Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.799, 5-year impact factor: 1.714
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651440633&partnerID=40&md5=06e7b1d40752b219b9c6e6289c3d2560
Keywords: Amphiphilic Gadolinium Complexes, Mri Contrast Agents, Octreotide Peptide, Small-Angle Neutron Scattering, Supramolecular Aggregates, 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid, Amphophile, Contrast Medium, Cyclopeptide, Ethylene Derivative, Gadolinium Pentetate, Gadoteric Acid, Glutamine, Lysine, Monomer, Nanoparticle, Pentetic Acid, Pentetic Acid Derivative, Somatostatin Receptor 2, Surfactant, Tryptophan, Water, Amino Terminal Sequence, Bilayer Membrane, Complex Formation, Drug Binding, Drug Receptor Binding, Fluorescence, Hydrophobicity, Macromolecule, Micelle, Nuclear Magnetic Resonance Imaging, Priority Journal, Protein Aggregation, Structure Analysis, Surface Property, Thickness,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB, University of Naples Federico II, IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry I.F.M., Molecular Imaging Centre, University of Turin, Via Nizza, 52, 10125 Turin, Italy
Juelich Centre for Neutron Science, Lichtenbergstrasse 1, D 85747 Garching, Germany
Helmholtz Zentrum Berlin, Glienicker Strasse 100, D-14109 Berlin, Germany
References:
Berthold, M., Bartfai, T., Modes of peptide binding in G Protein-Coupled Receptors (1997) Neurochem. Res., 22, pp. 1023-103
Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Lamberts, S.W.J., Octreotide: The Next Decade (1999), Bioscientifica: UK, Bristol, UKBauer, W., Briner, U., Doepfner, W., SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action (1982) Life Sci, 31, pp. 1133-1140
Veber, D.F., Freidinger, R.M., Schwenk-Perlow, D., Paleveda Jr, W.J., Holly, F.W., Strachan, R.G., Nurr, R.F., Hirschmann, R., A potent cyclic hexapeptide analogue of somatostatin (1981) Nature, 292, pp. 55-58
Patel, C.Y., Somatostatin and its receptor family (1999) Front. Neuroendocrinol., 20, pp. 157-198
Hofland, L.J., Internalization of [DOTA,125I-Tyr3]octreotide by somatostatin receptor-positive cells in vitro and in vivo: implications for somatostatin receptor-targeted radio-guided surgery (1999) Proc. Assoc. Am. Physicians, 111, pp. 63-69
Huang, C.M., Wu, Y.T., Chen, S.T., Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis (2000) Chem. Biol., 7, pp. 453-461
Mier, W., Eritja, R., Ashour, M., Haberkorn, U., Eisenhut, M., Peptide-PNA conjugates targeted transport of antisense therapeutics into tumours (2003) Angew. Chem. Int. Ed., 42, pp. 1968-1971
Lamberts, S.W.J., Krenning, E.P., Reubi, J.C., The role of somatostatin and its analogs in the diagnosis and treatment of tumors (1991) Endocr. Rev., 12, pp. 450-482
Krenning, E.P., Kwekkeboom, D.J., Pauwels, S., Kvols, L.K., Reubi, J.C., Nuclear Medicine Annual (1995) Somatostatin receptor scintigraphy, pp. 1-50. , Freeman LM (ed.). Lippincott-Raven: New York
Reubi, J.C., Waser, B., Schaer, J.C., Laissue, J.A., Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands (2001) Eur. J. Nucl. Med., 28, pp. 836-846. , Erratum in: Eur. J. Nucl. Med. 2001
Froidevaux, S., Eberle, A.N., Somatostatin analogues and radiopeptides in cancer therapy (2002) Biopolymers (Pept. Sci.), 66, pp. 161-183
Allen, T.M., Ligand-targeted therapeutics in anticancer therapy (2002) Nat. Rev. Cancer, 2, pp. 750-763
Wu, H., Chang, D., Peptide-mediated liposomal drug delivery system targeting tumor blood vessels in anticancer therapy (2010) J. Oncol., , ASAP DOI 10.1155/2010/723798
van Tilborg, G.A.F., Mulder, W.J.M., Deckers, N., Storm, G., Reutelingsperger, C.P.M., Strijkers, G.J., Nicolay, K., Annexin A5-functionalized bimodal lipid-based contrast agents for the detection of apoptosis (2006) Bioconjug. Chem., 17, pp. 741-749
Mulder, W.J.M., Strijkers, G.J., van Tilborg, G.A.F., Cormode, D.P., Fayad, Z.A., Nicolay, K., Nanoparticulate assemblies of amphiphiles and diagnostically active materials for multimodality imaging (2009) Acc. Chem. Res., 42, pp. 904-914
Bull, S.R., Guler, M.O., Bras, R.E., Maede, T.J., Stupp, S.I., Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents (2005) Nano Lett, 5, pp. 1-4
Kluza, E., van der Schaft, D.W.J., Hautvast, P.A.I., Mulder, W.J.M., Mayo, K.H., Griffioen, A.W., Strijkers, G.J., Nicolay, K., Synergistic targeting of αvβ3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis (2010) Nano Lett, 10, pp. 52-58
Ferrari, M., Cancer nanotechnology: opportunities and challenges (2005) Nat. Rev. Cancer, 5, pp. 161-171
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor specific contrast agents in MRI (2004) J. Am. Chem. Soc., 126, pp. 3097-3107
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., Structural and relaxometric characterization peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (2007) ChemPhysChem, 8, pp. 2526-2538
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Teixeira, J., Schillen, K., Aime, S., Morelli, G., Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (2007) ChemBioChem, 8, pp. 950-955
Accardo, A., Mansi, R., Morisco, A., Mangiapia, G., Paduano, L., Tesauro, D., Radulescu, A., Morelli, G., Peptide modified nanocarriers for selective targeting of bombesin receptors (2010) Mol. Biosyst., 6, pp. 878-887
Morisco, A., Accardo, A., Gianolio, E., Tesauro, D., Benedetti, E., Morelli, G., Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (2009) J. Pept. Sci., 15, pp. 242-250
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjug. Chem., 10, pp. 137-140
Schmitt, L., Dietrich, C., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Ellmann, G.L., Tissue sulfhydryl groups (1959) Arch. Biochem. Biophys., 82, pp. 70-77
Brunisholz, G., Randin, M., The separation of the rare earths by ethylenediamine-tetraacetic acid (EDTA). IX. A cycle for the separation of the rare earths by fractionation (1959) Helv. Chim. Acta, 42, pp. 1927-1938
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
Vaccaro, M., Accardo, A., Tesauro, D., Mangiapia, G., Löf, D., Schillen, K., Soederman, O., Paduano, L., Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: physicochemical characterization (2006) Langmuir, 22, pp. 6635-6643
Wignall, G.D., Bates, F.S., Absolute calibration of small-angle neutron scattering data (1987) J. Appl. Crystallogr., 20, pp. 28-40
Torchilin, V.P., Omelyanenko, V.G., Papisov, M.I., Bogdanov, A.J., Trubetskoy, V.S., Herron, J.N., Gentry, C.A., Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity (1994) Biochim. Biophys. Acta, 119, pp. 11-20
Wang, Q., Graham, K., Schauer, T., Fietz, T., Mohammed, A., Liu, X., Hoffend, J., Mier, W., Pharmacological properties of hydrophilic and lipophilic derivatives of octreotate (2004) Nucl. Med. Biol., 31, pp. 21-30
Anelli, P.L., Lattuada, L., Lorusso, V., Schneider, M., Tournier, H., Uggeri, F., Mixed micelles containing lipophilic gadolinium complexes as MRA contrast agents (2001) Magn. Res. Mater. Phys. Biol. Med., 12, pp. 114-120
Chan, W.C., White, P.D., Fmoc Solid Phase Peptide Synthesis (2000), Oxford University Press: New YorkLackowicz, J.R., Principles of Fluorescence Spectroscopy (1983), Plenum Press: New YorkCaravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications (1999) Chem. Rev., 99, pp. 2293-2352
