Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison (380 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
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Paper type: Journal Article,
Impact factor: 1.799, 5-year impact factor: 1.714
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79953789669&partnerID=40&md5=bef94658e1e7e4314f24408c4dc95e65
Keywords: Ga And In Complexes, Minigastrin And Cck8 Peptide Conjugates, Nuclear Medicine, Cholecystokinin B Receptor, Cholecystokinin Octapeptide Derivative, Gallium 68, Gastrin Derivative, Indium 111, Animal Experiment, Article, Comparative Study, Controlled Study, Drug Structure, Drug Transport, Drug Uptake, In Vitro Study, In Vivo Study, Internalization, Isotope Labeling, Mouse, Nonhuman, Priority Journal, Cell Line, Tumor, Gallium Radioisotopes, Indium Radioisotopes,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB, University of Naples Federico II, IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
Animal Experimentation Facility, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
INBIOS srl, Via Pietro Castellino 131, 80131 Naples, Italy
References:
Behr, T.M., Gotthardt, M., Barth, A., Behe, M., Imaging tumors with peptide-based radioligands (2001) Q. J. Nucl. Med., 45, pp. 189-20
Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Kwekkeboom, D., Krenning, E.P., De Jong, M., Peptide receptor imaging and therapy (2000) J. Nucl. Med., 41, pp. 1704-1713
Kwekkeboom, D.J., Mueller-Brand, J., Paganelli, G., Anthony, L.B., Pauwels, S., Kvols, L.K., O'Dorisio, T.M., Krenning, E.P., Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs (2005) J. Nucl. Med., 46 (SUPPL. 1), pp. 62S-66S
Wank, S.A., G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family (1998) Am. J. Physiol., 274, pp. G607-G613
Reubi, J.C., Schaer, J.C., Waser, B., Cholecystokinin CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Aloj, L., Caraco, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (2004) J. Nucl. Med., 45, pp. 485-494
Behr, T.M., Behe, M.P., Cholecystokinin-B/Gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies (2002) Semin. Nucl. Med., 32, pp. 97-109
Behe, M., Becker, W., Gotthardt, M., Angerstein, C., Behr, T.M., Improved kinetic stability of DTPA- dGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives (2003) Eur. J. Nucl. Med. Mol. Imaging, 30, pp. 1140-1146
Good, S., Walter, M.A., Waser, B., Wang, X., Muller-Brand, J., Behe, M.P., Reubi, J.C., Maecke, H.R., Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours (2008) Eur. J. Nucl. Med. Mol. Imaging, 35, pp. 1868-1877
Reubi, J.C., Waser, B., Schaer, J.C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M.A., Bugaj, J.E., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) Eur. J. Nucl. Med., 25, pp. 481-490
De Jong, M., Bakker, W.H., Bernard, B.F., Valkema, R., Kwekkeboom, D.J., Reubi, J.C., Srinivasan, A., Krenning, E.P., Preclinical and initial clinical evaluation of 111In-labeled nonsulfated CCK8 analog: a peptide for CCK-B receptor-targeted scintigraphy and radionuclide therapy (1999) J. Nucl. Med., 40, pp. 2081-2087
Kwekkeboom, D.J., Bakker, W.H., Kooij, P.P., Erion, J., Srinivasan, A., De Jong, M., Reubi, J.C., Krenning, E.P., Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma (2000) Eur. J. Nucl. Med., 27, pp. 1312-1317
Nock, B.A., Maina, T., Behe, M., Nikolopoulou, A., Gotthardt, M., Schmitt, J.S., Behr, T.M., Macke, H.R., CCK-2/gastrin receptor-targeted tumor imaging with 99m)Tc-labeled minigastrin analogs (2005) J. Nucl. Med., 46, pp. 1727-1736
Froberg, A.C., de Jong, M., Nock, B.A., Breeman, W.A., Erion, J.L., Maina, T., Verdijsseldonck, M., Krenning, E.P., Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma (2009) Eur. J. Nucl. Med. Mol. Imaging, 36, pp. 1265-1272
Gabriel, M., Decristoforo, C., Kendler, D., Dobrozemsky, G., Heute, D., Uprimny, C., Kovacs, P., Virgolini, I.J., 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT (2007) J. Nucl. Med., 48, pp. 508-518
Hofmann, M., Maecke, H., Borner, R., Weckesser, E., Schoffski, P., Oei, L., Schumacher, J., Knapp, H., Biokinetics and imaging with the somatostatin receptor PET radioligand 68)Ga-DOTATOC: preliminary data (2001) Eur. J. Nucl. Med., 28, pp. 1751-1757
Behr, T.M., Jenner, N., Behe, M., Angerstein, C., Gratz, S., Raue, F., Becker, W., Radiolabeled peptides for targeting cholecystokinin-B/gastrin receptor-expressing tumors (1999) J. Nucl. Med., 40, pp. 1029-1044
Behe, M., Kluge, G., Becker, W., Gotthardt, M., Behr, T.M., Use of polyglutamic acids to reduce uptake of radiometal-labeled minigastrin in the kidneys (2005) J. Nucl. Med., 46, pp. 1012-1015
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjugate Chem., 10, pp. 137-140
Zhernosekov, K.P., Filosofov, D.V., Baum, R.P., Aschoff, P., Bihl, H., Razbash, A.A., Jahn, M., Rosch, F., Processing of generator-produced 68Ga for medical application (2007) J. Nucl. Med., 48, pp. 1741-1748
Pellegrini, M., Mierke, D.F., Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy (1999) Biochemistry, 38, pp. 14775-14783
Roosenburg, S., Laverman, P., van Delft, F.L., Boerman, O.C., Radiolabeled CCK/gastrin peptides for imaging and therapy of CCK2 receptor-expressing tumors (2010) Amino Acids, , DOI: 10.1007/s00726-010-0501-y
Gotthardt, M., van Eerd-Vismale, J., Oyen, W.J., de Jong, M., Zhang, H., Rolleman, E., Maecke, H.R., Boerman, O., Indication for different mechanisms of kidney uptake of radiolabeled peptides (2007) J. Nucl. Med., 48, pp. 596-601
Otsuki, H., Brunetti, A., Owens, E.S., Finn, R.D., Blasberg, R.G., Comparison of Iron-59, Indium-111, and Gallium-68 transferrin as a macromolecular tracer of vascular permeability and the transferrin receptor (1989) J. Nucl. Med., 30, pp. 1676-1685
Mather, S.J., McKenzie, A.J., Sosabowski, J.K., Morris, T.M., Ellison, D., Watson, S.A., Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy (2007) J. Nucl. Med., 48, pp. 615-622
Behr, T. M., Gotthardt, M., Barth, A., Behe, M., Imaging tumors with peptide-based radioligands (2001) Q. J. Nucl. Med., 45, pp. 189-20
Reubi, J. C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Kwekkeboom, D. J., Mueller-Brand, J., Paganelli, G., Anthony, L. B., Pauwels, S., Kvols, L. K., O'Dorisio, T. M., Krenning, E. P., Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs (2005) J. Nucl. Med., 46 (SUPPL. 1), pp. 62S-66S
Wank, S. A., G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family (1998) Am. J. Physiol., 274, pp. G607-G613
Reubi, J. C., Schaer, J. C., Waser, B., Cholecystokinin CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Behr, T. M., Behe, M. P., Cholecystokinin-B/Gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies (2002) Semin. Nucl. Med., 32, pp. 97-109
Reubi, J. C., Waser, B., Schaer, J. C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M. A., Bugaj, J. E., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) Eur. J. Nucl. Med., 25, pp. 481-490
Nock, B. A., Maina, T., Behe, M., Nikolopoulou, A., Gotthardt, M., Schmitt, J. S., Behr, T. M., Macke, H. R., CCK-2/gastrin receptor-targeted tumor imaging with 99m) Tc-labeled minigastrin analogs (2005) J. Nucl. Med., 46, pp. 1727-1736
Froberg, A. C., de Jong, M., Nock, B. A., Breeman, W. A., Erion, J. L., Maina, T., Verdijsseldonck, M., Krenning, E. P., Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma (2009) Eur. J. Nucl. Med. Mol. Imaging, 36, pp. 1265-1272
Behr, T. M., Jenner, N., Behe, M., Angerstein, C., Gratz, S., Raue, F., Becker, W., Radiolabeled peptides for targeting cholecystokinin-B/gastrin receptor-expressing tumors (1999) J. Nucl. Med., 40, pp. 1029-1044
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjugate Chem., 10, pp. 137-140
Zhernosekov, K. P., Filosofov, D. V., Baum, R. P., Aschoff, P., Bihl, H., Razbash, A. A., Jahn, M., Rosch, F., Processing of generator-produced 68Ga for medical application (2007) J. Nucl. Med., 48, pp. 1741-1748
Mather, S. J., McKenzie, A. J., Sosabowski, J. K., Morris, T. M., Ellison, D., Watson, S. A., Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy (2007) J. Nucl. Med., 48, pp. 615-622
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 405-412.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.799, 5-year impact factor: 1.714
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79953789669&partnerID=40&md5=bef94658e1e7e4314f24408c4dc95e65
Keywords: Ga And In Complexes, Minigastrin And Cck8 Peptide Conjugates, Nuclear Medicine, Cholecystokinin B Receptor, Cholecystokinin Octapeptide Derivative, Gallium 68, Gastrin Derivative, Indium 111, Animal Experiment, Article, Comparative Study, Controlled Study, Drug Structure, Drug Transport, Drug Uptake, In Vitro Study, In Vivo Study, Internalization, Isotope Labeling, Mouse, Nonhuman, Priority Journal, Cell Line, Tumor, Gallium Radioisotopes, Indium Radioisotopes,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB, University of Naples Federico II, IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
Animal Experimentation Facility, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale, Via M. Semmola, 80131 Naples, Italy
