Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (401 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.891, 5-year impact factor: 3.959
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857321015&partnerID=40&md5=3fc429396bfbe636c1a7ac63e7aa70a3
Keywords: Antiinflammatory Agent, Apolipoprotein A1, Cholesterol Ester, Haptoglobin, High Density Lipoprotein Cholesterol, Isoenzyme, Nitric Oxide Synthase, Peptide P2a, Prostaglandin E2, Prostaglandin Synthase, Unclassified Drug, Animal Experiment, Animal Model, Antiinflammatory Activity, Article, Cholesterol Blood Level, Cholesterol Esterification, Controlled Study, Drug Effect, Drug Mechanism, Enzyme Linked Immunosorbent Assay, High Performance Liquid Chromatography, In Vivo Study, Mouse, Nonhuman, Paw Edema, Priority Journal, Protein Binding, Protein Blood Level, Protein Expression, Protein Function, Western Blotting, Amino Acid Sequence, Anti-Inflammatory Agents, Cyclooxygenase 2, Dinoprostone, Dose-Response Relationship, Molecular Sequence Data, Phosphatidylcholine-Sterol O-Acyltransferase,
Affiliations:
*** IBB - CNR ***
Department of Experimental Pharmacology, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.
Department of Biological Sciences, University of Naples Federico II, Naples, Italy
Biostructures and Bioimaging Institute, Consiglio Nazionale Delle Ricerche, Naples, Italy
References:
Braeckman, L., De Bacquer, D., Delanghe, J., Claeys, L., De Backer, G., Associations between haptoglobin polymorphism, lipids, lipoproteins and inflammatory variables (1999) Atherosclerosis, 143 (2), pp. 383-388. , DOI 10.1016/S0021-9150(98)00330-X, PII S002191509800330
Buga, G.M., Frank, J.S., Mottino, G.A., Hendizadeh, M., Hakhamian, A., Tillisch, J.H., Reddy, S.T., Fogelman, A.M., D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet (2006) Journal of Lipid Research, 47 (10), pp. 2148-2160. , http://www.jlr.org/cgi/reprint/47/10/2148, DOI 10.1194/jlr.M600214-JLR200
Burstein, M., Scholnick, H.R., Morfin, R., Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions (1970) J Lipid Res, 11, pp. 583-595
Cabana, V.G., Lukens, J.R., Rice, K.S., Hawkins, T.J., Getz, G.S., HDL content and composition in acute phase response in three species: Triglyceride enrichment of HDL a factor in its decrease (1996) J Lipid Res, 37, pp. 2662-2674
Cigliano, L., Pugliese, C.R., Spagnuolo, M.S., Palumbo, R., Abrescia, P., Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (2009) FEBS J, 276, pp. 6158-6171
Cigliano, L., Spagnuolo, M.S., Cuomo, G., Valentini, G., Niglio, A., Abrescia, P., Apolipoprotein A-I-dependent cholesterol esterification in patients with rheumatoid arthritis (2005) Life Sciences, 77 (1), pp. 108-120. , DOI 10.1016/j.lfs.2004.12.023
Coetzee, G.A., Strachan, A.F., Van Der, W.D.R., Serum amyloid A-containing human high density lipoprotein 3. Density, size, and apolipoprotein composition (1986) Journal of Biological Chemistry, 261 (21), pp. 9644-9651
De Bacquer, D., De Backer, G., Langlois, M., Delanghe, J., Kesteloot, H., Kornitzer, M., Haptoglobin polymorphism as a risk factor for coronary heart disease mortality (2001) Atherosclerosis, 157 (1), pp. 161-166. , DOI 10.1016/S0021-9150(00)00690-0, PII S0021915000006900
Degoma, E.M., Rader, D.J., Novel HDL-directed pharmacotherapeutic strategies (2011) Nat Rev Cardiol, 8, pp. 266-277
Delanghe, J., Cambier, B., Langlois, M., De Buyzere, M., Neels, H., De Bacquer, D., Van Cauwelaert, P., Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery (1997) Atherosclerosis, 132 (2), pp. 215-219. , DOI 10.1016/S0021-9150(97)00089-0, PII S0021915097000890
Esteve, E., Ricart, W., Fernández-Real, J.M., Dyslipidemia and inflammation: An evolutionary conserved mechanism (2005) Clin Nutr, 24, pp. 16-31
Furbee Jr., J.W., Francone, O., Parks, J.S., Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT (2001) Journal of Lipid Research, 42 (10), pp. 1626-1635
Gomaraschi, M., Calabresi, L., Rossoni, G., Iametti, S., Franceschini, G., Stonik, J.A., Remaley, A.T., Anti-inflammatory and cardioprotective activities of synthetic high-density lipoprotein containing apolipoprotein A-I mimetic peptides (2008) Journal of Pharmacology and Experimental Therapeutics, 324 (2), pp. 776-783. , http://jpet.aspetjournals.org/cgi/reprint/324/2/776, DOI 10.1124/jpet.107.129411
Khovidhunkit, W., Kim, M.-S., Memon, R.A., Shigenaga, J.K., Moser, A.H., Feingold, K.R., Grunfeld, C., Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host (2004) Journal of Lipid Research, 45 (7), pp. 1169-1196. , DOI 10.1194/jlr.R300019-JLR200
Kontush, A., Chapman, M.J., Functionally defective high-density lipoprotein: A new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis (2006) Pharmacological Reviews, 58 (3), pp. 342-374. , http://pharmrev.aspetjournals.org/cgi/reprint/58/3/342, DOI 10.1124/pr.58.3.1
Kruger, A.L., Peterson, S., Turkseven, S., Kaminski, P.M., Zhang, F.F., Quan, S., Wolin, M.S., Abraham, N.G., D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes (2005) Circulation, 111 (23), pp. 3126-3134. , DOI 10.1161/CIRCULATIONAHA.104.517102
Langlois, M.R., Delanghe, J.R., Biological and clinical significance of haptoglobin polymorphism in humans (1996) Clinical Chemistry, 42 (10), pp. 1589-1600
Lewis, K.E., Kirk, E.A., McDonald, T.O., Wang, S., Wight, T.N., O'Brien, K.D., Chait, A., Increase in serum amyloid A evoked by dietary cholesterol is associated with increased atherosclerosis in mice (2004) Circulation, 110 (5), pp. 540-545. , DOI 10.1161/01.CIR.0000136819.93989.E1
Libby, P., Inflammatory mechanisms: The molecular basis of inflammation and disease (2007) Nutr Rev, 65, pp. S140-S146
Matuszek, M.A., Aristoteli, L.P., Bannon, P.G., Hendel, P.N., Hughes, C.F., Jessup, W., Dean, R.T., Kritharides, L., Haptoglobin elutes from human atherosclerotic coronary arteries - A potential marker of arterial pathology (2003) Atherosclerosis, 168 (2), pp. 389-396. , DOI 10.1016/S0021-9150(03)00150-3
Navab, M., Anantharamaiah, G.M., Reddy, S.T., Hama, S., Hough, G., Frank, J.S., Grijalva, V.R., Fogelman, A.M., Oral small peptides render HDL antiinflammatory in mice and monkeys and reduce atherosclerosis in ApoE null mice (2005) Circulation Research, 97 (6), pp. 524-532. , DOI 10.1161/01.RES.0000181229.69508.2f
O'Brien, K.D., McDonald, T.O., Kunjathoor, V., Eng, K., Knopp, E.A., Lewis, K., Lopez, R., LeBoeuf, R.C., Serum amyloid A and lipoprotein retention in murine models of atherosclerosis (2005) Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (4), pp. 785-790. , DOI 10.1161/01.ATV.0000158383.65277.2b
Parks, J.S., Rudel, L.L., Alteration of high density lipoprotein subfraction distribution with induction of serum amyloid A protein (SAA) in the nonhuman primate (1985) Journal of Lipid Research, 26 (1), pp. 82-91
Peterson, S.J., Husney, D., Kruger, A.L., Olszanecki, R., Ricci, F., Rodella, L.F., Stacchiotti, A., Abraham, N.G., Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats (2007) Journal of Pharmacology and Experimental Therapeutics, 322 (2), pp. 514-520. , http://jpet.aspetjournals.org/cgi/reprint/322/2/514, DOI 10.1124/jpet.107.119479
Porta, A., Cassano, E., Balestrieri, M., Bianco, M., Picone, R., De Stefano, C., Abrescia, P., Haptoglobin transport into human ovarian follicles and its binding to apolipoprotein A-1 (1999) Zygote, 7 (1), pp. 67-77
Posadas, I., Bucci, M., Roviezzo, F., Rossi, A., Parente, L., Sautebin, L., Cirino, G., Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression (2004) British Journal of Pharmacology, 142 (2), pp. 331-338. , DOI 10.1038/sj.bjp.0705650
Rader, D.J., Molecular regulation of HDL metabolism and function: Implications for novel therapies (2006) J Clin Invest, 116, pp. 3090-3100
Rader, D.J., Alexander, E.T., Weibel, G.L., Billheimer, J., Rothblat, G.H., The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis (2009) J Lipid Res, 50, pp. S189-S194
Rader, D.J., Daugherty, A., Translating molecular discoveries into new therapies for atherosclerosis (2008) Nature, 451 (7181), pp. 904-913. , DOI 10.1038/nature06796, PII NATURE06796
Salvatore, A., Cigliano, L., Bucci, E.M., Corpillo, D., Velasco, S., Carlucci, A., Pedone, C., Abrescia, P., Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (2007) Biochemistry, 46 (39), pp. 11158-11168. , DOI 10.1021/bi7006349
Sherman, C.B., Peterson, S.J., Frishman, W.H., Apolipoprotein A-I mimetic peptides: A potential new therapy for the prevention of atherosclerosis (2010) Cardiol Rev, 18, pp. 141-147
Spagnuolo, M.S., Cigliano, L., Abrescia, P., The binding of haptoglobin to apolipoprotein Al: Influence of hemoglobin and concanavalin A (2003) Biological Chemistry, 384 (12), pp. 1593-1596. , DOI 10.1515/BC.2003.176
Subbaiah, P.V., Liu, M., Witt, T.R., Impaired cholesterol esterification in the plasma in patients with breast cancer (1997) Lipids, 32 (2), pp. 157-162. , DOI 10.1007/s11745-997-0020-5
Thomsen, L.L., Ching, L.-M., Baguley, B.C., Evidence for the production of nitric oxide by activated macrophages treated withe the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid (1990) Cancer Research, 50 (21), pp. 6966-6970
Buga, G. M., Frank, J. S., Mottino, G. A., Hendizadeh, M., Hakhamian, A., Tillisch, J. H., Reddy, S. T., Fogelman, A. M., D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet (2006) Journal of Lipid Research, 47 (10), pp. 2148-2160. , http: //www. jlr. org/cgi/reprint/47/10/2148, DOI 10. 1194/jlr. M600214-JLR200
Cabana, V. G., Lukens, J. R., Rice, K. S., Hawkins, T. J., Getz, G. S., HDL content and composition in acute phase response in three species: Triglyceride enrichment of HDL a factor in its decrease (1996) J Lipid Res, 37, pp. 2662-2674
