Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (595 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.925, 5-year impact factor: 5.866
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80053181978&partnerID=40&md5=791442516ea19e62238769d95735192c
Keywords: Aggregation, Metal-Protein Interactions, Ubiquitin, Zinc, Affinity Constants, Binding Modes, Copper Binding, Dynamic Equilibria, Equimolar Addition, In-Line, Neurodegeneration, Neutral Ph, Potentiometric Titrations, Preferential Binding, Protein Assembly, Protein Stability, Protein Thermal Stability, Ubiquitin-Proteasome System, Ubiquitinated Proteins, Zinc Complex, Agglomeration, Binding Energy, Binding Sites, Complexation, Differential Scanning Calorimetry, Metal Ions, Zinc Compounds, Metalloprotein, Article, Chemistry, Metabolism, Nuclear Magnetic Resonance Spectroscopy, Protein Binding,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy.
Istituto di Biostrutture e Bioimmagini-UOS CT, Consiglio Nazionale Delle Ricerche, V.le A. Doria 6, 95125 Catania, Italy
References:
Glickman, M.H., Ciechanover, A., (2002) Physiol. Rev., 82, pp. 373-42
Ulrich, H.D., (2002) Eukaryotic Cell, 1, pp. 1-10
Sun, L., Chen, Z.J., (2004) Curr. Opin. Cell Biol., 16, pp. 119-126
Hicke, L., Dunn, R., (2003) Annu. Rev. Cell. Dev. Biol., 19, pp. 141-172
Spence, J., Gali, R.R., Dittmar, G., Sherman, F., Karin, M., Finley, D., (2000) Cell, 102, pp. 67-76
Cummings, C.J., Mancini, M.A., Antalffy, B., De Franco, D.B., Orr, H.T., Zoghbi, H.Y., (1998) Nat. Genet., 19, pp. 148-154
Sherman, M.Y., Goldberg, A.L., (2001) Neuron, 29, pp. 15-32
Adams, J., (2004) Cancer Cell, 5, pp. 417-421
Borissenko, L., Groll, M., (2007) Chem. Rev., 107, pp. 687-717
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Shimizu, N., (1998) Nature, 392, pp. 605-608
Leroy, E., Boyer, R., Auburger, G., Leube, B., Ulm, G., Mezey, E., Harta, G., Polymeropoulos, M.H., (1998) Nature, 395, pp. 451-452
Amici, M., Forti, K., Nobili, C., Lupidi, G., Angeletti, M., Fioretti, E., Eleuteri, A.M., (2002) J. Biol. Inorg. Chem., 7, pp. 750-756
Pang, H., Chen, D., Cui, Q.C., Dou, Q.P., (2007) Int. J. Mol. Med., 19, pp. 809-816
Daniel, K.G., Chen, D., B, B.Y., Dou, Q.P., (2007) Front. Biosci., 12, pp. 135-144
Adsule, S., Barve, V., Chen, D., Ahmed, F., Dou, Q.P., Padhye, S., Sarkar, F.H., (2006) J. Med. Chem., 49, pp. 7242-7246
Daniel, K.G., Kuhn, D.J., Kazi, A., Dou, Q.P., (2005) Curr. Cancer Drug Targets, 5, pp. 529-541
Chen, D., Peng, F., Cui, Q.C., Daniel, K.G., Orlu, S., Liu, J., Dou, Q.P., (2005) Front. Biosci., 10, pp. 2932-2939
Nittis, T., Gitlin, J.D., (2004) J. Biol. Chem., 279, pp. 25696-25702
Daniel, K.G., Gupta, P., Harbach, R.H., Guida, W.C., Dou, Q.P., (2004) Biochem. Pharmacol., 67, pp. 1139-1151
Bertinato, J., Labbe, M.R., (2003) J. Biol. Chem., 278, pp. 35071-35078
Vijay-Kumar, S., Bugg, C.E., Cook, W.J., (1987) J. Mol. Biol., 194, pp. 531-544
Ciechanover, A., Brundin, P., (2003) Neuron, 40, pp. 427-446
Bush, A.I., (2003) Trends Neurosci., 26, pp. 207-214
Barnham, K.J., Bush, A.I., (2008) Curr. Opin. Chem. Biol., 12, pp. 222-228
Jackson, S.E., (2006) Org. Biomol. Chem., 4, pp. 1845-1853
Schweiker, K.L., Fitz, V.W., Makhatadze, G.I., (2009) Biochemistry, 48, pp. 10846-10851
Di Stefano, D.L., Wand, A.J., (1987) Biochemistry, 26, pp. 7272-7281
Nash, D., Jonas, J., (1997) Biochem. Biophys. Res. Commun., 238, pp. 289-291
Walters, K.J., Goh, A.M., Wang, Q., Wagner, G., Howley, P.M., (2004) Biochim. Biophys. Acta Mol. Cell Res., 1695, pp. 73-87
Milardi, D., Arnesano, F., Grasso, G., Magra, A., Tabba, G., Scintilla, S., Natile, G., Rizzarelli, E., (2007) Angew. Chem. Int. Ed., 46, pp. 7993-7995
Arnesano, F., Scintilla, S., Cala, V., Bonfrate, E., Ingrosso, C., Losacco, M., Pellegrino, T., Natile, G., (2009) PLoS One, 4, p. 7052
Boal, A.K., Rosenzweig, A.C., (2009) Chem. Rev., 109, pp. 4760-4779
Shen, H., Wang, F., Zhang, Y., Xu, J., Long, J., Qin, H., Liu, F., Guo, J., (2007) Biol. Trace Elem. Res., 119, pp. 166-174
Linkous, D.H., Flinn, J.M., Koh, J.Y., Lanzirotti, A., Bertsch, P.M., Jones, B.F., Giblin, L.J., Frederickson, C.J., (2008) J. Histochem. Cytochem., 56, pp. 3-6
Danscher, G., Jensen, K.B., Frederickson, C.J., Kemp, K., Andreasen, A., Juhl, S., Stoltenberg, M., Ravid, R.J., (1997) J. Neurosci. Methods, 76, pp. 53-59
Lovell, M.A., Robertson, J.D., Teesdale, W.J., Campbell, J.L., Markesbery, W.R., (1998) J. Neurol. Sci., 158, pp. 47-52
Opazo, C., Luza, S., Villemagne, V.L., Volitakis, I., Rowe, C., Barnham, K.J., Strozyk, D., Bush, A.I., (2006) Aging Cell, 5, pp. 69-79
Religa, D., Strozyk, D., Cherny, R.A., Volitakis, I., Haroutunian, V., Winblad, B., Naslund, J., Bush, A.I., (2006) Neurology, 67, pp. 69-75
Sensi, S.L., Paoletti, P., Bush, A.I., Sekler, I., (2009) Nat. Rev. Neurosci., 10, pp. 780-792
Koh, J.Y., Suh, S.W., Gwag, B.J., He, Y.Y., Hsu, C.Y., Choi, D.W., (1996) Science, 272, pp. 1013-1016
Suh, S.W., Chen, J.W., Motamedi, M., Bell, B., Listiak, K., Pons, N.F., Danscher, G., Frederickson, C.J., (2000) Brain Res., 852, pp. 268-273
Riba-Bosch, A., Perez-Clausell, J., (2004) Neuroscience, 125, pp. 803-818
Koh, J.-Y., Choi, D.W., (1994) Neuroscience, 60, pp. 1049-1057
Calderone, A., Jover, T., Mashiko, T., Noh, K., Tanaka, H., Bennett, M.V.L., Zukin, R.S., (2004) J. Neurosci., 24, pp. 9903-9913
Arnesano, F., Belviso, B.D., Caliandro, R., Falini, G., Fermani, S., Natile, G., Siliqi, D., (2011) Chem. Eur. J., 17, pp. 1569-1578
Sundd, M., Iverson, N., Ibarra-Molero, B., Sanchez-Ruiz, J.M., Robertson, A.D., (2002) Biochemistry, 41, pp. 7586-7596