INBIOS srl, Via Pietro Castellino 131, 80131 Naples, Italy
References:
Behr, T.M., Gotthardt, M., Barth, A., Behe, M., Imaging tumors with peptide-based radioligands (2001) Q. J. Nucl. Med., 45, pp. 189-20
Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Kwekkeboom, D., Krenning, E.P., De Jong, M., Peptide receptor imaging and therapy (2000) J. Nucl. Med., 41, pp. 1704-1713
Kwekkeboom, D.J., Mueller-Brand, J., Paganelli, G., Anthony, L.B., Pauwels, S., Kvols, L.K., O'Dorisio, T.M., Krenning, E.P., Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs (2005) J. Nucl. Med., 46 (SUPPL. 1), pp. 62S-66S
Wank, S.A., G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family (1998) Am. J. Physiol., 274, pp. G607-G613
Reubi, J.C., Schaer, J.C., Waser, B., Cholecystokinin CCK)-A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Aloj, L., Caraco, C., Panico, M., Zannetti, A., Del Vecchio, S., Tesauro, D., De Luca, S., Salvatore, M., In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (2004) J. Nucl. Med., 45, pp. 485-494
Behr, T.M., Behe, M.P., Cholecystokinin-B/Gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies (2002) Semin. Nucl. Med., 32, pp. 97-109
Behe, M., Becker, W., Gotthardt, M., Angerstein, C., Behr, T.M., Improved kinetic stability of DTPA- dGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives (2003) Eur. J. Nucl. Med. Mol. Imaging, 30, pp. 1140-1146
Good, S., Walter, M.A., Waser, B., Wang, X., Muller-Brand, J., Behe, M.P., Reubi, J.C., Maecke, H.R., Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours (2008) Eur. J. Nucl. Med. Mol. Imaging, 35, pp. 1868-1877
Reubi, J.C., Waser, B., Schaer, J.C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M.A., Bugaj, J.E., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) Eur. J. Nucl. Med., 25, pp. 481-490
De Jong, M., Bakker, W.H., Bernard, B.F., Valkema, R., Kwekkeboom, D.J., Reubi, J.C., Srinivasan, A., Krenning, E.P., Preclinical and initial clinical evaluation of 111In-labeled nonsulfated CCK8 analog: a peptide for CCK-B receptor-targeted scintigraphy and radionuclide therapy (1999) J. Nucl. Med., 40, pp. 2081-2087
Kwekkeboom, D.J., Bakker, W.H., Kooij, P.P., Erion, J., Srinivasan, A., De Jong, M., Reubi, J.C., Krenning, E.P., Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma (2000) Eur. J. Nucl. Med., 27, pp. 1312-1317
Nock, B.A., Maina, T., Behe, M., Nikolopoulou, A., Gotthardt, M., Schmitt, J.S., Behr, T.M., Macke, H.R., CCK-2/gastrin receptor-targeted tumor imaging with 99m)Tc-labeled minigastrin analogs (2005) J. Nucl. Med., 46, pp. 1727-1736
Froberg, A.C., de Jong, M., Nock, B.A., Breeman, W.A., Erion, J.L., Maina, T., Verdijsseldonck, M., Krenning, E.P., Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma (2009) Eur. J. Nucl. Med. Mol. Imaging, 36, pp. 1265-1272
Gabriel, M., Decristoforo, C., Kendler, D., Dobrozemsky, G., Heute, D., Uprimny, C., Kovacs, P., Virgolini, I.J., 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT (2007) J. Nucl. Med., 48, pp. 508-518
Hofmann, M., Maecke, H., Borner, R., Weckesser, E., Schoffski, P., Oei, L., Schumacher, J., Knapp, H., Biokinetics and imaging with the somatostatin receptor PET radioligand 68)Ga-DOTATOC: preliminary data (2001) Eur. J. Nucl. Med., 28, pp. 1751-1757
Behr, T.M., Jenner, N., Behe, M., Angerstein, C., Gratz, S., Raue, F., Becker, W., Radiolabeled peptides for targeting cholecystokinin-B/gastrin receptor-expressing tumors (1999) J. Nucl. Med., 40, pp. 1029-1044
Behe, M., Kluge, G., Becker, W., Gotthardt, M., Behr, T.M., Use of polyglutamic acids to reduce uptake of radiometal-labeled minigastrin in the kidneys (2005) J. Nucl. Med., 46, pp. 1012-1015
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjugate Chem., 10, pp. 137-140
Zhernosekov, K.P., Filosofov, D.V., Baum, R.P., Aschoff, P., Bihl, H., Razbash, A.A., Jahn, M., Rosch, F., Processing of generator-produced 68Ga for medical application (2007) J. Nucl. Med., 48, pp. 1741-1748
Pellegrini, M., Mierke, D.F., Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy (1999) Biochemistry, 38, pp. 14775-14783
Roosenburg, S., Laverman, P., van Delft, F.L., Boerman, O.C., Radiolabeled CCK/gastrin peptides for imaging and therapy of CCK2 receptor-expressing tumors (2010) Amino Acids, , DOI: 10.1007/s00726-010-0501-y
Gotthardt, M., van Eerd-Vismale, J., Oyen, W.J., de Jong, M., Zhang, H., Rolleman, E., Maecke, H.R., Boerman, O., Indication for different mechanisms of kidney uptake of radiolabeled peptides (2007) J. Nucl. Med., 48, pp. 596-601
Otsuki, H., Brunetti, A., Owens, E.S., Finn, R.D., Blasberg, R.G., Comparison of Iron-59, Indium-111, and Gallium-68 transferrin as a macromolecular tracer of vascular permeability and the transferrin receptor (1989) J. Nucl. Med., 30, pp. 1676-1685
Mather, S.J., McKenzie, A.J., Sosabowski, J.K., Morris, T.M., Ellison, D., Watson, S.A., Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy (2007) J. Nucl. Med., 48, pp. 615-622
Behr, T. M., Gotthardt, M., Barth, A., Behe, M., Imaging tumors with peptide-based radioligands (2001) Q. J. Nucl. Med., 45, pp. 189-20
Reubi, J. C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Kwekkeboom, D. J., Mueller-Brand, J., Paganelli, G., Anthony, L. B., Pauwels, S., Kvols, L. K., O'Dorisio, T. M., Krenning, E. P., Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs (2005) J. Nucl. Med., 46 (SUPPL. 1), pp. 62S-66S
Wank, S. A., G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family (1998) Am. J. Physiol., 274, pp. G607-G613
Reubi, J. C., Schaer, J. C., Waser, B., Cholecystokinin CCK) -A and CCK-B/gastrin receptors in human tumors (1997) Cancer Res., 57, pp. 1377-1386
Behr, T. M., Behe, M. P., Cholecystokinin-B/Gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies (2002) Semin. Nucl. Med., 32, pp. 97-109
Reubi, J. C., Waser, B., Schaer, J. C., Laederach, U., Erion, J., Srinivasan, A., Schmidt, M. A., Bugaj, J. E., Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo (1998) Eur. J. Nucl. Med., 25, pp. 481-490
Nock, B. A., Maina, T., Behe, M., Nikolopoulou, A., Gotthardt, M., Schmitt, J. S., Behr, T. M., Macke, H. R., CCK-2/gastrin receptor-targeted tumor imaging with 99m) Tc-labeled minigastrin analogs (2005) J. Nucl. Med., 46, pp. 1727-1736
Froberg, A. C., de Jong, M., Nock, B. A., Breeman, W. A., Erion, J. L., Maina, T., Verdijsseldonck, M., Krenning, E. P., Comparison of three radiolabelled peptide analogues for CCK-2 receptor scintigraphy in medullary thyroid carcinoma (2009) Eur. J. Nucl. Med. Mol. Imaging, 36, pp. 1265-1272
Behr, T. M., Jenner, N., Behe, M., Angerstein, C., Gratz, S., Raue, F., Becker, W., Radiolabeled peptides for targeting cholecystokinin-B/gastrin receptor-expressing tumors (1999) J. Nucl. Med., 40, pp. 1029-1044
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjugate Chem., 10, pp. 137-140
Zhernosekov, K. P., Filosofov, D. V., Baum, R. P., Aschoff, P., Bihl, H., Razbash, A. A., Jahn, M., Rosch, F., Processing of generator-produced 68Ga for medical application (2007) J. Nucl. Med., 48, pp. 1741-1748
Mather, S. J., McKenzie, A. J., Sosabowski, J. K., Morris, T. M., Ellison, D., Watson, S. A., Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy (2007) J. Nucl. Med., 48, pp. 615-622
Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison
The development of suitable radioligands for targeting CCK-2 receptor expressing tumors, such as medullary thyroid carcinoma, is of great clinical interest. In the search for the best CCK-2R binding peptides, we have synthesized, evaluated and compared the CCK8 peptide (Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2) and two gastrin analogs commonly referred to as MG0 (DGlu-Glu(5)-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) and MG11 (DGlu(1)-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2). The N-terminal portion of the three peptide sequences was derivatized by introducing the DTPAGlu or DOTA chelators to allow radiolobeling with 111In(III) and 68Ga(III), respectively. Saturation binding and cellular internalization experiments were performed on A431 cells overexpressing CCK2R (A431-CCK2R). All compounds showed Kd values in the nM range and were internalized with similar rates in CCK2 receptor overexpressing cells. Biodistribution experiments showed higher specific uptake of both MG0-based compounds compared to conjugates containing the CCK8 and MG11 peptide sequences. The higher retention levels of MG0-based peptides were associated with markedly elevated and undesired kidney uptake compared to the other compounds. Current indications suggest that the 5 Glu N-terminal residues while improving peptide stability and receptor-mediated tumor uptake cause unacceptably high kidney retention. Although displaying lower absolute tumor uptake values, the DOTA-coupled CCK8 peptide provided the best tumor to kidney uptake ratio and appears more suitable as lead compound for improvement of radiopharmaceutical properties. © 2011 European Peptide Society and John Wiley and Sons, Ltd.
