embryo, Enzyme Induction, Gene Expression, Genotoxicity, Human, Human Cell, Mouse, Nonhuman, Positive Feedback, Priority Journal, Prognosis, Promoter Region, Protein Expression, Protein Family, Transcription Initiation, Cell Cycle Proteins, Cell Line, Dna-Binding Proteins, Gene Expression Regulation, Neoplastic, Hmga Proteins, Mutagens, Phosphorylation, Genetic, Protein-Serine-Threonine Kinases, Tumor Suppressor Proteins, Ataxia Telangiectasia,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia Ed Oncologia Sperimentale Del CNR, Università Degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy
Istituto di Biostrutture e Bioimmagini Del CNR, Naples, Italy
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH, United States
NOGEC (Naples Oncogenomic Center), CEINGE Biotecnologie Avanzate, Via Comunale Margherita, Naples, Italy
References:
Bakkenist, C.J., Kastan, M.B., DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation (2003) Nature, 421 (6922), pp. 499-506. , DOI 10.1038/nature0136
Berkovich, E., Ginsberg, D., ATM is a target for positive regulation by E2F-1 (2003) Oncogene, 22 (2), pp. 161-167. , DOI 10.1038/sj.onc.1206144
Berlingieri, M.T., Pierantoni, G.M., Giancotti, V., Santoro, M., Fusco, A., Thyroid cell transformation requires the expression of the HMGA1 proteins (2002) Oncogene, 21 (19), pp. 2971-2980. , DOI 10.1038/sj/onc/1205368
Canman, C.E., Lim, D.-S., Cimprich, K.A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Siliciano, J.D., Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 (1998) Science, 281 (5383), pp. 1677-1679. , DOI 10.1126/science.281.5383.1677
Chiappetta, G., Avantaggiato, V., Visconti, R., Fedele, M., Battista, S., Trapasso, F., Merciai, B.M., Fusco, A., High level expression of the HMGI (Y) gene during embryonic development (1996) Oncogene, 13 (11), pp. 2439-2446
Crescenzi, E., Palumbo, G., De Boer, J., Brady, H.J.M., Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy (2008) Clinical Cancer Research, 14 (6), pp. 1877-1887. , http://clincancerres.aacrjournals.org/cgi/reprint/14/6/1877, DOI 10.1158/1078-0432.CCR-07-4298
D'Adda Di Fagagna, F., Living on a break: Cellular senescence as a DNA-damage response (2008) Nature Reviews Cancer, 8 (7), pp. 512-522. , DOI 10.1038/nrc2440, PII NRC2440
Fedele, M., Fusco, A., HMGA and cancer (2010) Biochim Biophys Acta, 1799, pp. 48-54
Fedele, M., Pierantoni, G.M., Berlingieri, M.T., Battista, S., Baldassarre, G., Munshi, N., Dentice, M., Fusco, A., Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells (2001) Cancer Research, 61 (11), pp. 4583-4590
Fedele, M., Visone, R., De Martino, I., Troncone, G., Palmieri, D., Battista, S., Ciarmiello, A., Fusco, A., HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity (2006) Cancer Cell, 9 (6), pp. 459-471. , DOI 10.1016/j.ccr.2006.04.024, PII S1535610806001474
Fusco, A., Fedele, M., Roles of HMGA proteins in cancer (2007) Nature Reviews Cancer, 7 (12), pp. 899-910. , DOI 10.1038/nrc2271, PII NRC2271
Gueven, N., Keating, K., Fukao, T., Loeffler, H., Kondo, N., Rodemann, H.P., Lavin, M.F., Site-directed mutagenesis of the ATM promoter: Consequences for response to proliferation and ionizing radiation (2003) Genes Chromosomes and Cancer, 38 (2), pp. 157-167. , DOI 10.1002/gcc.10261
Hickson, I., Zhao, Y., Richardson, C.J., Green, S.J., Martin, N.M.B., Orr, A.I., Reaper, P.M., Smith, G.C.M., Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM (2004) Cancer Research, 64 (24), pp. 9152-9159. , DOI 10.1158/0008-5472.CAN-04-2727
Jackson, S.P., The DNA-damage response: New molecular insights and new approaches to cancer therapy (2009) Biochem Soc Trans, 37, pp. 483-494
Johnson, K.R., Lehn, D.A., Reeves, R., Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y (1989) Molecular and Cellular Biology, 9 (5), pp. 2114-2123
Kuhne, M., Riballo, E., Rief, N., Rothkamm, K., Jeggo, P.A., Lobrich, M., Double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity (2004) Cancer Research, 64 (2), pp. 500-508. , DOI 10.1158/0008-5472.CAN-03-2384
Lavin, M.F., Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer (2008) Nat Rev Mol Cell Biol, 9, pp. 759-769
Lavin, M.F., Kozlov, S., ATM activation and DNA damage response (2007) Cell Cycle, 6 (8), pp. 931-942. , http://www.landesbioscience.com/journals/cc/article/lavinCC6-8.pdf
Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method (2001) Methods, 25 (4), pp. 402-408. , DOI 10.1006/meth.2001.1262
Hoyos, J.M., Fedele, M., Battista, S., Pentimalli, F., Kruhoffer, M., Arra, C., Orntoft, T.F., Fusco, A., Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: Tissue specificity of the HMGA1-dependent gene regulation (2004) Cancer Research, 64 (16), pp. 5728-5735. , DOI 10.1158/0008-5472.CAN-04-1410
Meyn, M.S., Strasfeld, L., Allen, C., Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiecta-sia (1994) Int J Radiat Biol, 66, pp. S141-S149
Nagpal, S., Ghosn, C., Disepio, D., Molina, Y., Sutter, M., Klein, E.S., Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor (1999) J Biol Chem, 274, pp. 22563-22568
Narita, M., Narita, M., Krizhanovsky, V., Nunez, S., Chicas, A., Hearn, S.A., Myers, M.P., Lowe, S.W., A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation (2006) Cell, 126 (3), pp. 503-514. , DOI 10.1016/j.cell.2006.05.052, PII S0092867406009135
O'Neill, T., Dwyer, A.J., Ziv, Y., Chan, D.W., Lees-Miller, S.P., Abraham, R.H., Lai, J.H., Rathbun, G.A., Utilization of oriented peptide libraries to identify substrate motifs selected by ATM (2000) Journal of Biological Chemistry, 275 (30), pp. 22719-22727. , DOI 10.1074/jbc.M001002200
Parrinello, S., Samper, E., Krtolica, A., Goldstein, J., Melov, S., Campisi, J., Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts (2003) Nature Cell Biology, 5 (8), pp. 741-747. , DOI 10.1038/ncb1024
Pentimalli, F., Palmieri, D., Pacelli, R., Garbi, C., Cesari, R., Martin, E., HMGA1 protein is a novel target of the ATM kinase (2008) Eur J Cancer, 44, pp. 2668-2679
Pierantoni, G.M., Fedele, M., Pentimalli, F., Benvenuto, G., Pero, R., Viglietto, G., Santoro, M., Fusco, A., High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth (2001) Oncogene, 20 (43), pp. 6132-6141. , DOI 10.1038/sj.onc.1204635
Pierantoni, G.M., Rinaldo, C., Esposito, F., Mottolese, M., Soddu, S., Fusco, A., High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity (2006) Cell Death Differ, 5, pp. 2045-2048
Reeves, R., Adair, J.E., Role of high mobility group (HMG) chromatin proteins in DNA repair (2005) DNA Repair, 4 (8), pp. 926-938. , DOI 10.1016/j.dnarep.2005.04.010, PII S1568786405000935
Reeves, R., Nissen, M.S., The A.T-DNA-binding domain of mammalian high mobility group i chromosomal proteins. A novel peptide motif for recognizing DNA structure (1990) J Biol Chem, 265, pp. 8573-8582
Sarkaria, J.N., Busby, E.C., Tibbetts, R.S., Roos, P., Taya, Y., Karnitz, L.M., Abraham, R.T., Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine (1999) Cancer Research, 59 (17), pp. 4375-4382
Sarkaria, J.N., Eshleman, J.S., ATM as a target for novel radiosensitizers (2001) Seminars in Radiation Oncology, 11 (4), pp. 316-327
Sarkaria, J.N., Tibbetts, R.S., Busby, E.C., Kennedy, A.P., Hill, D.E., Abraham, R.T., Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin (1998) Cancer Research, 58 (19), pp. 4375-4382
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., A single ataxia telangiectasia gene with a product similar to PI-3 kinase (1995) Science, 268, pp. 1749-1753
Viale, A., De Franco, F., Orleth, A., Cambiaghi, V., Giuliani, V., Bossi, D., Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells (2009) Nature, 457, pp. 51-56
Wood, L.J., Maher, J.F., Bunton, T.E., Resar, L.M.S., The oncogenic properties of the HMG-I gene family (2000) Cancer Research, 60 (15), pp. 4256-4261
Xu, Y., Ashley, T., Brainerd, E.E., Bronson, R.T., Meyn, M.S., Baltimore, D., Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma (1996) Genes and Development, 10 (19), pp. 2411-2422
Xu, Y., Yang, E.M., Brugarolas, J., Jacks, T., Baltimore, D., Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm(-/-) mice (1998) Molecular and Cellular Biology, 18 (7), pp. 4385-4390
Zhou, X., Benson, K.F., Ashar, H.R., Chada, K., Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C (1995) Nature, 376, pp. 771-774
