BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 9.599, 5-year impact factor: 11.85
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84855746317&partnerID=40&md5=373569bf397db8f269323fef5c3174f8
Keywords: Nerve Injury, Neuro-Glial Network, Ngf-Like Peptide, Reactive Astrocytosis, Synaptic Homeostasis, Astrogliosis, Beneficial Effects, Gabaergic, Glutamate Transporters, Glutathiones, Hyperalgesia, Immunohistochemical Analysis, Molecular Changes, Nerve Growth Factor, Nerve Injuries, Neurodegenerative Disorders, Neuropathic Pain, Neuroplastic Changes, Neuroprotection, Pathological Conditions, Peptidomimetics, Peripheral Nerves, Rat Model, Sciatic Nerves, Spinal Cords, Therapeutic Agents, Dosimetry, Neurodegenerative Diseases, Physiology, Analgesic Agent, Glutamic Acid, Glycine, Biomarker, Correlation, Inhibitor, Animal, Article, Chemistry, Disease Model, Drug Effect, Immunohistochemistry, Metabolism, Peripheral Nerve Injury, Spinal Cord Injury, Sprague Dawley Rat, Peripheral Nerve Injuries, Sprague-Dawley, Spinal Cord Injuries, Synapses, Rattus,
Affiliations:
*** IBB - CNR ***
Laboratory of Morphology of Neural Networks, Department of Medicina Pubblica Clinica e Preventiva, Second University of Napoli, 80138 Napoli, Italy
Laboratory of Neuroscience R. Levi-Montalcini, Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy
PRIMM Srl, Milano, Italy
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, Department of Biological Sciences, Univ. of Napoli Federico II and Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80138 Napoli, Italy
References:
Allen, N.J., Barres, B.A., Neuroscience: Glia - more than just brain glue (2009) Nature, 457, pp. 675-67
Apfel, S.C., Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold? (2002) Int Rev Neurobiol, 50, pp. 393-413
Bai, Y.H., Takemitsu, M., Atsuta, Y., Matsuno, T., Peripheral mononeuropathy induced by loose ligation of the sciatic nerve in the rat: behavioral, electrophysiological and histopathologic studies (1999) Exp Anim, 48, pp. 87-94
Bruno, M.A., Cuello, A.C., Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade (2006) Proc Natl Acad Sci USA, 103, pp. 6735-6740
Cavaliere, C., Cirillo, G., Bianco, M.R., Rossi, F., De Novellis, V., Maione, S., Gliosis alters expression and uptake of spinal glial amino acid transporters in a mouse neuropathic pain model (2007) Neuron Glia Biol, 3, pp. 141-153
Chao, M.V., Rajagopal, R., Lee, F.S., Neurotrophin signalling in health and disease (2006) Clin Sci, 2, pp. 167-173
Chaplan, S.R., Bach, F.W., Pogrel, J.W., Chung, J.M., Yaksh, T.L., Quantitative assessment of tactile allodynia in the rat paw (1994) J Neurosci Methods, 53, pp. 55-63
Cirillo, G., Maggio, N., Bianco, M.R., Vollono, C., Sellitti, S., Papa, M., Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats (2010) Neurochem Int, 56, pp. 152-160
Cirillo, G., Cavaliere, C., Bianco, M.R., De Simone, A., Colangelo, A.M., Sellitti, S., Intrathecal NGF Administration Reduces Reactive Astrocytosis and Changes Neurotrophin Receptors Expression Pattern in a Rat Model of Neuropathic Pain (2010) Cell Mol Neurobiol, 30, pp. 51-62
Colangelo, A.M., Bianco, M.R., Vitagliano, L., Cavaliere, C., Cirillo, G., De Gioia, L., A new nerve growth factor-mimetic peptide active on neuropathic pain in rats (2008) J Neurosci, 28, pp. 2698-2709
Cuello, A.C., Bruno, M.A., Bell, K.F., NGF-cholinergic dependency in brain aging, MCI and Alzheimer's disease (2007) Curr Alzheimer Res, 4, pp. 351-358
Decosterd, I., Woolf, C.J., Spared nerve injury: an animal model of persistent peripheral neuropathic pain (2000) Pain, 87, pp. 149-158
Domeniconi, M., Hempstead, B.L., Chao, M.V., Pro-NGF secreted by astrocytes promotes motor neuron cell death (2007) Mol Cell Neurosci, 34, pp. 271-279
Giaume, C., Koulakoff, A., Roux, L., Holcman, D., Rouach, N., Astroglial networks: a step further in neuroglial and gliovascular interactions (2010) Nat Rev Neurosci, 11, pp. 87-99
Giovannoni, R., Maggio, N., Rosaria Bianco, M., Cavaliere, C., Cirillo, G., Lavitrano, M., Reactive astrocytosis and glial glutamate transporter clustering are early changes in a spinocerebellar ataxia type 1 transgenic mouse model (2007) Neuron Glia Biol, 3, pp. 335-351
Hamilton, N.B., Attwell, D., Do astrocytes really exocytose neurotransmitters? (2010) Nat Rev Neurosci, 11, pp. 227-238
Hargreaves, K., Dubner, R., Brown, F., Flores, C., Joris, J., A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia (1988) Pain, 32, pp. 77-88
Harrington, A.W., Leiner, B., Blechschmitt, C., Arevalo, J.C., Lee, R., Mörl, K., Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury (2004) Proc Natl Acad Sci USA, 101, pp. 6226-6230
Henneberger, C., Papouin, T., Oliet, S.H., Rusakov, D.A., Long-term potentiation depends on release of D-serine from astrocytes (2010) Nature, 463, pp. 232-236
Kullander, K., Kaplan, D., Ebendal, T., Two restricted sites on the surface of the Nerve Growth Factor molecule independently determine specific trkA receptor binding and activation (1997) J Biol Chem, 272, pp. 9300-9307
Lobsiger, C.S., Cleveland, D.W., Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (2007) Nat Neurosci, 10, pp. 1355-1360
Longo, F.M., Manthorpe, M., Xie, Y.M., Varon, S., Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism (1997) J Neurosci Res, 48, pp. 1-17
Maliartchouk, S., Feng, Y., Ivanisevic, L., Debeir, T., Cuello, A.C., Burgess, K., A designed peptidomimetic agonistic ligand of TrkA nerve growth factor receptors (2000) Mol Pharmacol, 57, pp. 385-391
Massa, S.M., Yang, T., Xie, Y., Shi, J., Bilgen, M., Joyce, J.N., Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents (2010) J Clin Invest, 120, pp. 1774-1785
McDonald, N.Q., Chao, M.V., Structural determinants of neurotrophin action (1995) J Biol Chem, 270, pp. 19669-19672
Meisner, J.G., Marsh, A.D., Marsh, D.R., Loss of GABAergic interneurons in Laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain following spinal cord injury (2010) J Neurotrauma, 27, pp. 729-737
Ni, Y., Parpura, V., Dual regulation of Ca2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels (2009) Glia, 57, pp. 1296-1305
Nykjaer, A., Lee, R., Teng, K.K., Jansen, P., Madsen, P., Nielsen, M.S., Sortilin is essential for proNGF-induced neuronal cell death (2004) Nature, 427, pp. 843-848
Panatier, A., Theodosis, D.T., Mothet, J.P., Touquet, B., Pollegioni, L., Poulain, D.A., Glia derived D-serine controls NMDA receptor activity and synaptic memory (2006) Cell, 125, pp. 775-784
Papa, M., Boscia, F., Canitano, A., Castaldo, P., Sellitti, S., Annunziato, L., Expression pattern of the ether-a-gogo-related (ERG) K+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system (2003) J Comp Neurol, 466, pp. 119-135
Pekny, M., Nilsson, M., Astrocyte activation and reactive gliosis (2005) Glia, 50, pp. 427-434
Peleshok, J., Saragovi, H.U., Functional mimetics of neurotrophins and their receptors (2006) Biochem Soc Trans, 34, pp. 612-617
Poduslo, J.F., Curran, G.L., Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF (1996) Mol Brain Res, 36, pp. 280-286
Polgár, E., Todd, A.J., Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn (2008) Neuroscience, 156, pp. 193-202
Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., Giaume, C., Astroglial metabolic networks sustain hippocampal synaptic transmission (2008) Science, 322, pp. 1551-1555
Rydén, M., Ibànez, C.F., A second determinant of binding to the p75 neurotrophin receptor revealed by Alanine-Scanning mutagenesis of a conserved loop in Nerve Growth Factor (1997) J Biol Chem, 272, pp. 33085-33091
Scholz, J., Woolf, C.J., The neuropathic pain triad: neurons, immune cells and glia (2007) Nat Neurosci, 10, pp. 361-368
Shih, A., Laramee, G.R., Schmelzer, C.H., Burton, L.E., Winslow, J.W., Mutagenesis identifies amino-terminal residues of nerve growth factor necessary for Trk receptor binding and biological activity (1994) J Biol Chem, 269, pp. 27679-27686
