DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes(462 views) Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
Keywords: Circular Dna, Heteroduplex, High Mobility Group B1 Protein, Kinked Dna, Lipopolysaccharide, Peptide Nucleic Acid, Animal, Article, Bagg Albino Mouse, Binding Site, Cell Line, Cell Motion, Cell Proliferation, Chemical Structure, Chemically Induced Disorder, Chemistry, Conformation, Drug Antagonism, Drug Effect, Endotoxemia, Metabolism, Mortality, Nucleotide Sequence, Protein Binding, Protein Tertiary Structure, Survival Rate, Base Sequence, Cell Movement, Hmgb1 Protein, Inbred Balb C, Models, Molecular, Molecular Structure, Nucleic Acid Conformation, Nucleic Acid Heteroduplexes, Protein Structure, Time Factors,
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini - CNR, via Mezzocannone 16, 80134 Napoli, Italy
Bionucleon Srl, via Ribes 5, 10010 Colleretto Giacosa (TO), Italy
DIBIT, San Raffaele University, via Olgettina 58, 20132 Milano, Italy
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Huttunen, H. J., Kuja-Panula, J., Rauvala, H., Receptor for advanced glycation end products (RAGE) signaling induces CREB-dependent chromogranin expression during neuronal differentiation (2002) Journal of Biological Chemistry, 277 (41), pp. 38635-38646. , DOI 10. 1074/jbc. M202515200
Lander, H. M., Tauras, J. M., Ogiste, J. S., Hori, O., Moss, R. A., Schmidt, A. M., Activation of the receptor for advanced glycation end products triggers a p21 (ras) -dependent mitogen-activated protein kinase pathway regulated by oxidant stress (1997) Journal of Biological Chemistry, 272 (28), pp. 17810-17814. , DOI 10. 1074/jbc. 272. 28. 17810
Allain, F. H. -T., Yen, Y. -M., Masse, J. E., Schultze, P., Dieckmann, T., Johnson, R. C., Feigon, J., Solution structure of the HMG protein NHP6A and its interaction with DNA reveals the structural determinants for non-sequence-specific binding (1999) EMBO Journal, 18 (9), pp. 2563-2579. , DOI 10. 1093/emboj/18. 9. 2563
Bianchi, M. E., Falciola, L., Ferrari, S., Lilley, D. M., The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins (1992) EMBO J., 11, pp. 1055-1063
Hardman, C. H., Broadhurst, R. W., Raine, A. R. C., Grasser, K. D., Thomas, J. O., Laue, E. D., Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three- and four-dimensional NMR spectroscopy (1995) Biochemistry, 34 (51), pp. 16596-16607. , DOI 10. 1021/bi00051a007
Harley, V. R., Jackson, D. I., Hextall, P. J., Hawkins, J. R., Berkovitz, G. D., Sockanathan, S., Lovell-Badge, R., Goodfellow, P. N., DNA binding activity of recombinant SRY from normal males and XY females (1992) Science, 255 (5043), pp. 453-456
Weir, H. M., Kraulis, P. J., Hill, C. S., Raine, A. R. C., Laue, E. D., Thomas, J. O., Structure of the HMG box motif in the B-domain of HMG1 (1993) EMBO Journal, 12 (4), pp. 1311-1319
Nielsen, P. E., Egholm, M., Buchardt, O., Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone (1994) Bioconjugate Chemistry, 5 (1), pp. 3-7
Bucci, E. M., Valente, M., Musumeci, D., Sapio, R., Anro, V., Roviello, G. N., Moccia, M., ODN-based drugs for targeting of extracellular proteins (2007) Nucleosides, Nucleotides and Nucleic Acids, 26 (8-9), pp. 1047-1050. , DOI 10. 1080/15257770701509602, PII 787863451
Dumitriu, I. E., Baruah, P., Manfredi, A. A., Bianchi, M. E., Rovere-Querini, P., HMGB1: Guiding immunity from within (2005) Trends in Immunology, 26 (7), pp. 381-387. , DOI 10. 1016/j. it. 2005. 04. 009, PII S1471490605001080
Lotze, M. T., Tracey, K. J., High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal (2005) Nature Reviews Immunology, 5 (4), pp. 331-342. , DOI 10. 1038/nri1594
Oue, N., Phyu, P. A., Mitani, Y., Kuniyasu, H., Nakayama, H., Yasui, W., Genes involved in invasion and metastasis of gastric cancer identified by array-based hybridization and serial analysis of gene expression (2005) Oncology, 69 (SUPPL. 1), pp. 17-22. , DOI 10. 1159/000086627
Zeh III, H. J., Lotze, M. T., Addicted to death: Invasive cancer and the immune response to unscheduled cell death (2005) Journal of Immunotherapy, 28 (1), pp. 1-9
Ma, S. -F., Garcia, J. G. N., Reuning, U., Little, S. P., Bang, N. U., Dixon, E. P., Thrombin induces thrombomodulin mRNA expression via the proteolytically activated thrombin receptor in cultured bovine smooth muscle cells (1997) Journal of Laboratory and Clinical Medicine, 129 (6), pp. 611-619
DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes