Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (455 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.403, 5-year impact factor: 5.271
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79151481219&partnerID=40&md5=bfbb11267b9c39fc874eed55b3c6028a
Keywords: Nerve Growth Factor, Nerve Injury, Neuro-Glial Network, Reactive Astrocytosis, Synaptic Homeostasis, 4 Aminobutyric Acid, Calcium Binding Protein, Excitatory Amino Acid Transporter 3, Glial Fibrillary Acidic Protein, Glutamate Cysteine Ligase, Glutamate Decarboxylase 65, Glutamate Transporter, Glutamic Acid, Glutathione, Glycine Transporter, Ilomastat, Metalloproteinase, Vesicular Inhibitory Amino Acid Transporter, Animal Experiment, Animal Model, Animal Tissue, Article, Controlled Study, Enzyme Degradation, Lumbar Spinal Cord, Microglia, Nerve Cell Plasticity, Neuroprotection, Nonhuman, Peripheral Nerve Injury, Priority Journal, Protein Expression, Protein Metabolism, Sciatic Nerve, Synaptic Efficacy, Gliosis, Neural Pathways, Sprague-Dawley, Sciatic Neuropathy, Synapses,
Affiliations:
*** IBB - CNR ***
Laboratorio di Morfologia delle Reti Neuronali, Dipartimento di Medicina Pubblica Clinica e Preventiva, Seconda Università di Napoli, 80138 Naples, Italy
Laboratorio di Neuroscienze R. Levi-Montalcini and Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Milan, Italy
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi and Dipartimento delle Scienze Biologiche, Università di Napoli Federico II and Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80138 Naples, Italy
References:
Allen, N.J., Barres, B.A., Neuroscience: glia-more than just brain glue (2009) Nature, 457, pp. 675-67
Alvarez-Maubecin, V., Functional coupling between neurons and glia (2000) J. Neurosci., 20, pp. 4091-4098
Anand, P., Neurotrophic factors and their receptors in human sensory neuropathies (2004) Prog. Brain Res., 146, pp. 477-492
Apfel, S.C., Nerve growth factor regulates the expression of brain-derived neurotrophic factor mRNA in the peripheral nervous system (1996) Mol. Cell. Neurosci., 7, pp. 134-142
Apfel, S.C., Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. NGF Study Group (1998) Neurology, 51, pp. 695-702
Baudoux, S., Parker, D., Glial-toxin-mediated disruption of spinal cord locomotor network function and its modulation by 5-HT (2008) Neuroscience, 153, pp. 1332-1343
Blochl, A., Blochl, R., A cell-biological model of p75 NTR signaling (2007) J. Neurochem., 102, pp. 289-305
Bowes, M., Continuous intrathecal fluid infusions elevate nerve growth factor levels and prevent functional deficits after spinal cord ischemia (2000) Brain Res., 883, pp. 178-183
Bruno, M.A., Cuello, A.C., Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade (2006) Proc. Natl Acad. Sci. USA, 103, pp. 6735-6740
Cahill, C.M., Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain (2003) Neuropharmacology, 45, pp. 543-552
Calissano, P., Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease (2010) Dev. Neurobiol., 70, pp. 372-383
Capsoni, S., Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration (2010) Proc. Natl Acad. Sci. USA, 107, pp. 12299-12304
Cavaliere, C., Gliosis alters expression and uptake of spinal glial amino acid transporters in a mouse neuropathic pain model (2007) Neuron Glia Biol., 3, pp. 141-153
Choi, S., Friedman, W.J., Inflammatory cytokines IL-1beta and TNF-alpha regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms (2009) ASN NEURO, 1 (2). , art:e00010
Cirillo, G., Intrathecal NGF administration reduces reactive astrocytosis and changes neurotrophin receptors expression pattern in a rat model of neuropathic pain (2010) Cell. Mol. Neurobiol., 30, pp. 51-62
Cirillo, G., Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats (2010) Neurochem. Int., 56, pp. 152-160
Coderre, T.J., Melzack, R., The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury (1992) J. Neurosci., 12, pp. 3671-3675
Colangelo, A.M., A new nerve growth factor-mimetic peptide active on neuropathic pain in rats (2008) J. Neurosci., 28, pp. 2698-2709
