3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (1025 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
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Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.774, 5-year impact factor: 6.402
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84858608489&partnerID=40&md5=7f9fae30e4a8b0e2e9171ad4f3c1cc5c
Keywords: 18f-Flt, Egfr, Lung Cancer, Pet Ct, Fluorothymidine F 18, Cl 387 785, Epidermal Growth Factor Receptor Kinase Inhibitor, Erlotinib, Ki 67 Antigen, N [4 (3 Bromoanilino) 6 Quinazolinyl] 2 Butynamide, Navitoclax, Unclassified Drug, Wz 4002, Dideoxynucleoside Derivative, Aniline Derivative, Antineoplastic Agent, Diagnostic Agent, Protein Bcl X, Protein Kinase Inhibitor, Quinazoline Derivative, Radiopharmaceutical Agent, Sulfonamide, Animal Experiment, Animal Model, Animal Tissue, Apoptosis, Article, Cancer Cell Culture, Cell Cycle Arrest, Cell Cycle G1 Phase, Cell Cycle S Phase, Computer Assisted Emission Tomography, Concentration Response, Controlled Study, Dose Response, Drug Efficacy, Drug Megadose, Drug Resistance, Drug Sensitivity, Drug Tumor Level, Gene Mutation, Human, Human Cell, Image Analysis, Immunohistochemistry, Isotope Labeling, Low Drug Dose, Lung Non Small Cell Cancer, Mouse, Nonhuman, Priority Journal, Quantitative Study, Tumor Xenograft, Bagg Albino Mouse, Cell Proliferation, Drug Antagonism, Drug Effect, Female, Image Processing, Lung Tumor, Methodology, Scintiscanning, Tumor Cell Line, Western Blotting, Aniline Compounds, Bcl-X Protein, Carcinoma, Non-Small-Cell Lung, Computer-Assisted, Lung Neoplasms, Inbred Balb C, Positron-Emission Tomography And Computed Tomography, Aniline Compounds Therapeutic Use, Antineoplastic Agents Therapeutic Use, Apoptosis Drug Effects, Non-Small-Cell Lung Drug Therapy Radionuclide Imaging, Cell Proliferation Drug Effects, Dideoxynucleosides Diagnostic Use, Lung Neoplasms Drug Therapy Radionuclide Imaging, Multimodal Imaging Methods, Protein Kinase Inhibitors Therapeutic Use, Quinazolines Therapeutic Use, Radiopharmaceuticals Diagnostic Use, Epidermal Growth Factor Antagonists, Sulfonamides Therapeutic Use, X-Ray Computed, Bcl-X Protein Antagonists,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Research Council, Naples, Italy
Department of Biomorphological and Functional Sciences, University of Naples Federico II, Edificio 10, Via S. Pansini 5, 80131 Naples, Italy
References:
Not available.
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.774, 5-year impact factor: 6.402
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84858608489&partnerID=40&md5=7f9fae30e4a8b0e2e9171ad4f3c1cc5c
Keywords: 18f-Flt, Egfr, Lung Cancer, Pet Ct, Fluorothymidine F 18, Cl 387 785, Epidermal Growth Factor Receptor Kinase Inhibitor, Erlotinib, Ki 67 Antigen, N [4 (3 Bromoanilino) 6 Quinazolinyl] 2 Butynamide, Navitoclax, Unclassified Drug, Wz 4002, Dideoxynucleoside Derivative, Aniline Derivative, Antineoplastic Agent, Diagnostic Agent, Protein Bcl X, Protein Kinase Inhibitor, Quinazoline Derivative, Radiopharmaceutical Agent, Sulfonamide, Animal Experiment, Animal Model, Animal Tissue, Apoptosis, Article, Cancer Cell Culture, Cell Cycle Arrest, Cell Cycle G1 Phase, Cell Cycle S Phase, Computer Assisted Emission Tomography, Concentration Response, Controlled Study, Dose Response, Drug Efficacy, Drug Megadose, Drug Resistance, Drug Sensitivity, Drug Tumor Level, Gene Mutation, Human, Human Cell, Image Analysis, Immunohistochemistry, Isotope Labeling, Low Drug Dose, Lung Non Small Cell Cancer, Mouse, Nonhuman, Priority Journal, Quantitative Study, Tumor Xenograft, Bagg Albino Mouse, Cell Proliferation, Drug Antagonism, Drug Effect, Female, Image Processing, Lung Tumor, Methodology, Scintiscanning, Tumor Cell Line, Western Blotting, Aniline Compounds, Bcl-X Protein, Carcinoma, Non-Small-Cell Lung, Computer-Assisted, Lung Neoplasms, Inbred Balb C, Positron-Emission Tomography And Computed Tomography, Aniline Compounds Therapeutic Use, Antineoplastic Agents Therapeutic Use, Apoptosis Drug Effects, Non-Small-Cell Lung Drug Therapy Radionuclide Imaging, Cell Proliferation Drug Effects, Dideoxynucleosides Diagnostic Use, Lung Neoplasms Drug Therapy Radionuclide Imaging, Multimodal Imaging Methods, Protein Kinase Inhibitors Therapeutic Use, Quinazolines Therapeutic Use, Radiopharmaceuticals Diagnostic Use, Epidermal Growth Factor Antagonists, Sulfonamides Therapeutic Use, X-Ray Computed, Bcl-X Protein Antagonists,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimages, National Research Council, Naples, Italy
Department of Biomorphological and Functional Sciences, University of Naples Federico II, Edificio 10, Via S. Pansini 5, 80131 Naples, Italy
References:
Not available.
