Protonation of Histidine 55 Affects the Oxygen Access to Heme in the Alpha Chain of the Hemoglobin from the Antarctic Fish Trematomus bernacchii (370 views)
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 Mar; 63(3): 175-182.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.514, 5-year impact factor: 3.598
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79953251135&partnerID=40&md5=bd3fbfa1ae97560a93fd36a17ba9271c
Keywords: Hemoglobin, Implicit Ligand Sampling, Molecular Dynamics Simulations, Oxygen Binding, Trematomus Bernacchii, Histidine, Antarctica, Computer Simulation, Conference Paper, Controlled Study, Fish, Human, Nonhuman, Oxygen Affinity, Protein Conformation, Protein Function, Protein Structure, Proton Transport, Animals, Antarctic Regions, Models,
Affiliations:
*** IBB - CNR ***
Departamentos de Química Biologica y Química Inorgánica, Analítica y Química-Física (INQUIMAE-CONICET), Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
Istituto di Biostrutture e Bioimmagini, (C.N.R.), via Mezzocannone 16, Napoli I-80134, Italy
Dipartimento di Chimica Paolo Corradini, Universiàdegli Studi di Napoli Federico II, via Cintia, I-80126 Napoli, Italy
References:
Perutz, M.F., Fermi, G., Luisi, B., Shaanan, B., Liddington, R.C., Stereochemistry of cooperative mechanisms in hemoglobin (1987) Acc. Chem. Res., 9, pp. 309-32
Yokoyama, T., Chong, K.T., Miyazaki, G., Morimoto, H., Shih, D.T.-B., Unzai, S., Tame, J.R.H., Park, S.-Y., Novel mechanisms of pH sensitivity in tuna hemoglobin. A structural explanation of the root effect (2004) Journal of Biological Chemistry, 279 (27), pp. 28632-28640. , DOI 10.1074/jbc.M401740200
Brittain, T., The Root effect in hemoglobins (2005) J. Inorg. Biochem., 99, pp. 120-129
Tame, J.R., Wilson, J.C., Weber, R.E., The crystal structures of trout Hb i in the deoxy and carbonmonoxy forms J. Mol. Biol., 259, pp. 749-760
Mylvaganam, S.E., Bonaventura, C., Bonaventura, J., Getzoff, E.D., Structural basis for the root effect in haemoglobin (1996) Nature Structural Biology, 3 (3), pp. 275-283. , DOI 10.1038/nsb0396-275
Berenbrink, M., Koldkjaer, P., Kepp, O., Cossins, A.R., Evolution of oxygen secretion in fishes and the emergence of a complex physiological system (2005) Science, 307 (5716), pp. 1752-1757. , DOI 10.1126/science.1107793
Camardella, L., Caruso, C., D'Avino, R., Di Prisco, G., Rutigliano, B., Tamburini, M., Fermi, G., Perutz, M.F., Hemoglobin of the Antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative (1992) J. Mol. Biol., 224, pp. 449-460
Ito, N., Komiyama, N.H., Fermi, G., Structure of deoxyhemoglobin of the Antarctic fish Pagothenia bernacchii with an analysis of the structural basis of the Root effect by comparison of the liganded and unliganded hemoglobin structures (1995) J. Mol. Biol., 250, pp. 648-658
Mazzarella, L., Vergara, A., Vitagliano, L., Merlino, A., Bonomi, G., Scala, S., Verde, C., Di Prisco, G., High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect (2006) Proteins: Structure, Function and Genetics, 65 (2), pp. 490-498. , DOI 10.1002/prot.21114
Mazzarella, L., Bonomi, G., Lubrano, M.C., Merlino, A., Riccio, A., Vergara, A., Vitagliano, L., Di Prisco, G., Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (2006) Proteins: Structure, Function and Genetics, 62 (2), pp. 316-321. , DOI 10.1002/prot.20709
Mazzarella, L., D'Avino, R., Di Prisco, G., Savino, C., Vitagliano, L., Moody, P.C.E., Zagari, A., Crystal structure of trematomus newnesi haemoglobin re-opens the root effect question (1999) Journal of Molecular Biology, 287 (5), pp. 897-906. , DOI 10.1006/jmbi.1999.2632
Merlino, A., Verde, C., Di Prisco, G., Mazzarella, L., Vergara, A., Reduction of ferric hemoglobin from Trematomus bernacchii in a partial bis-histidyl state produces a deoxy coordination even when encapsulated into the crystal phase (2008) Spectroscopy, 22 (2-3), pp. 143-152. , DOI 10.3233/SPE-2008-0332, XII European Conference on the Spectroscopy of Biological Molecules, Bobigny, France, 1-6 September 2007, Part 1
Merlino, A., Vitagliano, L., Howes, B., Verde, C., Di Prisco, G., Smulevich, G., Sica, F., Vergara, A., Combined crystallographic and spectroscopic analysis of Trematomus bernacchii hemoglobin highlights analogies and differences in the peculiar oxidation pathway of Antarctic fish hemoglobins (2009) Biopolymers, 91, pp. 1117-1125
Vergara, A., Franzese, M., Merlino, A., Bonomi, G., Verde, C., Giordano, D., Di Prisco, G., Mazzarella, L., Correlation between hemichrome stability and the Root effect in tetrameric hemoglobins (2009) Biophys. J., 97, pp. 866-874
Vitagliano, L., Vergara, A., Bonomi, G., Merlino, A., Verde, C., Di Prisco, G., Howes, B.D., Mazzarella, L., Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (2008) J. Am. Chem. Soc., 130, pp. 10527-10535
Baldwin, J., Chothia, C., Haemoglobin: The structural changes related to ligand binding and its allosteric mechanism (1979) Journal of Molecular Biology, 129 (2), pp. 175-220. , DOI 10.1016/0022-2836(79)90277-8
Ackers, G.K., Deciphering the molecular code of hemoglobin allostery (1998) Advances in Protein Chemistry, 51, pp. 185-253
Merlino, A., Vergara, A., Sica, F., Aschi, M., Amadei, A., Di Nola, A., Mazzarella, L., Free-energy profile for CO binding to separated chains of human and Trematomus newnesi hemoglobin: Insights from molecular dynamics simulations and perturbed matrix method (2010) J. Phys. Chem. B, 114, pp. 7002-7008
Scott, E.E., Gibson, Q.H., Olson, J.S., Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin (2010) J. Biol. Chem., 285, pp. 8840-8854
Tilton, Jr.R.F., Kuntz, Jr.I.D., Petsko, G.A., Cavities in proteins: Structure of a metmyoglobin-xenon complex solved to 1.9 Å (1984) Biochemistry, 23, pp. 2849-2857
Tilton, Jr.R.F., Singh, U.C., Kuntz, Jr.I.D., Kollman, P.A., Protein-ligand dynamics. A 96 picosecond simulation of a myoglobin-xenon complex (1988) J. Mol. Biol., 199, pp. 195-211
Elber, R., Karplus, M., Enhanced sampling in molecular dynamics: Use of the time-dependent Hartree approximation for a simulation of carbon monoxide diffusion through myoglobin (1990) J. Am. Chem. Soc., 112, pp. 9161-9175
Boechi, L., Martí, M.A., Milani, M., Bolognesi, M., Luque, F.J., Estrin, D.A., Structural determinants of ligand migration in Mycobacterium tuberculosis truncated hemoglobin O (2008) Proteins Struct. Funct. Bioinf., 73, pp. 372-379
Capece, L., Estrin, D.A., Marti, M.A., Dynamical characterization of the heme NO oxygen binding (HNOX) domain. Insight into soluble guanylate cyclase allosteric transition (2008) Biochemistry, 47, pp. 9416-9427
Perissinotti, L.L., Marti, M.A., Doctorovich, F., Luque, F.J., Estrin, D.A., A microscopic study of the deoxyhemoglobin-catalyzed generation of nitric oxide from nitrite anion (2008) Biochemistry, 47, pp. 9793-9802
Capece, L., Marti, M.A., Bidon-Chanal, A., Nadra, A., Luque, F.J., Estrin, D.A., High pressure reveals structural determinants for globin hexacoordination: Neuroglobin and myoglobin cases (2009) Proteins Struct. Funct. Bioinf., 75, pp. 885-894
Martí, M.A., Estrin, D.A., Roitberg, A.E., Molecular basis for the pH dependent structural transition of Nitrophorin 4 (2009) J. Phys. Chem. B, 113, pp. 2135-2142
Pearlman, D.A., Case, D.A., Caldwell, J.W., Ross, W.S., Cheatham Iii, T.E., Debolt, S., Ferguson, D., Kollman, P., Amber, a Package of Computer-Programs for Applying Molecular Mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules (1995) Comp. Phys. Comm., 91, pp. 1-3. , 1-41
Hornak, V., Abel, R., Okur, A., Strockbine, B., Roitberg, A., Simmerling, C., Comparison of multiple amber force fields and development of improved protein backbone parameters (2006) Proteins: Structure, Function and Genetics, 65 (3), pp. 712-725. , DOI 10.1002/prot.21123
Mongan, J., Case, D.A., McCammon, J.A., Constant pH molecular dynamics in generalized born implicit solvent (2004) J. Comput. Chem., 25, pp. 2038-2048
Cohen, J., Olsen, K.W., Schulten, K., Finding gas migration pathways in proteins using implicit ligand sampling (2008) Methods Enzymol., 437, pp. 439-457
Humphrey, W., Dalke, A., Schulten, K., VMD-visual molecular dynamics (1996) J. Mol. Graph., 14, pp. 33-38
Lama, A., Pawaria, S., Bidon-Chanal, A., Anand, A., Gelpí, J.L., Arya, S., Martí, M., Dikshit, K.L., Role of Pre-A motif in nitric oxide scavenging by truncated hemoglobin, HbN, of Mycobacterium tuberculosis (2009) J. Biol. Chem., 284, pp. 14457-14468
Guallar, V., Jarzecki, A.A., Friesner, R.A., Spiro, T.G., Modeling of ligation-induced helix/loop displacements in myoglobin: Toward an understanding of hemoglobin allostery (2006) J. Am. Chem. Soc., 128, pp. 5427-5435
Alcantara, R.E., Xu, C., Spiro, T.G., Guallar, V., A quantum-chemical picture of hemoglobin affinity (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (47), pp. 18451-18455. , http://www.pnas.org/cgi/reprint/104/47/18451, DOI 10.1073/pnas.0706026104
Perutz, M.F., Mechanisms of cooperativity and allosteric regulation in proteins (1989) Q. Rev. Biophys., 22, pp. 139-237
Vallone, B., Nienhaus, K., Matthes, A., Brunori, M., Nienhaus, G.U., The structure of carbonmonoxy neuroglobin reveals a heme-sliding mechanism for control of ligand affinity (2004) Proceedings of the National Academy of Sciences of the United States of America, 101 (50), pp. 17351-17356. , DOI 10.1073/pnas.0407633101
Jenkins, J.D., Mausayev, F.N., Danso-Danquah, R., Abraham, D.J., Safo, M.K., Structure of relaxed-state of human haemoglobin:insight into ligand uptake, transport and release (2009) Acta Cryst. D, 65, pp. 41-48
Olson, J.S., Soman, J., Phillips Jr., G.N., Ligand pathways in myoglobin: A review of trp cavity mutations (2007) IUBMB Life, 59 (8-9), pp. 552-562. , DOI 10.1080/15216540701230495, PII 778491829, IUBMB Life Dedicated to Maurizio Brunori in the Occasion of his 70th Birthday
Yang, F., Phillips Jr., G.N., Crystal structures of CO-, Deoxy- and Met-myoglobins at various pH values (1996) Journal of Molecular Biology, 256 (4), pp. 762-774. , DOI 10.1006/jmbi.1996.0123
Perutz, M. F., Fermi, G., Luisi, B., Shaanan, B., Liddington, R. C., Stereochemistry of cooperative mechanisms in hemoglobin (1987) Acc. Chem. Res., 9, pp. 309-32
Tame, J. R., Wilson, J. C., Weber, R. E., The crystal structures of trout Hb i in the deoxy and carbonmonoxy forms J. Mol. Biol., 259, pp. 749-760
Mylvaganam, S. E., Bonaventura, C., Bonaventura, J., Getzoff, E. D., Structural basis for the root effect in haemoglobin (1996) Nature Structural Biology, 3 (3), pp. 275-283. , DOI 10. 1038/nsb0396-275
Ackers, G. K., Deciphering the molecular code of hemoglobin allostery (1998) Advances in Protein Chemistry, 51, pp. 185-253
Scott, E. E., Gibson, Q. H., Olson, J. S., Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin (2010) J. Biol. Chem., 285, pp. 8840-8854
Tilton, Jr. R. F., Kuntz, Jr. I. D., Petsko, G. A., Cavities in proteins: Structure of a metmyoglobin-xenon complex solved to 1. 9 (1984) Biochemistry, 23, pp. 2849-2857
Boechi, L., Mart, M. A., Milani, M., Bolognesi, M., Luque, F. J., Estrin, D. A., Structural determinants of ligand migration in Mycobacterium tuberculosis truncated hemoglobin O (2008) Proteins Struct. Funct. Bioinf., 73, pp. 372-379
Perissinotti, L. L., Marti, M. A., Doctorovich, F., Luque, F. J., Estrin, D. A., A microscopic study of the deoxyhemoglobin-catalyzed generation of nitric oxide from nitrite anion (2008) Biochemistry, 47, pp. 9793-9802
Mart, M. A., Estrin, D. A., Roitberg, A. E., Molecular basis for the pH dependent structural transition of Nitrophorin 4 (2009) J. Phys. Chem. B, 113, pp. 2135-2142
Pearlman, D. A., Case, D. A., Caldwell, J. W., Ross, W. S., Cheatham Iii, T. E., Debolt, S., Ferguson, D., Kollman, P., Amber, a Package of Computer-Programs for Applying Molecular Mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules (1995) Comp. Phys. Comm., 91, pp. 1-3. , 1-41
Alcantara, R. E., Xu, C., Spiro, T. G., Guallar, V., A quantum-chemical picture of hemoglobin affinity (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (47), pp. 18451-18455. , http: //www. pnas. org/cgi/reprint/104/47/18451, DOI 10. 1073/pnas. 0706026104
Perutz, M. F., Mechanisms of cooperativity and allosteric regulation in proteins (1989) Q. Rev. Biophys., 22, pp. 139-237
Jenkins, J. D., Mausayev, F. N., Danso-Danquah, R., Abraham, D. J., Safo, M. K., Structure of relaxed-state of human haemoglobin: insight into ligand uptake, transport and release (2009) Acta Cryst. D, 65, pp. 41-48
Olson, J. S., Soman, J., Phillips Jr., G. N., Ligand pathways in myoglobin: A review of trp cavity mutations (2007) IUBMB Life, 59 (8-9), pp. 552-562. , DOI 10. 1080/15216540701230495, PII 778491829, IUBMB Life Dedicated to Maurizio Brunori in the Occasion of his 70th Birthday
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 Mar; 63(3): 175-182.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.514, 5-year impact factor: 3.598
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79953251135&partnerID=40&md5=bd3fbfa1ae97560a93fd36a17ba9271c
Keywords: Hemoglobin, Implicit Ligand Sampling, Molecular Dynamics Simulations, Oxygen Binding, Trematomus Bernacchii, Histidine, Antarctica, Computer Simulation, Conference Paper, Controlled Study, Fish, Human, Nonhuman, Oxygen Affinity, Protein Conformation, Protein Function, Protein Structure, Proton Transport, Animals, Antarctic Regions, Models,