Cary, P.D., King, D.S., Crane-Robinson, C., Bradbury, E.M., Rabbani, A., Roodwin, G.H., Johns, E.W., (1980) Eur. J. Biochem., 112, pp. 577-580
Li, H., Robertson, A.D., Jensen, J.H., (2005) Proteins: Struct., Funct., Bioinf., 61, pp. 704-721
Edgcomb, S.P., Murphy, K.P., (2002) Proteins: Struct., Funct., Bioinf., 49, pp. 1-6
Di Marco, V.B., Bombi, G.G., (2006) Mass Spectrom. Rev., 25, pp. 347-379
Kállay, C., Asz, K., Dávid, A., Valastyán, Z., Malandrinos, G., Hadjiliadis, N., Sóvágó, I., (2007) Dalton Trans., 36, pp. 4040-4047
Sovago, I., Kiss, T., Gergerly, A., (1993) Pure Appl. Chem., 65, pp. 1029-1080
Privalov, P.L., Khechinashvili, N.N., (1974) J. Mol. Biol., 86, pp. 665-684
Wintrode, P.L., Makhatadze, G.I., Privalov, P.L., (1994) Proteins Struct. Funct. Bioinf., 18, pp. 246-253
Privalov, P.L., (1979) Adv. Protein Chem., 33, pp. 167-239
Milardi, D., Rosa, C.L., Grasso, D., (1994) Biophys. Chem., 52, pp. 183-189
Jain, N.K., Roy, I., (2009) Protein Sci., 18, pp. 24-36
Ignatova, Z., Gierasch, L.M., (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 13357-13361
Takahashi, T., Nakamura, H., Wada, A., (1992) Biopolymers, 32, pp. 897-909
Gran, G., (1952) Analyst, 77, pp. 661-671
Gans, P., Sabatini, A., Vacca, A., (1985) J. Chem. Soc. Dalton Trans., p. 1195
Arena, G., Cali, R., Lombardo, G.G., Sciotto, D., Rizzarelli, E., Ungaro, R., Casnati, A., (1992) Supramol. Chem., 1, pp. 19-24
La Rosa, C., Milardi, D., Grasso, D., Guzzi, R., Sportelli, L., (1995) J. Phys. Chem. A, 99, pp. 14864-14870
Hu, C.Q., Sturtevant, J.M., Thomson, J.A., Erickson, R.E., Pace, C.N., (1992) Biochemistry, 31, pp. 4876-4882
Manetto, G.D., Rosa, C.L., Grasso, D.M., Milardi, D., (2005) J. Therm. Anal. Calorim., 80, pp. 263-270
Grasso, D., La Rosa, C., Milardi, D., Fasone, S., (1995) Thermochim. Acta, 265, pp. 163-175
Russo, L., Palmieri, M., Baglivo, I., Esposito, S., Isernia, C., Malgieri, G., Pedone, P.V., Fattorusso, R., (2009) Biomol. NMR Assign., 4, pp. 55-56
Stejskal, E.O., Tanner, J.E., (1965) J. Chem. Phys., 42, pp. 288-292
Bartels, C., X, T.-H., Billeter, M., Wuthrich, K., (1995) J. Biomol. NMR, 5, pp. 1-10
Glickman, M. H., Ciechanover, A., (2002) Physiol. Rev., 82, pp. 373-42
Ulrich, H. D., (2002) Eukaryotic Cell, 1, pp. 1-10
Sun, L., Chen, Z. J., (2004) Curr. Opin. Cell Biol., 16, pp. 119-126
Cummings, C. J., Mancini, M. A., Antalffy, B., De Franco, D. B., Orr, H. T., Zoghbi, H. Y., (1998) Nat. Genet., 19, pp. 148-154
Sherman, M. Y., Goldberg, A. L., (2001) Neuron, 29, pp. 15-32
Daniel, K. G., Chen, D., B, B. Y., Dou, Q. P., (2007) Front. Biosci., 12, pp. 135-144
Daniel, K. G., Kuhn, D. J., Kazi, A., Dou, Q. P., (2005) Curr. Cancer Drug Targets, 5, pp. 529-541
Daniel, K. G., Gupta, P., Harbach, R. H., Guida, W. C., Dou, Q. P., (2004) Biochem. Pharmacol., 67, pp. 1139-1151
Bush, A. I., (2003) Trends Neurosci., 26, pp. 207-214
Barnham, K. J., Bush, A. I., (2008) Curr. Opin. Chem. Biol., 12, pp. 222-228
Jackson, S. E., (2006) Org. Biomol. Chem., 4, pp. 1845-1853
Schweiker, K. L., Fitz, V. W., Makhatadze, G. I., (2009) Biochemistry, 48, pp. 10846-10851
Di Stefano, D. L., Wand, A. J., (1987) Biochemistry, 26, pp. 7272-7281
Walters, K. J., Goh, A. M., Wang, Q., Wagner, G., Howley, P. M., (2004) Biochim. Biophys. Acta Mol. Cell Res., 1695, pp. 73-87
Boal, A. K., Rosenzweig, A. C., (2009) Chem. Rev., 109, pp. 4760-4779
Linkous, D. H., Flinn, J. M., Koh, J. Y., Lanzirotti, A., Bertsch, P. M., Jones, B. F., Giblin, L. J., Frederickson, C. J., (2008) J. Histochem. Cytochem., 56, pp. 3-6
Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., Markesbery, W. R., (1998) J. Neurol. Sci., 158, pp. 47-52
Sensi, S. L., Paoletti, P., Bush, A. I., Sekler, I., (2009) Nat. Rev. Neurosci., 10, pp. 780-792
Koh, J. Y., Suh, S. W., Gwag, B. J., He, Y. Y., Hsu, C. Y., Choi, D. W., (1996) Science, 272, pp. 1013-1016
Suh, S. W., Chen, J. W., Motamedi, M., Bell, B., Listiak, K., Pons, N. F., Danscher, G., Frederickson, C. J., (2000) Brain Res., 852, pp. 268-273
Koh, J. -Y., Choi, D. W., (1994) Neuroscience, 60, pp. 1049-1057
Cary, P. D., King, D. S., Crane-Robinson, C., Bradbury, E. M., Rabbani, A., Roodwin, G. H., Johns, E. W., (1980) Eur. J. Biochem., 112, pp. 577-580
Edgcomb, S. P., Murphy, K. P., (2002) Proteins: Struct., Funct., Bioinf., 49, pp. 1-6
Di Marco, V. B., Bombi, G. G., (2006) Mass Spectrom. Rev., 25, pp. 347-379
K llay, C., Asz, K., D vid, A., Valasty n, Z., Malandrinos, G., Hadjiliadis, N., S v g, I., (2007) Dalton Trans., 36, pp. 4040-4047
Privalov, P. L., Khechinashvili, N. N., (1974) J. Mol. Biol., 86, pp. 665-684
Wintrode, P. L., Makhatadze, G. I., Privalov, P. L., (1994) Proteins Struct. Funct. Bioinf., 18, pp. 246-253
Jain, N. K., Roy, I., (2009) Protein Sci., 18, pp. 24-36
Hu, C. Q., Sturtevant, J. M., Thomson, J. A., Erickson, R. E., Pace, C. N., (1992) Biochemistry, 31, pp. 4876-4882
Manetto, G. D., Rosa, C. L., Grasso, D. M., Milardi, D., (2005) J. Therm. Anal. Calorim., 80, pp. 263-270
Stejskal, E. O., Tanner, J. E., (1965) J. Chem. Phys., 42, pp. 288-292
Bartels, C., X, T. -H., Billeter, M., Wuthrich, K., (1995) J. Biomol. NMR, 5, pp. 1-10
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.925, 5-year impact factor: 5.866
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-80053181978&partnerID=40&md5=791442516ea19e62238769d95735192c