3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer
Epidermal growth factor receptor (EGFR) mutational status, activation of downstream signaling, and effective apoptotic cascade are all factors that may affect the tumor response to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). Here we test whether 3′-deoxy-3′- 18F-fluorothymidine ( 18F-FLT) PET/CT can provide clues for the selection of patients with NSCLC as candidates for treatment with reversible and irreversible EGFR TKIs or combination treatment with Bcl-x L inhibitors. Methods: HCC827, H1975, and H1650 NSCLC cells were subcutaneously injected into flanks of nude mice. Tumor-bearing animals were treated daily for 3 d by oral gavage with erlotinib at 50 and 150 mg/kg, CL-387,785 (an irreversible EGFR TKI) at 50 mg/kg, WZ4002 (a more potent irreversible EGFR TKI) at 25 and 50 mg/kg, ABT-263 (a Bcl-x Linhibitor) at 6.25 mg/kg, and a combination of erlotinib (50 mg/kg) and ABT-263 (6.25 mg/kg). Imaging studies were performed before and after 3 d of treatment by intravenous injection of 7.4 MBq of 18F-FLT and small-animal PET/CT of animals at 1 h after injection. Quantitative analysis of reconstructed images of baseline and posttreatment scans was performed, and the percentage change in 18F-FLT uptake in each animal was determined. Tumor sections were tested for Ki67 immunostaining and the percentage of apoptotic cells. Results: Sensitive tumors (HCC827) showed mean decreases in 18F-FLT uptake of 45% and 28% with high- and low-dose regimens of erlotinib, respectively. Resistant NSCLC cells bearing a T790M mutation (H1975) showed mean increases in 18F-FLT uptake of 27% and 33% with high and low doses of erlotinib, respectively. Treatment with CL-387,785, low-dose WZ4002, and high-dose WZ4002 caused mean decreases in tracer uptake of 21%, 26%, and 36%, respectively. NSCLC cells that were resistant because of dysregulation of Bcl-2 family members (H1650) showed mean reductions in 18F-FLT uptake of 49% and 23% with high and low doses of erlotinib, respectively, whereas the addition of ABT-263 did not affect tracer uptake but significantly increased the percentage of apoptotic cells in tumor sections. Conclusion: PET/CT with 18F-FLT may contribute to the selection of patients who may benefit from treatment with reversible and irreversible EGFR TKIs and may provide clues about which patients with NSCLC may be candidates for combination treatment with erlotinib and Bcl-x L inhibitors. Copyright © 2012 by the Society of Nuclear Medicine, Inc.