Cragnolini, A.B., Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor (2009) Glia, 57, pp. 1386-1392
Cuello, A.C., Bruno, M.A., The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease (2007) Neurochem. Res., 32, pp. 1041-1045
Decosterd, I., Woolf, C.J., Spared nerve injury: an animal model of persistent peripheral neuropathic pain (2000) Pain, 87, pp. 149-158
Dun, Y., Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress (2006) Cell Tissue Res., 324, pp. 189-202
Giaume, C., Astroglial networks: a step further in neuroglial and gliovascular interactions (2010) Nat. Rev. Neurosci., 11, pp. 87-99
Giovannoni, R., Reactive astrocytosis and glial glutamate transporter clustering are early changes in a spinocerebellar ataxia type 1 transgenic mouse model (2007) Neuron Glia Biol., 3, pp. 335-351
Hamilton, N.B., Attwell, D., Do astrocytes really exocytose neurotransmitters? (2010) Nat. Rev. Neurosci., 11, pp. 227-238
Heneka, M.T., Neuroglia in neurodegeneration (2010) Brain Res. Rev., 63, pp. 189-211
Henneberger, C., Long-term potentiation depends on release of D-serine from astrocytes (2010) Nature, 463, pp. 232-236
Hughes, E.G., Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis (2010) Mol. Cell. Neurosci., 43, pp. 136-145
Ji, R.R., MAP kinase and pain (2009) Brain Res. Rev., 60, pp. 135-148
Ji, R.R., Suter, M.R., P38 MAPK, microglial signaling, and neuropathic pain (2007) Mol. Pain, 3, p. 33
Kim, D., A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity (2007) J. Biol. Chem., 282, pp. 14975-14983
Leo, D., Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology (2009) Genes Brain Behav., 8, pp. 356-368
Lewerenz, J., Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc- protects from oxidative glutamate toxicity (2006) J. Neurochem., 98, pp. 916-925
Lobsiger, C.S., Cleveland, D.W., Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (2007) Nat. Neurosci., 10, pp. 1355-1360
Lu, P., Tuszynski, M.H., Growth factors and combinatorial therapies for CNS regeneration (2008) Exp. Neurol., 209, pp. 313-320
Lynch, G., Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease (2007) J. Neurosci., 27, pp. 4424-4434
Meisner, J.G., Loss of GABAergic interneurons in Laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain following spinal cord injury (2010) J. Neurotrauma, 4, pp. 729-737
Milligan, E.D., Watkins, L.R., Pathological and protective roles of glia in chronic pain (2009) Nat. Rev. Neurosci., 10, pp. 23-36
Musholt, K., Neonatal separation stress reduces glial fibrillary acidic protein- and S100beta-immunoreactive astrocytes in the rat medial precentral cortex (2009) Dev. Neurobiol., 69, pp. 203-211
Ni, Y., Parpura, V., Dual regulation of Ca 2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels (2009) Glia, 57, pp. 1296-1305
Okada-Ogawa, A., Astroglia in medullary dorsal horn (trigeminal spinal subnucleus caudalis) are involved in trigeminal neuropathic pain mechanisms (2009) J. Neurosci., 29, pp. 11161-11171
Oliet, S.H., Control of glutamate clearance and synaptic efficacy by glial coverage of neurons (2001) Science, 292, pp. 923-926
Oliveira, A.L., Apoptosis of spinal interneurons induced by sciatic nerve axotomy in the neonatal rat is counteracted by nerve growth factor and ciliary neurotrophic factor (2002) J. Comp. Neurol., 447, pp. 381-393
Panatier, A., Glia derived D-serine controls NMDA receptor activity and synaptic memory (2006) Cell, 125, pp. 775-784
Papa, M., Expression pattern of the ether-a-gogo-related (ERG) K+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system (2003) J. Comp. Neurol., 466, pp. 119-135
Pekny, M., Nilsson, M., Astrocyte activation and reactive gliosis (2005) Glia, 50, pp. 427-434
Perea, G., Tripartite synapses: astrocytes process and control synaptic information (2009) Trends Neurosci., 32, pp. 421-431
Rodríguez, J.J., Astroglia in dementia and Alzheimer's disease (2009) Cell Death Differ., 16, pp. 378-385
Rouach, N., Astroglial metabolic networks sustain hippocampal synaptic transmission (2008) Science, 322, pp. 1551-1555
Saijo, K., A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death (2009) Cell, 137, pp. 47-59
Sato, H., Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins (1999) J. Biol. Chem., 74, pp. 11455-11458
Shih, A.Y., Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation (2006) J. Neurosci., 26, pp. 10514-10523
Tzingounis, A.V., Wadiche, J.I., Glutamate transporters: confining runaway excitation by shaping synaptic transmission (2007) Nat. Rev. Neurosci., 8, pp. 935-947
Verkhratsky, A., Kirchhoff, F., Glutamate-mediated neuronal-glial transmission (2007) J. Anat., 210, pp. 651-660
Watkins, L.R., Spinal cord glia: new players in pain (2001) Pain, 93, pp. 201-205
Weidner, N., Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1 (1999) J. Comp. Neurol., 413, pp. 495-506
Zagami, C.J., Oxidative and excitotoxic insults exert differential effects on spinal motoneurons and astrocytic glutamate transporters: implications for the role of astrogliosis in amyotrophic lateral sclerosis (2009) Glia, 57, pp. 119-135
Allen, N. J., Barres, B. A., Neuroscience: glia-more than just brain glue (2009) Nature, 457, pp. 675-67
Apfel, S. C., Nerve growth factor regulates the expression of brain-derived neurotrophic factor mRNA in the peripheral nervous system (1996) Mol. Cell. Neurosci., 7, pp. 134-142
Apfel, S. C., Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. NGF Study Group (1998) Neurology, 51, pp. 695-702
Bruno, M. A., Cuello, A. C., Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade (2006) Proc. Natl Acad. Sci. USA, 103, pp. 6735-6740
Cahill, C. M., Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain (2003) Neuropharmacology, 45, pp. 543-552
Coderre, T. J., Melzack, R., The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury (1992) J. Neurosci., 12, pp. 3671-3675
Colangelo, A. M., A new nerve growth factor-mimetic peptide active on neuropathic pain in rats (2008) J. Neurosci., 28, pp. 2698-2709
Cragnolini, A. B., Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor (2009) Glia, 57, pp. 1386-1392
Cuello, A. C., Bruno, M. A., The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease (2007) Neurochem. Res., 32, pp. 1041-1045
Hamilton, N. B., Attwell, D., Do astrocytes really exocytose neurotransmitters? (2010) Nat. Rev. Neurosci., 11, pp. 227-238
Heneka, M. T., Neuroglia in neurodegeneration (2010) Brain Res. Rev., 63, pp. 189-211
Hughes, E. G., Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis (2010) Mol. Cell. Neurosci., 43, pp. 136-145
Ji, R. R., MAP kinase and pain (2009) Brain Res. Rev., 60, pp. 135-148
Ji, R. R., Suter, M. R., P38 MAPK, microglial signaling, and neuropathic pain (2007) Mol. Pain, 3, p. 33
Lobsiger, C. S., Cleveland, D. W., Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (2007) Nat. Neurosci., 10, pp. 1355-1360
Meisner, J. G., Loss of GABAergic interneurons in Laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain following spinal cord injury (2010) J. Neurotrauma, 4, pp. 729-737
Milligan, E. D., Watkins, L. R., Pathological and protective roles of glia in chronic pain (2009) Nat. Rev. Neurosci., 10, pp. 23-36
Oliet, S. H., Control of glutamate clearance and synaptic efficacy by glial coverage of neurons (2001) Science, 292, pp. 923-926
Oliveira, A. L., Apoptosis of spinal interneurons induced by sciatic nerve axotomy in the neonatal rat is counteracted by nerve growth factor and ciliary neurotrophic factor (2002) J. Comp. Neurol., 447, pp. 381-393
Rodr guez, J. J., Astroglia in dementia and Alzheimer's disease (2009) Cell Death Differ., 16, pp. 378-385
Shih, A. Y., Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation (2006) J. Neurosci., 26, pp. 10514-10523
Tzingounis, A. V., Wadiche, J. I., Glutamate transporters: confining runaway excitation by shaping synaptic transmission (2007) Nat. Rev. Neurosci., 8, pp. 935-947
Watkins, L. R., Spinal cord glia: new players in pain (2001) Pain, 93, pp. 201-205
Zagami, C. J., Oxidative and excitotoxic insults exert differential effects on spinal motoneurons and astrocytic glutamate transporters: implications for the role of astrogliosis in amyotrophic lateral sclerosis (2009) Glia, 57, pp. 119-135
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.403, 5-year impact factor: 5.271
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79151481219&partnerID=40&md5=bfbb11267b9c39fc874eed55b3c6028a
Keywords: Nerve Growth Factor, Nerve Injury, Neuro-Glial Network, Reactive Astrocytosis, Synaptic Homeostasis, 4 Aminobutyric Acid, Calcium Binding Protein, Excitatory Amino Acid Transporter 3, Glial Fibrillary Acidic Protein, Glutamate Cysteine Ligase, Glutamate Decarboxylase 65, Glutamate Transporter, Glutamic Acid, Glutathione, Glycine Transporter, Ilomastat, Metalloproteinase, Vesicular Inhibitory Amino Acid Transporter, Animal Experiment, Animal Model, Animal Tissue, Article, Controlled Study, Enzyme Degradation, Lumbar Spinal Cord, Microglia, Nerve Cell Plasticity, Neuroprotection, Nonhuman, Peripheral Nerve Injury, Priority Journal, Protein Expression, Protein Metabolism, Sciatic Nerve, Synaptic Efficacy, Gliosis, Neural Pathways, Sprague-Dawley, Sciatic Neuropathy, Synapses,
Affiliations:
*** IBB - CNR ***
Laboratorio di Morfologia delle Reti Neuronali, Dipartimento di Medicina Pubblica Clinica e Preventiva, Seconda Università di Napoli, 80138 Naples, Italy
Laboratorio di Neuroscienze R. Levi-Montalcini and Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Milan, Italy
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi and Dipartimento delle Scienze Biologiche, Università di Napoli Federico II and Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80138 Naples, Italy
References:
Allen, N.J., Barres, B.A., Neuroscience: glia-more than just brain glue (2009) Nature, 457, pp. 675-67
Alvarez-Maubecin, V., Functional coupling between neurons and glia (2000) J. Neurosci., 20, pp. 4091-4098
Anand, P., Neurotrophic factors and their receptors in human sensory neuropathies (2004) Prog. Brain Res., 146, pp. 477-492
Apfel, S.C., Nerve growth factor regulates the expression of brain-derived neurotrophic factor mRNA in the peripheral nervous system (1996) Mol. Cell. Neurosci., 7, pp. 134-142
Apfel, S.C., Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. NGF Study Group (1998) Neurology, 51, pp. 695-702
Baudoux, S., Parker, D., Glial-toxin-mediated disruption of spinal cord locomotor network function and its modulation by 5-HT (2008) Neuroscience, 153, pp. 1332-1343
Blochl, A., Blochl, R., A cell-biological model of p75 NTR signaling (2007) J. Neurochem., 102, pp. 289-305
Bowes, M., Continuous intrathecal fluid infusions elevate nerve growth factor levels and prevent functional deficits after spinal cord ischemia (2000) Brain Res., 883, pp. 178-183
Bruno, M.A., Cuello, A.C., Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade (2006) Proc. Natl Acad. Sci. USA, 103, pp. 6735-6740
Cahill, C.M., Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain (2003) Neuropharmacology, 45, pp. 543-552
Calissano, P., Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease (2010) Dev. Neurobiol., 70, pp. 372-383
Capsoni, S., Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration (2010) Proc. Natl Acad. Sci. USA, 107, pp. 12299-12304
Cavaliere, C., Gliosis alters expression and uptake of spinal glial amino acid transporters in a mouse neuropathic pain model (2007) Neuron Glia Biol., 3, pp. 141-153
Choi, S., Friedman, W.J., Inflammatory cytokines IL-1beta and TNF-alpha regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms (2009) ASN NEURO, 1 (2). , art:e00010
Cirillo, G., Intrathecal NGF administration reduces reactive astrocytosis and changes neurotrophin receptors expression pattern in a rat model of neuropathic pain (2010) Cell. Mol. Neurobiol., 30, pp. 51-62
Cirillo, G., Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats (2010) Neurochem. Int., 56, pp. 152-160
Coderre, T.J., Melzack, R., The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury (1992) J. Neurosci., 12, pp. 3671-3675
Colangelo, A.M., A new nerve growth factor-mimetic peptide active on neuropathic pain in rats (2008) J. Neurosci., 28, pp. 2698-2709