Affiliations:
*** IBB - CNR ***
Departamentos de Química Biologica y Química Inorgánica, Analítica y Química-Física (INQUIMAE-CONICET), Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
Istituto di Biostrutture e Bioimmagini, (C.N.R.), via Mezzocannone 16, Napoli I-80134, Italy
Dipartimento di Chimica Paolo Corradini, Universiàdegli Studi di Napoli Federico II, via Cintia, I-80126 Napoli, Italy
References:
Perutz, M.F., Fermi, G., Luisi, B., Shaanan, B., Liddington, R.C., Stereochemistry of cooperative mechanisms in hemoglobin (1987) Acc. Chem. Res., 9, pp. 309-32
Yokoyama, T., Chong, K.T., Miyazaki, G., Morimoto, H., Shih, D.T.-B., Unzai, S., Tame, J.R.H., Park, S.-Y., Novel mechanisms of pH sensitivity in tuna hemoglobin. A structural explanation of the root effect (2004) Journal of Biological Chemistry, 279 (27), pp. 28632-28640. , DOI 10.1074/jbc.M401740200
Brittain, T., The Root effect in hemoglobins (2005) J. Inorg. Biochem., 99, pp. 120-129
Tame, J.R., Wilson, J.C., Weber, R.E., The crystal structures of trout Hb i in the deoxy and carbonmonoxy forms J. Mol. Biol., 259, pp. 749-760
Mylvaganam, S.E., Bonaventura, C., Bonaventura, J., Getzoff, E.D., Structural basis for the root effect in haemoglobin (1996) Nature Structural Biology, 3 (3), pp. 275-283. , DOI 10.1038/nsb0396-275
Berenbrink, M., Koldkjaer, P., Kepp, O., Cossins, A.R., Evolution of oxygen secretion in fishes and the emergence of a complex physiological system (2005) Science, 307 (5716), pp. 1752-1757. , DOI 10.1126/science.1107793
Camardella, L., Caruso, C., D'Avino, R., Di Prisco, G., Rutigliano, B., Tamburini, M., Fermi, G., Perutz, M.F., Hemoglobin of the Antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative (1992) J. Mol. Biol., 224, pp. 449-460
Ito, N., Komiyama, N.H., Fermi, G., Structure of deoxyhemoglobin of the Antarctic fish Pagothenia bernacchii with an analysis of the structural basis of the Root effect by comparison of the liganded and unliganded hemoglobin structures (1995) J. Mol. Biol., 250, pp. 648-658
Mazzarella, L., Vergara, A., Vitagliano, L., Merlino, A., Bonomi, G., Scala, S., Verde, C., Di Prisco, G., High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect (2006) Proteins: Structure, Function and Genetics, 65 (2), pp. 490-498. , DOI 10.1002/prot.21114
Mazzarella, L., Bonomi, G., Lubrano, M.C., Merlino, A., Riccio, A., Vergara, A., Vitagliano, L., Di Prisco, G., Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (2006) Proteins: Structure, Function and Genetics, 62 (2), pp. 316-321. , DOI 10.1002/prot.20709
Mazzarella, L., D'Avino, R., Di Prisco, G., Savino, C., Vitagliano, L., Moody, P.C.E., Zagari, A., Crystal structure of trematomus newnesi haemoglobin re-opens the root effect question (1999) Journal of Molecular Biology, 287 (5), pp. 897-906. , DOI 10.1006/jmbi.1999.2632
Merlino, A., Verde, C., Di Prisco, G., Mazzarella, L., Vergara, A., Reduction of ferric hemoglobin from Trematomus bernacchii in a partial bis-histidyl state produces a deoxy coordination even when encapsulated into the crystal phase (2008) Spectroscopy, 22 (2-3), pp. 143-152. , DOI 10.3233/SPE-2008-0332, XII European Conference on the Spectroscopy of Biological Molecules, Bobigny, France, 1-6 September 2007, Part 1
Merlino, A., Vitagliano, L., Howes, B., Verde, C., Di Prisco, G., Smulevich, G., Sica, F., Vergara, A., Combined crystallographic and spectroscopic analysis of Trematomus bernacchii hemoglobin highlights analogies and differences in the peculiar oxidation pathway of Antarctic fish hemoglobins (2009) Biopolymers, 91, pp. 1117-1125
Vergara, A., Franzese, M., Merlino, A., Bonomi, G., Verde, C., Giordano, D., Di Prisco, G., Mazzarella, L., Correlation between hemichrome stability and the Root effect in tetrameric hemoglobins (2009) Biophys. J., 97, pp. 866-874
Vitagliano, L., Vergara, A., Bonomi, G., Merlino, A., Verde, C., Di Prisco, G., Howes, B.D., Mazzarella, L., Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (2008) J. Am. Chem. Soc., 130, pp. 10527-10535
Baldwin, J., Chothia, C., Haemoglobin: The structural changes related to ligand binding and its allosteric mechanism (1979) Journal of Molecular Biology, 129 (2), pp. 175-220. , DOI 10.1016/0022-2836(79)90277-8
Ackers, G.K., Deciphering the molecular code of hemoglobin allostery (1998) Advances in Protein Chemistry, 51, pp. 185-253
Merlino, A., Vergara, A., Sica, F., Aschi, M., Amadei, A., Di Nola, A., Mazzarella, L., Free-energy profile for CO binding to separated chains of human and Trematomus newnesi hemoglobin: Insights from molecular dynamics simulations and perturbed matrix method (2010) J. Phys. Chem. B, 114, pp. 7002-7008
Scott, E.E., Gibson, Q.H., Olson, J.S., Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin (2010) J. Biol. Chem., 285, pp. 8840-8854
Tilton, Jr.R.F., Kuntz, Jr.I.D., Petsko, G.A., Cavities in proteins: Structure of a metmyoglobin-xenon complex solved to 1.9 Å (1984) Biochemistry, 23, pp. 2849-2857
Tilton, Jr.R.F., Singh, U.C., Kuntz, Jr.I.D., Kollman, P.A., Protein-ligand dynamics. A 96 picosecond simulation of a myoglobin-xenon complex (1988) J. Mol. Biol., 199, pp. 195-211
Elber, R., Karplus, M., Enhanced sampling in molecular dynamics: Use of the time-dependent Hartree approximation for a simulation of carbon monoxide diffusion through myoglobin (1990) J. Am. Chem. Soc., 112, pp. 9161-9175
Boechi, L., Martí, M.A., Milani, M., Bolognesi, M., Luque, F.J., Estrin, D.A., Structural determinants of ligand migration in Mycobacterium tuberculosis truncated hemoglobin O (2008) Proteins Struct. Funct. Bioinf., 73, pp. 372-379
Capece, L., Estrin, D.A., Marti, M.A., Dynamical characterization of the heme NO oxygen binding (HNOX) domain. Insight into soluble guanylate cyclase allosteric transition (2008) Biochemistry, 47, pp. 9416-9427
Perissinotti, L.L., Marti, M.A., Doctorovich, F., Luque, F.J., Estrin, D.A., A microscopic study of the deoxyhemoglobin-catalyzed generation of nitric oxide from nitrite anion (2008) Biochemistry, 47, pp. 9793-9802
Capece, L., Marti, M.A., Bidon-Chanal, A., Nadra, A., Luque, F.J., Estrin, D.A., High pressure reveals structural determinants for globin hexacoordination: Neuroglobin and myoglobin cases (2009) Proteins Struct. Funct. Bioinf., 75, pp. 885-894
Martí, M.A., Estrin, D.A., Roitberg, A.E., Molecular basis for the pH dependent structural transition of Nitrophorin 4 (2009) J. Phys. Chem. B, 113, pp. 2135-2142
Pearlman, D.A., Case, D.A., Caldwell, J.W., Ross, W.S., Cheatham Iii, T.E., Debolt, S., Ferguson, D., Kollman, P., Amber, a Package of Computer-Programs for Applying Molecular Mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules (1995) Comp. Phys. Comm., 91, pp. 1-3. , 1-41