Epidermal growth factor receptor (EGFR) mutational status, activation of downstream signaling, and effective apoptotic cascade are all factors that may affect the tumor response to EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC). Here we test whether 3′-deoxy-3′- 18F-fluorothymidine ( 18F-FLT) PET/CT can provide clues for the selection of patients with NSCLC as candidates for treatment with reversible and irreversible EGFR TKIs or combination treatment with Bcl-x L inhibitors. Methods: HCC827, H1975, and H1650 NSCLC cells were subcutaneously injected into flanks of nude mice. Tumor-bearing animals were treated daily for 3 d by oral gavage with erlotinib at 50 and 150 mg/kg, CL-387,785 (an irreversible EGFR TKI) at 50 mg/kg, WZ4002 (a more potent irreversible EGFR TKI) at 25 and 50 mg/kg, ABT-263 (a Bcl-x Linhibitor) at 6.25 mg/kg, and a combination of erlotinib (50 mg/kg) and ABT-263 (6.25 mg/kg). Imaging studies were performed before and after 3 d of treatment by intravenous injection of 7.4 MBq of 18F-FLT and small-animal PET/CT of animals at 1 h after injection. Quantitative analysis of reconstructed images of baseline and posttreatment scans was performed, and the percentage change in 18F-FLT uptake in each animal was determined. Tumor sections were tested for Ki67 immunostaining and the percentage of apoptotic cells. Results: Sensitive tumors (HCC827) showed mean decreases in 18F-FLT uptake of 45% and 28% with high- and low-dose regimens of erlotinib, respectively. Resistant NSCLC cells bearing a T790M mutation (H1975) showed mean increases in 18F-FLT uptake of 27% and 33% with high and low doses of erlotinib, respectively. Treatment with CL-387,785, low-dose WZ4002, and high-dose WZ4002 caused mean decreases in tracer uptake of 21%, 26%, and 36%, respectively. NSCLC cells that were resistant because of dysregulation of Bcl-2 family members (H1650) showed mean reductions in 18F-FLT uptake of 49% and 23% with high and low doses of erlotinib, respectively, whereas the addition of ABT-263 did not affect tracer uptake but significantly increased the percentage of apoptotic cells in tumor sections. Conclusion: PET/CT with 18F-FLT may contribute to the selection of patients who may benefit from treatment with reversible and irreversible EGFR TKIs and may provide clues about which patients with NSCLC may be candidates for combination treatment with erlotinib and Bcl-x L inhibitors. Copyright © 2012 by the Society of Nuclear Medicine, Inc.
3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer
| ▼ Translational Molecular Imaging in Cancer |
| ▼ Molecular imaging for personalized therapy in oncology |
3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer
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Gridelli C, Manzione L, Perrone F, Veltri E, Cioffi R, Caprio MG, Frontini L, Rossi A, Barletta E, Barzelloni ML, Bilancia D, Gallo C
* Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study (514 views) (PDF 264 views)
Br J Cancer (ISSN: 0007-0920print, 0007-0920linking), 2001 Jan 5; 84(1): 38-41.
Impact Factor: 3.942
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Wang H, Maurea S, Mainolfi C, Fiore F, Gravina A, Panico M, Bazzicalupo L, Salvatore M
Tc-99m MIBI scintigraphy in patients with lung cancer comparison with CT and fluorine-18 FDG PET imaging (609 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1997 Apr; 22(4): 243-249.
Impact Factor: 0.34
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Cappabianca S, Sirignano C, Cangiano G L, Iula G F, Sandomenico F, Schilliro' F, Del Vecchio W
Vascular Infiltration From Lung Cancer: Evaluation With Turbo-Flash Sequence (391 views)
European Radiology, 1997; nd: nd-nd.
Impact Factor: 0
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Wang H, Maurea S, Mainolfi C, Fiore F, Panico M, Alfano B, Gravina A, Bazzicalupo L, Salvatore M
Tc-99m MIBI imaging in patients with lung cancer: Comparison with CT and fluorine-18 FDG PET studies (467 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 May; 37(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (476 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (626 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Alfano B, Coucourde F, Malgieri F, Ragozzino A
PET/CT and radiotherapy (3223 views)
Q J Nucl Med Mol Imaging, 1980 Oct; 50(1): 4-14.
Impact Factor: 0
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* ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors (309 views)
Cancer Metab (ISSN: 2049-3002linking), 2023 Nov 6; 11(1): 20-20.
Impact Factor: 5.9
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Monti S, Xu T, Liao Z, Mohan R, Cella L, Palma G
* On the interplay between dosiomics and genomics in radiation-induced lymphopenia of lung cancer patients (180 views)
Radiother Oncol (ISSN: 0167-8140linking, 1879-0887), 2022 Feb; 167: 219-225.
Impact Factor: 6.28
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Cella L, Monti S, Thor M, Rimner A, Deasy JO, Palma G
* Radiation-Induced Dyspnea in Lung Cancer Patients Treated with Stereotactic Body Radiation Therapy (297 views)
Cancers (ISSN: 2072-6694linking), 2021 Jul 25; 13(15): N/D-N/D.