Shih, A.Y., Erb, H., Sun, X., Toda, S., Kalivas, P.W., Murphy, T.H., Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation (2006) J Neurosci, 26, pp. 10514-10523
Todd, A.J., Neuronal circuitry for pain processing in the dorsal horn (2010) Nat Rev Neurosci, 12, pp. 823-836
Tuszynski, M.H., Thal, L., Pay, M., Salmon, D.P.U.H.S., Bakay, R., Patel, P., Blesch, A., Conner, J., A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease (2005) Nat Med, 11, pp. 551-555
Wang, W., Wang, W., Mei, X., Huang, J., Wei, Y., Wang, Y., Crosstalk between spinal astrocytes and neurons in nerve injury-induced neuropathic pain (2009) PLoS One, 4, pp. e6973
Wiesmann, C., Ultsch, M.H., Bass, S.H., de Vos, A.M., Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor (1999) Nature, 401, pp. 184-188
Yang, T., Knowles, J.K., Lu, Q., Zhang, H., Arancio, O., Moore, L.A., Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment (2008) PLoS One, 3, pp. e3604
Yasaka, T., Tiong, S.Y., Hughes, D.I., Riddell, J.S., Todd, A.J., Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach (2010) Pain, 2, pp. 475-488
Zaccaro, M.C., Lee, H.B., Pattarawarapan, M., Xia, Z., Caron, A., L'Heureux, P.J., Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities (2005) Chem Biol, 12, pp. 1015-1028
Allen, N. J., Barres, B. A., Neuroscience: Glia - more than just brain glue (2009) Nature, 457, pp. 675-67
Apfel, S. C., Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold? (2002) Int Rev Neurobiol, 50, pp. 393-413
Bai, Y. H., Takemitsu, M., Atsuta, Y., Matsuno, T., Peripheral mononeuropathy induced by loose ligation of the sciatic nerve in the rat: behavioral, electrophysiological and histopathologic studies (1999) Exp Anim, 48, pp. 87-94
Bruno, M. A., Cuello, A. C., Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade (2006) Proc Natl Acad Sci USA, 103, pp. 6735-6740
Chao, M. V., Rajagopal, R., Lee, F. S., Neurotrophin signalling in health and disease (2006) Clin Sci, 2, pp. 167-173
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., Yaksh, T. L., Quantitative assessment of tactile allodynia in the rat paw (1994) J Neurosci Methods, 53, pp. 55-63
Colangelo, A. M., Bianco, M. R., Vitagliano, L., Cavaliere, C., Cirillo, G., De Gioia, L., A new nerve growth factor-mimetic peptide active on neuropathic pain in rats (2008) J Neurosci, 28, pp. 2698-2709
Cuello, A. C., Bruno, M. A., Bell, K. F., NGF-cholinergic dependency in brain aging, MCI and Alzheimer's disease (2007) Curr Alzheimer Res, 4, pp. 351-358
Hamilton, N. B., Attwell, D., Do astrocytes really exocytose neurotransmitters? (2010) Nat Rev Neurosci, 11, pp. 227-238
Harrington, A. W., Leiner, B., Blechschmitt, C., Arevalo, J. C., Lee, R., M rl, K., Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury (2004) Proc Natl Acad Sci USA, 101, pp. 6226-6230
Lobsiger, C. S., Cleveland, D. W., Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (2007) Nat Neurosci, 10, pp. 1355-1360
Longo, F. M., Manthorpe, M., Xie, Y. M., Varon, S., Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism (1997) J Neurosci Res, 48, pp. 1-17
Massa, S. M., Yang, T., Xie, Y., Shi, J., Bilgen, M., Joyce, J. N., Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents (2010) J Clin Invest, 120, pp. 1774-1785
McDonald, N. Q., Chao, M. V., Structural determinants of neurotrophin action (1995) J Biol Chem, 270, pp. 19669-19672
Meisner, J. G., Marsh, A. D., Marsh, D. R., Loss of GABAergic interneurons in Laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain following spinal cord injury (2010) J Neurotrauma, 27, pp. 729-737
Poduslo, J. F., Curran, G. L., Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF (1996) Mol Brain Res, 36, pp. 280-286
Polg r, E., Todd, A. J., Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA (A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn (2008) Neuroscience, 156, pp. 193-202
Ryd n, M., Ib nez, C. F., A second determinant of binding to the p75 neurotrophin receptor revealed by Alanine-Scanning mutagenesis of a conserved loop in Nerve Growth Factor (1997) J Biol Chem, 272, pp. 33085-33091
Shih, A. Y., Erb, H., Sun, X., Toda, S., Kalivas, P. W., Murphy, T. H., Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation (2006) J Neurosci, 26, pp. 10514-10523
Todd, A. J., Neuronal circuitry for pain processing in the dorsal horn (2010) Nat Rev Neurosci, 12, pp. 823-836
Tuszynski, M. H., Thal, L., Pay, M., Salmon, D. P. U. H. S., Bakay, R., Patel, P., Blesch, A., Conner, J., A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease (2005) Nat Med, 11, pp. 551-555
Zaccaro, M. C., Lee, H. B., Pattarawarapan, M., Xia, Z., Caron, A., L'Heureux, P. J., Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities (2005) Chem Biol, 12, pp. 1015-1028
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 9.599, 5-year impact factor: 11.85
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84855746317&partnerID=40&md5=373569bf397db8f269323fef5c3174f8
Keywords: Nerve Injury, Neuro-Glial Network, Ngf-Like Peptide, Reactive Astrocytosis, Synaptic Homeostasis, Astrogliosis, Beneficial Effects, Gabaergic, Glutamate Transporters, Glutathiones, Hyperalgesia, Immunohistochemical Analysis, Molecular Changes, Nerve Growth Factor, Nerve Injuries, Neurodegenerative Disorders, Neuropathic Pain, Neuroplastic Changes, Neuroprotection, Pathological Conditions, Peptidomimetics, Peripheral Nerves, Rat Model, Sciatic Nerves, Spinal Cords, Therapeutic Agents, Dosimetry, Neurodegenerative Diseases, Physiology, Analgesic Agent, Glutamic Acid, Glycine, Biomarker, Correlation, Inhibitor, Animal, Article, Chemistry, Disease Model, Drug Effect, Immunohistochemistry, Metabolism, Peripheral Nerve Injury, Spinal Cord Injury, Sprague Dawley Rat, Peripheral Nerve Injuries, Sprague-Dawley, Spinal Cord Injuries, Synapses, Rattus,
Affiliations:
*** IBB - CNR ***
Laboratory of Morphology of Neural Networks, Department of Medicina Pubblica Clinica e Preventiva, Second University of Napoli, 80138 Napoli, Italy
Laboratory of Neuroscience R. Levi-Montalcini, Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy
PRIMM Srl, Milano, Italy
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, Department of Biological Sciences, Univ. of Napoli Federico II and Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80138 Napoli, Italy
References:
Allen, N.J., Barres, B.A., Neuroscience: Glia - more than just brain glue (2009) Nature, 457, pp. 675-67
Apfel, S.C., Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold? (2002) Int Rev Neurobiol, 50, pp. 393-413
Bai, Y.H., Takemitsu, M., Atsuta, Y., Matsuno, T., Peripheral mononeuropathy induced by loose ligation of the sciatic nerve in the rat: behavioral, electrophysiological and histopathologic studies (1999) Exp Anim, 48, pp. 87-94
Bruno, M.A., Cuello, A.C., Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade (2006) Proc Natl Acad Sci USA, 103, pp. 6735-6740
Cavaliere, C., Cirillo, G., Bianco, M.R., Rossi, F., De Novellis, V., Maione, S., Gliosis alters expression and uptake of spinal glial amino acid transporters in a mouse neuropathic pain model (2007) Neuron Glia Biol, 3, pp. 141-153
Chao, M.V., Rajagopal, R., Lee, F.S., Neurotrophin signalling in health and disease (2006) Clin Sci, 2, pp. 167-173
Chaplan, S.R., Bach, F.W., Pogrel, J.W., Chung, J.M., Yaksh, T.L., Quantitative assessment of tactile allodynia in the rat paw (1994) J Neurosci Methods, 53, pp. 55-63
Cirillo, G., Maggio, N., Bianco, M.R., Vollono, C., Sellitti, S., Papa, M., Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats (2010) Neurochem Int, 56, pp. 152-160
Cirillo, G., Cavaliere, C., Bianco, M.R., De Simone, A., Colangelo, A.M., Sellitti, S., Intrathecal NGF Administration Reduces Reactive Astrocytosis and Changes Neurotrophin Receptors Expression Pattern in a Rat Model of Neuropathic Pain (2010) Cell Mol Neurobiol, 30, pp. 51-62
