TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach (461 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2011 Jun 15; 21(12): 3541-3545.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.554, 5-year impact factor: 2.539
Url: Not available.
Keywords: Combinatorial Library, Dipeptides, Hydantoins, Sar Studies, Trpv1, Lysine, Molecular Scaffold, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor Blocking Agent, Pyridine, Tryptophan, Vanilloid Receptor 1, Vanilloid Receptor 1 Antagonist, Amino Terminal Sequence, Carboxy Terminal Sequence, Drug Potency, Drug Selectivity, Drug Synthesis, Structure Activity Relation, Anti-Inflammatory Agents, Combinatorial Chemistry Techniques, Humans, Indoles, Molecular Structure, Small Molecule Libraries, Structure-Activity Relationship, Trpv Cation Channels,
Affiliations:
*** IBB - CNR ***
Combinatorial Chemistry Unit, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
Istituto di Biostrutture e Bioimmagini CNR, Napoli 80134, Italy
Instituto de Química Medica CSIC, Madrid 28006, Spain
Centro de Biología Molecular Y Celular, Universidad Miguel Hernandez, Elche, Alicante 03202, Spain
Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
CIBER-BBN, Networking Centre on Bioengineering Biomaterials and Nanomedicine, Barcelona 08028, Spain
Department of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain
Instituto de Qu mica Medica CSIC, Madrid 28006, Spain
Centro de Biolog a Molecular Y Celular, Universidad Miguel Hernandez, Elche, Alicante 03202, Spain
References:
Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D., Julius, D., (1997) Nature, 389, p. 81
Caterina, M.J., Leffler, A., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K.R., Koltzenburg, M., Julius, D., (2000) Science, 288, p. 306
Cortright, D.N., Krause, J.E., Broom, D.C., (2007) Biochim. Biophys. Acta, 1772, p. 978
Palazzo, E., Rossi, F., Maione, S., (2008) Mol. Cell. Endocrinol., 286, pp. S79
Willis Jr., W.D., (2009) Exp. Brain Res., 196, p. 5
Cortright, D.N., Szallasi, A., (2009) Curr. Pharm. Des., 15, p. 1736
Tominaga, M., Caterina, M.J., Malmberg, A.B., Rosen, T.A., Gilbert, H., Skinner, K., Raumann, B.E., Julius, D., (1998) Neuron, 21, p. 531
Ross, R.A., (2003) Br. J. Pharmacol., 140, p. 790
Hwang, S.W., Cho, H., Kwak, J., Lee, S.Y., Kang, C.J., Jung, J., Cho, S., Oh, U., (2000) Proc. Natl. Acad. Sci. U.S.A., 97, p. 6155
Huang, J., Zhang, X., McNaughton, P.A., (2006) Curr. Neuropharmacol., 4, p. 197
Silva, C., Silva, J., Castro, H., Reis, F., Dinis, P., Avelino, A., Cruz, F., (2007) BMC Urol., 7, p. 9
Brooks, S.M., (2008) Lung, 186, pp. S88
Holzer, P., (2008) Gut, 57, p. 882
Shimizu, T., (2009) Brain Nerve., 61, p. 949
Bley, K.R., (2004) Expert. Opin. Investig. Drugs, 13, p. 1445
Knotkova, H., Pappagallo, M., Szallasi, A., (2008) Clin. J. Pain, 24, p. 142
Conway, S., (2008) J. Chem. Soc. Rev., 37, p. 1530
Pal, M., Angaru, S., Kodimuthali, A., Dhingra, N., (2009) Curr. Pharm. Des., 15, p. 1008
Broad, L.M., Keding, S.J., Blanco, M., (2008) J. Curr. Top. Med. Chem., 8, p. 1431
Szallasi, A., Cortright, D.N., Blum, C.A., Eid, S.R., (2007) Nat. Rev. Drug Discov., 6, p. 357
Kym, P.R., Kort, M.E., Hutchins, C.W., (2009) Biochem. Pharmacol., 78, p. 211
Szallasi, A., Blumberg, P.M., (1999) Pharmacol. Rev., 51, p. 159
Szallasi, A., Appendino, G., (2004) J. Med. Chem., 47, p. 2717
McLeod, R.L., Correll, C.C., Jia, Y., Anthes, J.C., (2008) Lung, 186, pp. S59
Gunthorpe, M.J., Chizh, B.A., (2009) Drug Discovery Today, 14, p. 56
Wong, G.Y., Gavva, N.R., (2009) Brain Res. Rev., 60, p. 267
Bonache, M.A., Garcia-Martinez, C., De Garcia Diego, L., Carreno, C., Perez De Vega, M.J., Garcia-Lopez, M.T., Ferrer-Montiel, A., Gonzalez-Muniz, R., (2006) ChemMedChem, 1, p. 429
(2008) The Power of Functional Resins in Organic Chemistry, , Tulla-Puche, J., Albericio, F., Eds.