Keywords: Aggregation, Metal-Protein Interactions, Ubiquitin, Zinc, Affinity Constants, Binding Modes, Copper Binding, Dynamic Equilibria, Equimolar Addition, In-Line, Neurodegeneration, Neutral Ph, Potentiometric Titrations, Preferential Binding, Protein Assembly, Protein Stability, Protein Thermal Stability, Ubiquitin-Proteasome System, Ubiquitinated Proteins, Zinc Complex, Agglomeration, Binding Energy, Binding Sites, Complexation, Differential Scanning Calorimetry, Metal Ions, Zinc Compounds, Metalloprotein, Article, Chemistry, Metabolism, Nuclear Magnetic Resonance Spectroscopy, Protein Binding,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy.
Istituto di Biostrutture e Bioimmagini-UOS CT, Consiglio Nazionale Delle Ricerche, V.le A. Doria 6, 95125 Catania, Italy
References:
Glickman, M.H., Ciechanover, A., (2002) Physiol. Rev., 82, pp. 373-42
Ulrich, H.D., (2002) Eukaryotic Cell, 1, pp. 1-10
Sun, L., Chen, Z.J., (2004) Curr. Opin. Cell Biol., 16, pp. 119-126
Hicke, L., Dunn, R., (2003) Annu. Rev. Cell. Dev. Biol., 19, pp. 141-172
Spence, J., Gali, R.R., Dittmar, G., Sherman, F., Karin, M., Finley, D., (2000) Cell, 102, pp. 67-76
Cummings, C.J., Mancini, M.A., Antalffy, B., De Franco, D.B., Orr, H.T., Zoghbi, H.Y., (1998) Nat. Genet., 19, pp. 148-154
Sherman, M.Y., Goldberg, A.L., (2001) Neuron, 29, pp. 15-32
Adams, J., (2004) Cancer Cell, 5, pp. 417-421
Borissenko, L., Groll, M., (2007) Chem. Rev., 107, pp. 687-717
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Shimizu, N., (1998) Nature, 392, pp. 605-608
Leroy, E., Boyer, R., Auburger, G., Leube, B., Ulm, G., Mezey, E., Harta, G., Polymeropoulos, M.H., (1998) Nature, 395, pp. 451-452
Amici, M., Forti, K., Nobili, C., Lupidi, G., Angeletti, M., Fioretti, E., Eleuteri, A.M., (2002) J. Biol. Inorg. Chem., 7, pp. 750-756
Pang, H., Chen, D., Cui, Q.C., Dou, Q.P., (2007) Int. J. Mol. Med., 19, pp. 809-816
Daniel, K.G., Chen, D., B, B.Y., Dou, Q.P., (2007) Front. Biosci., 12, pp. 135-144
Adsule, S., Barve, V., Chen, D., Ahmed, F., Dou, Q.P., Padhye, S., Sarkar, F.H., (2006) J. Med. Chem., 49, pp. 7242-7246
Daniel, K.G., Kuhn, D.J., Kazi, A., Dou, Q.P., (2005) Curr. Cancer Drug Targets, 5, pp. 529-541
Chen, D., Peng, F., Cui, Q.C., Daniel, K.G., Orlu, S., Liu, J., Dou, Q.P., (2005) Front. Biosci., 10, pp. 2932-2939
Nittis, T., Gitlin, J.D., (2004) J. Biol. Chem., 279, pp. 25696-25702
Daniel, K.G., Gupta, P., Harbach, R.H., Guida, W.C., Dou, Q.P., (2004) Biochem. Pharmacol., 67, pp. 1139-1151
Bertinato, J., Labbe, M.R., (2003) J. Biol. Chem., 278, pp. 35071-35078
Vijay-Kumar, S., Bugg, C.E., Cook, W.J., (1987) J. Mol. Biol., 194, pp. 531-544
Ciechanover, A., Brundin, P., (2003) Neuron, 40, pp. 427-446
Bush, A.I., (2003) Trends Neurosci., 26, pp. 207-214
Barnham, K.J., Bush, A.I., (2008) Curr. Opin. Chem. Biol., 12, pp. 222-228
Jackson, S.E., (2006) Org. Biomol. Chem., 4, pp. 1845-1853
Schweiker, K.L., Fitz, V.W., Makhatadze, G.I., (2009) Biochemistry, 48, pp. 10846-10851
Di Stefano, D.L., Wand, A.J., (1987) Biochemistry, 26, pp. 7272-7281
Nash, D., Jonas, J., (1997) Biochem. Biophys. Res. Commun., 238, pp. 289-291
Walters, K.J., Goh, A.M., Wang, Q., Wagner, G., Howley, P.M., (2004) Biochim. Biophys. Acta Mol. Cell Res., 1695, pp. 73-87
Milardi, D., Arnesano, F., Grasso, G., Magra, A., Tabba, G., Scintilla, S., Natile, G., Rizzarelli, E., (2007) Angew. Chem. Int. Ed., 46, pp. 7993-7995
Arnesano, F., Scintilla, S., Cala, V., Bonfrate, E., Ingrosso, C., Losacco, M., Pellegrino, T., Natile, G., (2009) PLoS One, 4, p. 7052
Boal, A.K., Rosenzweig, A.C., (2009) Chem. Rev., 109, pp. 4760-4779
Shen, H., Wang, F., Zhang, Y., Xu, J., Long, J., Qin, H., Liu, F., Guo, J., (2007) Biol. Trace Elem. Res., 119, pp. 166-174
Linkous, D.H., Flinn, J.M., Koh, J.Y., Lanzirotti, A., Bertsch, P.M., Jones, B.F., Giblin, L.J., Frederickson, C.J., (2008) J. Histochem. Cytochem., 56, pp. 3-6
Danscher, G., Jensen, K.B., Frederickson, C.J., Kemp, K., Andreasen, A., Juhl, S., Stoltenberg, M., Ravid, R.J., (1997) J. Neurosci. Methods, 76, pp. 53-59
Lovell, M.A., Robertson, J.D., Teesdale, W.J., Campbell, J.L., Markesbery, W.R., (1998) J. Neurol. Sci., 158, pp. 47-52
Opazo, C., Luza, S., Villemagne, V.L., Volitakis, I., Rowe, C., Barnham, K.J., Strozyk, D., Bush, A.I., (2006) Aging Cell, 5, pp. 69-79
Religa, D., Strozyk, D., Cherny, R.A., Volitakis, I., Haroutunian, V., Winblad, B., Naslund, J., Bush, A.I., (2006) Neurology, 67, pp. 69-75
Sensi, S.L., Paoletti, P., Bush, A.I., Sekler, I., (2009) Nat. Rev. Neurosci., 10, pp. 780-792
Koh, J.Y., Suh, S.W., Gwag, B.J., He, Y.Y., Hsu, C.Y., Choi, D.W., (1996) Science, 272, pp. 1013-1016
Suh, S.W., Chen, J.W., Motamedi, M., Bell, B., Listiak, K., Pons, N.F., Danscher, G., Frederickson, C.J., (2000) Brain Res., 852, pp. 268-273
Riba-Bosch, A., Perez-Clausell, J., (2004) Neuroscience, 125, pp. 803-818
Koh, J.-Y., Choi, D.W., (1994) Neuroscience, 60, pp. 1049-1057
Calderone, A., Jover, T., Mashiko, T., Noh, K., Tanaka, H., Bennett, M.V.L., Zukin, R.S., (2004) J. Neurosci., 24, pp. 9903-9913
Arnesano, F., Belviso, B.D., Caliandro, R., Falini, G., Fermani, S., Natile, G., Siliqi, D., (2011) Chem. Eur. J., 17, pp. 1569-1578
Sundd, M., Iverson, N., Ibarra-Molero, B., Sanchez-Ruiz, J.M., Robertson, A.D., (2002) Biochemistry, 41, pp. 7586-7596
Cary, P.D., King, D.S., Crane-Robinson, C., Bradbury, E.M., Rabbani, A., Roodwin, G.H., Johns, E.W., (1980) Eur. J. Biochem., 112, pp. 577-580
Li, H., Robertson, A.D., Jensen, J.H., (2005) Proteins: Struct., Funct., Bioinf., 61, pp. 704-721
Edgcomb, S.P., Murphy, K.P., (2002) Proteins: Struct., Funct., Bioinf., 49, pp. 1-6
Di Marco, V.B., Bombi, G.G., (2006) Mass Spectrom. Rev., 25, pp. 347-379
Kállay, C., Asz, K., Dávid, A., Valastyán, Z., Malandrinos, G., Hadjiliadis, N., Sóvágó, I., (2007) Dalton Trans., 36, pp. 4040-4047
Sovago, I., Kiss, T., Gergerly, A., (1993) Pure Appl. Chem., 65, pp. 1029-1080
Privalov, P.L., Khechinashvili, N.N., (1974) J. Mol. Biol., 86, pp. 665-684
Wintrode, P.L., Makhatadze, G.I., Privalov, P.L., (1994) Proteins Struct. Funct. Bioinf., 18, pp. 246-253
Privalov, P.L., (1979) Adv. Protein Chem., 33, pp. 167-239
Milardi, D., Rosa, C.L., Grasso, D., (1994) Biophys. Chem., 52, pp. 183-189
Jain, N.K., Roy, I., (2009) Protein Sci., 18, pp. 24-36
Ignatova, Z., Gierasch, L.M., (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 13357-13361
Takahashi, T., Nakamura, H., Wada, A., (1992) Biopolymers, 32, pp. 897-909
Gran, G., (1952) Analyst, 77, pp. 661-671
Gans, P., Sabatini, A., Vacca, A., (1985) J. Chem. Soc. Dalton Trans., p. 1195
Arena, G., Cali, R., Lombardo, G.G., Sciotto, D., Rizzarelli, E., Ungaro, R., Casnati, A., (1992) Supramol. Chem., 1, pp. 19-24
La Rosa, C., Milardi, D., Grasso, D., Guzzi, R., Sportelli, L., (1995) J. Phys. Chem. A, 99, pp. 14864-14870
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Zinc(II) complexes of ubiquitin: speciation, affinity and binding features
Intraneuronal inclusions consisting of hypermetallated, (poly-)ubiquitinated proteins are a hallmark of neurodegeneration. To highlight the possible role played by metal ions in the dysfunction of the ubiquitin-proteasome system, here we report on zinc(II)/ubiquitin binding in terms of affinity constants, speciation, preferential binding sites and effects on protein stability and self-assembly. Potentiometric titrations allowed us to establish that at neutral pH only two species, ZnUb and Zn(2)Ub, are present in solution, in line with ESI-MS data. A change in the diffusion coefficient of ubiquitin was observed by NMR DOSY experiments after addition of Zn(II) ions, and thus indicates metal-promoted formation of protein assemblies. Analysis of (1)H, (15)N, (13)Calpha and (13)CO chemical-shift perturbation after equimolar addition of Zn(II) ions to ubiquitin outlined two different metal-binding modes. The first involves a dynamic equilibrium in which zinc(II) is shared between a region including Met1, Gln2, Ile3, Phe4, Thr12, Leu15, Glu16, Val17, Glu18, Ile61 and Gln62 residues, which represent a site already described for copper binding, and a domain comprising Ile23, Glu24, Lys27, Ala28, Gln49, Glu51, Asp52, Arg54 and Thr55 residues. A second looser binding mode is centred on His68. Differential scanning calorimetry evidenced that addition of increasing amounts of Zn(II) ions does not affect protein thermal stability; rather it influences the shape of thermograms because of the increased propensity of ubiquitin to self-associate. The results presented here indicate that Zn(II) ions may interact with specific regions of ubiquitin and promote protein-protein contacts. Copyright 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Intraneuronal inclusions consisting of hypermetallated, (poly-)ubiquitinated proteins are a hallmark of neurodegeneration. To highlight the possible role played by metal ions in the dysfunction of the ubiquitin-proteasome system, here we report on zinc(II)/ubiquitin binding in terms of affinity constants, speciation, preferential binding sites and effects on protein stability and self-assembly. Potentiometric titrations allowed us to establish that at neutral pH only two species, ZnUb and Zn(2)Ub, are present in solution, in line with ESI-MS data. A change in the diffusion coefficient of ubiquitin was observed by NMR DOSY experiments after addition of Zn(II) ions, and thus indicates metal-promoted formation of protein assemblies. Analysis of (1)H, (15)N, (13)Calpha and (13)CO chemical-shift perturbation after equimolar addition of Zn(II) ions to ubiquitin outlined two different metal-binding modes. The first involves a dynamic equilibrium in which zinc(II) is shared between a region including Met1, Gln2, Ile3, Phe4, Thr12, Leu15, Glu16, Val17, Glu18, Ile61 and Gln62 residues, which represent a site already described for copper binding, and a domain comprising Ile23, Glu24, Lys27, Ala28, Gln49, Glu51, Asp52, Arg54 and Thr55 residues. A second looser binding mode is centred on His68. Differential scanning calorimetry evidenced that addition of increasing amounts of Zn(II) ions does not affect protein thermal stability; rather it influences the shape of thermograms because of the increased propensity of ubiquitin to self-associate. The results presented here indicate that Zn(II) ions may interact with specific regions of ubiquitin and promote protein-protein contacts. Copyright 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Zinc(II) complexes of ubiquitin: speciation, affinity and binding features
| ▼ Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications |
Zinc(II) complexes of ubiquitin: speciation, affinity and binding features
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Impact Factor: 5.696
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (778 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Di Natale G, Osz K, Kállay C, Pappalardo G, Sanna D, Impellizzeri G, Sóvágó I, Rizzarelli E
* Affinity, speciation, and molecular features of copper(II) complexes with a prion tetraoctarepeat domain in aqueous solution: insights into old and new results (422 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2013 Mar 11; 19(11): 3751-3761.