Cragnolini, A.B., Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor (2009) Glia, 57, pp. 1386-1392
Cuello, A.C., Bruno, M.A., The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease (2007) Neurochem. Res., 32, pp. 1041-1045
Decosterd, I., Woolf, C.J., Spared nerve injury: an animal model of persistent peripheral neuropathic pain (2000) Pain, 87, pp. 149-158
Dun, Y., Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress (2006) Cell Tissue Res., 324, pp. 189-202
Giaume, C., Astroglial networks: a step further in neuroglial and gliovascular interactions (2010) Nat. Rev. Neurosci., 11, pp. 87-99
Giovannoni, R., Reactive astrocytosis and glial glutamate transporter clustering are early changes in a spinocerebellar ataxia type 1 transgenic mouse model (2007) Neuron Glia Biol., 3, pp. 335-351
Hamilton, N.B., Attwell, D., Do astrocytes really exocytose neurotransmitters? (2010) Nat. Rev. Neurosci., 11, pp. 227-238
Heneka, M.T., Neuroglia in neurodegeneration (2010) Brain Res. Rev., 63, pp. 189-211
Henneberger, C., Long-term potentiation depends on release of D-serine from astrocytes (2010) Nature, 463, pp. 232-236
Hughes, E.G., Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis (2010) Mol. Cell. Neurosci., 43, pp. 136-145
Ji, R.R., MAP kinase and pain (2009) Brain Res. Rev., 60, pp. 135-148
Ji, R.R., Suter, M.R., P38 MAPK, microglial signaling, and neuropathic pain (2007) Mol. Pain, 3, p. 33
Kim, D., A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity (2007) J. Biol. Chem., 282, pp. 14975-14983
Leo, D., Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology (2009) Genes Brain Behav., 8, pp. 356-368
Lewerenz, J., Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc- protects from oxidative glutamate toxicity (2006) J. Neurochem., 98, pp. 916-925
Lobsiger, C.S., Cleveland, D.W., Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (2007) Nat. Neurosci., 10, pp. 1355-1360
Lu, P., Tuszynski, M.H., Growth factors and combinatorial therapies for CNS regeneration (2008) Exp. Neurol., 209, pp. 313-320
Lynch, G., Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease (2007) J. Neurosci., 27, pp. 4424-4434
Meisner, J.G., Loss of GABAergic interneurons in Laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain following spinal cord injury (2010) J. Neurotrauma, 4, pp. 729-737
Milligan, E.D., Watkins, L.R., Pathological and protective roles of glia in chronic pain (2009) Nat. Rev. Neurosci., 10, pp. 23-36
Musholt, K., Neonatal separation stress reduces glial fibrillary acidic protein- and S100beta-immunoreactive astrocytes in the rat medial precentral cortex (2009) Dev. Neurobiol., 69, pp. 203-211
Ni, Y., Parpura, V., Dual regulation of Ca 2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels (2009) Glia, 57, pp. 1296-1305
Okada-Ogawa, A., Astroglia in medullary dorsal horn (trigeminal spinal subnucleus caudalis) are involved in trigeminal neuropathic pain mechanisms (2009) J. Neurosci., 29, pp. 11161-11171
Oliet, S.H., Control of glutamate clearance and synaptic efficacy by glial coverage of neurons (2001) Science, 292, pp. 923-926
Oliveira, A.L., Apoptosis of spinal interneurons induced by sciatic nerve axotomy in the neonatal rat is counteracted by nerve growth factor and ciliary neurotrophic factor (2002) J. Comp. Neurol., 447, pp. 381-393
Panatier, A., Glia derived D-serine controls NMDA receptor activity and synaptic memory (2006) Cell, 125, pp. 775-784
Papa, M., Expression pattern of the ether-a-gogo-related (ERG) K+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system (2003) J. Comp. Neurol., 466, pp. 119-135
Pekny, M., Nilsson, M., Astrocyte activation and reactive gliosis (2005) Glia, 50, pp. 427-434
Perea, G., Tripartite synapses: astrocytes process and control synaptic information (2009) Trends Neurosci., 32, pp. 421-431
Rodríguez, J.J., Astroglia in dementia and Alzheimer's disease (2009) Cell Death Differ., 16, pp. 378-385
Rouach, N., Astroglial metabolic networks sustain hippocampal synaptic transmission (2008) Science, 322, pp. 1551-1555
Saijo, K., A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death (2009) Cell, 137, pp. 47-59