Wiley-VCH Verlag GmbH: KGaA, Weinheim (Germany)
Nandy, J.P., Prakesch, M., Khadem, S., Reddy, P.T., Sharma, U., Arya, P., (2009) Chem. Rev., 109, p. 1999
Kates, S.A., Albericio, F., (2000) Solid-Phase Synthesis. A Practical Guide, , Marcel Dekker: New York (NY, USA)
Carpino, L.A., Han, G.Y., (1972) J. Org. Chem., 37, p. 3404
Vazques, J., Royo, M., Albericio, F., (2004) Lett. Org. Chem., 1, p. 224
Chen, S., Xu, J., (1992) Tetrahedron Lett., 33, p. 647
Farrera-Sinfreu, J., Royo, M., Albericio, F., (2002) Tetrahedron Lett., 43, p. 7813
noteUR - http://www.scopus.com/inward/record.url?eid=2-s2.0-79957876139&partnerID=40&md5=8205ccf9ba4dadcff7dc556527ba886d
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., Julius, D., (1997) Nature, 389, p. 81
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Julius, D., (2000) Science, 288, p. 306
Cortright, D. N., Krause, J. E., Broom, D. C., (2007) Biochim. Biophys. Acta, 1772, p. 978
Willis Jr., W. D., (2009) Exp. Brain Res., 196, p. 5
Cortright, D. N., Szallasi, A., (2009) Curr. Pharm. Des., 15, p. 1736
Ross, R. A., (2003) Br. J. Pharmacol., 140, p. 790
Hwang, S. W., Cho, H., Kwak, J., Lee, S. Y., Kang, C. J., Jung, J., Cho, S., Oh, U., (2000) Proc. Natl. Acad. Sci. U. S. A., 97, p. 6155
Brooks, S. M., (2008) Lung, 186, pp. S88
Bley, K. R., (2004) Expert. Opin. Investig. Drugs, 13, p. 1445
Broad, L. M., Keding, S. J., Blanco, M., (2008) J. Curr. Top. Med. Chem., 8, p. 1431
Kym, P. R., Kort, M. E., Hutchins, C. W., (2009) Biochem. Pharmacol., 78, p. 211
McLeod, R. L., Correll, C. C., Jia, Y., Anthes, J. C., (2008) Lung, 186, pp. S59
Gunthorpe, M. J., Chizh, B. A., (2009) Drug Discovery Today, 14, p. 56
Wong, G. Y., Gavva, N. R., (2009) Brain Res. Rev., 60, p. 267
Bonache, M. A., Garcia-Martinez, C., De Garcia Diego, L., Carreno, C., Perez De Vega, M. J., Garcia-Lopez, M. T., Ferrer-Montiel, A., Gonzalez-Muniz, R., (2006) ChemMedChem, 1, p. 429
(2008) The Power of Functional Resins in Organic Chemistry, , Tulla-Puche, J., Albericio, F., Eds.
Nandy, J. P., Prakesch, M., Khadem, S., Reddy, P. T., Sharma, U., Arya, P., (2009) Chem. Rev., 109, p. 1999
Kates, S. A., Albericio, F., (2000) Solid-Phase Synthesis. A Practical Guide, , Marcel Dekker: New York (NY, USA)
Carpino, L. A., Han, G. Y., (1972) J. Org. Chem., 37, p. 3404
noteUR - http: //www. scopus. com/inward/record. url? eid=2-s2. 0-79957876139&partnerID=40&md5=8205ccf9ba4dadcff7dc556527ba886d
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2011 Jun 15; 21(12): 3541-3545.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.554, 5-year impact factor: 2.539
Url: Not available.