Hornak, V., Abel, R., Okur, A., Strockbine, B., Roitberg, A., Simmerling, C., Comparison of multiple amber force fields and development of improved protein backbone parameters (2006) Proteins: Structure, Function and Genetics, 65 (3), pp. 712-725. , DOI 10.1002/prot.21123
Mongan, J., Case, D.A., McCammon, J.A., Constant pH molecular dynamics in generalized born implicit solvent (2004) J. Comput. Chem., 25, pp. 2038-2048
Cohen, J., Olsen, K.W., Schulten, K., Finding gas migration pathways in proteins using implicit ligand sampling (2008) Methods Enzymol., 437, pp. 439-457
Humphrey, W., Dalke, A., Schulten, K., VMD-visual molecular dynamics (1996) J. Mol. Graph., 14, pp. 33-38
Lama, A., Pawaria, S., Bidon-Chanal, A., Anand, A., Gelpí, J.L., Arya, S., Martí, M., Dikshit, K.L., Role of Pre-A motif in nitric oxide scavenging by truncated hemoglobin, HbN, of Mycobacterium tuberculosis (2009) J. Biol. Chem., 284, pp. 14457-14468
Guallar, V., Jarzecki, A.A., Friesner, R.A., Spiro, T.G., Modeling of ligation-induced helix/loop displacements in myoglobin: Toward an understanding of hemoglobin allostery (2006) J. Am. Chem. Soc., 128, pp. 5427-5435
Alcantara, R.E., Xu, C., Spiro, T.G., Guallar, V., A quantum-chemical picture of hemoglobin affinity (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (47), pp. 18451-18455. , http://www.pnas.org/cgi/reprint/104/47/18451, DOI 10.1073/pnas.0706026104
Perutz, M.F., Mechanisms of cooperativity and allosteric regulation in proteins (1989) Q. Rev. Biophys., 22, pp. 139-237
Vallone, B., Nienhaus, K., Matthes, A., Brunori, M., Nienhaus, G.U., The structure of carbonmonoxy neuroglobin reveals a heme-sliding mechanism for control of ligand affinity (2004) Proceedings of the National Academy of Sciences of the United States of America, 101 (50), pp. 17351-17356. , DOI 10.1073/pnas.0407633101
Jenkins, J.D., Mausayev, F.N., Danso-Danquah, R., Abraham, D.J., Safo, M.K., Structure of relaxed-state of human haemoglobin:insight into ligand uptake, transport and release (2009) Acta Cryst. D, 65, pp. 41-48
Olson, J.S., Soman, J., Phillips Jr., G.N., Ligand pathways in myoglobin: A review of trp cavity mutations (2007) IUBMB Life, 59 (8-9), pp. 552-562. , DOI 10.1080/15216540701230495, PII 778491829, IUBMB Life Dedicated to Maurizio Brunori in the Occasion of his 70th Birthday
Yang, F., Phillips Jr., G.N., Crystal structures of CO-, Deoxy- and Met-myoglobins at various pH values (1996) Journal of Molecular Biology, 256 (4), pp. 762-774. , DOI 10.1006/jmbi.1996.0123
Perutz, M. F., Fermi, G., Luisi, B., Shaanan, B., Liddington, R. C., Stereochemistry of cooperative mechanisms in hemoglobin (1987) Acc. Chem. Res., 9, pp. 309-32
Tame, J. R., Wilson, J. C., Weber, R. E., The crystal structures of trout Hb i in the deoxy and carbonmonoxy forms J. Mol. Biol., 259, pp. 749-760
Mylvaganam, S. E., Bonaventura, C., Bonaventura, J., Getzoff, E. D., Structural basis for the root effect in haemoglobin (1996) Nature Structural Biology, 3 (3), pp. 275-283. , DOI 10. 1038/nsb0396-275
Ackers, G. K., Deciphering the molecular code of hemoglobin allostery (1998) Advances in Protein Chemistry, 51, pp. 185-253
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Protonation of Histidine 55 Affects the Oxygen Access to Heme in the Alpha Chain of the Hemoglobin from the Antarctic Fish Trematomus bernacchii
The Root effect describes the drastic drop of oxygen affinity and loss of cooperativity at acidic pH expressed in the hemoglobins (Hb) of certain fish. The comparison between the deoxy structures of the Root effect Hb from the Antarctic fish Trematomus bernacchii (HbTb) at different pHs (pH = 6.2 and pH = 8.4) shows that the most significant differences are localized at the CD alpha region, where a salt bridge between Asp48 and His55 breaks during the low-to-high pH transition. In order to shed light on the relationship between pH, CD alpha loop structure and dynamics, and oxygen access to the active site in the alpha chain of HbTb, different computer simulation techniques were performed. Our results highlight the importance of the protonation of His55 in regulating oxygen access, underscoring its pivotal role in the structural and functional properties of HbTb. These data provide further support to the hypothesis that this residue might contribute to the release of Root protons in HbTb and underline the fact that an efficient transport of molecular oxygen in Hbs relies on a subtle balance of tertiary structure and protein conformational flexibility. (C) 2011 IUBMB IUBMB Life, 63(3): 175-182, 2011
The Root effect describes the drastic drop of oxygen affinity and loss of cooperativity at acidic pH expressed in the hemoglobins (Hb) of certain fish. The comparison between the deoxy structures of the Root effect Hb from the Antarctic fish Trematomus bernacchii (HbTb) at different pHs (pH = 6.2 and pH = 8.4) shows that the most significant differences are localized at the CD alpha region, where a salt bridge between Asp48 and His55 breaks during the low-to-high pH transition. In order to shed light on the relationship between pH, CD alpha loop structure and dynamics, and oxygen access to the active site in the alpha chain of HbTb, different computer simulation techniques were performed. Our results highlight the importance of the protonation of His55 in regulating oxygen access, underscoring its pivotal role in the structural and functional properties of HbTb. These data provide further support to the hypothesis that this residue might contribute to the release of Root protons in HbTb and underline the fact that an efficient transport of molecular oxygen in Hbs relies on a subtle balance of tertiary structure and protein conformational flexibility. (C) 2011 IUBMB IUBMB Life, 63(3): 175-182, 2011
Protonation of Histidine 55 Affects the Oxygen Access to Heme in the Alpha Chain of the Hemoglobin from the Antarctic Fish Trematomus bernacchii
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Protonation of Histidine 55 Affects the Oxygen Access to Heme in the Alpha Chain of the Hemoglobin from the Antarctic Fish Trematomus bernacchii
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* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (401 views)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
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Merlino A, Verde C, Di Prisco G, Mazzarella L, Vergara A
* Reduction of ferric hemoglobin from Trematomus bernacchii in a partial bis-histidyl state produces a deoxy coordination even when encapsulated into the crystal phase (382 views)
Spectroscopy An International Journal (ISSN: 0712-4813), 2008; 22(2-3): 143-152.