The development of suitable radioligands for targeting CCK-2 receptor expressing tumors, such as medullary thyroid carcinoma, is of great clinical interest. In the search for the best CCK-2R binding peptides, we have synthesized, evaluated and compared the CCK8 peptide (Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2) and two gastrin analogs commonly referred to as MG0 (DGlu-Glu(5)-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) and MG11 (DGlu(1)-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2). The N-terminal portion of the three peptide sequences was derivatized by introducing the DTPAGlu or DOTA chelators to allow radiolobeling with 111In(III) and 68Ga(III), respectively. Saturation binding and cellular internalization experiments were performed on A431 cells overexpressing CCK2R (A431-CCK2R). All compounds showed Kd values in the nM range and were internalized with similar rates in CCK2 receptor overexpressing cells. Biodistribution experiments showed higher specific uptake of both MG0-based compounds compared to conjugates containing the CCK8 and MG11 peptide sequences. The higher retention levels of MG0-based peptides were associated with markedly elevated and undesired kidney uptake compared to the other compounds. Current indications suggest that the 5 Glu N-terminal residues while improving peptide stability and receptor-mediated tumor uptake cause unacceptably high kidney retention. Although displaying lower absolute tumor uptake values, the DOTA-coupled CCK8 peptide provided the best tumor to kidney uptake ratio and appears more suitable as lead compound for improvement of radiopharmaceutical properties. © 2011 European Peptide Society and John Wiley and Sons, Ltd.
Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison
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Gastrin and cholecystokinin peptide-based radiopharmaceuticals: An in vivo and in vitro comparison
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Caporale A, Bolzati C, Incisivo GM, Salvarese N, Grieco P, Ruvo M
* Improved synthesis on solid phase of dithiocarbamic cRGD-derivative and (99m) Tc-radiolabelling (199 views)
J Pept Sci (ISSN: 1075-2617linking, 1099-1387electronic), 2019 Feb; 25(2): e3140-e3140.
Impact Factor: 1.807
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Greco A, Auletta L, Orlandella FM, Iervolino PLC, Klain M, Salvatore G, Mancini M
* Preclinical Imaging for the Study of Mouse Models of Thyroid Cancer (800 views) (PDF 167 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Dec 16; 18(12): 1-18.
Impact Factor: 3.687
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Morbelli S, Arbizu J, Booij J, Chen M-K, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Jafari L, Lammertsma AA, Law I, Mathews D, Minoshima S, Mosci K, Pagani M, Pappata S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, Barthel H
* Erratum to: The need of standardization and of large clinical studies in an emerging indication of [18F]FDG PET: the autoimmune encephalitis (European Journal of Nuclear Medicine and Molecular Imaging, (2017), 44, 3, (353-357), 10. 1007/s00259-016-3589-9) (195 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2017; 44(3): 559-560.
Impact Factor: 7.704
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Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P, Buechel RR, Cuocolo A, van Eck-Smit BL, Flotats A, Hacker M, Hindorf C, Kaufmann PA, Lindner O, Ljungberg M, Lonsdale M, Manrique A, Minarik D, Scholte AJ, Slart RH, Tragardh E, de Wit TC, Hesse B
* EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision (364 views) (PDF 218 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015 Aug 21; 42(12): 1929-1940.
Impact Factor: 5.537
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Behnia F, Gross JA, Ragucci M, Monti S, Mancini M, Elman S, Vesselle H, Mannelli L
* Nuclear medicine and the emergency department patient: an illustrative case-based approach (357 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 0033-8362linking), 2015 Jan; 120(1): 158-170.
Impact Factor: 1.523
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Pellegrino T, Piscopo V, Petretta M, Cuocolo A
* 123I-Metaiodobenzylguanidine cardiac innervation imaging: methods and interpretation (218 views)
Clin Transl Imaging (ISSN: 2281-5872, 2281-5872print, 2281-7565online), 2015; 3(5): 357-363.
Impact Factor: 0
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Russo P, Larobina M, Di Lillo F, Del Vecchio S, Mettivier G
* Combined SPECT/CT and PET/CT for breast imaging (451 views)
Nucl Instrum Meth A (ISSN: 0168-9002), 2015; 809: 58-66.
Impact Factor: 1.2
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Marini C, Acampa W, Bauckneht M, Daniele S, Capitanio S, Cantoni V, Fiz F, Zampella E, Dib B, Assante R, Bruzzi P, Sambuceti G, Cuocolo A
* Added prognostic value of ischaemic threshold in radionuclide myocardial perfusion imaging: a common-sense integration of exercise tolerance and ischaemia severity (502 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2014 Dec 5; 42(5): 750-760.