Sato, H., Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins (1999) J. Biol. Chem., 74, pp. 11455-11458
Shih, A.Y., Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation (2006) J. Neurosci., 26, pp. 10514-10523
Tzingounis, A.V., Wadiche, J.I., Glutamate transporters: confining runaway excitation by shaping synaptic transmission (2007) Nat. Rev. Neurosci., 8, pp. 935-947
Verkhratsky, A., Kirchhoff, F., Glutamate-mediated neuronal-glial transmission (2007) J. Anat., 210, pp. 651-660
Watkins, L.R., Spinal cord glia: new players in pain (2001) Pain, 93, pp. 201-205
Weidner, N., Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1 (1999) J. Comp. Neurol., 413, pp. 495-506
Zagami, C.J., Oxidative and excitotoxic insults exert differential effects on spinal motoneurons and astrocytic glutamate transporters: implications for the role of astrogliosis in amyotrophic lateral sclerosis (2009) Glia, 57, pp. 119-135
Allen, N. J., Barres, B. A., Neuroscience: glia-more than just brain glue (2009) Nature, 457, pp. 675-67
Apfel, S. C., Nerve growth factor regulates the expression of brain-derived neurotrophic factor mRNA in the peripheral nervous system (1996) Mol. Cell. Neurosci., 7, pp. 134-142
Apfel, S. C., Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. NGF Study Group (1998) Neurology, 51, pp. 695-702
Bruno, M. A., Cuello, A. C., Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade (2006) Proc. Natl Acad. Sci. USA, 103, pp. 6735-6740
Cahill, C. M., Intrathecal nerve growth factor restores opioid effectiveness in an animal model of neuropathic pain (2003) Neuropharmacology, 45, pp. 543-552
Coderre, T. J., Melzack, R., The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury (1992) J. Neurosci., 12, pp. 3671-3675
Colangelo, A. M., A new nerve growth factor-mimetic peptide active on neuropathic pain in rats (2008) J. Neurosci., 28, pp. 2698-2709
Cragnolini, A. B., Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor (2009) Glia, 57, pp. 1386-1392
Cuello, A. C., Bruno, M. A., The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease (2007) Neurochem. Res., 32, pp. 1041-1045
Hamilton, N. B., Attwell, D., Do astrocytes really exocytose neurotransmitters? (2010) Nat. Rev. Neurosci., 11, pp. 227-238
Heneka, M. T., Neuroglia in neurodegeneration (2010) Brain Res. Rev., 63, pp. 189-211
Hughes, E. G., Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis (2010) Mol. Cell. Neurosci., 43, pp. 136-145
Ji, R. R., MAP kinase and pain (2009) Brain Res. Rev., 60, pp. 135-148
Ji, R. R., Suter, M. R., P38 MAPK, microglial signaling, and neuropathic pain (2007) Mol. Pain, 3, p. 33
Lobsiger, C. S., Cleveland, D. W., Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (2007) Nat. Neurosci., 10, pp. 1355-1360
Meisner, J. G., Loss of GABAergic interneurons in Laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain following spinal cord injury (2010) J. Neurotrauma, 4, pp. 729-737
Milligan, E. D., Watkins, L. R., Pathological and protective roles of glia in chronic pain (2009) Nat. Rev. Neurosci., 10, pp. 23-36
Oliet, S. H., Control of glutamate clearance and synaptic efficacy by glial coverage of neurons (2001) Science, 292, pp. 923-926
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Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor
Reactive gliosis has been implicated in both inflammatory and neurodegenerative diseases. However, mechanisms by which astrocytic activation affects synaptic efficacy have been poorly elucidated. We have used the spared nerve injury (SNI) of the sciatic nerve to induce reactive astrocytosis in the lumbar spinal cord and investigate its potential role in disrupting the neuro-glial circuitry. Analysis of spinal cord sections revealed that SNI was associated with an increase of microglial (Iba1) and astrocytic (GFAP) markers. These changes, indicative of reactive gliosis, were paralleled by (i) a decrease of glial amino acid transporters (GLT1 and GlyT1) and increased levels of (ii) neuronal glutamate transporter EAAC1, (iii) neuronal vesicular GABA