Impact Factor: 5.696
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (471 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (737 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (457 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Arena G, La Mendola D, Pappalardo G, Sovago I, Rizzarelli E
* Interactions of Cu 2+ with prion family peptide fragments: Considerations on affinity, speciation and coordination (489 views)
Coord Chem Rev (ISSN: 0010-8545), 2012 Oct; 256(19-20): 2202-2218.
Impact Factor: 11.016
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Roviello GN, Mottola A, Musumeci D, Bucci EM, Pedone C
* Synthesis and aggregation properties of a novel enzymatically resistant nucleoamino acid (423 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Oct; 43(4): 1465-1470.
Impact Factor: 3.914
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Stanzione F, De Simone A, Esposito L, Vitagliano L
* Dynamical Properties of Steric Zipper Polymorphs Formed by a IAPP-Derived Peptide (462 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Sep; 19(8): 846-851.
Impact Factor: 1.994
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Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
* Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (462 views)
Chem Rev (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
Impact Factor: 41.298
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Ascione G, de Pascale D, De Santi C, Pedone C, Dathan NA, Monti SM
* Native expression and purification of hormone-sensitive lipase from Psychrobacter sp. TA144 enhances protein stability and activity (510 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2012 Apr 13; 420(3): 542-546.
Impact Factor: 2.406
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (469 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Raimondi S, Guglielmi F, Giorgetti S, Di Gaetano S, Arciello A, Monti DM, Relini A, Nichino D, Doglia SM, Natalello A, Pucci P, Mangione P, Obici L, Merlini G, Stoppini M, Robustelli P, Tartaglia GG, Vendruscolo M, Dobson CM, Piccoli R, Bellotti V
* Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I (459 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2011 Apr 1; 407(3): 465-476.
Impact Factor: 4.001
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (449 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (1316 views)
Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Impact Factor: 7.047
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Mazzaglia A, Micali N, Scolaro LM, Attanasio F, Magrí A, Pappalardo G, Villari V
* Aggregation properties of the peptide fragments derived from the 17-29 region of the human and rat IAPP: A comparative study with two PEG-conjugated variants of the human sequence (441 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Jan 21; 114(2): 705-713.
Impact Factor: 3.603
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D'Urso L, Grasso G, Messina E, Bongiorno C, Scuderi V, Scalese S, Puglisi O, Spoto G, Compagnini G
* The Role of Linear Carbon Chains in the Aggregation of Copper, Silver, and Gold Nanoparticles (521 views)
J Phys Chem C (ISSN: 1932-7447), 2010 Jan 21; 114(2): 907-915.
Impact Factor: 4.524
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (534 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (698 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (499 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (664 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (638 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
Impact Factor: 2.648
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (449 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
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Milardi D, Pappalardo M, Pannuzzo M, Grasso DM, Rosa CL
* The role of the Cys2-Cys7 disulfide bridge in the early steps of Islet amyloid polypeptide aggregation: A molecular dynamics study (447 views)
Chem Phys Lett (ISSN: 0009-2614), 2008 Oct 1; 463(4-6): 396-399.
Impact Factor: 2.169
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De Simone A, Pedone C, Vitagliano L
* Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF (503 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Feb 15; 366(3): 800-806.
Impact Factor: 2.648
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Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
* Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (402 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2008; 47(51): 9879-9882.
Impact Factor: 10.879
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Grasso G, Rizzarelli E, Spoto G
* AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin (511 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2007 Dec; 42(12): 1590-1598.
Impact Factor: 3.062
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Pietropaolo A, Raiola L, Muccioli L, Tiberio G, Zannoni C, Fattorusso R, Isernia C, La Mendola D, Pappalardo G, Rizzarelli E
* An NMR and molecular dynamics investigation of the avian prion hexarepeat conformational features in solution (290 views)
Chem Phys Lett (ISSN: 0009-2614), 2007 Jul 6; 442(1-3): 110-118.
Impact Factor: 2.207
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (606 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Attanasio F, Cascio C, Fisichella S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Trehalose effects on alpha-crystallin aggregates (675 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 0006-291xlinking), 2007 Mar 23; 354(4): 899-905.
Impact Factor: 2.749
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (553 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (378 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (768 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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Ronga L, Tizzano B, Palladino P, Ragone R, Urso E, Maffia M, Ruvo M, Benedetti E, Rossi F
* The prion protein: structural features and related toxic peptides (544 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2006 Sep; 68(3): 139-147.
Impact Factor: 2.507
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Merlino A, Esposito L, Vitagliano L
* Polyglutamine Repeats And Beta-Helix Structure: Molecular Dynamics Study (511 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jun 1; 63(4): 918-927.
Impact Factor: 3.73
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Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
* Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (691 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 15; 62(3): 604-616.
Impact Factor: 3.73
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Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (417 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
Impact Factor: 2.286
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Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (451 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2005 Jul 1; 116(2): 89-95.
Impact Factor: 1.925
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Tizzano B, Palladino P, De Capua A, Marasco D, Rossi F, Benedetti E, Pedone C, Ragone R, Ruvo M
* The Human Prion Protein Alpha2 Helix: A Thermodynamic Study Of Its Conformational Preferences (533 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2005 Apr 1; 59(1): 72-79.