Impact Factor: 5.383
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Picano E, Vañó E, Rehani MM, Cuocolo A, Mont L, Bodi V, Bar O, Maccia C, Pierard L, Sicari R, Plein S, Mahrholdt H, Lancellotti P, Knuuti J, Heidbuchel H, Di Mario C, Badano LP
* The appropriate and justified use of medical radiation in cardiovascular imaging: a position document of the ESC Associations of Cardiovascular Imaging, Percutaneous Cardiovascular Interventions and Electrophysiology (767 views)
Eur Heart J (ISSN: 0195-668x), 2014 Mar; 35(10): 665-672.
Impact Factor: 15.203
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Petretta M, Petretta A, Pellegrino T, Nappi C, Cantoni V, Cuocolo A
* Nuclear Cardiology in Heart Failure (379 views)
Curr Cardiovasc Imaging Rep (ISSN: 1941-9066), 2014 Jan; 7(3): 1-7.
Impact Factor: 0
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (538 views)
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Impact Factor: 5.217
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Petretta M, Cuocolo A
Prognosis in the era of comparative effectiveness research (321 views)
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Impact Factor: 2.645
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Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
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Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (463 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
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Impact Factor: 5.036
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (596 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Darcourt J, Booij J, Tatsch K, Varrone A, Borght TV, Kapucu OL, Nagren K, Nobili F, Walker Z, Van Laere K
* EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version (723 views)
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Impact Factor: 5.036
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Cuocolo A, Breatnach E
* Multimodality imaging in Europe: a survey by the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) (413 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2010 Jan; 37(1): 163-167.
Impact Factor: 5.036
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Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (573 views)
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Impact Factor: 4.531
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Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, Mckiddie F, Schaefer WM, Stegger L, Underw
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Impact Factor: 4.532
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
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Impact Factor: 2.823
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Mainenti PP, Salvatore B, Sirignano C, De Falco T, Speranza A, Fiumara G, Ricci F, Evangelista L, Pace L, Salvatore M
* PET/CT colonography in patients with colo-rectal polyps: A feasibility study (291 views)
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Impact Factor: 4.101
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Adam A, Cuocolo A
The "White paper of the European Society of Radiology (ESR) and the European Association of Nuclear Medicine (EANM) on multimodality imaging": a message from the ESR and EANM Presidents (338 views)
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Impact Factor: 3.405
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Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
* White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (303 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Sep; 34(8): 1147-1151.
Impact Factor: 4.101
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Maggi A, Salvatore M
Molecular imaging (327 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (400 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (352 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (523 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
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Impact Factor: 4.041
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (359 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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Del Vecchio S, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (600 views) (PDF 182 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(SUPPL.1): S88-S88.
Impact Factor: 3.935
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (587 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
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Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (519 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
Impact Factor: 1.091
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Pace L, Salvatore M, Del Vecchio S
* A new role for nuclear medicine in multiple Myeloma (322 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Sep; 44(8): 1369-1369.
Impact Factor: 4.899
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Cuocolo A, Acampa W, Evangelista L
* Nuclear medicine and positron emission tomography imaging in cardiology (397 views)
Nucl Med Rev (ISSN: 1506-9680), 2003; 6(1): 59-63.
Impact Factor: 0.155
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (467 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (455 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
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Impact Factor: 2.372
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Cuocolo A, Acampa W
* Nuclear cardiology in the new millennium (324 views)
Rev Esp Med Nucl (ISSN: 0212-6982), 2001 Jun; 20(4): 305-308.
Impact Factor: 0.155
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Acampa W, Di Benedetto C, Cuocolo A
An overview of radiotracers in nuclear cardiology (376 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Nov; 7(6): 701-707.
Impact Factor: 1.854
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Salvatore M, Del Vecchio S
Dynamic imaging: Scintimammography (383 views)
Eur J Radiol Elsevier Sci Ireland Ltd (ISSN: 0720-048x), 1998 May; 27(SUPPL.2): S259-S259.
Impact Factor: 0.537
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Alfano B, Pace L, Ciarmiello A, Mansi L, Gaeta G, Salvatore M
Pattern recognition method in nuclear medicine: First application in liver scintigraphy (341 views)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 1991; 7(4): 153-156.
Impact Factor: 0.142
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* Improved synthesis on solid phase of dithiocarbamic cRGD-derivative and (99m) Tc-radiolabelling (199 views)
J Pept Sci (ISSN: 1075-2617linking, 1099-1387electronic), 2019 Feb; 25(2): e3140-e3140.
Impact Factor: 1.807
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Greco A, Auletta L, Orlandella FM, Iervolino PLC, Klain M, Salvatore G, Mancini M
* Preclinical Imaging for the Study of Mouse Models of Thyroid Cancer (800 views) (PDF 167 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Dec 16; 18(12): 1-18.
Impact Factor: 3.687
View Export to BibTeX Export to EndNote
Morbelli S, Arbizu J, Booij J, Chen M-K, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Jafari L, Lammertsma AA, Law I, Mathews D, Minoshima S, Mosci K, Pagani M, Pappata S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, Barthel H
* Erratum to: The need of standardization and of large clinical studies in an emerging indication of [18F]FDG PET: the autoimmune encephalitis (European Journal of Nuclear Medicine and Molecular Imaging, (2017), 44, 3, (353-357), 10. 1007/s00259-016-3589-9) (195 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2017; 44(3): 559-560.