transporter (vGAT) and (iv) the GABAergic neuron marker GAD65/67. Besides the increase of Glutamate/GABA ratio, indicative of the perturbation of synaptic circuitry homeostasis, the boost of glutamate also compromised glial function in neuroprotection by up-regulating the xCT subunit of the glutamate-cystine antiport system and reducing glutathione (GSH) production. Finally, this study also shows that all these structural changes were linked to an alteration of endogenous NGF metabolism, as demonstrated by the decrease of endogenous NGF expression levels and increased activity of the NGF-degrading metalloproteinases. All the changes displayed by SNI-animals were reversed by a 7-days i.t. administration of NGF or GM6001, a generic metalloproteinase inhibitor, as compared to vehicle (ACSF)-treated animals. All together, these data strongly support the correlation between reactive astrogliosis and mechanisms underlying the perturbation of the synaptic circuitry in the SNI model of peripheral nerve injury, and the essential role of NGF in restoring both synaptic homeostasis and the neuroprotective function of glia. (C) 2010 Elsevier Inc. All rights reserved.
Reactive gliosis has been implicated in both inflammatory and neurodegenerative diseases. However, mechanisms by which astrocytic activation affects synaptic efficacy have been poorly elucidated. We have used the spared nerve injury (SNI) of the sciatic nerve to induce reactive astrocytosis in the lumbar spinal cord and investigate its potential role in disrupting the neuro-glial circuitry. Analysis of spinal cord sections revealed that SNI was associated with an increase of microglial (Iba1) and astrocytic (GFAP) markers. These changes, indicative of reactive gliosis, were paralleled by (i) a decrease of glial amino acid transporters (GLT1 and GlyT1) and increased levels of (ii) neuronal glutamate transporter EAAC1, (iii) neuronal vesicular GABA transporter (vGAT) and (iv) the GABAergic neuron marker GAD65/67. Besides the increase of Glutamate/GABA ratio, indicative of the perturbation of synaptic circuitry homeostasis, the boost of glutamate also compromised glial function in neuroprotection by up-regulating the xCT subunit of the glutamate-cystine antiport system and reducing glutathione (GSH) production. Finally, this study also shows that all these structural changes were linked to an alteration of endogenous NGF metabolism, as demonstrated by the decrease of endogenous NGF expression levels and increased activity of the NGF-degrading metalloproteinases. All the changes displayed by SNI-animals were reversed by a 7-days i.t. administration of NGF or GM6001, a generic metalloproteinase inhibitor, as compared to vehicle (ACSF)-treated animals. All together, these data strongly support the correlation between reactive astrogliosis and mechanisms underlying the perturbation of the synaptic circuitry in the SNI model of peripheral nerve injury, and the essential role of NGF in restoring both synaptic homeostasis and the neuroprotective function of glia. (C) 2010 Elsevier Inc. All rights reserved.
Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor
| ▼ New peptide–based molecules as NGF mimetics in the therapy of neurological dysfunctions |
Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor
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Giuffrida ML, Copani A, Rizzarelli E
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Impact Factor: 0
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Pietropaolo A, Magri A, Greco V, Losasso V, La Mendola D, Sciuto S, Carloni P, Rizzarelli E
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Travaglia A, Pietropaolo A, Di Martino R, Nicoletti VG, La Mendola D, Calissano P, Rizzarelli E
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Impact Factor: 4.348
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Forte G, Travaglia A, Magrì A, Satriano C, La Mendola D
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Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2014; 16(4): 1536-1544.