Colangelo, A.M., Bianco, M.R., Vitagliano, L., Cavaliere, C., Cirillo, G., De Gioia, L., A new nerve growth factor-mimetic peptide active on neuropathic pain in rats (2008) J Neurosci, 28, pp. 2698-2709
Cuello, A.C., Bruno, M.A., Bell, K.F., NGF-cholinergic dependency in brain aging, MCI and Alzheimer's disease (2007) Curr Alzheimer Res, 4, pp. 351-358
Decosterd, I., Woolf, C.J., Spared nerve injury: an animal model of persistent peripheral neuropathic pain (2000) Pain, 87, pp. 149-158
Domeniconi, M., Hempstead, B.L., Chao, M.V., Pro-NGF secreted by astrocytes promotes motor neuron cell death (2007) Mol Cell Neurosci, 34, pp. 271-279
Giaume, C., Koulakoff, A., Roux, L., Holcman, D., Rouach, N., Astroglial networks: a step further in neuroglial and gliovascular interactions (2010) Nat Rev Neurosci, 11, pp. 87-99
Giovannoni, R., Maggio, N., Rosaria Bianco, M., Cavaliere, C., Cirillo, G., Lavitrano, M., Reactive astrocytosis and glial glutamate transporter clustering are early changes in a spinocerebellar ataxia type 1 transgenic mouse model (2007) Neuron Glia Biol, 3, pp. 335-351
Hamilton, N.B., Attwell, D., Do astrocytes really exocytose neurotransmitters? (2010) Nat Rev Neurosci, 11, pp. 227-238
Hargreaves, K., Dubner, R., Brown, F., Flores, C., Joris, J., A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia (1988) Pain, 32, pp. 77-88
Harrington, A.W., Leiner, B., Blechschmitt, C., Arevalo, J.C., Lee, R., Mörl, K., Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury (2004) Proc Natl Acad Sci USA, 101, pp. 6226-6230
Henneberger, C., Papouin, T., Oliet, S.H., Rusakov, D.A., Long-term potentiation depends on release of D-serine from astrocytes (2010) Nature, 463, pp. 232-236
Kullander, K., Kaplan, D., Ebendal, T., Two restricted sites on the surface of the Nerve Growth Factor molecule independently determine specific trkA receptor binding and activation (1997) J Biol Chem, 272, pp. 9300-9307
Lobsiger, C.S., Cleveland, D.W., Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease (2007) Nat Neurosci, 10, pp. 1355-1360
Longo, F.M., Manthorpe, M., Xie, Y.M., Varon, S., Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism (1997) J Neurosci Res, 48, pp. 1-17
Maliartchouk, S., Feng, Y., Ivanisevic, L., Debeir, T., Cuello, A.C., Burgess, K., A designed peptidomimetic agonistic ligand of TrkA nerve growth factor receptors (2000) Mol Pharmacol, 57, pp. 385-391
Massa, S.M., Yang, T., Xie, Y., Shi, J., Bilgen, M., Joyce, J.N., Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents (2010) J Clin Invest, 120, pp. 1774-1785
McDonald, N.Q., Chao, M.V., Structural determinants of neurotrophin action (1995) J Biol Chem, 270, pp. 19669-19672
Meisner, J.G., Marsh, A.D., Marsh, D.R., Loss of GABAergic interneurons in Laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain following spinal cord injury (2010) J Neurotrauma, 27, pp. 729-737
Ni, Y., Parpura, V., Dual regulation of Ca2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels (2009) Glia, 57, pp. 1296-1305
Nykjaer, A., Lee, R., Teng, K.K., Jansen, P., Madsen, P., Nielsen, M.S., Sortilin is essential for proNGF-induced neuronal cell death (2004) Nature, 427, pp. 843-848
Panatier, A., Theodosis, D.T., Mothet, J.P., Touquet, B., Pollegioni, L., Poulain, D.A., Glia derived D-serine controls NMDA receptor activity and synaptic memory (2006) Cell, 125, pp. 775-784
Papa, M., Boscia, F., Canitano, A., Castaldo, P., Sellitti, S., Annunziato, L., Expression pattern of the ether-a-gogo-related (ERG) K+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system (2003) J Comp Neurol, 466, pp. 119-135
Pekny, M., Nilsson, M., Astrocyte activation and reactive gliosis (2005) Glia, 50, pp. 427-434
Peleshok, J., Saragovi, H.U., Functional mimetics of neurotrophins and their receptors (2006) Biochem Soc Trans, 34, pp. 612-617