Impact Factor: 4.684
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La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (512 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
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Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (605 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
Impact Factor: 4.507
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Pedone E, Bartolucci S, Rossi M, Pierfederici FM, Scire A, Cacciamani T, Tanfani F
* Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study (548 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2003 Sep 1; 373: 875-883.
Impact Factor: 4.101
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Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Free energy perturbation and molecular dynamics calculations of copper binding to azurin (382 views)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2003 Apr 30; 24(6): 779-785.
Impact Factor: 3.186
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Grasso D, Milardi D, Guantieri V, La Rosa C, Rizzarelli E
* Interaction of prion peptide PrP 180-193 with DPPC model membranes: A thermodynamic study (384 views)
New J Chem (ISSN: 1144-0546), 2003; 27(2): 359-364.
Impact Factor: 2.272
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Pappalardo G, Impellizzeri G, Bonomo RP, Campagna T, Grasso G, Saita MG
* Copper(II) and nickel(II) binding modes in a histidine-containing model dodecapeptide (331 views)
New J Chem (ISSN: 1144-0546), 2002; 26(5): 593-600.
Impact Factor: 2.06
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (504 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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* Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions (19 views)
Int J Mol Sci (ISSN: 1422-0067linking), 2021 Oct 2; 22 (19 ): N/D-N/D.
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Balasco N, Diaferia C, Morelli G, Vitagliano L, Accardo A
* Amyloid-Like Aggregation in Diseases and Biomaterials: Osmosis of Structural Information (21 views)
Front Bioeng Biotechnol (ISSN: 2296-4185linking), 2021 Mar 3; 9: 641372-641372.
Impact Factor: 5.48
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Marasco D, Vicidomini C, Krupa P, Cioffi F, Pham DQH, Li MS, Florio D, Broersen K, De Pandis MF, Roviello GN
* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
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Fik-jaskółkaa MA, Mkrtchyand AF, Saghyand AS, Palumbo R, Belter A, Hayriyand LA, Simonyane H, Roviello V, Roviello GN
* Biological macromolecule binding and anticancer activity of synthetic alkyne-containing L-phenylalanine derivatives (143 views)
Amino Acids (ISSN: 0939-4451linking, 1438-2199electronic), 2020 May; 52(5): 755-769.
Impact Factor: 3.063
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Cozzolino A, Vergalito F, Tremonte P, Iorizzo M, Lombardi SJ, Sorrentino E, Luongo D, Coppola R, Marco RD, Succi M
* Preliminary Evaluation of the Safety and Probiotic Potential of Akkermansia muciniphila DSM 22959 in Comparison with Lactobacillus rhamnosus GG (174 views)
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Impact Factor: 4.167
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Esposito L, Donnarumma F, Ruggiero A, Leone S, Vitagliano L, Picone D
* Structure, stability and aggregation propensity of a Ribonuclease A-Onconase chimera (292 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jul 15; 133: 1125-1133.
Impact Factor: 4.784
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Pirone L, Caldinelli L, Di Lascio S, Di Girolamo R, Di Gaetano S, Fornasari D, Pollegioni L, Benfante R, Pedone E
* Molecular insights into the role of the polyalanine region in mediating PHOX2B aggregation (353 views) (PDF 55 views)
Febs J (ISSN: 1742-464xlinking), 2019 Apr 7; 286(13): 2505-2521.
Impact Factor: 3.129
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (379 views)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2018 May 15; DOI10.1007/s00726-01: 933-941.
Impact Factor: 3.173
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Avitabile C, Diaferia C, Della Ventura B, Mercurio FA, Leone M, Roviello V, Saviano M, Velotta R, Morelli G, Accardo A, Romanelli A
* Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates (891 views)
Chemistry (ISSN: 1521-3765electronic, 0947-6539linking), 2018 Mar 26; 24(18): 4729-4735.
Impact Factor: 5.476
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Sciacca MFM, Chillemi R, Sciuto S, Greco V, Messineo C, Kotler SA, Lee DK, Brender JR, Ramamoorthy A, La Rosa C, Milardi D
* A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage (297 views) (PDF 115 views)
Bba-Gen Subjects (ISSN: 0005-2736print, 0005-2736linking), 2018 Mar 17; N/D: 1793-1902.
Impact Factor: 4.647
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (489 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (544 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Diaferia C, Sibillano T, Altamura D, Roviello V, Vitagliano L, Giannini C, Morelli G, Accardo A
* Structural Characterization of PEGylated Hexaphenylalanine Nanostructures Exhibiting Green Photoluminescence Emission (888 views) (PDF 223 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 Oct 09; 23(56): 14039-14048.
Impact Factor: 5.16
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Villari V, Tosto R, Di Natale G, Sinopoli A, Tomasello M, Lazzaro S, Micali N, Pappalardo G
* A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity (430 views)
Chemistryselect (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.
Impact Factor: 1.505
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Di Natale G, Bellia F, Sciacca F, Campagna T, Pappalardo G
* Tau-peptide fragments and their copper(II) complexes: Effects on Amyloid-beta aggregation (407 views)
Inorganica Chimica Acta, 2017 Sep; N/D: N/D-N/D.
Impact Factor: 2.002
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Picone D, Donnarumma F, Ferraro G, Gotte G, Fagagnini A, Butera G, Donadelli M, Merlino A
* A comparison study on RNase A oligomerization induced by cisplatin, carboplatin and oxaliplatin (343 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2017 Aug; 173: 105-112.
Impact Factor: 3.063
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Grasso GI, Bellia F, Arena G, Satriano C, Vecchio G, Rizzarelli E
* Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity (417 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jul 28; 135: 447-457.
Impact Factor: 4.816
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Musumeci D, Roviello GN, Rigione G, Capasso D, Di Gaetano S, Riccardi C, Roviello V, Montesarchio D
* Benzodifuran derivatives as potential antiproliferative agents: possible correlation between the bioactivity and their aggregation properties (477 views)
Chempluschem, 2017; 82: 251-260.
Impact Factor: 2.8
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Oliveri V, Bellia F, Vecchio G
* Structural Isomers of Cyclodextrin-Bearing IOX1 Compound as Inhibitors of Aβ Aggregation (340 views)
Chemistryselect (ISSN: 2365-6549), 2017; 2(2): 655-659.
Impact Factor: 1.505
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Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
* Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease (460 views)
Acs Med Chem Lett (ISSN: 1948-5875, 1948-5875linking), 2016 Sep 26; 7(12): 1145-1150.
Impact Factor: 3.746
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Scognamiglio PL, Di Natale C, Leone M, Cascella R, Cecchi C, Lirussi L, Antoniali G, Riccardi D, Morelli G, Tell G, Chiti F, Marasco D
* Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia (396 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2016 Sep 13; 7(37): 59129-59143.
Impact Factor: 5.168
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La Mendola D, Arnesano F, Hansson O, Giacomelli C, Calo V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E
* Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity (407 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2016 Jan 20; 8(1): 118-124.