Impact Factor: 0.82
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of A Tetrameric Hemoglobin Oxidation Pathway Reveals Structural Features Of A Functional Intermediate R/T State (278 views)
Biophys J, 2008; 94: 4031-4040.
Impact Factor: 3.832
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Vergara A, Vitagliano L, Verde C, di Prisco G, Mazzarella L
* Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobins (426 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 2008; 436: 425-444.
Impact Factor: 2.312
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Vergara A, Vitagliano L, Di Prisco G, Verde C, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of Hemichromes In Tetrameric Hemoglobins (321 views)
Methods In Enzymology, 2008; 436: 421-440.
Impact Factor: 2.194
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Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
* Time-resolved fluorescence spectroscopy and molecular dynamics simulations point out the effects of pressure on the stability and dynamics of the porcine odorant-binding protein (608 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 89(4): 284-291.
Impact Factor: 2.823
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Giordano D, Vergara A, Lee HC, Peisach J, Balestrieri M, Mazzarella L, Parisi E, Di Priseo G, Verde C
* Hemoglobin structure/function and globin-gene evolution in the Arctic fish Liparis tunicatus (389 views)
Gene (ISSN: 0378-1119), 2007 Dec 30; 406(1-2): 58-68.
Impact Factor: 2.871
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (720 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Vergara A, Franzese M, Merlino A, Vitagliano L, Verde C, Di Prisco G, Lee HC, Peisach J, Mazzarella L
* Structural characterization of ferric hemoglobins from three Antarctic fish species of the suborder notothenioidei (375 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Oct; 93(8): 2822-2829.
Impact Factor: 4.627
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Mazzarella L, Vergara A, Vitagliano L, Merlino A, Bonomi G, Scala S, Verde C, Di Prisco G
* High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect (389 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Nov 1; 65(2): 490-498.
Impact Factor: 3.73
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Langella E, Improta R, Crescenzi O, Barone V
* Assessing the acid-base and conformational properties of histidine residues in human prion protein (125-228) by means of pKα calculations and molecular dynamics simulations (580 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jul 1; 64(1): 167-177.
Impact Factor: 3.73
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Merlino A, Esposito L, Vitagliano L
* Polyglutamine Repeats And Beta-Helix Structure: Molecular Dynamics Study (504 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jun 1; 63(4): 918-927.
Impact Factor: 3.73
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Mazzarella L, Bonomi G, Lubrano MC, Merlino A, Riccio A, Vergara A, Vitagliano L, Verde C, Di Prisco G
* Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (506 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 1; 62(2): 316-321.
Impact Factor: 3.73
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (614 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (602 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
Impact Factor: 4.507
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Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (479 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
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Vitagliano L, Bonomi G, Franzese M, Merlino A, Vergara A, Verde C, Di Prisco G, Mazzarella L
* Structural Characterization Of The Oxidation Pathway Of Antarctic Fish Hemoglobins (313 views)
Acta Crystallogr D Biol Crystallogr, 2005; N/D: N/D-N/D.
Impact Factor: 2.069
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Langella E, Improta R, Barone V
* Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (427 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Dec; 87(6): 3623-3632.
Impact Factor: 4.585
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Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (378 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
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Vitagliano L, Bonomi G, Riccio A, di Prisco G, Smulevich G, Mazzarella L
* The oxidation process of Antarctic fish hemoglobins (451 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 May; 271(9): 1651-1659.
Impact Factor: 3.26
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* The crystal structure of a tetrameric hemoglobin in a partial hemichrome state (505 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2002 Jul 23; 99(15): 9801-9806.
Impact Factor: 10.7
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Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (869 views)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* Liganded and unliganded forms of Antarctic fish haemoglobins in polyethylene glycol: crystallization of an R-state haemichrome intermediate (392 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2001 Sep; 57: 1144-1146.
Impact Factor: 2.124
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Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (549 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
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Mazzarella L, D'Avino R, Di Prisco G, Savino C, Vitagliano L, Moody P, Zagari A
Crystal structure of Trematomus newnesi haemoglobin re-opens the Root effect question (388 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Apr 16; 287(5): 897-906.
Impact Factor: 5.501
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Pacelli R, Taira J, Cook JA, Wink DA, Krishna MC
Hydroxyurea reacts with heme proteins to generate nitric oxide [6] (334 views)
Lancet (ISSN: 0140-6736), 1996 Mar 30; 347(9005): 900-900.
Impact Factor: 16.135
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Manna R, Salvatore M, Di Leo MA, Scuderi F, Greco AV, Ghirlanda G, Gambassi G
Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes (432 views)
Diabetes Res (ISSN: 0265-5985), 1991 May; 17(1): 33-36.
Impact Factor: 0
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Salvati AM, d'Onofrio G, Berti P, Cappabianca MP, Marsili G, De Philippis C, Cossa L, Quarantelli M, Zini G, Mango G
An assessment of the operating characteristics of Coulter Counter model S-Plus STKR (585 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1991 Mar; 76(2): 94-103.
Impact Factor: 2.56
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* Electronic Circular Dichroism Spectra of DNA Quadruple Helices Studied by Molecular Dynamics Simulations and Excitonic Calculations including Charge Transfer States (13 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Aug 7; 26(16): N/D-N/D.
Impact Factor: 4.411
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Farina B, Andrea C, Del Gatto A, Comegna D, Di Gaetano S, Capasso D, Paladino A, Acconcia C, Teresa Gentile M, Saviano M, Fattorusso R, Zaccaro L, Russo L
* A novel approach for studying receptor-ligand interactions on living cells surface by using NUS/T1ρ-NMR methodologies combined with computational techniques: The RGDechi15D-α(v)β(5) integrin complex (42 views)
Comput Struct Biotechnol J (ISSN: 2001-0370linking), 2021 May 29; 19: 3303-3318.
Impact Factor:
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Troisi R, Balasco N, Vitagliano L, Sica F
* Molecular dynamics simulations of human α-thrombin in different structural contexts: evidence for an aptamer-guided cooperation between the two exosites (65 views)
J Biomol Struct Dyn (ISSN: 0739-1102linking, 1538-0254electronic), 2021 Apr; 39(6): 2199-2209.
Impact Factor: 4.986
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Balasco N, Vitagliano L, Merlino A, Verde C, Mazzarella L, Vergara A
* The unique structural features of carbonmonoxy hemoglobin from the sub-Antarctic fish Eleginops maclovinus (176 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2019 Dec 12; 9(1): 18987-18987.
Impact Factor: 5.078
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Scollo F, Tempra C, Lolicato F, Sciacca MFM, Raudino A, Milardi D, La Rosa C
* Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes (420 views) (PDF 117 views)
J Phys Chem Lett (ISSN: 1948-7185electronic, 1948-7185linking), 2018 Sep 6; 9(17): 5125-5129.
Impact Factor: 6.687
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Mazzarella L, Merlino A, Balasco N, Balsamo A, Vergara A
* Crystal structure of the ferric homotetrameric beta4 human hemoglobin (238 views)
Biophys Chem (ISSN: 0301-4622linking), 2018 Sep; 240: 9-14.
Impact Factor: 1.87
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Diaferia C, Balasco N, Sibillano T, Giannini C, Vitagliano L, Morelli G, Accardo A
* Structural Characterization of Self-Assembled Tetra-Tryptophan Based Nanostructures: Variations on a Common Theme (76 views)
Chemphyschem (ISSN: 1439-4235linking, 1439-7641), 2018 Jul 5; 19 (13 ): 1635-1642.
Impact Factor: 3.502
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Vitagliano L, Mazzarella L, Merlino A, Vergara A
* Fine Sampling of the R--> T Quaternary-Structure Transition of a Tetrameric Hemoglobin (332 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 Jan 12; 23(3): 605-613.
Impact Factor: 5.16
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Caviglia GP, Cabianca L, Fagoonee S, Gili FM
* Colorectal cancer detection in an asymptomatic population: Fecal immunochemical test for hemoglobin vs. Fecal M2-type pyruvate kinase (329 views)
Biochem Medica (ISSN: 1330-0962), 2016; 26(1): 114-120.
Impact Factor: 2.934
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Calvanese L, Falcigno L, D'Auria G
* Essential Dynamics Analysis Captures the Concerted Motion of the Integrin-Binding Site in Jerdostatin, an RTS Disintegrin (403 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2015 Mar; 103(3): 158-166.
Impact Factor: 2.248
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Balasco N, Barone D, Vitagliano L
* Structural conversion of the transformer protein RfaH: new insights derived from protein structure prediction and molecular dynamics simulations (432 views)
J Biomol Struct Dyn (ISSN: 0739-1102, 1538-0254electronic, 0739-1102linking), 2015 Jan 12; 33(10): 2173-2179.
Impact Factor: 2.3
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Vitiello G, Falanga A, Petruk AA, Merlino A, Fragneto G, Paduano L, Galdiero S, D'Errico G
* Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism (381 views)
Soft Matter (ISSN: 1744-683x), 2015; 11(15): 3003-3016.
Impact Factor: 3.798
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Bisconte MG, Caldora M, Musollino G, Cardiero G, Flagiello A, La Porta G, Lagona L, Prezioso R, Qualtieri G, Gaudiano C, Medulla E, Merlino A, Pucci P, Lacerra G
* α-thalassemia associated with Hb instability: A tale of two features. The case of Hb Rogliano or α1 Cod 108(G15)Thr→Asn and Hb Policoro or α2 Cod 124(H7)Ser→Pro (420 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015; 10(3): N/D-N/D.
Impact Factor: 3.057
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Russo L, Palmieri M, Caso JV, Abrosca GD, Diana D, Malgieri G, Baglivo I, Isernia C, Pedone PV, Fattorusso R
* Towards understanding the molecular recognition process in prokaryotic zinc-finger domain (415 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015; 91: 100-108.
Impact Factor: 3.902
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Autiero I, Saviano M, Langella E
* Molecular Dynamics Simulations Of Pna-Pna And Pna-Dna Duplexes By The Use Of New Parameters Implemented In The Gromacs Package: A Conformational And Dynamics Study (593 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2014; 16(5): 1868-1874.
Impact Factor: 4.493
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Alcides Petruk A, Vergara A, Estrin D, Merlino A
* Molecular basis of the NO trans influence in quaternary T-state human hemoglobin: A computational study (393 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013 Sep 2; 587(15): 2393-2398.
Impact Factor: 3.341
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Paolillo S, Rengo G, Pagano G, Pellegrino T, Savarese G, Femminella GD, Tuccillo M, Boemio A, Attena E, Formisano R, Petraglia L, Scopacasa F, Galasso G, Leosco D, Trimarco B, Cuocolo A, Perrone-Filardi P
* Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study (313 views)
Diabetes Care (ISSN: 1935-5548, 0149-5992), 2013 Sep; 36(8): 2395-2401.
Impact Factor: 8.57
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Ronda L, Merlino A, Bettati S, Verde C, Balsamo A, Mazzarella L, Mozzarelli A, Vergara A
* Role of tertiary structures on the Root effect in fish hemoglobins (496 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Sep; 1834(9): 1885-1893.
Impact Factor: 3.191
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Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FSN, Pompidor G, Mazzarella L, Vergara A
* Selective X-ray-induced NO photodissociation in haemoglobin crystals: evidence from a Raman-assisted crystallographic study (339 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Jan; 69: 137-140.
Impact Factor: 7.232
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Vitiello G, Fragneto G, Petruk AA, Falanga A, Galdiero S, D'Ursi A, Merlino A, D'Errico G
* Cholesterol modulates the fusogenic activity of a membranotropic domain of the FIV glycoprotein gp36 (410 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(28): 6442-6456.
Impact Factor: 4.151
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (572 views)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
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Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FSN, Pompidor G, Mazzarella L, Vergara A
* Selective X-Ray Induced No-Photodissociation In Hemoglobin Crystals: Evidence From A Raman Assisted-Crystallographic Study (302 views)
Acta Cryst D 69, 2013; 1: 137-140.
Impact Factor: 0
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Fonti R, Larobina M, Del Vecchio S, Fabbricini R, Catalano L, Pane F, Salvatore M, Pace L
* Metabolic tumor volume assessed by 18F-FDG PET/CT for the prediction of outcome in patients with multiple myeloma (576 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Dec; 53(12): 1829-1835.
Impact Factor: 5.774
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Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C
* ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus (343 views)
Molecular Biosystems (ISSN: 1742-206x), 2012 Oct 30; 8(12): 3295-3304.
Impact Factor: 3.35
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Risitano AM, Imbriaco M, Marando L, Seneca E, Soscia E, Malcovati L, Iori AP, Pane F, Notaro R, Matarazzo M
* From perpetual haemosiderinuria to possible iron overload: iron redistribution in paroxysmal nocturnal haemoglobinuria patients on eculizumab by magnetic resonance imaging (359 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2012 Sep; 158(3): 415-418.
Impact Factor: 4.942
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De Rosa A, Rossi F, Lieto M, Bruno R, De Renzo A, Palma V, Quarantelli M, De Michele G
* Subacute combined degeneration of the spinal cord in a vegan (355 views)
Clin Neurol Neurosurg (ISSN: 0303-8467), 2012 Sep; 114(7): 1000-1002.
Impact Factor: 1.234
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Marciano C, Galderisi M, Gargiulo P, Acampa W, D'Amore C, Esposito R, Capasso E, Savarese G, Casaretti L, Lo Iudice F, Esposito G, Rengo G, Leosco D, Cuocolo A, Perrone-Filardi P
* Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (708 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Jul; 39(7): 1199-1206.
Impact Factor: 5.114
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Balsamo A, Sannino F, Merlino A, Parrilli E, Tutino ML, Mazzarella L, Vergara A
* Role of the tertiary and quaternary structure in the formation of bis-histidyl adducts in cold-adapted hemoglobins (407 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 Apr; 94(4): 953-960.
Impact Factor: 3.142
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Merlino A, Vitiello G, Grimaldi M, Sica F, Busi E, Basosi R, D’Ursi A, Fragneto G, Paduano L, D’Errico G
* Destabilization of Lipid Membranes by a Peptide Derived from Glycoprotein gp36 of Feline Immunodeficiency Virus: A Combined Molecular Dynamics/Experimental Study (470 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2012 Jan 12; 116(1): 401-412.
Impact Factor: 3.607
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Striano P, Caranci F, Pappata S, Zara F, Striano S
* Hemidystonia in uncontrolled type 2 diabetes mellitus (275 views)
Arch Neurol (ISSN: 1538-3687electronic, 0003-9942linking), 2011 May; 68(5): 674-675.
Impact Factor: 7.584
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Merlino A, Howes BD, Prisco G, Verde C, Smulevich G, Mazzarella L, Vergara A
* Occurrence and formation of endogenous histidine hexa-coordination in cold-adapted hemoglobins (410 views)
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 May; 63(5): 295-303.
Impact Factor: 3.514
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Riccio A, Mangiapia G, Giordano D, Flagiello A, Tedesco R, Bruno S, Vergara A, Mazzarella L, di Prisco G, Pucci P, Paduano L, Verde C
* Polymerization of Hemoglobins in Arctic Fish: Lycodes reticulatus and Gadus morhua (361 views)
Iubmb Life (ISSN: 1521-6543, 1521-6551), 2011 May; 63(5): 346-354.
Impact Factor: 3.514
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Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
* Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (418 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2011 Jan; 41(1): 39-44.
Impact Factor: 3.018
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Merlino A, Vitagliano L, Balsamo A, Nicoletti FP, Howes BD, Giordano D, Coppola D, Di Prisco G, Verde C, Smulevich G, Mazzarella L, Vergara A
* Crystallization, preliminary X-ray diffraction studies and Raman microscopy of the major haemoglobin from the sub-Antarctic fish Eleginops maclovinus in the carbomonoxy form (317 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2010 Nov; 66: 1536-1540.
Impact Factor: 0.563
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Vergara A, Vitagliano L, Merlino A, Sica F, Marino K, Verde C, di Prisco G, Mazzarella L
* An Order-Disorder Transition Plays a Role in Switching Off the Root Effect in Fish Hemoglobins (363 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Oct 15; 285(42): 32568-32575.
Impact Factor: 5.328
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Coppola D, Giordano D, Vergara A, Mazzarella L, Di Prisco G, Verde C, Russo R
* The hemoglobins of sub-Antarctic fishes of the suborder Notothenioidei (350 views)
Polar Science (ISSN: 1873-9652), 2010 Sep; 4(2): 295-308.
Impact Factor: 31.477
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Mainenti PP, Segreto S, Mancini M, Rispo A, Cozzolino I, Masone S, Rinaldi CR, Nardone G, Salvatore M
* Intestinal amyloidosis: two cases with different patterns of clinical and imaging presentation (386 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2010 May 28; 16(20): 2566-2570.
Impact Factor: 2.24
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Merlino A, Vergara A, Sica F, Aschi M, Amadei A, Di Nola A, Mazzarella L
* Free-Energy Profile for CO Binding to Separated Chains of Human and Trematomus newnesi Hemoglobin: Insights from Molecular Dynamics Simulations and Perturbed Matrix Method (301 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 May 27; 114(20): 7002-7008.
Impact Factor: 3.603
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Diana D, Ziaco B, Scarabelli G, Pedone C, Colombo G, D'Andrea LD, Fattorusso R
* Structural analysis of a helical peptide unfolding pathway (461 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2010 May 10; 16(18): 5400-5407.
Impact Factor: 5.476
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Merlino A, Vitagliano L, Howes BD, Verde C, Di Prisco G, Smulevich G, Sica F, Vergara A
* Combined Crystallographic and Spectroscopic Analysis of Trematomus bernacchii Hemoglobin Highlights Analogies and Differences in the Peculiar Oxidation Pathway of Antarctic Fish Hemoglobins (413 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1117-1125.
Impact Factor: 2.605
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Vitagliano L, Stanzione F, De Simone A, Esposito L
* Dynamics and Stability of Amyloid-Like Steric Zipper Assemblies with Hydrophobic Dry Interfaces (549 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1161-1171.
Impact Factor: 2.605
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Risitano AM, Seneca E, Marando L, Imbriaco M, Soscia E, Soscia F, Pizzuti LM, Malcovati L, Fenu S, Iori AP, Notaro R, Matarazzo M, Rotoli B
* From Renal Siderosis Due to Perpetual Hemosiderinuria to Possible Liver Overload Due to Extravascular Hemolysis: Changes in Iron Metabolism in Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients On Eculizumab (353 views)
Haematologica (ISSN: 0006-4971, 0006-6497, 0390-6078), 2009 Nov 20; 114(22): N/D-N/D.
Impact Factor: 10.555
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (396 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
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Vergara A, Franzese M, Merlino A, Bonomi G, Verde C, Giordano D, Di Prisco G, Lee HC, Peisach J, Mazzarella L
* Correlation between Hemichrome Stability and the Root Effect in Tetrameric Hemoglobins (404 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2009 Sep 5; 97(3): 866-874.
Impact Factor: 4.39
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Giordano D, Boechi L, Vergara A, Marti MA, Samuni U, Dantsker D, Grassi L, Estrin DA, Friedman JM, Mazzarella L, Di Prisco G, Verde C
* The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species - oxygen-binding equilibria, kinetics and molecular dynamics (708 views)
Febs Journal (ISSN: 1742-464x), 2009 Apr; 276(8): 2266-2277.
Impact Factor: 3.042
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Verde C, Giordano D, Russo R, Riccio A, Vergara A, Mazzarella L, Di Prisco G
* Hemoproteins in the cold (275 views)
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 67-73.
Impact Factor: 1.2
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Merlino A, Vergara A, Sica F, Mazzarella L
* The bis-histidyl complex in hemoproteins: A detailed conformational analysis of database protein structures and the case of Antarctic fish hemoglobins (331 views)
Marine Genomics (ISSN: 1874-7787), 2009 Mar; 2(1): 51-56.
Impact Factor: 1.2
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Verde C, Vergara A, Mazzarella L, Di Prisco G
* The Hemoglobins of Fishes Living at Polar Latitudes - Current Knowledge on Structural Adaptations in a Changing Environment (389 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Dec; 9(6): 578-590.
Impact Factor: 3.011
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Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (962 views)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (400 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10527-10535.
Impact Factor: 8.091
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Esposito L, Paladino A, Pedone C, Vitagliano L
* Insights into structure, stability, and toxicity of monomeric and aggregated polyglutamine models from molecular dynamics simulations (416 views)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 May 15; 94(10): 4031-4040.
Impact Factor: 4.683
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Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (401 views)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
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Merlino A, Verde C, Di Prisco G, Mazzarella L, Vergara A
* Reduction of ferric hemoglobin from Trematomus bernacchii in a partial bis-histidyl state produces a deoxy coordination even when encapsulated into the crystal phase (382 views)
Spectroscopy An International Journal (ISSN: 0712-4813), 2008; 22(2-3): 143-152.
Impact Factor: 0.82
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of A Tetrameric Hemoglobin Oxidation Pathway Reveals Structural Features Of A Functional Intermediate R/T State (278 views)
Biophys J, 2008; 94: 4031-4040.
Impact Factor: 3.832
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Vergara A, Vitagliano L, Verde C, di Prisco G, Mazzarella L
* Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobins (426 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 2008; 436: 425-444.
Impact Factor: 2.312
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Vergara A, Vitagliano L, Di Prisco G, Verde C, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of Hemichromes In Tetrameric Hemoglobins (321 views)
Methods In Enzymology, 2008; 436: 421-440.
Impact Factor: 2.194
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Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
* Time-resolved fluorescence spectroscopy and molecular dynamics simulations point out the effects of pressure on the stability and dynamics of the porcine odorant-binding protein (608 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 89(4): 284-291.
Impact Factor: 2.823
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Giordano D, Vergara A, Lee HC, Peisach J, Balestrieri M, Mazzarella L, Parisi E, Di Priseo G, Verde C
* Hemoglobin structure/function and globin-gene evolution in the Arctic fish Liparis tunicatus (389 views)
Gene (ISSN: 0378-1119), 2007 Dec 30; 406(1-2): 58-68.
Impact Factor: 2.871
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (720 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Vergara A, Franzese M, Merlino A, Vitagliano L, Verde C, Di Prisco G, Lee HC, Peisach J, Mazzarella L
* Structural characterization of ferric hemoglobins from three Antarctic fish species of the suborder notothenioidei (375 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Oct; 93(8): 2822-2829.
Impact Factor: 4.627
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Mazzarella L, Vergara A, Vitagliano L, Merlino A, Bonomi G, Scala S, Verde C, Di Prisco G
* High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect (389 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Nov 1; 65(2): 490-498.
Impact Factor: 3.73
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Langella E, Improta R, Crescenzi O, Barone V
* Assessing the acid-base and conformational properties of histidine residues in human prion protein (125-228) by means of pKα calculations and molecular dynamics simulations (580 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jul 1; 64(1): 167-177.
Impact Factor: 3.73
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Merlino A, Esposito L, Vitagliano L
* Polyglutamine Repeats And Beta-Helix Structure: Molecular Dynamics Study (504 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Jun 1; 63(4): 918-927.
Impact Factor: 3.73
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Mazzarella L, Bonomi G, Lubrano MC, Merlino A, Riccio A, Vergara A, Vitagliano L, Verde C, Di Prisco G
* Minimal structural requirements for root effect: Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus newnesi (506 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2006 Feb 1; 62(2): 316-321.
Impact Factor: 3.73
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De Capua A, Goodman M, Amino Y, Saviano M, Benedetti E
* Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies (614 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2006 Feb; 7(2): 377-387.
Impact Factor: 4.1
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Merlino A, Ceruso MA, Vitagliano L, Mazzarella L
* Open interface and large quaternary structure movements in 3D domain swapped proteins: Insights from molecular dynamics simulations of the C-terminal swapped dimer of ribonuclease (602 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2005 Mar; 88(3): 2003-2012.
Impact Factor: 4.507
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Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (479 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
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Vitagliano L, Bonomi G, Franzese M, Merlino A, Vergara A, Verde C, Di Prisco G, Mazzarella L
* Structural Characterization Of The Oxidation Pathway Of Antarctic Fish Hemoglobins (313 views)
Acta Crystallogr D Biol Crystallogr, 2005; N/D: N/D-N/D.
Impact Factor: 2.069
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Langella E, Improta R, Barone V
* Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: Effect of protonation of histidine residues (427 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2004 Dec; 87(6): 3623-3632.
Impact Factor: 4.585
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Di Costanzo L, Geremia S, Randaccio L, Nastri F, Maglio O, Lombardi A, Pavone V
* Miniaturized heme proteins: crystal structure of Co(III)-mimochrome IV (378 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2004 Dec; 9(8): 1017-1027.
Impact Factor: 3.3
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Vitagliano L, Bonomi G, Riccio A, di Prisco G, Smulevich G, Mazzarella L
* The oxidation process of Antarctic fish hemoglobins (451 views)
Eur J Biochem (ISSN: 0014-2956, 0014-2956print), 2004 May; 271(9): 1651-1659.
Impact Factor: 3.26
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* The crystal structure of a tetrameric hemoglobin in a partial hemichrome state (505 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2002 Jul 23; 99(15): 9801-9806.
Impact Factor: 10.7
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Tedesco I, Russo GL, Nazzaro F, Russo M, Palumbo R
* Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes (869 views)
J Nutr Biochem (ISSN: 0955-2863), 2001 Sep; 12(9): 505-511.
Impact Factor: 1.039
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* Liganded and unliganded forms of Antarctic fish haemoglobins in polyethylene glycol: crystallization of an R-state haemichrome intermediate (392 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2001 Sep; 57: 1144-1146.
Impact Factor: 2.124
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Tedesco I, Russo M, Russo P, Iacomino G, Russo GL, Carraturo A, Faruolo C, Moio L, Palumbo R
Antioxidant effect of red wine polyphenols on red blood cells (549 views)
J Nutr Biochem (ISSN: 0955-2863), 2000 Feb; 11(2): 114-119.
Impact Factor: 1.083
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Mazzarella L, D'Avino R, Di Prisco G, Savino C, Vitagliano L, Moody P, Zagari A
Crystal structure of Trematomus newnesi haemoglobin re-opens the Root effect question (388 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 1999 Apr 16; 287(5): 897-906.
Impact Factor: 5.501
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Pacelli R, Taira J, Cook JA, Wink DA, Krishna MC
Hydroxyurea reacts with heme proteins to generate nitric oxide [6] (334 views)
Lancet (ISSN: 0140-6736), 1996 Mar 30; 347(9005): 900-900.
Impact Factor: 16.135
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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Manna R, Salvatore M, Di Leo MA, Scuderi F, Greco AV, Ghirlanda G, Gambassi G
Relationship between urinary neopterin excretion and islet cell antibodies in type 1 (insulin-dependent) diabetes (432 views)
Diabetes Res (ISSN: 0265-5985), 1991 May; 17(1): 33-36.
Impact Factor: 0
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Salvati AM, d'Onofrio G, Berti P, Cappabianca MP, Marsili G, De Philippis C, Cossa L, Quarantelli M, Zini G, Mango G
An assessment of the operating characteristics of Coulter Counter model S-Plus STKR (585 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1991 Mar; 76(2): 94-103.
Impact Factor: 2.56
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81 Records (77 excluding Abstracts).
Total impact factor: 357.76 (323.227 excluding Abstracts).
Total 5 year impact factor: 401.913 (344.173 excluding Abstracts).
Total impact factor: 357.76 (323.227 excluding Abstracts).
Total 5 year impact factor: 401.913 (344.173 excluding Abstracts).
370 views. Last view on Saturday 14 January 2023, 20:00:30
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