Impact Factor: 7.704
View Export to BibTeX Export to EndNote
Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P, Buechel RR, Cuocolo A, van Eck-Smit BL, Flotats A, Hacker M, Hindorf C, Kaufmann PA, Lindner O, Ljungberg M, Lonsdale M, Manrique A, Minarik D, Scholte AJ, Slart RH, Tragardh E, de Wit TC, Hesse B
* EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision (364 views) (PDF 218 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015 Aug 21; 42(12): 1929-1940.
Impact Factor: 5.537
View Export to BibTeX Export to EndNote
Behnia F, Gross JA, Ragucci M, Monti S, Mancini M, Elman S, Vesselle H, Mannelli L
* Nuclear medicine and the emergency department patient: an illustrative case-based approach (357 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 0033-8362linking), 2015 Jan; 120(1): 158-170.
Impact Factor: 1.523
View Export to BibTeX Export to EndNote
Pellegrino T, Piscopo V, Petretta M, Cuocolo A
* 123I-Metaiodobenzylguanidine cardiac innervation imaging: methods and interpretation (218 views)
Clin Transl Imaging (ISSN: 2281-5872, 2281-5872print, 2281-7565online), 2015; 3(5): 357-363.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Russo P, Larobina M, Di Lillo F, Del Vecchio S, Mettivier G
* Combined SPECT/CT and PET/CT for breast imaging (451 views)
Nucl Instrum Meth A (ISSN: 0168-9002), 2015; 809: 58-66.
Impact Factor: 1.2
View Export to BibTeX Export to EndNote
Marini C, Acampa W, Bauckneht M, Daniele S, Capitanio S, Cantoni V, Fiz F, Zampella E, Dib B, Assante R, Bruzzi P, Sambuceti G, Cuocolo A
* Added prognostic value of ischaemic threshold in radionuclide myocardial perfusion imaging: a common-sense integration of exercise tolerance and ischaemia severity (502 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2014 Dec 5; 42(5): 750-760.
Impact Factor: 5.383
View Export to BibTeX Export to EndNote
Picano E, Vañó E, Rehani MM, Cuocolo A, Mont L, Bodi V, Bar O, Maccia C, Pierard L, Sicari R, Plein S, Mahrholdt H, Lancellotti P, Knuuti J, Heidbuchel H, Di Mario C, Badano LP
* The appropriate and justified use of medical radiation in cardiovascular imaging: a position document of the ESC Associations of Cardiovascular Imaging, Percutaneous Cardiovascular Interventions and Electrophysiology (767 views)
Eur Heart J (ISSN: 0195-668x), 2014 Mar; 35(10): 665-672.
Impact Factor: 15.203
View Export to BibTeX Export to EndNote
Petretta M, Petretta A, Pellegrino T, Nappi C, Cantoni V, Cuocolo A
* Nuclear Cardiology in Heart Failure (379 views)
Curr Cardiovasc Imaging Rep (ISSN: 1941-9066), 2014 Jan; 7(3): 1-7.
Impact Factor: 0
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (538 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
View Export to BibTeX Export to EndNote
Petretta M, Cuocolo A
Prognosis in the era of comparative effectiveness research (321 views)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2013 Apr; 20(2): 313-313.
Impact Factor: 2.645
View Export to BibTeX Export to EndNote
Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowskijk, Breeman WA, Reubi JC, Decristoforo C
* Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607 (708 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Sep; 38(8): 1426-1435.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (463 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
* In-111-pentetreotide scintigraphy: procedure guidelines for tumour imaging (479 views)
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Impact Factor: 5.036
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (596 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Darcourt J, Booij J, Tatsch K, Varrone A, Borght TV, Kapucu OL, Nagren K, Nobili F, Walker Z, Van Laere K
* EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version (723 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Feb; 37(2): 443-450.
Impact Factor: 5.036
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Cuocolo A, Breatnach E
* Multimodality imaging in Europe: a survey by the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) (413 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2010 Jan; 37(1): 163-167.
Impact Factor: 5.036
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Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (573 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.
Impact Factor: 4.531
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Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, Mckiddie F, Schaefer WM, Stegger L, Underw
* EANM/ESC guidelines for radionuclide imaging of cardiac function (572 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Apr; 35(4): 851-885.
Impact Factor: 4.532
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D'Andrea LD, Testa I, Panico M, Di Stasi R, Carac C, Tarallo L, Arra C, Barbieri A, Romanelli A, Aloj L
* In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with Tc-99m-tricarbonyl (424 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 90(5): 707-712.
Impact Factor: 2.823
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Mainenti PP, Salvatore B, Sirignano C, De Falco T, Speranza A, Fiumara G, Ricci F, Evangelista L, Pace L, Salvatore M
* PET/CT colonography in patients with colo-rectal polyps: A feasibility study (291 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34(10): 1594-1603.