Impact Factor: 3.975
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Langella E, D'Ambrosio K, D'Ascenzio M, Carradori S, Monti SM, Supuran CT, De Simone G
* A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases (336 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Jan 4; 22(1): 97-100.
Impact Factor: 5.317
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Giglio V, Bellia F, Oliveri V, Vecchio G
* Aminocyclodextrin Oligomers as Protective Agents of Protein Aggregation (452 views)
Chempluschem, 2016; 81(7): 660-665.
Impact Factor: 0
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Ribaldone DG, Fagoonee S, Hickman I, Altruda F, Saracco GM, Pellicano R
* Helicobacter pylori infection and ischemic heart disease: Could experimental data lead to clinical studies? (315 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2016; 64(6): 686-696.
Impact Factor: 0.695
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Del Giudice R, Arciello A, Itri F, Merlino A, Monti M, Buonanno M, Penco A, Canetti D, Petruk G, Monti SM, Relini A, Pucci P, Piccoli R, Monti DM
* Protein conformational perturbations in hereditary amyloidosis: Differential impact of single point mutations in ApoAI amyloidogenic variants (412 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2016; 1860(2): 434-444.
Impact Factor: 5.476
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Roviello GN, Roviello V, Autiero I, Saviano M
* Solid phase synthesis of TyrT, a thymine-tyrosine conjugate with poly(A) RNA-binding ability (505 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(33): 27607-27613.
Impact Factor: 3.108
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Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
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Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (943 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (805 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
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Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (517 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin 3-functionalized with 8-hydroxyquinoline as an antioxidant inhibitor of metal-induced amyloid aggregation (426 views)
Chempluschem (ISSN: 2192-6506), 2015; 80(4): 762-770.
Impact Factor: 2.836
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Pietropaolo A, Satriano C, Strano G, La Mendola D, Rizzarelli E
* Different zinc(II) complex species and binding modes at Aβ N-terminus drive distinct long range cross-talks in the Aβ monomers (416 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; N/D: N/D-N/D.
Impact Factor: 3.205
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Picone D, Donnarumma F, Ferraro G, Russo Krauss I, Fagagnini A, Gotte G, Merlino A
* Platinated oligomers of bovine pancreatic ribonuclease: Structure and stability (414 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 146: 37-43.
Impact Factor: 3.205
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Lolicato F, Raudino A, Milardi D, La Rosa C
* Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study (688 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015; 92: 876-881.
Impact Factor: 3.902
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Oliveri V, Grasso GI, Bellia F, Attanasio F, Viale M, Vecchio G
* Soluble sugar-based quinoline derivatives as new antioxidant modulators of metal-induced amyloid aggregation (684 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2015; 54(6): 2591-2602.
Impact Factor: 4.82
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Oliveri V, Bellia F, Pietropaolo A, Vecchio G
* Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (684 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015; 21(40): 14047-14059.
Impact Factor: 5.771
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Sinopoli A, Magri A, Milardi D, Pappalardo M, Pucci P, Flagiello A, Titman JJ, Nicoletti VG, Caruso G, Pappalardo G, GrassoG
* The role of copper(II) in the aggregation of human amylin (492 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014 Oct; 6(10): 1841-1852.
Impact Factor: 3.585
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Saghyan AS, Simonyan HM, Petrosyan SG, Geolchanyan AV, Roviello GN, Musumeci D, Roviello V
* Thiophenyl-substituted triazolyl-thione L-alanine: asymmetric synthesis, aggregation and biological properties (489 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2014 Oct; 46(10): 2325-2332.
Impact Factor: 3.293
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (710 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (635 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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Villari V, Attanasio F, Micali N
* Control of the structural stability of α-crystallin under thermal and chemical stress: The role of carnosine (415 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207linking), 2014; 118(47): 13770-13776.
Impact Factor: 3.302
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (586 views)
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking, 1664-2392print), 2014; 5(DEC): 216-216.
Impact Factor: 3.675
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Attanasio F, Bonaccorso C, Bellia F, Cataldo S, Fortuna CG, Musumarra G, Pignataro B, Rizzarelli E
* (E)-2-Cyano-3-(5 Alpha-Piperidin-1-Yl-2, 2 Alpha-Bithien-5-Yl)acrylic Acid: A Fluorescent Probe For Detecting Prefibrillar Oligomers (449 views)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2013 Jun; (18): 3635-3639.
Impact Factor: 3.154
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De Simonea A, Stanzione F, Marasco D, Vitagliano L, Esposito L
* The Intrinsic Stability Of The Human Prion Beta-Sheet Region Investigated By Molecular Dynamics (700 views)
Journal Of Biomolecular Structure & Dynamics, 2013 May 1; 31(5): 441-452.
Impact Factor: 2.983
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Hunger K, Buschhaus L, Biemann L, Braun M, Kovalenko S, Improta R, Kleinermanns K
* UV-light-induced hydrogen transfer in guanosine-guanosine aggregates (431 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Apr; 19(17): 5425-5431.
Impact Factor: 5.696
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (778 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Di Natale G, Osz K, Kállay C, Pappalardo G, Sanna D, Impellizzeri G, Sóvágó I, Rizzarelli E
* Affinity, speciation, and molecular features of copper(II) complexes with a prion tetraoctarepeat domain in aqueous solution: insights into old and new results (422 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2013 Mar 11; 19(11): 3751-3761.
Impact Factor: 5.696
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (471 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (737 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (457 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Arena G, La Mendola D, Pappalardo G, Sovago I, Rizzarelli E
* Interactions of Cu 2+ with prion family peptide fragments: Considerations on affinity, speciation and coordination (489 views)
Coord Chem Rev (ISSN: 0010-8545), 2012 Oct; 256(19-20): 2202-2218.
Impact Factor: 11.016
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Roviello GN, Mottola A, Musumeci D, Bucci EM, Pedone C
* Synthesis and aggregation properties of a novel enzymatically resistant nucleoamino acid (423 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Oct; 43(4): 1465-1470.
Impact Factor: 3.914
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Stanzione F, De Simone A, Esposito L, Vitagliano L
* Dynamical Properties of Steric Zipper Polymorphs Formed by a IAPP-Derived Peptide (462 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Sep; 19(8): 846-851.
Impact Factor: 1.994
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Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
* Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (462 views)
Chem Rev (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
Impact Factor: 41.298
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Ascione G, de Pascale D, De Santi C, Pedone C, Dathan NA, Monti SM
* Native expression and purification of hormone-sensitive lipase from Psychrobacter sp. TA144 enhances protein stability and activity (510 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2012 Apr 13; 420(3): 542-546.
Impact Factor: 2.406
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Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M, Leone M
* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (469 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Raimondi S, Guglielmi F, Giorgetti S, Di Gaetano S, Arciello A, Monti DM, Relini A, Nichino D, Doglia SM, Natalello A, Pucci P, Mangione P, Obici L, Merlini G, Stoppini M, Robustelli P, Tartaglia GG, Vendruscolo M, Dobson CM, Piccoli R, Bellotti V
* Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I (459 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2011 Apr 1; 407(3): 465-476.