Keywords: Combinatorial Library, Dipeptides, Hydantoins, Sar Studies, Trpv1, Lysine, Molecular Scaffold, N Methyl Dextro Aspartic Acid Receptor, N Methyl Dextro Aspartic Acid Receptor Blocking Agent, Pyridine, Tryptophan, Vanilloid Receptor 1, Vanilloid Receptor 1 Antagonist, Amino Terminal Sequence, Carboxy Terminal Sequence, Drug Potency, Drug Selectivity, Drug Synthesis, Structure Activity Relation, Anti-Inflammatory Agents, Combinatorial Chemistry Techniques, Humans, Indoles, Molecular Structure, Small Molecule Libraries, Structure-Activity Relationship, Trpv Cation Channels,
Affiliations:
*** IBB - CNR ***
Combinatorial Chemistry Unit, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
Istituto di Biostrutture e Bioimmagini CNR, Napoli 80134, Italy
Instituto de Química Medica CSIC, Madrid 28006, Spain
Centro de Biología Molecular Y Celular, Universidad Miguel Hernandez, Elche, Alicante 03202, Spain
Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
CIBER-BBN, Networking Centre on Bioengineering Biomaterials and Nanomedicine, Barcelona 08028, Spain
Department of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain
Instituto de Qu mica Medica CSIC, Madrid 28006, Spain
Centro de Biolog a Molecular Y Celular, Universidad Miguel Hernandez, Elche, Alicante 03202, Spain
References:
Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D., Julius, D., (1997) Nature, 389, p. 81
Caterina, M.J., Leffler, A., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K.R., Koltzenburg, M., Julius, D., (2000) Science, 288, p. 306
Cortright, D.N., Krause, J.E., Broom, D.C., (2007) Biochim. Biophys. Acta, 1772, p. 978
Palazzo, E., Rossi, F., Maione, S., (2008) Mol. Cell. Endocrinol., 286, pp. S79
Willis Jr., W.D., (2009) Exp. Brain Res., 196, p. 5
Cortright, D.N., Szallasi, A., (2009) Curr. Pharm. Des., 15, p. 1736
Tominaga, M., Caterina, M.J., Malmberg, A.B., Rosen, T.A., Gilbert, H., Skinner, K., Raumann, B.E., Julius, D., (1998) Neuron, 21, p. 531
Ross, R.A., (2003) Br. J. Pharmacol., 140, p. 790
Hwang, S.W., Cho, H., Kwak, J., Lee, S.Y., Kang, C.J., Jung, J., Cho, S., Oh, U., (2000) Proc. Natl. Acad. Sci. U.S.A., 97, p. 6155
Huang, J., Zhang, X., McNaughton, P.A., (2006) Curr. Neuropharmacol., 4, p. 197
Silva, C., Silva, J., Castro, H., Reis, F., Dinis, P., Avelino, A., Cruz, F., (2007) BMC Urol., 7, p. 9
Brooks, S.M., (2008) Lung, 186, pp. S88
Holzer, P., (2008) Gut, 57, p. 882
Shimizu, T., (2009) Brain Nerve., 61, p. 949
Bley, K.R., (2004) Expert. Opin. Investig. Drugs, 13, p. 1445
Knotkova, H., Pappagallo, M., Szallasi, A., (2008) Clin. J. Pain, 24, p. 142
Conway, S., (2008) J. Chem. Soc. Rev., 37, p. 1530
Pal, M., Angaru, S., Kodimuthali, A., Dhingra, N., (2009) Curr. Pharm. Des., 15, p. 1008
Broad, L.M., Keding, S.J., Blanco, M., (2008) J. Curr. Top. Med. Chem., 8, p. 1431
Szallasi, A., Cortright, D.N., Blum, C.A., Eid, S.R., (2007) Nat. Rev. Drug Discov., 6, p. 357
Kym, P.R., Kort, M.E., Hutchins, C.W., (2009) Biochem. Pharmacol., 78, p. 211
Szallasi, A., Blumberg, P.M., (1999) Pharmacol. Rev., 51, p. 159
Szallasi, A., Appendino, G., (2004) J. Med. Chem., 47, p. 2717
McLeod, R.L., Correll, C.C., Jia, Y., Anthes, J.C., (2008) Lung, 186, pp. S59
Gunthorpe, M.J., Chizh, B.A., (2009) Drug Discovery Today, 14, p. 56
Wong, G.Y., Gavva, N.R., (2009) Brain Res. Rev., 60, p. 267
Bonache, M.A., Garcia-Martinez, C., De Garcia Diego, L., Carreno, C., Perez De Vega, M.J., Garcia-Lopez, M.T., Ferrer-Montiel, A., Gonzalez-Muniz, R., (2006) ChemMedChem, 1, p. 429
(2008) The Power of Functional Resins in Organic Chemistry, , Tulla-Puche, J., Albericio, F., Eds.
Wiley-VCH Verlag GmbH: KGaA, Weinheim (Germany)
Nandy, J.P., Prakesch, M., Khadem, S., Reddy, P.T., Sharma, U., Arya, P., (2009) Chem. Rev., 109, p. 1999
Kates, S.A., Albericio, F., (2000) Solid-Phase Synthesis. A Practical Guide, , Marcel Dekker: New York (NY, USA)
Carpino, L.A., Han, G.Y., (1972) J. Org. Chem., 37, p. 3404
Vazques, J., Royo, M., Albericio, F., (2004) Lett. Org. Chem., 1, p. 224
Chen, S., Xu, J., (1992) Tetrahedron Lett., 33, p. 647
Farrera-Sinfreu, J., Royo, M., Albericio, F., (2002) Tetrahedron Lett., 43, p. 7813
noteUR - http://www.scopus.com/inward/record.url?eid=2-s2.0-79957876139&partnerID=40&md5=8205ccf9ba4dadcff7dc556527ba886d
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., Julius, D., (1997) Nature, 389, p. 81
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Julius, D., (2000) Science, 288, p. 306
Cortright, D. N., Krause, J. E., Broom, D. C., (2007) Biochim. Biophys. Acta, 1772, p. 978
Willis Jr., W. D., (2009) Exp. Brain Res., 196, p. 5
Cortright, D. N., Szallasi, A., (2009) Curr. Pharm. Des., 15, p. 1736
Ross, R. A., (2003) Br. J. Pharmacol., 140, p. 790
Hwang, S. W., Cho, H., Kwak, J., Lee, S. Y., Kang, C. J., Jung, J., Cho, S., Oh, U., (2000) Proc. Natl. Acad. Sci. U. S. A., 97, p. 6155
Brooks, S. M., (2008) Lung, 186, pp. S88
Bley, K. R., (2004) Expert. Opin. Investig. Drugs, 13, p. 1445
Broad, L. M., Keding, S. J., Blanco, M., (2008) J. Curr. Top. Med. Chem., 8, p. 1431
Kym, P. R., Kort, M. E., Hutchins, C. W., (2009) Biochem. Pharmacol., 78, p. 211
McLeod, R. L., Correll, C. C., Jia, Y., Anthes, J. C., (2008) Lung, 186, pp. S59
Gunthorpe, M. J., Chizh, B. A., (2009) Drug Discovery Today, 14, p. 56
Wong, G. Y., Gavva, N. R., (2009) Brain Res. Rev., 60, p. 267
Bonache, M. A., Garcia-Martinez, C., De Garcia Diego, L., Carreno, C., Perez De Vega, M. J., Garcia-Lopez, M. T., Ferrer-Montiel, A., Gonzalez-Muniz, R., (2006) ChemMedChem, 1, p. 429
(2008) The Power of Functional Resins in Organic Chemistry, , Tulla-Puche, J., Albericio, F., Eds.
Nandy, J. P., Prakesch, M., Khadem, S., Reddy, P. T., Sharma, U., Arya, P., (2009) Chem. Rev., 109, p. 1999
Kates, S. A., Albericio, F., (2000) Solid-Phase Synthesis. A Practical Guide, , Marcel Dekker: New York (NY, USA)
Carpino, L. A., Han, G. Y., (1972) J. Org. Chem., 37, p. 3404
noteUR - http: //www. scopus. com/inward/record. url? eid=2-s2. 0-79957876139&partnerID=40&md5=8205ccf9ba4dadcff7dc556527ba886d
TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach
A discrete library of linear and hydantoin-containing dipeptide derivatives, based on the Lys-Trp(Nps) scaffold, was prepared by solid-phase synthesis. SAR studies indicated that potency for TRPV1 blockade and selectivity towards NMDA is mainly dictated by the side-chain length and the basic nature of alpha, omega-groups in the N-terminal residue. The 2-Nps moiety at position 2 of Trp indole ring is preferred over the 2-pyridine one. (C) 2011 Elsevier Ltd. All rights reserved.
A discrete library of linear and hydantoin-containing dipeptide derivatives, based on the Lys-Trp(Nps) scaffold, was prepared by solid-phase synthesis. SAR studies indicated that potency for TRPV1 blockade and selectivity towards NMDA is mainly dictated by the side-chain length and the basic nature of alpha, omega-groups in the N-terminal residue. The 2-Nps moiety at position 2 of Trp indole ring is preferred over the 2-pyridine one. (C) 2011 Elsevier Ltd. All rights reserved.
TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach
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TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach
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Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
Determination of superoxide dismutase-like activity of copper(II) complexes. Relevance of the speciation for the correct interpretation of in vitro O2 - scavenger activity (605 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Jun; 50(4): 273-281.
Impact Factor: 1.342
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Di Blasio B, Pavone V, Nastri F, Isernia C, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
Conformation for a β-cyclodextrin monosubstituted with a cyclic dipeptide (500 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 1992 Sep 1; 89(15): 7218-7221.
Impact Factor: 9.04
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Alberghina M, Lupo G, La Spina G, Mangiameli A, Gulisano M, Sciotto D, Rizzarelli E
Cytoprotective effect of copper(II) complexes against ethanol-induced damage to rat gastric mucosa (428 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1992 Mar; 45(4): 245-259.
Impact Factor: 1.342
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Arena G, Impellizzeri G, Maccarrone G, Pappalardo G, Sciotto D, Rizzarelli E
Thermodynamic and 1H-NMR Study of Proton Complex Formation of Histidine-Containing Cyclodipeptides in Aqueous Solution (396 views)
J Chem Soc, 1992; N/D: 371-376.
Impact Factor: 0
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Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (1341 views)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
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* Synthesis, self-assembly-behavior and biomolecular recognition properties of thyminyl dipeptides (444 views) (PDF 78 views)
Arabian Journal Of Chemistry, 2020; 13: 1966-1974.
Impact Factor: 4.762
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Fusco S, Capasso D, Centore R, Di Gaetano S, Parisi E
* A new biologically active molecular scaffold: crystal structure of 7-(3-hydroxyphenyl)-4-methyl-2H-[1, 2, 4]triazolo[3, 2-c][1, 2, 4]triazole and selective antiproliferative activity of three isomeric triazolo-triazoles (105 views)
Acta Crystallogr C Struct Chem (ISSN: 2053-2296linking), 2019 Oct 1; 75(Pt10): 1398-1404.
Impact Factor: 0.93
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Pirone L, Di Gaetano S, Rizzarelli E, Bellia F, Pedone E
* Focusing on the functional characterization of the anserinase from Oreochromis niloticus (201 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Feb 22; 130: 158-165.
Impact Factor: 4.784
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Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (853 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
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Bellia F, Vecchio G, Rizzarelli E
* Carnosinases, Their Substrates And Diseases (809 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2014 Feb 21; 19(2): 2299-2329.
Impact Factor: 2.416
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Ruggiero A, Smaldone G, Squeglia F, Berisio R
* Enhanced crystallizability by protein engineering approaches: A general overview (2086 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Jul; 19(7): 732-742.
Impact Factor: 1.994
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Riccio A, Cubellis MV
* Gain of function in CDKN1C (510 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
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Scognamiglio PL, Doti N, Grieco P, Pedone C, Ruvo M, Marasco D
* Discovery Of Small Peptide Antagonists Of Ped/Pea15-D4alpha Interaction From Simplified Combinatorial Libraries (504 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2011 May; 77(5): 319-327.
Impact Factor: 2.282
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (775 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
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Pérez de Vega MJ, García-López MT, Zaccaro L, Royo M, Albericio F, Fernández-Carvajal A, Ferrer-Montiel A, González-Muñiz R
* Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers (518 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2010 Jul 15; 15(7): 4924-4933.
Impact Factor: 1.988
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Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (507 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (615 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Bellia F, Amorini AM, La Mendola D, Vecchio G, Tavazzi B, Giardina B, Di Pietro V, Lazzarino G, Rizzarelli E
* New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity (463 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2008 Feb; 43(2): 373-380.
Impact Factor: 2.882
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La Rosa C, Milardi D, Amato E, Pappalardo M, Grasso D
* Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly (512 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2005 Mar 1; 435(1): 182-189.
Impact Factor: 3.152
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De Simone G, Lombardi A, Galdiero S, Nastri F, Di Costanzo L, Gohda S, Sano A, Yamada T, Pavone V
The crystal structure of a Dcp-containing peptide (456 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 182-188.
Impact Factor: 2.405
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Lombardi A, De Simone G, Galdiero S, Nastri F, Di Costanzo L, Makihiara K, Yamada T, Pavone V
The crystal structure of Afc-containing peptide (457 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000 Feb; 53(2): 150-160.
Impact Factor: 2.405
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Oliva R, Falcigno L, D'Auria G, Zanotti G, Paolillo L
Conformation and calcium-binding properties of a bicyclic nonapeptide (380 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2000; 56(1): 27-36.
Impact Factor: 2.405
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Lombardi A, D'Auria G, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
A novel rigid β-turn molecular scaffold (461 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 1998; 120(24): 5879-5886.
Impact Factor: 5.725
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Cucinotta V, Grasso D, Grasso G, Milardi D
Calorimetric evidences for Copper(II)-regulated chiral recognition between decanucleotide 5'd(CTGGATCCAG)2 and Ala-Trp dipeptides (398 views)
Nucleosides Nucleotides (ISSN: 0732-8311), 1997; 16(10-11): 1847-1854.
Impact Factor: 0.905
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Lombardi A, D'Auria G, Saviano M, Maglio O, Nastri F, Quartara L, Pedone C, Pavone V
Bicyclic Peptides As Type I/Type Ii Beta-Turn Scaffolds (514 views)
Biopolym Pept Sci Sect, 1996; 40(5): 505-518.
Impact Factor: 0
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Bonomo RP, Marchelli R, Tabbì G
Study of H2O2 interaction with copper(II) complexes with diamino-diamide type ligands, diastereoisomeric dipeptides, and tripeptides (513 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Nov 15; 60(3): 205-218.
Impact Factor: 1.342
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Di Blasio B, Saviano M, Del Duca V, De Simone G, Rossi F, Pedone C, Benedetti E, Lorenzi GP
CONFORMATIONAL STUDIES OF HETEROCHIRAL PEPTIDES WITH DIASTEREOISOMERIC RESIDUES - CRYSTAL AND MOLECULAR-STRUCTURES OF LINEAR DIPEPTIDES DERIVED FROM LEUCINE, ISOLEUCINE, AND ALLO-ISOLEUCINE (396 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1995 Oct; 36(4): 401-408.
Impact Factor: 2.425
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Costanzo LL, De Guidi G, Giuffrida S, Rizzarelli E, Vecchio G
Determination of superoxide dismutase-like activity of copper(II) complexes. Relevance of the speciation for the correct interpretation of in vitro O2 - scavenger activity (605 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Jun; 50(4): 273-281.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
Di Blasio B, Pavone V, Nastri F, Isernia C, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
Conformation for a β-cyclodextrin monosubstituted with a cyclic dipeptide (500 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 1992 Sep 1; 89(15): 7218-7221.
Impact Factor: 9.04
View Export to BibTeX Export to EndNote
Alberghina M, Lupo G, La Spina G, Mangiameli A, Gulisano M, Sciotto D, Rizzarelli E
Cytoprotective effect of copper(II) complexes against ethanol-induced damage to rat gastric mucosa (428 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1992 Mar; 45(4): 245-259.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
Arena G, Impellizzeri G, Maccarrone G, Pappalardo G, Sciotto D, Rizzarelli E
Thermodynamic and 1H-NMR Study of Proton Complex Formation of Histidine-Containing Cyclodipeptides in Aqueous Solution (396 views)
J Chem Soc, 1992; N/D: 371-376.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (1341 views)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
View Export to BibTeX Export to EndNote
27 Records (27 excluding Abstracts).
Total impact factor: 111.851 (111.851 excluding Abstracts).
Total 5 year impact factor: 115.263 (115.263 excluding Abstracts).
Total impact factor: 111.851 (111.851 excluding Abstracts).
Total 5 year impact factor: 115.263 (115.263 excluding Abstracts).
461 views. Last view on Saturday 27 May 2023, 0:15:47
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