Impact Factor: 4.493
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Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (338 views)
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Impact Factor: 4.151
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Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (506 views)
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Impact Factor: 5.831
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Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
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Impact Factor: 2.659
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Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (522 views)
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Impact Factor: 3.197
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
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Impact Factor: 9.599
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Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (498 views)
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Impact Factor: 5.925
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Stanzione F, Esposito L, Paladino A, Pedone C, Morelli G, Vitagliano L
* Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors (455 views)
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Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E
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Impact Factor: 7.452
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Bianco MR, Cirillo G, Cavaliere C, Colangelo AM, Vitagliano L, Morelli G, Sarmientos P, Martegani E, Alberghina L, Papa M
* A new Nerve Growth Factor (NGF)-mimetic peptide reduces gliosis and is active on neuropathic pain in rats (316 views)
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Impact Factor: 6.636
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
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Impact Factor: 2.296
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* A promising connection between BDNF and Alzheimer's disease (249 views)
Aging (ISSN: 1945-4589linking), 2018 Aug 6; 10(8): 1791-1792.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Pietropaolo A, Magri A, Greco V, Losasso V, La Mendola D, Sciuto S, Carloni P, Rizzarelli E
* Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays (233 views)
Acs Chem Neurosci (ISSN: 1948-7193electronic, 1948-7193linking), 2018 Jan 12; N/D: N/D-N/D.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Lanza V, Travaglia A, Malgieri G, Fattorusso R, GrassoG, Di Natale G, Zito V, Arena G, Milardi D, Rizzarelli E
* Ubiquitin Associates with the N-Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions (279 views) (PDF 172 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Dec 05; 22(49): 17767-17775.
Impact Factor: 5.317
View Export to BibTeX Export to EndNote
Travaglia A, Pietropaolo A, Di Martino R, Nicoletti VG, La Mendola D, Calissano P, Rizzarelli E
* A Small Linear Peptide Encompassing the NGF N-Terminus Partly Mimics the Biological Activities of the Entire Neurotrophin in PC12 Cells (337 views)
Acs Chem Neurosci (ISSN: 1948-7193, 1948-7193electronic, 1948-7193linking), 2015; 6(8): 1379-1392.
Impact Factor: 4.348
View Export to BibTeX Export to EndNote
Forte G, Travaglia A, Magrì A, Satriano C, La Mendola D
* Adsorption of NGF and BDNF derived peptides on gold surfaces (504 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2014; 16(4): 1536-1544.
Impact Factor: 4.493
View Export to BibTeX Export to EndNote
Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (338 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
View Export to BibTeX Export to EndNote
Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (506 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (626 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (522 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
View Export to BibTeX Export to EndNote
Travaglia A, Arena G, Fattorusso R, Isernia C, La Mendola D, Malgieri G, Nicoletti VG, Rizzarelli E
* The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor (498 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Mar 21; 17(13): 3726-3738.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Stanzione F, Esposito L, Paladino A, Pedone C, Morelli G, Vitagliano L
* Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors (455 views)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2010 Oct 6; 99(7): 2273-2278.
Impact Factor: 4.218
View Export to BibTeX Export to EndNote
Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E
* A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (657 views)
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Impact Factor: 7.452
View Export to BibTeX Export to EndNote
Bianco MR, Cirillo G, Cavaliere C, Colangelo AM, Vitagliano L, Morelli G, Sarmientos P, Martegani E, Alberghina L, Papa M
* A new Nerve Growth Factor (NGF)-mimetic peptide reduces gliosis and is active on neuropathic pain in rats (316 views)
Neuron Glia Biology (ISSN: 1740-925x), 2007; 2: N/D-N/D.
Impact Factor: 6.636
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
15 Records (14 excluding Abstracts).
Total impact factor: 70.47 (63.834 excluding Abstracts).
Total 5 year impact factor: 72.135 (68.267 excluding Abstracts).
Total impact factor: 70.47 (63.834 excluding Abstracts).
Total 5 year impact factor: 72.135 (68.267 excluding Abstracts).
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