3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer
3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer(614 views) Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Keywords: 18f-Flt, Egfr, Lung Cancer, Pet Ct, Fluorothymidine F 18, Cl 387 785, Epidermal Growth Factor Receptor Kinase Inhibitor, Erlotinib, Ki 67 Antigen, N [4 (3 Bromoanilino) 6 Quinazolinyl] 2 Butynamide, Navitoclax, Unclassified Drug, Wz 4002, Dideoxynucleoside Derivative, Aniline Derivative, Antineoplastic Agent, Diagnostic Agent, Protein Bcl X, Protein Kinase Inhibitor, Quinazoline Derivative, Radiopharmaceutical Agent, Sulfonamide, Animal Experiment, Animal Model, Animal Tissue, Apoptosis, Article, Cancer Cell Culture, Cell Cycle Arrest, Cell Cycle G1 Phase, Cell Cycle S Phase, Computer Assisted Emission Tomography, Concentration Response, Controlled Study, Dose Response, Drug Efficacy, Drug Megadose, Drug Resistance, Drug Sensitivity, Drug Tumor Level, Gene Mutation, Human, Human Cell, Image Analysis, Immunohistochemistry, Isotope Labeling, Low Drug Dose, Lung Non Small Cell Cancer, Mouse, Nonhuman, Priority Journal, Quantitative Study, Tumor Xenograft, Bagg Albino Mouse, Cell Proliferation, Drug Antagonism, Drug Effect, Female, Image Processing, Lung Tumor, Methodology, Scintiscanning, Tumor Cell Line, Western Blotting, Aniline Compounds, Bcl-X Protein, Carcinoma, Non-Small-Cell Lung, Computer-Assisted, Lung Neoplasms, Inbred Balb C, Positron-Emission Tomography And Computed Tomography, Aniline Compounds Therapeutic Use, Antineoplastic Agents Therapeutic Use, Apoptosis Drug Effects, Non-Small-Cell Lung Drug Therapy Radionuclide Imaging, Cell Proliferation Drug Effects, Dideoxynucleosides Diagnostic Use, Lung Neoplasms Drug Therapy Radionuclide Imaging, Multimodal Imaging Methods, Protein Kinase Inhibitors Therapeutic Use, Quinazolines Therapeutic Use, Radiopharmaceuticals Diagnostic Use, Epidermal Growth Factor Antagonists, Sulfonamides Therapeutic Use, X-Ray Computed, Bcl-X Protein Antagonists,
Affiliations: *** IBB - CNR ***
Institute of Biostructures and Bioimages, National Research Council, Naples, Italy
Department of Biomorphological and Functional Sciences, University of Naples Federico II, Edificio 10, Via S. Pansini 5, 80131 Naples, Italy
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Engelman, J. A., Janne, P. A., Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer (2008) Clin Cancer Res, 14, pp. 2895-2899
Yun, C. -H., Mengwasser, K. E., Toms, A. V., Woo, M. S., Greulich, H., Wong, K. -K., Meyerson, M., Eck, M. J., The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP (2008) Proceedings of the National Academy of Sciences of the United States of America, 105 (6), pp. 2070-2075. , http: //www. pnas. org/cgi/reprint/105/6/2070, DOI 10. 1073/pnas. 0709662105
Engelman, J. A., Zejnullahu, K., Mitsudomi, T., Song, Y., Hyland, C., Joon, O. P., Lindeman, N., Janne, P. A., MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling (2007) Science, 316 (5827), pp. 1039-1043. , DOI 10. 1126/science. 1141478
Sequist, L. V., Von Pawel, J., Garmey, E. G., Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer (2011) J Clin Oncol, 29, pp. 3307-3315
Costa, D. B., Halmos, B., Kumar, A., BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations (2007) PLoS Med, 4, pp. 1669-1679
Oh, S. J., Mosdzianowski, C., Chi, D. Y., Fully automated synthesis system of 3 -deoxy-3 - [18F] fluorothymidine (2004) Nucl Med Biol, 31, pp. 803-809
Tseng, J. R., Kang, K. W., Dandekar, M., Preclinical efficacy of the c-Met inhibitor CE-355621 in a U87 MG mouse xenograft model evaluated by 18F-FDG small-animal PET (2008) J Nucl Med, 49, pp. 129-134
Wei, L. H., Su, H., Hildebrandt, I. J., Changes in tumor metabolism as readout for mammalian target of rapamycin kinase inhibition by rapamycin in glioblastoma (2008) Clin Cancer Res, 14, pp. 3416-3426
Ullrich, R. T., Zander, T., Neumaier, B., Early detection of erlotinib treatment response in NSCLC by 3 -deoxy-3 - [F] -fluoro-l-thymidine ([F] FLT) positron emission tomography (PET) (2008) PLoS One, 3, pp. e3908
Sequist, L. V., Waltman, B. A., Dias-Santagata, D., Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors (2011) Sci Transl Med, 3, pp. 75ra26
3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer
3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer
3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer