Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (474 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
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Paper type: Journal Article,
Impact factor: 1.799, 5-year impact factor: 1.714
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79953789669&partnerID=40&md5=bef94658e1e7e4314f24408c4dc95e65
Keywords: Ga And In Complexes, Minigastrin And Cck8 Peptide Conjugates, Nuclear Medicine, Cholecystokinin B Receptor, Cholecystokinin Octapeptide Derivative, Gallium 68, Gastrin Derivative, Indium 111, Animal Experiment, Article, Comparative Study, Controlled Study, Drug Structure, Drug Transport, Drug Uptake, In Vitro Study, In Vivo Study, Internalization, Isotope Labeling, Mouse, Nonhuman, Priority Journal, Cell Line, Tumor, Gallium Radioisotopes, Indium Radioisotopes,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB, University of Naples Federico II, IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
Animal Experimentation Facility, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
INBIOS srl, Via Pietro Castellino 131, 80131 Naples, Italy
References:
Not available.
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.799, 5-year impact factor: 1.714
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79953789669&partnerID=40&md5=bef94658e1e7e4314f24408c4dc95e65
Keywords: Ga And In Complexes, Minigastrin And Cck8 Peptide Conjugates, Nuclear Medicine, Cholecystokinin B Receptor, Cholecystokinin Octapeptide Derivative, Gallium 68, Gastrin Derivative, Indium 111, Animal Experiment, Article, Comparative Study, Controlled Study, Drug Structure, Drug Transport, Drug Uptake, In Vitro Study, In Vivo Study, Internalization, Isotope Labeling, Mouse, Nonhuman, Priority Journal, Cell Line, Tumor, Gallium Radioisotopes, Indium Radioisotopes,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB, University of Naples Federico II, IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
Animal Experimentation Facility, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
INBIOS srl, Via Pietro Castellino 131, 80131 Naples, Italy
References:
Not available.
Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison
The development of suitable radioligands for targeting CCK-2 receptor expressing tumors, such as medullary thyroid carcinoma, is of great clinical interest. In the search for the best CCK-2R binding peptides, we have synthesized, evaluated and compared the CCK8 peptide (Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2) and two gastrin analogs commonly referred to as MG0 (DGlu-Glu(5)-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) and MG11 (DGlu(1)-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2). The N-terminal portion of the three peptide sequences was derivatized by introducing the DTPAGlu or DOTA chelators to allow radiolobeling with 111In(III) and 68Ga(III), respectively. Saturation binding and cellular internalization experiments were performed on A431 cells overexpressing CCK2R (A431-CCK2R). All compounds showed Kd values in the nM range and were internalized with similar rates in CCK2 receptor overexpressing cells. Biodistribution experiments showed higher specific uptake of both MG0-based compounds compared to conjugates containing the CCK8 and MG11 peptide sequences. The higher retention levels of MG0-based peptides were associated with markedly elevated and undesired kidney uptake compared to the other compounds. Current indications suggest that the 5 Glu N-terminal residues while improving peptide stability and receptor-mediated tumor uptake cause unacceptably high kidney retention. Although displaying lower absolute tumor uptake values, the DOTA-coupled CCK8 peptide provided the best tumor to kidney uptake ratio and appears more suitable as lead compound for improvement of radiopharmaceutical properties. © 2011 European Peptide Society and John Wiley and Sons, Ltd.
The development of suitable radioligands for targeting CCK-2 receptor expressing tumors, such as medullary thyroid carcinoma, is of great clinical interest. In the search for the best CCK-2R binding peptides, we have synthesized, evaluated and compared the CCK8 peptide (Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2) and two gastrin analogs commonly referred to as MG0 (DGlu-Glu(5)-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) and MG11 (DGlu(1)-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2). The N-terminal portion of the three peptide sequences was derivatized by introducing the DTPAGlu or DOTA chelators to allow radiolobeling with 111In(III) and 68Ga(III), respectively. Saturation binding and cellular internalization experiments were performed on A431 cells overexpressing CCK2R (A431-CCK2R). All compounds showed Kd values in the nM range and were internalized with similar rates in CCK2 receptor overexpressing cells. Biodistribution experiments showed higher specific uptake of both MG0-based compounds compared to conjugates containing the CCK8 and MG11 peptide sequences. The higher retention levels of MG0-based peptides were associated with markedly elevated and undesired kidney uptake compared to the other compounds. Current indications suggest that the 5 Glu N-terminal residues while improving peptide stability and receptor-mediated tumor uptake cause unacceptably high kidney retention. Although displaying lower absolute tumor uptake values, the DOTA-coupled CCK8 peptide provided the best tumor to kidney uptake ratio and appears more suitable as lead compound for improvement of radiopharmaceutical properties. © 2011 European Peptide Society and John Wiley and Sons, Ltd.
Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison
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Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison
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Morbelli S, Arbizu J, Booij J, Chen M-K, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Jafari L, Lammertsma AA, Law I, Mathews D, Minoshima S, Mosci K, Pagani M, Pappata S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, Barthel H
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Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2017; 44(3): 559-560.
Impact Factor: 7.704
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Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P, Buechel RR, Cuocolo A, van Eck-Smit BL, Flotats A, Hacker M, Hindorf C, Kaufmann PA, Lindner O, Ljungberg M, Lonsdale M, Manrique A, Minarik D, Scholte AJ, Slart RH, Tragardh E, de Wit TC, Hesse B
* EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision (478 views) (PDF 243 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015 Aug 21; 42(12): 1929-1940.
Impact Factor: 5.537
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Behnia F, Gross JA, Ragucci M, Monti S, Mancini M, Elman S, Vesselle H, Mannelli L
* Nuclear medicine and the emergency department patient: an illustrative case-based approach (475 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 0033-8362linking), 2015 Jan; 120(1): 158-170.
Impact Factor: 1.523
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Pellegrino T, Piscopo V, Petretta M, Cuocolo A
* 123I-Metaiodobenzylguanidine cardiac innervation imaging: methods and interpretation (403 views)
Clin Transl Imaging (ISSN: 2281-5872, 2281-5872print, 2281-7565online), 2015; 3(5): 357-363.
Impact Factor: 0
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Russo P, Larobina M, Di Lillo F, Del Vecchio S, Mettivier G
* Combined SPECT/CT and PET/CT for breast imaging (522 views)
Nucl Instrum Meth A (ISSN: 0168-9002), 2015; 809: 58-66.
Impact Factor: 1.2
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Marini C, Acampa W, Bauckneht M, Daniele S, Capitanio S, Cantoni V, Fiz F, Zampella E, Dib B, Assante R, Bruzzi P, Sambuceti G, Cuocolo A
* Added prognostic value of ischaemic threshold in radionuclide myocardial perfusion imaging: a common-sense integration of exercise tolerance and ischaemia severity (604 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2014 Dec 5; 42(5): 750-760.
Impact Factor: 5.383
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Picano E, Vañó E, Rehani MM, Cuocolo A, Mont L, Bodi V, Bar O, Maccia C, Pierard L, Sicari R, Plein S, Mahrholdt H, Lancellotti P, Knuuti J, Heidbuchel H, Di Mario C, Badano LP
* The appropriate and justified use of medical radiation in cardiovascular imaging: a position document of the ESC Associations of Cardiovascular Imaging, Percutaneous Cardiovascular Interventions and Electrophysiology (1293 views)
Eur Heart J (ISSN: 0195-668x), 2014 Mar; 35(10): 665-672.
Impact Factor: 15.203
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Petretta M, Petretta A, Pellegrino T, Nappi C, Cantoni V, Cuocolo A
* Nuclear Cardiology in Heart Failure (541 views)
Curr Cardiovasc Imaging Rep (ISSN: 1941-9066), 2014 Jan; 7(3): 1-7.