Poduslo, J.F., Curran, G.L., Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF (1996) Mol Brain Res, 36, pp. 280-286
Polgár, E., Todd, A.J., Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn (2008) Neuroscience, 156, pp. 193-202
Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., Giaume, C., Astroglial metabolic networks sustain hippocampal synaptic transmission (2008) Science, 322, pp. 1551-1555
Rydén, M., Ibànez, C.F., A second determinant of binding to the p75 neurotrophin receptor revealed by Alanine-Scanning mutagenesis of a conserved loop in Nerve Growth Factor (1997) J Biol Chem, 272, pp. 33085-33091
Scholz, J., Woolf, C.J., The neuropathic pain triad: neurons, immune cells and glia (2007) Nat Neurosci, 10, pp. 361-368
Shih, A., Laramee, G.R., Schmelzer, C.H., Burton, L.E., Winslow, J.W., Mutagenesis identifies amino-terminal residues of nerve growth factor necessary for Trk receptor binding and biological activity (1994) J Biol Chem, 269, pp. 27679-27686
Shih, A.Y., Erb, H., Sun, X., Toda, S., Kalivas, P.W., Murphy, T.H., Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation (2006) J Neurosci, 26, pp. 10514-10523
Todd, A.J., Neuronal circuitry for pain processing in the dorsal horn (2010) Nat Rev Neurosci, 12, pp. 823-836
Tuszynski, M.H., Thal, L., Pay, M., Salmon, D.P.U.H.S., Bakay, R., Patel, P., Blesch, A., Conner, J., A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease (2005) Nat Med, 11, pp. 551-555
Wang, W., Wang, W., Mei, X., Huang, J., Wei, Y., Wang, Y., Crosstalk between spinal astrocytes and neurons in nerve injury-induced neuropathic pain (2009) PLoS One, 4, pp. e6973
Wiesmann, C., Ultsch, M.H., Bass, S.H., de Vos, A.M., Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor (1999) Nature, 401, pp. 184-188
Yang, T., Knowles, J.K., Lu, Q., Zhang, H., Arancio, O., Moore, L.A., Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment (2008) PLoS One, 3, pp. e3604
Yasaka, T., Tiong, S.Y., Hughes, D.I., Riddell, J.S., Todd, A.J., Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach (2010) Pain, 2, pp. 475-488
Zaccaro, M.C., Lee, H.B., Pattarawarapan, M., Xia, Z., Caron, A., L'Heureux, P.J., Selective small molecule peptidomimetic ligands of TrkC and TrkA receptors afford discrete or complete neurotrophic activities (2005) Chem Biol, 12, pp. 1015-1028
Allen, N. J., Barres, B. A., Neuroscience: Glia - more than just brain glue (2009) Nature, 457, pp. 675-67
Apfel, S. C., Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold? (2002) Int Rev Neurobiol, 50, pp. 393-413
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BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury
Peptidomimetics hold a great promise as therapeutic agents for neurodegenerative disorders. We previously described a Nerve Growth Factor (NGF)-like peptide, now named BB14, which was found to act as a strong TrkA agonist and to be effective in the sciatic nerve injury model of neuropathic pain. In this report we present the effects of BB14 in reducing reactive astrocytosis and reverting neuroplastic changes of the glutamate/GABAergic circuitry in the lumbar spinal cord following spared nerve injury (SNI) of the sciatic nerve. Immunohistochemical analysis of spinal cord sections revealed that SNI was associated with increased microglial (Iba1) and astrocytic (GFAP) responses, indicative of reactive gliosis. These changes were paralleled by (i) decreased glial aminoacid transporters (GLT1 and GlyT1) and increased levels of (ii) neuronal glutamate transporter EAAC1, (iii) neuronal vesicular GABA transporter (vGAT) and (iv) the GABAergic neuron marker GAD65/67. A remarkable increase of the Glutamate/GABA ratio and the reduction of glutathione (GSH) levels were also indicative of modifications of glial function in neuroprotection. All these molecular changes were found to be linked to an alteration of endogenous NGF metabolism, as demonstrated by decreased levels of mature NGF, increase of proNGF and increased activity of NGF-degrading methallo-proteinases (MMPs). Biochemical alterations and SNI-related neuropathic behavior, characterized by allodynia and hyperalgesia, were reversed by 7-days i.t, administration of the NGF-like peptide BB14, as well as by increasing endogenous NGF levels by it. infusion of GM6001, a MMPs inhibitor. All together, while confirming the correlation between reactive astrogliosis and perturbation of synaptic circuitry in the SNI model of peripheral nerve injury, these data strongly support the beneficial effect of BB14 in reducing reactive astrogliosis and restoring synaptic homeostasis under pathological conditions linked to alteration of NGF availability and signaling, thereby suggesting a potential role of BB14 as a therapeutic agent. (C) 2011 Published by Elsevier Inc.
Peptidomimetics hold a great promise as therapeutic agents for neurodegenerative disorders. We previously described a Nerve Growth Factor (NGF)-like peptide, now named BB14, which was found to act as a strong TrkA agonist and to be effective in the sciatic nerve injury model of neuropathic pain. In this report we present the effects of BB14 in reducing reactive astrocytosis and reverting neuroplastic changes of the glutamate/GABAergic circuitry in the lumbar spinal cord following spared nerve injury (SNI) of the sciatic nerve. Immunohistochemical analysis of spinal cord sections revealed that SNI was associated with increased microglial (Iba1) and astrocytic (GFAP) responses, indicative of reactive gliosis. These changes were paralleled by (i) decreased glial aminoacid transporters (GLT1 and GlyT1) and increased levels of (ii) neuronal glutamate transporter EAAC1, (iii) neuronal vesicular GABA transporter (vGAT) and (iv) the GABAergic neuron marker GAD65/67. A remarkable increase of the Glutamate/GABA ratio and the reduction of glutathione (GSH) levels were also indicative of modifications of glial function in neuroprotection. All these molecular changes were found to be linked to an alteration of endogenous NGF metabolism, as demonstrated by decreased levels of mature NGF, increase of proNGF and increased activity of NGF-degrading methallo-proteinases (MMPs). Biochemical alterations and SNI-related neuropathic behavior, characterized by allodynia and hyperalgesia, were reversed by 7-days i.t, administration of the NGF-like peptide BB14, as well as by increasing endogenous NGF levels by it. infusion of GM6001, a MMPs inhibitor. All together, while confirming the correlation between reactive astrogliosis and perturbation of synaptic circuitry in the SNI model of peripheral nerve injury, these data strongly support the beneficial effect of BB14 in reducing reactive astrogliosis and restoring synaptic homeostasis under pathological conditions linked to alteration of NGF availability and signaling, thereby suggesting a potential role of BB14 as a therapeutic agent. (C) 2011 Published by Elsevier Inc.
BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury
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BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury
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Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (441 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
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* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (441 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
View Export to BibTeX Export to EndNote
1 Records (1 excluding Abstracts).
Total impact factor: 5.403 (5.403 excluding Abstracts).
Total 5 year impact factor: 5.271 (5.271 excluding Abstracts).
Total impact factor: 5.403 (5.403 excluding Abstracts).
Total 5 year impact factor: 5.271 (5.271 excluding Abstracts).
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