Coetzee, G. A., Strachan, A. F., Van Der, W. D. R., Serum amyloid A-containing human high density lipoprotein 3. Density, size, and apolipoprotein composition (1986) Journal of Biological Chemistry, 261 (21), pp. 9644-9651
Degoma, E. M., Rader, D. J., Novel HDL-directed pharmacotherapeutic strategies (2011) Nat Rev Cardiol, 8, pp. 266-277
Furbee Jr., J. W., Francone, O., Parks, J. S., Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT (2001) Journal of Lipid Research, 42 (10), pp. 1626-1635
Kruger, A. L., Peterson, S., Turkseven, S., Kaminski, P. M., Zhang, F. F., Quan, S., Wolin, M. S., Abraham, N. G., D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes (2005) Circulation, 111 (23), pp. 3126-3134. , DOI 10. 1161/CIRCULATIONAHA. 104. 517102
Langlois, M. R., Delanghe, J. R., Biological and clinical significance of haptoglobin polymorphism in humans (1996) Clinical Chemistry, 42 (10), pp. 1589-1600
Lewis, K. E., Kirk, E. A., McDonald, T. O., Wang, S., Wight, T. N., O'Brien, K. D., Chait, A., Increase in serum amyloid A evoked by dietary cholesterol is associated with increased atherosclerosis in mice (2004) Circulation, 110 (5), pp. 540-545. , DOI 10. 1161/01. CIR. 0000136819. 93989. E1
Matuszek, M. A., Aristoteli, L. P., Bannon, P. G., Hendel, P. N., Hughes, C. F., Jessup, W., Dean, R. T., Kritharides, L., Haptoglobin elutes from human atherosclerotic coronary arteries - A potential marker of arterial pathology (2003) Atherosclerosis, 168 (2), pp. 389-396. , DOI 10. 1016/S0021-9150 (03) 00150-3
O'Brien, K. D., McDonald, T. O., Kunjathoor, V., Eng, K., Knopp, E. A., Lewis, K., Lopez, R., LeBoeuf, R. C., Serum amyloid A and lipoprotein retention in murine models of atherosclerosis (2005) Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (4), pp. 785-790. , DOI 10. 1161/01. ATV. 0000158383. 65277. 2b
Parks, J. S., Rudel, L. L., Alteration of high density lipoprotein subfraction distribution with induction of serum amyloid A protein (SAA) in the nonhuman primate (1985) Journal of Lipid Research, 26 (1), pp. 82-91
Peterson, S. J., Husney, D., Kruger, A. L., Olszanecki, R., Ricci, F., Rodella, L. F., Stacchiotti, A., Abraham, N. G., Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats (2007) Journal of Pharmacology and Experimental Therapeutics, 322 (2), pp. 514-520. , http: //jpet. aspetjournals. org/cgi/reprint/322/2/514, DOI 10. 1124/jpet. 107. 119479
Rader, D. J., Molecular regulation of HDL metabolism and function: Implications for novel therapies (2006) J Clin Invest, 116, pp. 3090-3100
Rader, D. J., Alexander, E. T., Weibel, G. L., Billheimer, J., Rothblat, G. H., The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis (2009) J Lipid Res, 50, pp. S189-S194
Rader, D. J., Daugherty, A., Translating molecular discoveries into new therapies for atherosclerosis (2008) Nature, 451 (7181), pp. 904-913. , DOI 10. 1038/nature06796, PII NATURE06796
Sherman, C. B., Peterson, S. J., Frishman, W. H., Apolipoprotein A-I mimetic peptides: A potential new therapy for the prevention of atherosclerosis (2010) Cardiol Rev, 18, pp. 141-147
Spagnuolo, M. S., Cigliano, L., Abrescia, P., The binding of haptoglobin to apolipoprotein Al: Influence of hemoglobin and concanavalin A (2003) Biological Chemistry, 384 (12), pp. 1593-1596. , DOI 10. 1515/BC. 2003. 176
Subbaiah, P. V., Liu, M., Witt, T. R., Impaired cholesterol esterification in the plasma in patients with breast cancer (1997) Lipids, 32 (2), pp. 157-162. , DOI 10. 1007/s11745-997-0020-5
Thomsen, L. L., Ching, L. -M., Baguley, B. C., Evidence for the production of nitric oxide by activated macrophages treated withe the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid (1990) Cancer Research, 50 (21), pp. 6966-6970
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.891, 5-year impact factor: 3.959
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857321015&partnerID=40&md5=3fc429396bfbe636c1a7ac63e7aa70a3
Keywords: Antiinflammatory Agent, Apolipoprotein A1, Cholesterol Ester, Haptoglobin, High Density Lipoprotein Cholesterol, Isoenzyme, Nitric Oxide Synthase, Peptide P2a, Prostaglandin E2, Prostaglandin Synthase, Unclassified Drug, Animal Experiment, Animal Model, Antiinflammatory Activity, Article, Cholesterol Blood Level, Cholesterol Esterification, Controlled Study, Drug Effect, Drug Mechanism, Enzyme Linked Immunosorbent Assay, High Performance Liquid Chromatography, In Vivo Study, Mouse, Nonhuman, Paw Edema, Priority Journal, Protein Binding, Protein Blood Level, Protein Expression, Protein Function, Western Blotting, Amino Acid Sequence, Anti-Inflammatory Agents, Cyclooxygenase 2, Dinoprostone, Dose-Response Relationship, Molecular Sequence Data, Phosphatidylcholine-Sterol O-Acyltransferase,
Affiliations:
*** IBB - CNR ***
Department of Experimental Pharmacology, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.