Impact Factor: 6.126
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Cella L, Monti S, Xu T, Liuzzi R, Stanzione A, Durante M, Mohan R, Liao Z, Palma G
* Probing thoracic dose patterns associated to pericardial effusion and mortality in patients treated with photons and protons for locally advanced non-small-cell lung cancer (334 views)
Radiother Oncol (ISSN: 0167-8140linking, 1879-0887), 2021 May 9; 160: 148-158.
Impact Factor: 4.856
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Iommelli F, De Rosa V, Terlizzi C, Fonti R, Camerlingo R, Stoppelli MP, Stewart CA, Byers LA, Piwnica-worms D, Del Vecchio S
* A Reversible Shift of Driver Dependence from EGFR to Notch1 in Non-Small Cell Lung Cancer as a Cause of Resistance to Tyrosine Kinase Inhibitors (443 views)
Cancers (ISSN: 2072-6694linking), 2021 Apr 22; 13(9): N/D-N/D.
Impact Factor: 6.126
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De Rosa V, Fonti R, Del Vecchio S, Iommelli F
* Non-invasive detection of epithelial mesenchymal transition phenotype and metastatic dissemination of lung cancer by liquid biopsy (357 views) (PDF 71 views)
Exploration Of Targeted Anti-Tumor Therapy, 2021 Mar; N/D: 36-47.
Impact Factor: 0
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Pellegrino S, Fonti R, Pulcrano A, Del Vecchio S
* PET-Based Volumetric Biomarkers for Risk Stratification of Non-Small Cell Lung Cancer Patients (168 views)
Diagnostics (ISSN: 2075-4418linking, 2075-4418electronic), 2021 Jan 30; 11(2): N/D-N/D.
Impact Factor: 3.706
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Pellegrino S, Fonti R, Mazziotti E, Piccin L, Mozzillo E, Damiano V, Matano E, De Placido S, Del Vecchio S
* Total metabolic tumor volume by 18F-FDG PET/CT for the prediction of outcome in patients with non-small cell lung cancer (326 views)
Ann Nucl Med (ISSN: 0914-7187linking, 1864-6433), 2019 Dec; 33(12): 937-944.
Impact Factor: 1.41
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Palma G, Monti S, Xu T, Scifoni E, Yang P, Hahn SM, Durante M, Mohan R, Liao Z, Cella L
* Spatial Dose Patterns Associated With Radiation Pneumonitis in a Randomized Trial Comparing Intensity-Modulated Photon Therapy With Passive Scattering Proton Therapy for Locally Advanced Non-Small Cell Lung Cancer (579 views)
Int J Radiat Oncol (ISSN: 0360-3016linking, 1879-355x), 2019 Aug 1; 104(5): 1124-1132.
Impact Factor: 5.859
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Palma G, Monti S, Thor M, Rimner A, Deasy JO, Cella L
* Spatial signature of dose patterns associated with acute radiation-induced lung damage in lung cancer patients treated with Stereotactic Body Radiation Therapy (406 views)
Phys Med Biol (ISSN: 0031-9155linking), 2019 Jul 1; N/D: N/D-N/D.
Impact Factor: 3.1
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Iommelli F, De Rosa V, Terlizzi C, Monti M, Panico M, Fonti R, Del Vecchio S
* Inositol Trisphosphate Receptor Type 3-mediated Enhancement of EGFR and MET Cotargeting Efficacy in Non-Small Cell Lung Cancer Detected by (18)F-fluorothymidine (785 views)
Clin Cancer Res (ISSN: 1078-0432print, 1078-0432linking), 2018 Jul 1; 24(13): 3126-3136.
Impact Factor: 10.199
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Ciarmiello A, Fonti R, Giovacchini G, Del Vecchio S
* Imaging of immunotherapy response in non-small cell lung cancer: challenges and perspectives (355 views)
Clinical And Translational Imaging, 2018; N/D: N/D-N/D.
Impact Factor: 0
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De Rosa V, Iommelli F, Monti M, Mainolfi CG, Fonti R, Del Vecchio S
* Early 18F-FDG uptake as a reliable imaging biomarker of T790M-mediated resistance but not MET amplification in non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors (612 views)
Ejnmmi Res, 2016 Dec; 6(1): 74-74.
Impact Factor: 1.761
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Nappi A, Gallicchio R, Simeon V, Nardelli A, Pelagalli A, Zupa A, Vita G, Venetucci A, Di Cosola M, Barbato F, Storto G
* [F-18] FDG-PET/CT parameters as predictors of outcome in inoperable NSCLC patients (511 views)
Radiol Oncol (ISSN: 1318-2099), 2015 Nov 27; 49(4): 320-326.