Bakkenist, C. J., Kastan, M. B., DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation (2003) Nature, 421 (6922), pp. 499-506. , DOI 10. 1038/nature0136
Berlingieri, M. T., Pierantoni, G. M., Giancotti, V., Santoro, M., Fusco, A., Thyroid cell transformation requires the expression of the HMGA1 proteins (2002) Oncogene, 21 (19), pp. 2971-2980. , DOI 10. 1038/sj/onc/1205368
Canman, C. E., Lim, D. -S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Siliciano, J. D., Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 (1998) Science, 281 (5383), pp. 1677-1679. , DOI 10. 1126/science. 281. 5383. 1677
Jackson, S. P., The DNA-damage response: New molecular insights and new approaches to cancer therapy (2009) Biochem Soc Trans, 37, pp. 483-494
Johnson, K. R., Lehn, D. A., Reeves, R., Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y (1989) Molecular and Cellular Biology, 9 (5), pp. 2114-2123
Lavin, M. F., Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer (2008) Nat Rev Mol Cell Biol, 9, pp. 759-769
Lavin, M. F., Kozlov, S., ATM activation and DNA damage response (2007) Cell Cycle, 6 (8), pp. 931-942. , http: //www. landesbioscience. com/journals/cc/article/lavinCC6-8. pdf
Livak, K. J., Schmittgen, T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2- CT method (2001) Methods, 25 (4), pp. 402-408. , DOI 10. 1006/meth. 2001. 1262
Hoyos, J. M., Fedele, M., Battista, S., Pentimalli, F., Kruhoffer, M., Arra, C., Orntoft, T. F., Fusco, A., Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: Tissue specificity of the HMGA1-dependent gene regulation (2004) Cancer Research, 64 (16), pp. 5728-5735. , DOI 10. 1158/0008-5472. CAN-04-1410
Meyn, M. S., Strasfeld, L., Allen, C., Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiecta-sia (1994) Int J Radiat Biol, 66, pp. S141-S149
Pierantoni, G. M., Fedele, M., Pentimalli, F., Benvenuto, G., Pero, R., Viglietto, G., Santoro, M., Fusco, A., High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth (2001) Oncogene, 20 (43), pp. 6132-6141. , DOI 10. 1038/sj. onc. 1204635
Sarkaria, J. N., Busby, E. C., Tibbetts, R. S., Roos, P., Taya, Y., Karnitz, L. M., Abraham, R. T., Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine (1999) Cancer Research, 59 (17), pp. 4375-4382
Sarkaria, J. N., Eshleman, J. S., ATM as a target for novel radiosensitizers (2001) Seminars in Radiation Oncology, 11 (4), pp. 316-327
Sarkaria, J. N., Tibbetts, R. S., Busby, E. C., Kennedy, A. P., Hill, D. E., Abraham, R. T., Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin (1998) Cancer Research, 58 (19), pp. 4375-4382
Wood, L. J., Maher, J. F., Bunton, T. E., Resar, L. M. S., The oncogenic properties of the HMG-I gene family (2000) Cancer Research, 60 (15), pp. 4256-4261
Xu, Y., Yang, E. M., Brugarolas, J., Jacks, T., Baltimore, D., Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm (-/-) mice (1998) Molecular and Cellular Biology, 18 (7), pp. 4385-4390
HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents
DNA-damaging therapies represent a keystone in cancer treatment. Unfortunately, many tumors often relapse because of a group of cancer cells, which are resistant to conventional therapies. High-mobility group A (HMGA) proteins has a key role in cell transformation, and their overexpression is a common feature of human malignant neoplasias, representing a poor prognostic index often correlated to anti-cancer drug resistance. Our previous results demonstrated that HMGA1 is a substrate of ataxia-telangiectasia mutated (ATM), the main cellular sensor of genotoxic stress. Here we also report thatHMGA2, the other member of the HMGA family, is a novel substrate of ATM. Interestingly, we found that HMGA proteins positively regulate ATM gene expression. Moreover, induction of ATM kinase activity by DNA-damaging agents enhances HMGA-dependent transcriptional activation of ATM promoter, suggesting that ATM expression is modulated by a DNA-damage- and HMGA-dependent positive feedback loop. Finally, inhibition of HMGA expression in mouse embryonic fibroblasts and in cancer cells strongly reduces ATM protein levels, impairing the cellular DNA-damage response and enhancing the sensitivity to DNA-damaging agents. These findings indicate this novel HMGA-ATM pathway as a new potential target to improve the effectiveness of conventional anti-neoplastic treatments on the genotoxic-drug resistant cancer cells. © 2011 Macmillan Publishers Limited All rights reserved.
DNA-damaging therapies represent a keystone in cancer treatment. Unfortunately, many tumors often relapse because of a group of cancer cells, which are resistant to conventional therapies. High-mobility group A (HMGA) proteins has a key role in cell transformation, and their overexpression is a common feature of human malignant neoplasias, representing a poor prognostic index often correlated to anti-cancer drug resistance. Our previous results demonstrated that HMGA1 is a substrate of ataxia-telangiectasia mutated (ATM), the main cellular sensor of genotoxic stress. Here we also report thatHMGA2, the other member of the HMGA family, is a novel substrate of ATM. Interestingly, we found that HMGA proteins positively regulate ATM gene expression. Moreover, induction of ATM kinase activity by DNA-damaging agents enhances HMGA-dependent transcriptional activation of ATM promoter, suggesting that ATM expression is modulated by a DNA-damage- and HMGA-dependent positive feedback loop. Finally, inhibition of HMGA expression in mouse embryonic fibroblasts and in cancer cells strongly reduces ATM protein levels, impairing the cellular DNA-damage response and enhancing the sensitivity to DNA-damaging agents. These findings indicate this novel HMGA-ATM pathway as a new potential target to improve the effectiveness of conventional anti-neoplastic treatments on the genotoxic-drug resistant cancer cells. © 2011 Macmillan Publishers Limited All rights reserved.
HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents
| ▼ Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events |
HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents
Other filter: ([btitle,keywords] "Dna Repair" OR [btit ...
Esposito MV, Minopoli G, Esposito L, D'Argenio V, Di Maggio F, Sasso E, D'Aiuto M, Zambrano N, Salvatore F
* A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA Repair (142 views)
Cancers (ISSN: 2072-6694linking), 2019 Sep 28; 11(10): N/D-N/D.
Impact Factor: 6.102
View Export to BibTeX Export to EndNote
Forestier A, Douki T, De Rosa V, Beal D, Rachidi W
* Combination of Abeta Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC (353 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Jul 30; 16(8): 17422-17444.
Impact Factor: 3.257
View Export to BibTeX Export to EndNote
Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
* Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata (599 views)
Environ Pollut (ISSN: 0269-7491), 2015; 203: 145-152.
Impact Factor: 4.839
View Export to BibTeX Export to EndNote
Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (462 views)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
View Export to BibTeX Export to EndNote
Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (609 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
View Export to BibTeX Export to EndNote
D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
* The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin (395 views)
European Journal Of Cancer (ISSN: 0959-8049), 2013 Mar; 49(5): 1142-1151.
Impact Factor: 4.819
View Export to BibTeX Export to EndNote
Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
View Export to BibTeX Export to EndNote
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (660 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
View Export to BibTeX Export to EndNote
Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (520 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
View Export to BibTeX Export to EndNote
De Rosa V, Alan D, Alain F, Thierry D, Walid R
* The anticancer effect of selenium: study of its role in DNA repair activity and resistance to oxidative stress (250 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2009 Mar; 96: N/D-N/D.