Department of Biological Sciences, University of Naples Federico II, Naples, Italy
Biostructures and Bioimaging Institute, Consiglio Nazionale Delle Ricerche, Naples, Italy
References:
Braeckman, L., De Bacquer, D., Delanghe, J., Claeys, L., De Backer, G., Associations between haptoglobin polymorphism, lipids, lipoproteins and inflammatory variables (1999) Atherosclerosis, 143 (2), pp. 383-388. , DOI 10.1016/S0021-9150(98)00330-X, PII S002191509800330
Buga, G.M., Frank, J.S., Mottino, G.A., Hendizadeh, M., Hakhamian, A., Tillisch, J.H., Reddy, S.T., Fogelman, A.M., D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet (2006) Journal of Lipid Research, 47 (10), pp. 2148-2160. , http://www.jlr.org/cgi/reprint/47/10/2148, DOI 10.1194/jlr.M600214-JLR200
Burstein, M., Scholnick, H.R., Morfin, R., Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions (1970) J Lipid Res, 11, pp. 583-595
Cabana, V.G., Lukens, J.R., Rice, K.S., Hawkins, T.J., Getz, G.S., HDL content and composition in acute phase response in three species: Triglyceride enrichment of HDL a factor in its decrease (1996) J Lipid Res, 37, pp. 2662-2674
Cigliano, L., Pugliese, C.R., Spagnuolo, M.S., Palumbo, R., Abrescia, P., Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (2009) FEBS J, 276, pp. 6158-6171
Cigliano, L., Spagnuolo, M.S., Cuomo, G., Valentini, G., Niglio, A., Abrescia, P., Apolipoprotein A-I-dependent cholesterol esterification in patients with rheumatoid arthritis (2005) Life Sciences, 77 (1), pp. 108-120. , DOI 10.1016/j.lfs.2004.12.023
Coetzee, G.A., Strachan, A.F., Van Der, W.D.R., Serum amyloid A-containing human high density lipoprotein 3. Density, size, and apolipoprotein composition (1986) Journal of Biological Chemistry, 261 (21), pp. 9644-9651
De Bacquer, D., De Backer, G., Langlois, M., Delanghe, J., Kesteloot, H., Kornitzer, M., Haptoglobin polymorphism as a risk factor for coronary heart disease mortality (2001) Atherosclerosis, 157 (1), pp. 161-166. , DOI 10.1016/S0021-9150(00)00690-0, PII S0021915000006900
Degoma, E.M., Rader, D.J., Novel HDL-directed pharmacotherapeutic strategies (2011) Nat Rev Cardiol, 8, pp. 266-277
Delanghe, J., Cambier, B., Langlois, M., De Buyzere, M., Neels, H., De Bacquer, D., Van Cauwelaert, P., Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery (1997) Atherosclerosis, 132 (2), pp. 215-219. , DOI 10.1016/S0021-9150(97)00089-0, PII S0021915097000890
Esteve, E., Ricart, W., Fernández-Real, J.M., Dyslipidemia and inflammation: An evolutionary conserved mechanism (2005) Clin Nutr, 24, pp. 16-31
Furbee Jr., J.W., Francone, O., Parks, J.S., Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT (2001) Journal of Lipid Research, 42 (10), pp. 1626-1635
Gomaraschi, M., Calabresi, L., Rossoni, G., Iametti, S., Franceschini, G., Stonik, J.A., Remaley, A.T., Anti-inflammatory and cardioprotective activities of synthetic high-density lipoprotein containing apolipoprotein A-I mimetic peptides (2008) Journal of Pharmacology and Experimental Therapeutics, 324 (2), pp. 776-783. , http://jpet.aspetjournals.org/cgi/reprint/324/2/776, DOI 10.1124/jpet.107.129411
Khovidhunkit, W., Kim, M.-S., Memon, R.A., Shigenaga, J.K., Moser, A.H., Feingold, K.R., Grunfeld, C., Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host (2004) Journal of Lipid Research, 45 (7), pp. 1169-1196. , DOI 10.1194/jlr.R300019-JLR200
Kontush, A., Chapman, M.J., Functionally defective high-density lipoprotein: A new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis (2006) Pharmacological Reviews, 58 (3), pp. 342-374. , http://pharmrev.aspetjournals.org/cgi/reprint/58/3/342, DOI 10.1124/pr.58.3.1
Kruger, A.L., Peterson, S., Turkseven, S., Kaminski, P.M., Zhang, F.F., Quan, S., Wolin, M.S., Abraham, N.G., D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes (2005) Circulation, 111 (23), pp. 3126-3134. , DOI 10.1161/CIRCULATIONAHA.104.517102
Langlois, M.R., Delanghe, J.R., Biological and clinical significance of haptoglobin polymorphism in humans (1996) Clinical Chemistry, 42 (10), pp. 1589-1600
Lewis, K.E., Kirk, E.A., McDonald, T.O., Wang, S., Wight, T.N., O'Brien, K.D., Chait, A., Increase in serum amyloid A evoked by dietary cholesterol is associated with increased atherosclerosis in mice (2004) Circulation, 110 (5), pp. 540-545. , DOI 10.1161/01.CIR.0000136819.93989.E1
Libby, P., Inflammatory mechanisms: The molecular basis of inflammation and disease (2007) Nutr Rev, 65, pp. S140-S146
Matuszek, M.A., Aristoteli, L.P., Bannon, P.G., Hendel, P.N., Hughes, C.F., Jessup, W., Dean, R.T., Kritharides, L., Haptoglobin elutes from human atherosclerotic coronary arteries - A potential marker of arterial pathology (2003) Atherosclerosis, 168 (2), pp. 389-396. , DOI 10.1016/S0021-9150(03)00150-3
Navab, M., Anantharamaiah, G.M., Reddy, S.T., Hama, S., Hough, G., Frank, J.S., Grijalva, V.R., Fogelman, A.M., Oral small peptides render HDL antiinflammatory in mice and monkeys and reduce atherosclerosis in ApoE null mice (2005) Circulation Research, 97 (6), pp. 524-532. , DOI 10.1161/01.RES.0000181229.69508.2f
O'Brien, K.D., McDonald, T.O., Kunjathoor, V., Eng, K., Knopp, E.A., Lewis, K., Lopez, R., LeBoeuf, R.C., Serum amyloid A and lipoprotein retention in murine models of atherosclerosis (2005) Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (4), pp. 785-790. , DOI 10.1161/01.ATV.0000158383.65277.2b