Impact Factor: 4.001
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (508 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (449 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Tosco A, Monti MC, Fontanella B, Montefusco S, D'Andrea LD, Ziaco B, Baldantoni D, Rio MC, Marzullo L
* Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity (1316 views)
Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2010 Jun; 67(11): 1943-1955.
Impact Factor: 7.047
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Mazzaglia A, Micali N, Scolaro LM, Attanasio F, Magrí A, Pappalardo G, Villari V
* Aggregation properties of the peptide fragments derived from the 17-29 region of the human and rat IAPP: A comparative study with two PEG-conjugated variants of the human sequence (441 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Jan 21; 114(2): 705-713.
Impact Factor: 3.603
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D'Urso L, Grasso G, Messina E, Bongiorno C, Scuderi V, Scalese S, Puglisi O, Spoto G, Compagnini G
* The Role of Linear Carbon Chains in the Aggregation of Copper, Silver, and Gold Nanoparticles (521 views)
J Phys Chem C (ISSN: 1932-7447), 2010 Jan 21; 114(2): 907-915.
Impact Factor: 4.524
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (534 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (698 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (499 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (664 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Vitagliano L, Esposito L, Pedone C, De Simone A
* Stability of single sheet GNNQQNY aggregates analyzed by replica exchange molecular dynamics: antiparallel versus parallel association (638 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Dec 26; 377(4): 1036-1041.
Impact Factor: 2.648
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La Mendola D, Pietropaolo A, Pappalardo G, Zannoni C, Rizzarelli E
* Prion proteins leading to neurodegeneration (449 views)
Current Alzheimer Research (ISSN: 1567-2050), 2008 Dec; 5(6): 579-590.
Impact Factor: 4.132
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Milardi D, Pappalardo M, Pannuzzo M, Grasso DM, Rosa CL
* The role of the Cys2-Cys7 disulfide bridge in the early steps of Islet amyloid polypeptide aggregation: A molecular dynamics study (447 views)
Chem Phys Lett (ISSN: 0009-2614), 2008 Oct 1; 463(4-6): 396-399.
Impact Factor: 2.169
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De Simone A, Pedone C, Vitagliano L
* Structure, dynamics, and stability of assemblies of the human prion fragment SNQNNF (503 views)
Biochem Biophys Res Commun (ISSN: 1090-2104, 0006-291x, 1090-2104electronic), 2008 Feb 15; 366(3): 800-806.
Impact Factor: 2.648
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Randazzo R, Mammana A, D'Urso A, Lauceri R, Purrello R
* Reversible "chiral memory" in ruthenium tris(phenanthroline)- anionic porphyrin complexes (402 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2008; 47(51): 9879-9882.
Impact Factor: 10.879
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Grasso G, Rizzarelli E, Spoto G
* AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin (511 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2007 Dec; 42(12): 1590-1598.
Impact Factor: 3.062
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Pietropaolo A, Raiola L, Muccioli L, Tiberio G, Zannoni C, Fattorusso R, Isernia C, La Mendola D, Pappalardo G, Rizzarelli E
* An NMR and molecular dynamics investigation of the avian prion hexarepeat conformational features in solution (290 views)
Chem Phys Lett (ISSN: 0009-2614), 2007 Jul 6; 442(1-3): 110-118.
Impact Factor: 2.207
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (606 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Attanasio F, Cascio C, Fisichella S, Nicoletti VG, Pignataro B, Savarino A, Rizzarelli E
* Trehalose effects on alpha-crystallin aggregates (675 views)
Biochem Biophys Res Commun (ISSN: 0006-291x, 0006-291xlinking), 2007 Mar 23; 354(4): 899-905.
Impact Factor: 2.749
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (553 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (433 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Milardi D, Arnesano F, Grasso G, Magrì A, Tabbì G, Scintilla S, Natile G, Rizzarelli E
* Ubiquitin stability and the Lys63-linked polyubiquitination site are compromised on copper binding (378 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2007; 46(42): 7993-7995.
Impact Factor: 10.031
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Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (768 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
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Ronga L, Tizzano B, Palladino P, Ragone R, Urso E, Maffia M, Ruvo M, Benedetti E, Rossi F
* The prion protein: structural features and related toxic peptides (544 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2006 Sep; 68(3): 139-147.
Impact Factor: 2.507
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Merlino A, Esposito L, Vitagliano L
* Polyglutamine Repeats And Beta-Helix Structure: Molecular Dynamics Study (511 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jun 1; 63(4): 918-927.
Impact Factor: 3.73
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Mannini R, Rivieccio V, D'Auria S, Tanfani F, Ausili A, Pedone C, Grimaldi G, Facchiano A
* Structure/function of KRAB repression domains: Structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses (691 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 15; 62(3): 604-616.
Impact Factor: 3.73
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Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (417 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
Impact Factor: 2.286
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Bucci E, Vitagliano L, Barone R, Sorrentino S, D'Alessio G, Graziano G
* On the thermal stability of the two dimeric forms of ribonuclease (451 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2005 Jul 1; 116(2): 89-95.
Impact Factor: 1.925
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Tizzano B, Palladino P, De Capua A, Marasco D, Rossi F, Benedetti E, Pedone C, Ragone R, Ruvo M
* The Human Prion Protein Alpha2 Helix: A Thermodynamic Study Of Its Conformational Preferences (533 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2005 Apr 1; 59(1): 72-79.
Impact Factor: 4.684
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La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (512 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
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Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (605 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
Impact Factor: 4.507
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Pedone E, Bartolucci S, Rossi M, Pierfederici FM, Scire A, Cacciamani T, Tanfani F
* Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study (548 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2003 Sep 1; 373: 875-883.
Impact Factor: 4.101
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Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Free energy perturbation and molecular dynamics calculations of copper binding to azurin (382 views)
J Comput Chem (ISSN: 0192-8651, 1096-987xelectronic), 2003 Apr 30; 24(6): 779-785.
Impact Factor: 3.186
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Grasso D, Milardi D, Guantieri V, La Rosa C, Rizzarelli E
* Interaction of prion peptide PrP 180-193 with DPPC model membranes: A thermodynamic study (384 views)
New J Chem (ISSN: 1144-0546), 2003; 27(2): 359-364.
Impact Factor: 2.272
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Pappalardo G, Impellizzeri G, Bonomo RP, Campagna T, Grasso G, Saita MG
* Copper(II) and nickel(II) binding modes in a histidine-containing model dodecapeptide (331 views)
New J Chem (ISSN: 1144-0546), 2002; 26(5): 593-600.
Impact Factor: 2.06
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (504 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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98 Records (96 excluding Abstracts).
Total impact factor: 411.228 (403.202 excluding Abstracts).
Total 5 year impact factor: 404.024 (399.641 excluding Abstracts).
Total impact factor: 411.228 (403.202 excluding Abstracts).
Total 5 year impact factor: 404.024 (399.641 excluding Abstracts).
595 views. Last view on Friday 02 June 2023, 18:52:34
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