Impact Factor: 1.736
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De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (874 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2015 Nov 15; 21(22): 5110-5120.
Impact Factor: 8.738
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Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
* New therapeutic perspectives in CCDC6 deficient lung cancer cells (847 views)
Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
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De Rosa V, Iommelli F, Monti M, Fonti R, Del Vecchio S
* Early reduction of 18F-FDG uptake in non-small lung cancer treated with EGFR tyrosine kinase inhibitors reflects reversal of Warburg effect and reactivation of oxidative phosphorylation (484 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2014 Oct; 41: N/D-N/D.
Impact Factor: 5.383
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Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Gramanzini M, Fonti R, Del Vecchio S
* Monitoring Reversal of Concurrent Mechanisms of Resistance to EGFR TKIs in Non-Small Cell Lung Cancer by 18F-FLT PET/CT (490 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2014 Oct; 41: N/D-N/D.
Impact Factor: 5.383
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Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (859 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
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Gallicchio R, Giacomobono S, Nardelli A, Pellegrino T, Simeon V, Gattozzi D, Maddalena F, Mainenti PP, Storto G
* Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain (860 views)
J Bone Miner Metab (ISSN: 0914-8779), 2014 Jul; 32(4): 434-440.
Impact Factor: 2.46
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Nguyen XC, Nguyen VK, Tran MT, Maurea S, Salvatore M
* Prognostic Value of Fluoro-D-glucose Uptake of Primary Tumor and Metastatic Lesions in Advanced Nonsmall Cell Lung Cancer (450 views)
World Journal Of Nuclear Medicine (ISSN: 1450-1147), 2014 May; 13(2): 112-119.
Impact Factor: 5.563
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Pedicini P, Strigari L, Benassi M, Caivano R, Fiorentino A, Nappi A, Salvatore M, Storto G
* Critical dose and toxicity index of organs at risk in radiotherapy: analyzing the calculated effects of modified dose fractionation in non-small cell lung cancer (1406 views)
Med Dosim (ISSN: 0958-3947, 1873-4022), 2014 Mar; 39(1): 23-30.
Impact Factor: 0.76
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Iommelli F, De Rosa V, Fonti R, Del Vecchio S
* Molecular Imaging For Detection Of Sensitivity And Resistance To Egfr Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer (497 views)
Clin Transl Imaging (ISSN: 2281-5872print, 2281-7565online), 2014 Feb 20; 2(1): 43-53.
Impact Factor: 0
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Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Ortosecco G, Greco A, Gramanzini M, Fonti R, Brunetti A, Del Vecchio S
* 18F-FLT PET/CT for Detection of Functional Cross-talk between MET and EGFR in Non-small Cell Lung Cancer Resistant to EGFR Inhibitors (639 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
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De Rosa V, Iommelli F, Votta G, Monti M, Ortosecco G, Fonti R, Mainolfi C, Stoppelli M, Del Vecchio S
* Changes of Glycolytic Pathway in Response to Efficient Inhibition of EGFR Signaling in Non-small Cell Lung Cancer (NSCLC) (402 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Oct; 40: N/D-N/D.
Impact Factor: 5.217
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Bera S, De Rosa V, Rachidi W, Diamond AM
* Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? (1357 views)
Mutagenesismutagenesis (ISSN: 0267-8357, 1464-3804electronic, 0267-8357linking), 2013 Mar; 28(2): 127-134.
Impact Factor: 3.497
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Cella L, Conson M, Pressello MC, Molinelli S, Schneider U, Donato V, Orecchia R, Salvatore M, Pacelli R
* Hodgkin's lymphoma emerging radiation treatment techniques: Trade-offs between late radio-induced toxicities and secondary malignant neoplasms (683 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2013 Jan 30; 8(1): 22-22.
Impact Factor: 2.36
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Zannetti A, Iommelli F, De Rosa V, Nardelli A, Ortosecco G, Del Vecchio S
* Combined Imaging with 18F-FLT PET/CT and 99m-Tc-Hynic-Annexin V SPECT for Personalized Therapy with EGFR Antagonists and Bcl-xL Inhibitors in Non-Small Cell Lung Cancer (659 views)
European Journal Of Cancer (ISSN: 0959-8049), 2012 Nov; 48: N/D-N/D.
Impact Factor: 5.061
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Zannetti A, Iommelli F, De Rosa V, Salvatore M, Del Vecchio S
* Small animal SPECT with 99m-Tc-Hynic-annexin V for detection of non-small cell lung cancer resistance to EGFR antagonists and its reversal by Bcl-xL inhibitors (626 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Oct; 39: N/D-N/D.
Impact Factor: 5.114
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Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer (967 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Mar 1; 53(3): 443-450.
Impact Factor: 5.774
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Zeppa P, Barra E, Napolitano V, Cozzolino I, Troncone G, Picardi M, De Renzo A, Mainenti PP, Vetrani A, Palombini L
* Impact of Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) in Lymph Nodal and Mediastinal Lesions: A Multicenter Experience (864 views)
Diagnostic Cytopathology (ISSN: 8755-1039), 2011 Oct; 39(10): 723-729.
Impact Factor: 1.16
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Storto G, Di Giorgio E, De Renzo A, Pizzuti LM, Cerciello G, Nardelli A, Capacchione D, Castaldi E, Ortosecco G, Pace L
* Assessment of metabolic activity by PET-CT with F-18-FDG in patients with T-cell lymphoma (1029 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2010 Oct; 151(2): 195-197.
Impact Factor: 4.942
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (1006 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (757 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Imaging of lung cancer resistance to EGFR tyrosine kinase inhibitors through Bcl-2/Bcl-x(L) modulation of inositol trisphosphate receptor type (653 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (979 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Imaging Of Lung Cancer Resistance To Egfr Tyrosine Kinase Inhibitors Trough Bcl-2/Bcl-Xl Modulation Of Inositol Trisphosphate Receptor Type (590 views)
Eur J Nucl Med, 2008; suppl2: N/D-N/D.
Impact Factor: 5.563
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (798 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (1064 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari R
* Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter (839 views)
Oncology Research (ISSN: 0965-0407), 2005; 15(7-8): 373-383.
Impact Factor: 1.844
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (680 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Del Vecchio S, Zannetti A, Aloj L, Salvatore M
* MIBI as prognostic factor in breast cancer (767 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2003 Mar; 47(1): 46-50.
Impact Factor: 2.222
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Gridelli C, Manzione L, Perrone F, Veltri E, Cioffi R, Caprio MG, Frontini L, Rossi A, Barletta E, Barzelloni ML, Bilancia D, Gallo C
* Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study (514 views) (PDF 264 views)
Br J Cancer (ISSN: 0007-0920print, 0007-0920linking), 2001 Jan 5; 84(1): 38-41.
Impact Factor: 3.942
View Export to BibTeX Export to EndNote
Wang H, Maurea S, Mainolfi C, Fiore F, Gravina A, Panico M, Bazzicalupo L, Salvatore M
Tc-99m MIBI scintigraphy in patients with lung cancer comparison with CT and fluorine-18 FDG PET imaging (609 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1997 Apr; 22(4): 243-249.
Impact Factor: 0.34
View Export to BibTeX Export to EndNote
Cappabianca S, Sirignano C, Cangiano G L, Iula G F, Sandomenico F, Schilliro' F, Del Vecchio W
Vascular Infiltration From Lung Cancer: Evaluation With Turbo-Flash Sequence (391 views)
European Radiology, 1997; nd: nd-nd.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Wang H, Maurea S, Mainolfi C, Fiore F, Panico M, Alfano B, Gravina A, Bazzicalupo L, Salvatore M
Tc-99m MIBI imaging in patients with lung cancer: Comparison with CT and fluorine-18 FDG PET studies (467 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 May; 37(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
View Export to BibTeX Export to EndNote
Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (476 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
View Export to BibTeX Export to EndNote
DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (626 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
View Export to BibTeX Export to EndNote
Alfano B, Coucourde F, Malgieri F, Ragozzino A
PET/CT and radiotherapy (3223 views)
Q J Nucl Med Mol Imaging, 1980 Oct; 50(1): 4-14.
Impact Factor: 0
View Export to BibTeX Export to EndNote
49 Records (38 excluding Abstracts).
Total impact factor: 185.575 (137.922 excluding Abstracts).
Total 5 year impact factor: 168.207 (118.435 excluding Abstracts).
Total impact factor: 185.575 (137.922 excluding Abstracts).
Total 5 year impact factor: 168.207 (118.435 excluding Abstracts).
1025 views. Last view on Friday 21 March 2025, 23:44:56
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