Impact Factor: 0
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (780 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Petretta M, Cuocolo A
Prognosis in the era of comparative effectiveness research (613 views)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2013 Apr; 20(2): 313-313.
Impact Factor: 2.645
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (973 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (688 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (501 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
* In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (654 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448.
Impact Factor: 5.036
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (720 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Darcourt J, Booij J, Tatsch K, Varrone A, Borght TV, Kapucu OL, Nagren K, Nobili F, Walker Z, Van Laere K
* EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version (1290 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Feb; 37(2): 443-450.
Impact Factor: 5.036
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Cuocolo A, Breatnach E
* Multimodality imaging in Europe: a survey by the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) (602 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2010 Jan; 37(1): 163-167.
Impact Factor: 5.036
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Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (911 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.
Impact Factor: 4.531
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Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, Mckiddie F, Schaefer WM, Stegger L, Underw
* EANM/ESC guidelines for radionuclide imaging of cardiac function (944 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Apr; 35(4): 851-885.
Impact Factor: 4.532
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (495 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Mainenti PP, Salvatore B, Sirignano C, De Falco T, Speranza A, Fiumara G, Ricci F, Evangelista L, Pace L, Salvatore M
* PET/CT colonography in patients with colo-rectal polyps: A feasibility study (608 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34(10): 1594-1603.
Impact Factor: 4.101
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (550 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Adam A, Cuocolo A
The "White paper of the European Society of Radiology (ESR) and the European Association of Nuclear Medicine (EANM) on multimodality imaging": a message from the ESR and EANM Presidents (485 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2007 Sep; 17(8): 1924-1925.
Impact Factor: 3.405
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Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
* White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (551 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Sep; 34(8): 1147-1151.
Impact Factor: 4.101
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Maggi A, Salvatore M
Molecular imaging (381 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (844 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (526 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (804 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (561 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (652 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (805 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (570 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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Del Vecchio S, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (763 views) (PDF 208 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(SUPPL.1): S88-S88.
Impact Factor: 3.935
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (474 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (697 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
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Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (668 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
Impact Factor: 1.091
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (567 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Pace L, Salvatore M, Del Vecchio S
* A new role for nuclear medicine in multiple Myeloma (399 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Sep; 44(8): 1369-1369.
Impact Factor: 4.899
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Cuocolo A, Acampa W, Evangelista L
* Nuclear medicine and positron emission tomography imaging in cardiology (494 views)
Nucl Med Rev (ISSN: 1506-9680), 2003; 6(1): 59-63.
Impact Factor: 0.155
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (589 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (610 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (652 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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Cuocolo A, Acampa W
* Nuclear cardiology in the new millennium (414 views)
Rev Esp Med Nucl (ISSN: 0212-6982), 2001 Jun; 20(4): 305-308.
Impact Factor: 0.155
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Acampa W, Di Benedetto C, Cuocolo A
An overview of radiotracers in nuclear cardiology (490 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Nov; 7(6): 701-707.
Impact Factor: 1.854
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Salvatore M, Del Vecchio S
Dynamic imaging: Scintimammography (479 views)
Eur J Radiol Elsevier Sci Ireland Ltd (ISSN: 0720-048x), 1998 May; 27(SUPPL.2): S259-S259.
Impact Factor: 0.537
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Alfano B, Pace L, Ciarmiello A, Mansi L, Gaeta G, Salvatore M
Pattern recognition method in nuclear medicine: First application in liver scintigraphy (430 views)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 1991; 7(4): 153-156.
Impact Factor: 0.142
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48 Records (41 excluding Abstracts).
Total impact factor: 146.739 (131.914 excluding Abstracts).
Total 5 year impact factor: 149.411 (129.064 excluding Abstracts).
Total impact factor: 146.739 (131.914 excluding Abstracts).
Total 5 year impact factor: 149.411 (129.064 excluding Abstracts).
474 views. Last view on Monday 02 December 2024, 23:41:59
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