Impact Factor: 4.101
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De Luca S, De Capua A, Saviano M, Della Moglie R, Aloj L, Tarallo L, Pedone C, Morelli G
* Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor (398 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Sep 1; 15(17): 5845-5853.
Impact Factor: 2.662
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Adam A, Cuocolo A
The "White paper of the European Society of Radiology (ESR) and the European Association of Nuclear Medicine (EANM) on multimodality imaging": a message from the ESR and EANM Presidents (338 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2007 Sep; 17(8): 1924-1925.
Impact Factor: 3.405
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Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
* White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (303 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Sep; 34(8): 1147-1151.
Impact Factor: 4.101
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Maggi A, Salvatore M
Molecular imaging (327 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (616 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Agostini S, Bolzati C, Didonè E, Cavazza-Ceccato M, Refosco F, Aloj L, Arra C, Aurilio M, Tornesello AL, Tesauro D, Morelli G
* The (Tc(N)(PNP))2+ metal fragment labeled cholecystokinin-8 (CCK8) peptide for CCK-2 receptors imaging: In vitro and in vivo studies (400 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2007 Apr; 13(4): 211-219.
Impact Factor: 1.768
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (352 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M
* The EEE project (449 views)
Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980.
Impact Factor: 0
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Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (523 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (584 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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De Luca S, Sanseverino M, Zocchi I, Pedone C, Morelli G, Ragone R
* Receptor fragment approach to the binding between CCK8 peptide and cholecystokinin receptors: A fluorescence study on type B receptor fragment CCKB-R (352-379) (359 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2005 Mar; 77(4): 205-211.
Impact Factor: 2.545
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Del Vecchio S, Salvatore M
* Tc-99m-MIBI in the evaluation of breast cancer biology (600 views) (PDF 182 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Jun; 31(SUPPL.1): S88-S88.
Impact Factor: 3.935
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De Luca S, Morelli G
* Synthesis and characterization of a sulfated and a non-sulfated cyclic CCK8 analogue functionalized with a chelating group for metal labelling (395 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 May; 10(5): 265-273.
Impact Factor: 1.652
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Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M
* In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging (587 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2004 Mar; 45(3): 485-494.
Impact Factor: 5.362
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Aloj L, Panico M, Caraco C, Del Vecchio S, Arra C, Affuso A, Accardo A, Mansi R, Tesauro D, De Luca S, Pedone C, Visentin R, Mazzi U, Morelli G, Salvatore M
* In vitro and in vivo characterization of Indium-111 and Technetium-99m labeled CCK-8 derivatives for CCK-B receptor imaging (519 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004 Feb; 19(1): 93-98.
Impact Factor: 1.091
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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Pace L, Salvatore M, Del Vecchio S
* A new role for nuclear medicine in multiple Myeloma (322 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Sep; 44(8): 1369-1369.
Impact Factor: 4.899
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Cuocolo A, Acampa W, Evangelista L
* Nuclear medicine and positron emission tomography imaging in cardiology (397 views)
Nucl Med Rev (ISSN: 1506-9680), 2003; 6(1): 59-63.
Impact Factor: 0.155
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (467 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (455 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Aloj L, Panico M, Caracó C, Zannetti A, Del Vecchio S, Di Nuzzo C, Arra C, Morelli G, Tesauro D, De Luca S, Pedone C, Salvatore M
* Radiolabeling approaches for cholecystokinin B receptor imaging (496 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2002; 66(6): 370-380.
Impact Factor: 2.372
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Cuocolo A, Acampa W
* Nuclear cardiology in the new millennium (324 views)
Rev Esp Med Nucl (ISSN: 0212-6982), 2001 Jun; 20(4): 305-308.
Impact Factor: 0.155
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Acampa W, Di Benedetto C, Cuocolo A
An overview of radiotracers in nuclear cardiology (376 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Nov; 7(6): 701-707.
Impact Factor: 1.854
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Salvatore M, Del Vecchio S
Dynamic imaging: Scintimammography (383 views)
Eur J Radiol Elsevier Sci Ireland Ltd (ISSN: 0720-048x), 1998 May; 27(SUPPL.2): S259-S259.
Impact Factor: 0.537
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Alfano B, Pace L, Ciarmiello A, Mansi L, Gaeta G, Salvatore M
Pattern recognition method in nuclear medicine: First application in liver scintigraphy (341 views)
Phys Med (ISSN: 1120-1797, 1120-1797linking), 1991; 7(4): 153-156.
Impact Factor: 0.142
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48 Records (43 excluding Abstracts).
Total impact factor: 146.739 (135.377 excluding Abstracts).
Total 5 year impact factor: 149.411 (133.424 excluding Abstracts).
Total impact factor: 146.739 (135.377 excluding Abstracts).
Total 5 year impact factor: 149.411 (133.424 excluding Abstracts).
380 views. Last view on Wednesday 25 January 2023, 14:06:58
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