Impact Factor: 0.792
View Export to BibTeX Export to EndNote
Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (388 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
View Export to BibTeX Export to EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
View Export to BibTeX Export to EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
View Export to BibTeX Export to EndNote
* A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA Repair (142 views)
Cancers (ISSN: 2072-6694linking), 2019 Sep 28; 11(10): N/D-N/D.
Impact Factor: 6.102
View Export to BibTeX Export to EndNote
Forestier A, Douki T, De Rosa V, Beal D, Rachidi W
* Combination of Abeta Secretion and Oxidative Stress in an Alzheimer-Like Cell Line Leads to the Over-Expression of the Nucleotide Excision Repair Proteins DDB2 and XPC (353 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015 Jul 30; 16(8): 17422-17444.
Impact Factor: 3.257
View Export to BibTeX Export to EndNote
Galdiero E, Maselli V, Falanga A, Gesuele R, Galdiero S, Fulgione D, Guida M
* Integrated analysis of the ecotoxicological and genotoxic effects of the antimicrobial peptide melittin on Daphnia magna and Pseudokirchneriella subcapitata (599 views)
Environ Pollut (ISSN: 0269-7491), 2015; 203: 145-152.
Impact Factor: 4.839
View Export to BibTeX Export to EndNote
Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (462 views)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
View Export to BibTeX Export to EndNote
Perri F, Pacelli R, Della Vittoria Scarpati G, Cella L, Giuliano M, Caponigro F, Pepe S
* Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (522 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Impact Factor: 2.76
View Export to BibTeX Export to EndNote
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
View Export to BibTeX Export to EndNote
Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (609 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
View Export to BibTeX Export to EndNote
D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
* The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin (395 views)
European Journal Of Cancer (ISSN: 0959-8049), 2013 Mar; 49(5): 1142-1151.
Impact Factor: 4.819
View Export to BibTeX Export to EndNote
Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
View Export to BibTeX Export to EndNote
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G
* Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells (660 views)
Mol Biol Cell (ISSN: 1059-1524), 2012 Oct 15; 23(20): 4079-4096.
Impact Factor: 4.803
View Export to BibTeX Export to EndNote
Merolla F, Luise C, Muller MT, Pacelli R, Fusco A, Celetti A
* Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 May 24; 7(5): N/D-N/D.
Impact Factor: 3.73
View Export to BibTeX Export to EndNote
De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (520 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
View Export to BibTeX Export to EndNote
De Rosa V, Alan D, Alain F, Thierry D, Walid R
* The anticancer effect of selenium: study of its role in DNA repair activity and resistance to oxidative stress (250 views)
Bulletin Du Cancer (ISSN: 0007-4551), 2009 Mar; 96: N/D-N/D.
Impact Factor: 0.792
View Export to BibTeX Export to EndNote
Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Merolla F, Pentimalli F, Pacelli R, Vecchio G, Fusco A, Grieco M, Celetti A
* Involvement of H4(D10S170) protein in ATM-dependent response to DNA damage (606 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2007 Sep 13; 26(42): 6167-6175.
Impact Factor: 6.44
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM, Fusco A, Brunetti A
* Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (388 views)
Nat Med (ISSN: 1078-8956, 0034-7264), 2005 Jul; 11(7): 765-773.
Impact Factor: 28.878
View Export to BibTeX Export to EndNote
Herscher LL, Cook JA, Pacelli R, Pass HI, Russo A, Mitchell JB
Principles of chemoradiation: Theoretical and practical considerations (406 views)
Oncology (ISSN: 0890-9091), 1999 Oct; 13(10SUPPL.5): 11-22.
Impact Factor: 0.933
View Export to BibTeX Export to EndNote
Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (486 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
View Export to BibTeX Export to EndNote
21 Records (20 excluding Abstracts).
Total impact factor: 104.462 (100.732 excluding Abstracts).
Total 5 year impact factor: 102.306 (98.062 excluding Abstracts).
Total impact factor: 104.462 (100.732 excluding Abstracts).
Total 5 year impact factor: 102.306 (98.062 excluding Abstracts).
870 views. Last view on Friday 24 March 2023, 7:19:48
ibb.cnr.it