Parks, J.S., Rudel, L.L., Alteration of high density lipoprotein subfraction distribution with induction of serum amyloid A protein (SAA) in the nonhuman primate (1985) Journal of Lipid Research, 26 (1), pp. 82-91
Peterson, S.J., Husney, D., Kruger, A.L., Olszanecki, R., Ricci, F., Rodella, L.F., Stacchiotti, A., Abraham, N.G., Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats (2007) Journal of Pharmacology and Experimental Therapeutics, 322 (2), pp. 514-520. , http://jpet.aspetjournals.org/cgi/reprint/322/2/514, DOI 10.1124/jpet.107.119479
Porta, A., Cassano, E., Balestrieri, M., Bianco, M., Picone, R., De Stefano, C., Abrescia, P., Haptoglobin transport into human ovarian follicles and its binding to apolipoprotein A-1 (1999) Zygote, 7 (1), pp. 67-77
Posadas, I., Bucci, M., Roviezzo, F., Rossi, A., Parente, L., Sautebin, L., Cirino, G., Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression (2004) British Journal of Pharmacology, 142 (2), pp. 331-338. , DOI 10.1038/sj.bjp.0705650
Rader, D.J., Molecular regulation of HDL metabolism and function: Implications for novel therapies (2006) J Clin Invest, 116, pp. 3090-3100
Rader, D.J., Alexander, E.T., Weibel, G.L., Billheimer, J., Rothblat, G.H., The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis (2009) J Lipid Res, 50, pp. S189-S194
Rader, D.J., Daugherty, A., Translating molecular discoveries into new therapies for atherosclerosis (2008) Nature, 451 (7181), pp. 904-913. , DOI 10.1038/nature06796, PII NATURE06796
Salvatore, A., Cigliano, L., Bucci, E.M., Corpillo, D., Velasco, S., Carlucci, A., Pedone, C., Abrescia, P., Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (2007) Biochemistry, 46 (39), pp. 11158-11168. , DOI 10.1021/bi7006349
Sherman, C.B., Peterson, S.J., Frishman, W.H., Apolipoprotein A-I mimetic peptides: A potential new therapy for the prevention of atherosclerosis (2010) Cardiol Rev, 18, pp. 141-147
Spagnuolo, M.S., Cigliano, L., Abrescia, P., The binding of haptoglobin to apolipoprotein Al: Influence of hemoglobin and concanavalin A (2003) Biological Chemistry, 384 (12), pp. 1593-1596. , DOI 10.1515/BC.2003.176
Subbaiah, P.V., Liu, M., Witt, T.R., Impaired cholesterol esterification in the plasma in patients with breast cancer (1997) Lipids, 32 (2), pp. 157-162. , DOI 10.1007/s11745-997-0020-5
Thomsen, L.L., Ching, L.-M., Baguley, B.C., Evidence for the production of nitric oxide by activated macrophages treated withe the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid (1990) Cancer Research, 50 (21), pp. 6966-6970
Buga, G. M., Frank, J. S., Mottino, G. A., Hendizadeh, M., Hakhamian, A., Tillisch, J. H., Reddy, S. T., Fogelman, A. M., D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet (2006) Journal of Lipid Research, 47 (10), pp. 2148-2160. , http: //www. jlr. org/cgi/reprint/47/10/2148, DOI 10. 1194/jlr. M600214-JLR200
Cabana, V. G., Lukens, J. R., Rice, K. S., Hawkins, T. J., Getz, G. S., HDL content and composition in acute phase response in three species: Triglyceride enrichment of HDL a factor in its decrease (1996) J Lipid Res, 37, pp. 2662-2674
Coetzee, G. A., Strachan, A. F., Van Der, W. D. R., Serum amyloid A-containing human high density lipoprotein 3. Density, size, and apolipoprotein composition (1986) Journal of Biological Chemistry, 261 (21), pp. 9644-9651
Degoma, E. M., Rader, D. J., Novel HDL-directed pharmacotherapeutic strategies (2011) Nat Rev Cardiol, 8, pp. 266-277
Furbee Jr., J. W., Francone, O., Parks, J. S., Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT (2001) Journal of Lipid Research, 42 (10), pp. 1626-1635
Kruger, A. L., Peterson, S., Turkseven, S., Kaminski, P. M., Zhang, F. F., Quan, S., Wolin, M. S., Abraham, N. G., D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes (2005) Circulation, 111 (23), pp. 3126-3134. , DOI 10. 1161/CIRCULATIONAHA. 104. 517102
Langlois, M. R., Delanghe, J. R., Biological and clinical significance of haptoglobin polymorphism in humans (1996) Clinical Chemistry, 42 (10), pp. 1589-1600
Lewis, K. E., Kirk, E. A., McDonald, T. O., Wang, S., Wight, T. N., O'Brien, K. D., Chait, A., Increase in serum amyloid A evoked by dietary cholesterol is associated with increased atherosclerosis in mice (2004) Circulation, 110 (5), pp. 540-545. , DOI 10. 1161/01. CIR. 0000136819. 93989. E1
Matuszek, M. A., Aristoteli, L. P., Bannon, P. G., Hendel, P. N., Hughes, C. F., Jessup, W., Dean, R. T., Kritharides, L., Haptoglobin elutes from human atherosclerotic coronary arteries - A potential marker of arterial pathology (2003) Atherosclerosis, 168 (2), pp. 389-396. , DOI 10. 1016/S0021-9150 (03) 00150-3
O'Brien, K. D., McDonald, T. O., Kunjathoor, V., Eng, K., Knopp, E. A., Lewis, K., Lopez, R., LeBoeuf, R. C., Serum amyloid A and lipoprotein retention in murine models of atherosclerosis (2005) Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (4), pp. 785-790. , DOI 10. 1161/01. ATV. 0000158383. 65277. 2b
Parks, J. S., Rudel, L. L., Alteration of high density lipoprotein subfraction distribution with induction of serum amyloid A protein (SAA) in the nonhuman primate (1985) Journal of Lipid Research, 26 (1), pp. 82-91
Peterson, S. J., Husney, D., Kruger, A. L., Olszanecki, R., Ricci, F., Rodella, L. F., Stacchiotti, A., Abraham, N. G., Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats (2007) Journal of Pharmacology and Experimental Therapeutics, 322 (2), pp. 514-520. , http: //jpet. aspetjournals. org/cgi/reprint/322/2/514, DOI 10. 1124/jpet. 107. 119479
Rader, D. J., Molecular regulation of HDL metabolism and function: Implications for novel therapies (2006) J Clin Invest, 116, pp. 3090-3100
Rader, D. J., Alexander, E. T., Weibel, G. L., Billheimer, J., Rothblat, G. H., The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis (2009) J Lipid Res, 50, pp. S189-S194
Rader, D. J., Daugherty, A., Translating molecular discoveries into new therapies for atherosclerosis (2008) Nature, 451 (7181), pp. 904-913. , DOI 10. 1038/nature06796, PII NATURE06796
Sherman, C. B., Peterson, S. J., Frishman, W. H., Apolipoprotein A-I mimetic peptides: A potential new therapy for the prevention of atherosclerosis (2010) Cardiol Rev, 18, pp. 141-147
Spagnuolo, M. S., Cigliano, L., Abrescia, P., The binding of haptoglobin to apolipoprotein Al: Influence of hemoglobin and concanavalin A (2003) Biological Chemistry, 384 (12), pp. 1593-1596. , DOI 10. 1515/BC. 2003. 176
Subbaiah, P. V., Liu, M., Witt, T. R., Impaired cholesterol esterification in the plasma in patients with breast cancer (1997) Lipids, 32 (2), pp. 157-162. , DOI 10. 1007/s11745-997-0020-5
Thomsen, L. L., Ching, L. -M., Baguley, B. C., Evidence for the production of nitric oxide by activated macrophages treated withe the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid (1990) Cancer Research, 50 (21), pp. 6966-6970
Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo
The acute-phase protein haptoglobin (Hpt) binds apolipoprotein A-I (ApoA-I) and impairs its action on lecithin-cholesterol acyltransferase, an enzyme that plays a key role in reverse cholesterol transport. We have previously shown that an ApoA-I mimetic peptide, P2a, displaces Hpt from ApoA-I, restoring the enzyme activity in vitro. The aim of this study was to evaluate whether P2a displaces Hpt from ApoA-I in vivo and whether this event leads to anti-inflammatory activity. Mice received subplantar injections of carrageenan. Paw volume was measured before the injection and 2, 4, 6, 24, 48, 72, and 96 h thereafter. At the same time points, concentrations of HDL cholesterol (C) and cholesterol esters (CEs) were measured by high-performance liquid chromatography, and Hpt and ApoA-I plasma levels were evaluated by enzyme-linked immunosorbent assay. Western blotting analysis for nitric-oxide synthase and cyclooxygenase (COX) isoforms was also performed on paw homogenates. CEs significantly decreased in carrageenan-treated mice during edema development and negatively correlated with the Hpt/ApoA-I ratio. P2a administration significantly restored the CE/C ratio. In addition, P2a displayed an anti-inflammatory effect on the late phase of edema with a significant reduction in COX2 expression coupled to an inhibition of prostaglandin E2 synthesis, implying that, in the presence of P2a, CE/C ratio rescue and edema inhibition were strictly related. In conclusion, the P2a effect is due to its binding to Hpt with consequent displacement of ApoA-I that exerts anti-inflammatory activity. Therefore, it is feasible to design drugs that, by enhancing the physiological endogenous protective role of ApoA-I, may be useful in inflammation-based diseases. Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics.
The acute-phase protein haptoglobin (Hpt) binds apolipoprotein A-I (ApoA-I) and impairs its action on lecithin-cholesterol acyltransferase, an enzyme that plays a key role in reverse cholesterol transport. We have previously shown that an ApoA-I mimetic peptide, P2a, displaces Hpt from ApoA-I, restoring the enzyme activity in vitro. The aim of this study was to evaluate whether P2a displaces Hpt from ApoA-I in vivo and whether this event leads to anti-inflammatory activity. Mice received subplantar injections of carrageenan. Paw volume was measured before the injection and 2, 4, 6, 24, 48, 72, and 96 h thereafter. At the same time points, concentrations of HDL cholesterol (C) and cholesterol esters (CEs) were measured by high-performance liquid chromatography, and Hpt and ApoA-I plasma levels were evaluated by enzyme-linked immunosorbent assay. Western blotting analysis for nitric-oxide synthase and cyclooxygenase (COX) isoforms was also performed on paw homogenates. CEs significantly decreased in carrageenan-treated mice during edema development and negatively correlated with the Hpt/ApoA-I ratio. P2a administration significantly restored the CE/C ratio. In addition, P2a displayed an anti-inflammatory effect on the late phase of edema with a significant reduction in COX2 expression coupled to an inhibition of prostaglandin E2 synthesis, implying that, in the presence of P2a, CE/C ratio rescue and edema inhibition were strictly related. In conclusion, the P2a effect is due to its binding to Hpt with consequent displacement of ApoA-I that exerts anti-inflammatory activity. Therefore, it is feasible to design drugs that, by enhancing the physiological endogenous protective role of ApoA-I, may be useful in inflammation-based diseases. Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics.
Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo
No results. |
Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo
Other filter: ([btitle,keywords] "Antiinflammatory Age ...
Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (532 views)
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
View Export to BibTeX Export to EndNote
Gallicchio R, Giacomobono S, Nardelli A, Pellegrino T, Simeon V, Gattozzi D, Maddalena F, Mainenti PP, Storto G
* Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain (395 views)
J Bone Miner Metab (ISSN: 0914-8779), 2014 Jul; 32(4): 434-440.
Impact Factor: 2.46
View Export to BibTeX Export to EndNote
Cigliano L, De Rosa L, Diana D, Di Stasi R, Spagnuolo MS, Maresca B, Fattorusso R, D'Andrea LD
* Structure and biological activity of a conformational constrained apolipoprotein A-I-derived helical peptide targeting the protein haptoglobin (401 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(93): 51353-51361.
Impact Factor: 3.84
View Export to BibTeX Export to EndNote
Vitale M, Luongo D, Naviglio D, Bozzetto L, Mirabella M, Rivieccio AM, Giacco A, Rivellese AA
* Trans fatty acids consumption in type 1 diabetic patients: evaluation by dietary records and measurement in serum phospholipids (388 views)
Acta Diabetol (ISSN: 0940-5429, 1432-5233electronic), 2013 Aug; 50(4): 651-654.
Impact Factor: 3.679
View Export to BibTeX Export to EndNote
Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
* Impact of F-18-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (346 views) (PDF 10 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897, 0969-8051linking), 2013 May; 40(4): 518-523.
Impact Factor: 2.408
View Export to BibTeX Export to EndNote
Spagnuolo MS, Di Stasi R, De Rosa L, Maresca B, Cigliano L, D'Andrea LD
* Analysis of the haptoglobin binding region on the apolipoprotein A-I-derived P2a peptide (376 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 220-226.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
View Export to BibTeX Export to EndNote
Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (377 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
View Export to BibTeX Export to EndNote
Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (579 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Lanzillo R, Orefice G, Quarantelli M, Rinaldi C, Prinster A, Ventrella G, Spitaleri D, Lus G, Vacca G, Carotenuto B, Salvatore E, Brunetti A, Tedeschi G, Brescia Morra V
* Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: A longitudinal controlled trial of combination therapy (559 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2010 Apr; 16(4): 450-454.
Impact Factor: 4.23
View Export to BibTeX Export to EndNote
Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (410 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
View Export to BibTeX Export to EndNote
Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (416 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
View Export to BibTeX Export to EndNote
Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (396 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
View Export to BibTeX Export to EndNote
Capparelli R, Romanelli A, Iannaccone M, Nocerino N, Ripa R, Pensato S, Pedone C, Iannelli D
* Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in vivo (452 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 28; 4(9): e7191-e7191.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin Binds The Anti-Atherogenic Protein Apolipoprotein E: Impairment Of The Apolipoprotein E Stimulation On Both The Enzyme Lecithin-Cholesterol Acyl-Transferase Activity And The Cholesterol Uptake By Hepatocytes (274 views)
Febs J, 2009; 276: 6158-6171.
Impact Factor: 3.986
View Export to BibTeX Export to EndNote
Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (393 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
View Export to BibTeX Export to EndNote
Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (962 views)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
View Export to BibTeX Export to EndNote
Rendina D, De Filippo G, Viceconti R, Soscia E, Sirignano C, Salvatore M, Della Monica M, Scarano G, Mossetti G
* Interleukin (il)-6 And Receptor Activator Of Nuclear Factor (nf)-Kappab Ligand (rankl) Are Increased In The Serum Of A Patient With Primary Pachydermoperiostosis (476 views)
Scand J Rheumatol (ISSN: 0300-9742), 2008 May; 37(3): 225-229.
Impact Factor: 2.345
View Export to BibTeX Export to EndNote
Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (401 views)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
View Export to BibTeX Export to EndNote
Scarpa R, Cuocolo A, Peluso R, Atteno M, Gisonni P, Iervolino S, Di Minno MND, Nicolai E, Salvatore M, Del Puente A
* Early psoriatic arthritis: the clinical spectrum (410 views)
The Journal Of Rheumatology (ISSN: 0315-162x), 2008 Jan; 35(1): 137-141.
Impact Factor: 3.282
View Export to BibTeX Export to EndNote
Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
View Export to BibTeX Export to EndNote
Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (365 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
View Export to BibTeX Export to EndNote
Santamaria F, Montella S, Camera L, Palumbo C, Greco L, Boner AL
* Lung structure abnormalities, but normal lung function in pediatric bronchiectasis (431 views)
Chest (ISSN: 0012-3692), 2006 Sep; 130(2): 480-486.
Impact Factor: 3.924
View Export to BibTeX Export to EndNote
Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (311 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (422 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
View Export to BibTeX Export to EndNote
Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (479 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (486 views)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
View Export to BibTeX Export to EndNote
Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (611 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
View Export to BibTeX Export to EndNote
Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (369 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (379 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (443 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
De Simone G, Galdiero S, Manco G, Lang D, Rossi M, Pedone C
A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase (574 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Nov 10; 303(5): 761-771.
Impact Factor: 5.388
View Export to BibTeX Export to EndNote
Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (375 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
View Export to BibTeX Export to EndNote
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (532 views)
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
View Export to BibTeX Export to EndNote
Gallicchio R, Giacomobono S, Nardelli A, Pellegrino T, Simeon V, Gattozzi D, Maddalena F, Mainenti PP, Storto G
* Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain (395 views)
J Bone Miner Metab (ISSN: 0914-8779), 2014 Jul; 32(4): 434-440.
Impact Factor: 2.46
View Export to BibTeX Export to EndNote
Cigliano L, De Rosa L, Diana D, Di Stasi R, Spagnuolo MS, Maresca B, Fattorusso R, D'Andrea LD
* Structure and biological activity of a conformational constrained apolipoprotein A-I-derived helical peptide targeting the protein haptoglobin (401 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(93): 51353-51361.
Impact Factor: 3.84
View Export to BibTeX Export to EndNote
Vitale M, Luongo D, Naviglio D, Bozzetto L, Mirabella M, Rivieccio AM, Giacco A, Rivellese AA
* Trans fatty acids consumption in type 1 diabetic patients: evaluation by dietary records and measurement in serum phospholipids (388 views)
Acta Diabetol (ISSN: 0940-5429, 1432-5233electronic), 2013 Aug; 50(4): 651-654.
Impact Factor: 3.679
View Export to BibTeX Export to EndNote
Storto G, Gallicchio R, Pellegrino T, Nardelli A, Capacchione D, Sirignano C, Pace L
* Impact of F-18-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (346 views) (PDF 10 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897, 0969-8051linking), 2013 May; 40(4): 518-523.
Impact Factor: 2.408
View Export to BibTeX Export to EndNote
Spagnuolo MS, Di Stasi R, De Rosa L, Maresca B, Cigliano L, D'Andrea LD
* Analysis of the haptoglobin binding region on the apolipoprotein A-I-derived P2a peptide (376 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 220-226.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (508 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
View Export to BibTeX Export to EndNote
Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (377 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
View Export to BibTeX Export to EndNote
Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (579 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Lanzillo R, Orefice G, Quarantelli M, Rinaldi C, Prinster A, Ventrella G, Spitaleri D, Lus G, Vacca G, Carotenuto B, Salvatore E, Brunetti A, Tedeschi G, Brescia Morra V
* Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: A longitudinal controlled trial of combination therapy (559 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2010 Apr; 16(4): 450-454.
Impact Factor: 4.23
View Export to BibTeX Export to EndNote
Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (410 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
View Export to BibTeX Export to EndNote
Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (416 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
View Export to BibTeX Export to EndNote
Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (396 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
View Export to BibTeX Export to EndNote
Capparelli R, Romanelli A, Iannaccone M, Nocerino N, Ripa R, Pensato S, Pedone C, Iannelli D
* Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in vivo (452 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 28; 4(9): e7191-e7191.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin Binds The Anti-Atherogenic Protein Apolipoprotein E: Impairment Of The Apolipoprotein E Stimulation On Both The Enzyme Lecithin-Cholesterol Acyl-Transferase Activity And The Cholesterol Uptake By Hepatocytes (274 views)
Febs J, 2009; 276: 6158-6171.
Impact Factor: 3.986
View Export to BibTeX Export to EndNote
Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (393 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
View Export to BibTeX Export to EndNote
Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (962 views)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
View Export to BibTeX Export to EndNote
Rendina D, De Filippo G, Viceconti R, Soscia E, Sirignano C, Salvatore M, Della Monica M, Scarano G, Mossetti G
* Interleukin (il)-6 And Receptor Activator Of Nuclear Factor (nf)-Kappab Ligand (rankl) Are Increased In The Serum Of A Patient With Primary Pachydermoperiostosis (476 views)
Scand J Rheumatol (ISSN: 0300-9742), 2008 May; 37(3): 225-229.
Impact Factor: 2.345
View Export to BibTeX Export to EndNote
Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (401 views)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
View Export to BibTeX Export to EndNote
Scarpa R, Cuocolo A, Peluso R, Atteno M, Gisonni P, Iervolino S, Di Minno MND, Nicolai E, Salvatore M, Del Puente A
* Early psoriatic arthritis: the clinical spectrum (410 views)
The Journal Of Rheumatology (ISSN: 0315-162x), 2008 Jan; 35(1): 137-141.
Impact Factor: 3.282
View Export to BibTeX Export to EndNote
Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (407 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
View Export to BibTeX Export to EndNote
Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (365 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
View Export to BibTeX Export to EndNote
Santamaria F, Montella S, Camera L, Palumbo C, Greco L, Boner AL
* Lung structure abnormalities, but normal lung function in pediatric bronchiectasis (431 views)
Chest (ISSN: 0012-3692), 2006 Sep; 130(2): 480-486.
Impact Factor: 3.924
View Export to BibTeX Export to EndNote
Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (311 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (422 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
View Export to BibTeX Export to EndNote
Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (479 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (486 views)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
View Export to BibTeX Export to EndNote
Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (611 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
View Export to BibTeX Export to EndNote
Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (369 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (379 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
View Export to BibTeX Export to EndNote
Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (443 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
De Simone G, Galdiero S, Manco G, Lang D, Rossi M, Pedone C
A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase (574 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Nov 10; 303(5): 761-771.
Impact Factor: 5.388
View Export to BibTeX Export to EndNote
Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (375 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
View Export to BibTeX Export to EndNote
34 Records (32 excluding Abstracts).
Total impact factor: 118.345 (111.586 excluding Abstracts).
Total 5 year impact factor: 101.208 (94.367 excluding Abstracts).
Total impact factor: 118.345 (111.586 excluding Abstracts).
Total 5 year impact factor: 101.208 (94.367 excluding Abstracts).
401 views. Last view on Monday 27 March 2023, 15:42:42
ibb.cnr.it