Bloembergen, N., Morgan, L.O., Proton relaxation times in paramagnetic solutions. Effects of electron spin relaxation (1961) J. Chem. Phys., 34, pp. 842-850
Lipari, G., Szabo, A., Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity (1982) J. Am. Chem. Soc., 104, pp. 4546-4559
Aime, S., Botta, M., Fasano, M., Paoletti, S., Terreno, E., Relaxometric determination of the exchange rate of the coordinated water protons in a neutral Gd-III chelate (1997) Chem. Eur. J., 3, pp. 1499-1504
Powell, D.H., Favre, M., Graeppi, N., Dhubhghaill, O.M.N., Pubanz, D., Merbach, A.E., Solution kinetic behaviour of lanthanide (III) polyamino carboxylates from O-17 NMR-studies (1995) J. Alloys Compd., 225, pp. 246-252
Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., Metal containing nanosized systems for MR-molecular imaging applications (2008) Coord. Chem. Rev., 252, pp. 2424-2443
Reubi, J. C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Lamberts, S. W. J., Octreotide: The Next Decade (1999), Bioscientifica: UK, Bristol, UKBauer, W., Briner, U., Doepfner, W., SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action (1982) Life Sci, 31, pp. 1133-1140
Veber, D. F., Freidinger, R. M., Schwenk-Perlow, D., Paleveda Jr, W. J., Holly, F. W., Strachan, R. G., Nurr, R. F., Hirschmann, R., A potent cyclic hexapeptide analogue of somatostatin (1981) Nature, 292, pp. 55-58
Patel, C. Y., Somatostatin and its receptor family (1999) Front. Neuroendocrinol., 20, pp. 157-198
Hofland, L. J., Internalization of [DOTA, 125I-Tyr3] octreotide by somatostatin receptor-positive cells in vitro and in vivo: implications for somatostatin receptor-targeted radio-guided surgery (1999) Proc. Assoc. Am. Physicians, 111, pp. 63-69
Huang, C. M., Wu, Y. T., Chen, S. T., Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis (2000) Chem. Biol., 7, pp. 453-461
Krenning, E. P., Kwekkeboom, D. J., Pauwels, S., Kvols, L. K., Reubi, J. C., Nuclear Medicine Annual (1995) Somatostatin receptor scintigraphy, pp. 1-50. , Freeman LM (ed.). Lippincott-Raven: New York
Reubi, J. C., Waser, B., Schaer, J. C., Laissue, J. A., Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands (2001) Eur. J. Nucl. Med., 28, pp. 836-846. , Erratum in: Eur. J. Nucl. Med. 2001
Allen, T. M., Ligand-targeted therapeutics in anticancer therapy (2002) Nat. Rev. Cancer, 2, pp. 750-763
van Tilborg, G. A. F., Mulder, W. J. M., Deckers, N., Storm, G., Reutelingsperger, C. P. M., Strijkers, G. J., Nicolay, K., Annexin A5-functionalized bimodal lipid-based contrast agents for the detection of apoptosis (2006) Bioconjug. Chem., 17, pp. 741-749
Mulder, W. J. M., Strijkers, G. J., van Tilborg, G. A. F., Cormode, D. P., Fayad, Z. A., Nicolay, K., Nanoparticulate assemblies of amphiphiles and diagnostically active materials for multimodality imaging (2009) Acc. Chem. Res., 42, pp. 904-914
Bull, S. R., Guler, M. O., Bras, R. E., Maede, T. J., Stupp, S. I., Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents (2005) Nano Lett, 5, pp. 1-4
Anelli, P. L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjug. Chem., 10, pp. 137-140
Ellmann, G. L., Tissue sulfhydryl groups (1959) Arch. Biochem. Biophys., 82, pp. 70-77
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
Wignall, G. D., Bates, F. S., Absolute calibration of small-angle neutron scattering data (1987) J. Appl. Crystallogr., 20, pp. 28-40
Torchilin, V. P., Omelyanenko, V. G., Papisov, M. I., Bogdanov, A. J., Trubetskoy, V. S., Herron, J. N., Gentry, C. A., Poly (ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity (1994) Biochim. Biophys. Acta, 119, pp. 11-20
Anelli, P. L., Lattuada, L., Lorusso, V., Schneider, M., Tournier, H., Uggeri, F., Mixed micelles containing lipophilic gadolinium complexes as MRA contrast agents (2001) Magn. Res. Mater. Phys. Biol. Med., 12, pp. 114-120
Chan, W. C., White, P. D., Fmoc Solid Phase Peptide Synthesis (2000), Oxford University Press: New YorkLackowicz, J. R., Principles of Fluorescence Spectroscopy (1983), Plenum Press: New YorkCaravan, P., Ellison, J. J., McMurry, T. J., Lauffer, R. B., Gadolinium (III) chelates as MRI contrast agents: structure, dynamics, and applications (1999) Chem. Rev., 99, pp. 2293-2352
Powell, D. H., Favre, M., Graeppi, N., Dhubhghaill, O. M. N., Pubanz, D., Merbach, A. E., Solution kinetic behaviour of lanthanide (III) polyamino carboxylates from O-17 NMR-studies (1995) J. Alloys Compd., 225, pp. 246-252
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.799, 5-year impact factor: 1.714
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651440633&partnerID=40&md5=06e7b1d40752b219b9c6e6289c3d2560
Keywords: Amphiphilic Gadolinium Complexes, Mri Contrast Agents, Octreotide Peptide, Small-Angle Neutron Scattering, Supramolecular Aggregates, 10 Tetraazacyclododecane 1, 10 Tetraacetic Acid, Amphophile, Contrast Medium, Cyclopeptide, Ethylene Derivative, Gadolinium Pentetate, Gadoteric Acid, Glutamine, Lysine, Monomer, Nanoparticle, Pentetic Acid, Pentetic Acid Derivative, Somatostatin Receptor 2, Surfactant, Tryptophan, Water, Amino Terminal Sequence, Bilayer Membrane, Complex Formation, Drug Binding, Drug Receptor Binding, Fluorescence, Hydrophobicity, Macromolecule, Micelle, Nuclear Magnetic Resonance Imaging, Priority Journal, Protein Aggregation, Structure Analysis, Surface Property, Thickness,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB, University of Naples Federico II, IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy
Department of Chemistry I.F.M., Molecular Imaging Centre, University of Turin, Via Nizza, 52, 10125 Turin, Italy
Juelich Centre for Neutron Science, Lichtenbergstrasse 1, D 85747 Garching, Germany
Helmholtz Zentrum Berlin, Glienicker Strasse 100, D-14109 Berlin, Germany
References:
Berthold, M., Bartfai, T., Modes of peptide binding in G Protein-Coupled Receptors (1997) Neurochem. Res., 22, pp. 1023-103
Reubi, J.C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Lamberts, S.W.J., Octreotide: The Next Decade (1999), Bioscientifica: UK, Bristol, UKBauer, W., Briner, U., Doepfner, W., SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action (1982) Life Sci, 31, pp. 1133-1140
Veber, D.F., Freidinger, R.M., Schwenk-Perlow, D., Paleveda Jr, W.J., Holly, F.W., Strachan, R.G., Nurr, R.F., Hirschmann, R., A potent cyclic hexapeptide analogue of somatostatin (1981) Nature, 292, pp. 55-58
Patel, C.Y., Somatostatin and its receptor family (1999) Front. Neuroendocrinol., 20, pp. 157-198
Hofland, L.J., Internalization of [DOTA,125I-Tyr3]octreotide by somatostatin receptor-positive cells in vitro and in vivo: implications for somatostatin receptor-targeted radio-guided surgery (1999) Proc. Assoc. Am. Physicians, 111, pp. 63-69
Huang, C.M., Wu, Y.T., Chen, S.T., Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis (2000) Chem. Biol., 7, pp. 453-461
Mier, W., Eritja, R., Ashour, M., Haberkorn, U., Eisenhut, M., Peptide-PNA conjugates targeted transport of antisense therapeutics into tumours (2003) Angew. Chem. Int. Ed., 42, pp. 1968-1971
Lamberts, S.W.J., Krenning, E.P., Reubi, J.C., The role of somatostatin and its analogs in the diagnosis and treatment of tumors (1991) Endocr. Rev., 12, pp. 450-482
Krenning, E.P., Kwekkeboom, D.J., Pauwels, S., Kvols, L.K., Reubi, J.C., Nuclear Medicine Annual (1995) Somatostatin receptor scintigraphy, pp. 1-50. , Freeman LM (ed.). Lippincott-Raven: New York
Reubi, J.C., Waser, B., Schaer, J.C., Laissue, J.A., Somatostatin receptor sst1-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands (2001) Eur. J. Nucl. Med., 28, pp. 836-846. , Erratum in: Eur. J. Nucl. Med. 2001
Froidevaux, S., Eberle, A.N., Somatostatin analogues and radiopeptides in cancer therapy (2002) Biopolymers (Pept. Sci.), 66, pp. 161-183
Allen, T.M., Ligand-targeted therapeutics in anticancer therapy (2002) Nat. Rev. Cancer, 2, pp. 750-763
Wu, H., Chang, D., Peptide-mediated liposomal drug delivery system targeting tumor blood vessels in anticancer therapy (2010) J. Oncol., , ASAP DOI 10.1155/2010/723798
van Tilborg, G.A.F., Mulder, W.J.M., Deckers, N., Storm, G., Reutelingsperger, C.P.M., Strijkers, G.J., Nicolay, K., Annexin A5-functionalized bimodal lipid-based contrast agents for the detection of apoptosis (2006) Bioconjug. Chem., 17, pp. 741-749
Mulder, W.J.M., Strijkers, G.J., van Tilborg, G.A.F., Cormode, D.P., Fayad, Z.A., Nicolay, K., Nanoparticulate assemblies of amphiphiles and diagnostically active materials for multimodality imaging (2009) Acc. Chem. Res., 42, pp. 904-914
Bull, S.R., Guler, M.O., Bras, R.E., Maede, T.J., Stupp, S.I., Self-assembled peptide amphiphile nanofibers conjugated to MRI contrast agents (2005) Nano Lett, 5, pp. 1-4
Kluza, E., van der Schaft, D.W.J., Hautvast, P.A.I., Mulder, W.J.M., Mayo, K.H., Griffioen, A.W., Strijkers, G.J., Nicolay, K., Synergistic targeting of αvβ3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis (2010) Nano Lett, 10, pp. 52-58
Ferrari, M., Cancer nanotechnology: opportunities and challenges (2005) Nat. Rev. Cancer, 5, pp. 161-171
Accardo, A., Tesauro, D., Roscigno, P., Gianolio, E., Paduano, L., D'Errico, G., Pedone, C., Morelli, G., Physicochemical properties of mixed micellar aggregates containing CCK peptides and Gd complexes designed as tumor specific contrast agents in MRI (2004) J. Am. Chem. Soc., 126, pp. 3097-3107
Vaccaro, M., Mangiapia, G., Paduano, L., Gianolio, E., Accardo, A., Tesauro, D., Morelli, G., Structural and relaxometric characterization peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (2007) ChemPhysChem, 8, pp. 2526-2538
Tesauro, D., Accardo, A., Gianolio, E., Paduano, L., Teixeira, J., Schillen, K., Aime, S., Morelli, G., Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (2007) ChemBioChem, 8, pp. 950-955
Accardo, A., Mansi, R., Morisco, A., Mangiapia, G., Paduano, L., Tesauro, D., Radulescu, A., Morelli, G., Peptide modified nanocarriers for selective targeting of bombesin receptors (2010) Mol. Biosyst., 6, pp. 878-887
Morisco, A., Accardo, A., Gianolio, E., Tesauro, D., Benedetti, E., Morelli, G., Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (2009) J. Pept. Sci., 15, pp. 242-250
Anelli, P.L., Fedeli, F., Gazzotti, O., Lattuada, L., Lux, G., Rebasti, F., L-glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands (1999) Bioconjug. Chem., 10, pp. 137-140
Schmitt, L., Dietrich, C., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Ellmann, G.L., Tissue sulfhydryl groups (1959) Arch. Biochem. Biophys., 82, pp. 70-77
Brunisholz, G., Randin, M., The separation of the rare earths by ethylenediamine-tetraacetic acid (EDTA). IX. A cycle for the separation of the rare earths by fractionation (1959) Helv. Chim. Acta, 42, pp. 1927-1938
Edelhoch, H., Spectroscopic determination of tryptophan and tyrosine in proteins (1967) Biochemistry, 6, pp. 1948-1954
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci, 4, pp. 2411-2423
Vaccaro, M., Accardo, A., Tesauro, D., Mangiapia, G., Löf, D., Schillen, K., Soederman, O., Paduano, L., Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: physicochemical characterization (2006) Langmuir, 22, pp. 6635-6643
Wignall, G.D., Bates, F.S., Absolute calibration of small-angle neutron scattering data (1987) J. Appl. Crystallogr., 20, pp. 28-40
Torchilin, V.P., Omelyanenko, V.G., Papisov, M.I., Bogdanov, A.J., Trubetskoy, V.S., Herron, J.N., Gentry, C.A., Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity (1994) Biochim. Biophys. Acta, 119, pp. 11-20
Wang, Q., Graham, K., Schauer, T., Fietz, T., Mohammed, A., Liu, X., Hoffend, J., Mier, W., Pharmacological properties of hydrophilic and lipophilic derivatives of octreotate (2004) Nucl. Med. Biol., 31, pp. 21-30
Anelli, P.L., Lattuada, L., Lorusso, V., Schneider, M., Tournier, H., Uggeri, F., Mixed micelles containing lipophilic gadolinium complexes as MRA contrast agents (2001) Magn. Res. Mater. Phys. Biol. Med., 12, pp. 114-120
Chan, W.C., White, P.D., Fmoc Solid Phase Peptide Synthesis (2000), Oxford University Press: New YorkLackowicz, J.R., Principles of Fluorescence Spectroscopy (1983), Plenum Press: New YorkCaravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications (1999) Chem. Rev., 99, pp. 2293-2352
Bloembergen, N., Morgan, L.O., Proton relaxation times in paramagnetic solutions. Effects of electron spin relaxation (1961) J. Chem. Phys., 34, pp. 842-850
Lipari, G., Szabo, A., Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity (1982) J. Am. Chem. Soc., 104, pp. 4546-4559
Aime, S., Botta, M., Fasano, M., Paoletti, S., Terreno, E., Relaxometric determination of the exchange rate of the coordinated water protons in a neutral Gd-III chelate (1997) Chem. Eur. J., 3, pp. 1499-1504
Powell, D.H., Favre, M., Graeppi, N., Dhubhghaill, O.M.N., Pubanz, D., Merbach, A.E., Solution kinetic behaviour of lanthanide (III) polyamino carboxylates from O-17 NMR-studies (1995) J. Alloys Compd., 225, pp. 246-252
Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., Metal containing nanosized systems for MR-molecular imaging applications (2008) Coord. Chem. Rev., 252, pp. 2424-2443
Reubi, J. C., Peptide receptors as molecular targets for cancer diagnosis and therapy (2003) Endocr. Rev., 24, pp. 389-427
Lamberts, S. W. J., Octreotide: The Next Decade (1999), Bioscientifica: UK, Bristol, UKBauer, W., Briner, U., Doepfner, W., SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action (1982) Life Sci, 31, pp. 1133-1140
Veber, D. F., Freidinger, R. M., Schwenk-Perlow, D., Paleveda Jr, W. J., Holly, F. W., Strachan, R. G., Nurr, R. F., Hirschmann, R., A potent cyclic hexapeptide analogue of somatostatin (1981) Nature, 292, pp. 55-58
Patel, C. Y., Somatostatin and its receptor family (1999) Front. Neuroendocrinol., 20, pp. 157-198
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Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications
New mixed nanoparticles were obtained by self-aggregation of two amphiplic monomers. The first monomer (C18) 2L5-Oct contains two C18 hydrophobic moieties bound to the N-terminus of the cyclic peptide octreotide, and spaced from the bioactive peptide by five units of dioxoethylene linkers. The second monomer, (C18) 2DTPAGlu, (C18) 2DTPA or (C18) 2DOTA, and the corresponding Gd (III) complexes, contains two C18 hydrophobic moieties bound through a lysine residue to different polyamino-polycarboxy ligands: DTPAGlu, DTPA or DOTA. Mixed aggregates have been obtained and structurally characterized by small angle neutron scattering (SANS) techniques and for their relaxometric behavior. According to a decrease of negative charges in the surfactant head-group, a total or a partial micelle-to-vesicle transition is observed by passing from (C18) 2DTPAGlu to (C18) 2DOTA. The thicknesses of the bilayers are substantially constant, around 50, in the analyzed systems. Moreover, the mixed aggregates, in which a small amount of amphiphilic octreotide monomer (C18) 2L5-Oct (10% mol/mol) was inserted, do not differ significantly from the respective self-assembled systems. Fluorescence emission of tryptophan residue at 340 nm indicates low mobility of water molecules at the peptide surface. The proton relaxivity of mixed aggregates based on (C18) 2DTPAGlu (Gd), (C18) 2DTPA (Gd) and (C18) 2DOTA (Gd) resulted to be 17. 6, 15. 2 and 10. 0 mM-1 s-1 (at 20 MHz and 298K), respectively. The decrease in the relaxivity values can be ascribed to the increase in M (81, 205 and 750 ns). The presence of amphiphilic octreotide monomer exposed on mixed aggregate surface gives the entire nanoparticles a potential binding selectivity toward somatostatin sstr2 receptor subtype, and these systems could act as MRI target-specific contrast agent. Mixed nanoparticles (micelles and liposomes) are obtained by co-aggregation of lipophilic octreotide with gadolinium complex containing amphiphilic monomers for MRI applications. Copyright 2010 European Peptide Society and John Wiley & Sons, Ltd
New mixed nanoparticles were obtained by self-aggregation of two amphiplic monomers. The first monomer (C18) 2L5-Oct contains two C18 hydrophobic moieties bound to the N-terminus of the cyclic peptide octreotide, and spaced from the bioactive peptide by five units of dioxoethylene linkers. The second monomer, (C18) 2DTPAGlu, (C18) 2DTPA or (C18) 2DOTA, and the corresponding Gd (III) complexes, contains two C18 hydrophobic moieties bound through a lysine residue to different polyamino-polycarboxy ligands: DTPAGlu, DTPA or DOTA. Mixed aggregates have been obtained and structurally characterized by small angle neutron scattering (SANS) techniques and for their relaxometric behavior. According to a decrease of negative charges in the surfactant head-group, a total or a partial micelle-to-vesicle transition is observed by passing from (C18) 2DTPAGlu to (C18) 2DOTA. The thicknesses of the bilayers are substantially constant, around 50, in the analyzed systems. Moreover, the mixed aggregates, in which a small amount of amphiphilic octreotide monomer (C18) 2L5-Oct (10% mol/mol) was inserted, do not differ significantly from the respective self-assembled systems. Fluorescence emission of tryptophan residue at 340 nm indicates low mobility of water molecules at the peptide surface. The proton relaxivity of mixed aggregates based on (C18) 2DTPAGlu (Gd), (C18) 2DTPA (Gd) and (C18) 2DOTA (Gd) resulted to be 17. 6, 15. 2 and 10. 0 mM-1 s-1 (at 20 MHz and 298K), respectively. The decrease in the relaxivity values can be ascribed to the increase in M (81, 205 and 750 ns). The presence of amphiphilic octreotide monomer exposed on mixed aggregate surface gives the entire nanoparticles a potential binding selectivity toward somatostatin sstr2 receptor subtype, and these systems could act as MRI target-specific contrast agent. Mixed nanoparticles (micelles and liposomes) are obtained by co-aggregation of lipophilic octreotide with gadolinium complex containing amphiphilic monomers for MRI applications. Copyright 2010 European Peptide Society and John Wiley & Sons, Ltd
Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications
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Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
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* A snapshot of the vast array of diamagnetic CEST MRI contrast agents (6 views)
Nmr Biomed (ISSN: 0952-3480linking), 2022 Feb 20; N/D: e4715-N/D.
Impact Factor: 4.044
View Export to BibTeX Export to EndNote
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Impact Factor: 12.959
View Export to BibTeX Export to EndNote
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Impact Factor: 4.857
View Export to BibTeX Export to EndNote
Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (454 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
View Export to BibTeX Export to EndNote
Accardo A, Ringhieri P, Palumbo R, Morelli G
* Influence of PEG length on conformational and binding properties of CCK peptides exposed by supramolecular aggregates (394 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Apr; 101(4): 304-312.
Impact Factor: 2.385
View Export to BibTeX Export to EndNote
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Impact Factor: 4.383
View Export to BibTeX Export to EndNote
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Impact Factor: 7.232
View Export to BibTeX Export to EndNote
Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
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Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
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Impact Factor: 8.535
View Export to BibTeX Export to EndNote
Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
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Impact Factor: 3.151
View Export to BibTeX Export to EndNote
Accardo A, Morisco A, Palladino P, Palumbo R, Tesauro D, Morelli G
* Amphiphilic CCK peptides assembled in supramolecular aggregates: Structural investigations and in vitro studies (492 views)
Mol Biosyst (ISSN: 1742-206x), 2011 Mar; 7(3): 862-870.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (590 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (528 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (361 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
View Export to BibTeX Export to EndNote
Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Del Pozzo L, Mangiapia G, Paduano L, Morelli G
* Micelles by self-assembling peptide-conjugate amphiphile: Synthesis and structural characterization (402 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): 903-910.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Benedetti E, Pedone C, Morelli G
* Naposomes: A new class of peptide containing supramolecular aggregates as target selective delivery systems (258 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (391 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
View Export to BibTeX Export to EndNote
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
View Export to BibTeX Export to EndNote
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
View Export to BibTeX Export to EndNote
Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (441 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
24 Records (22 excluding Abstracts).
Total impact factor: 98.073 (96.419 excluding Abstracts).
Total 5 year impact factor: 101.59 (99.808 excluding Abstracts).
Total impact factor: 98.073 (96.419 excluding Abstracts).
Total 5 year impact factor: 101.59 (99.808 excluding Abstracts).
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