Keywords: Antiinflammatory Agent, Apolipoprotein A1, Cholesterol Ester, Haptoglobin, High Density Lipoprotein Cholesterol, Isoenzyme, Nitric Oxide Synthase, Peptide P2a, Prostaglandin E2, Prostaglandin Synthase, Unclassified Drug, Animal Experiment, Animal Model, Antiinflammatory Activity, Article, Cholesterol Blood Level, Cholesterol Esterification, Controlled Study, Drug Effect, Drug Mechanism, Enzyme Linked Immunosorbent Assay, High Performance Liquid Chromatography, In Vivo Study, Mouse, Nonhuman, Paw Edema, Priority Journal, Protein Binding, Protein Blood Level, Protein Expression, Protein Function, Western Blotting, Amino Acid Sequence, Anti-Inflammatory Agents, Cyclooxygenase 2, Dinoprostone, Dose-Response Relationship, Molecular Sequence Data, Phosphatidylcholine-Sterol O-Acyltransferase,
Affiliations: *** IBB - CNR ***
Department of Experimental Pharmacology, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.
Department of Biological Sciences, University of Naples Federico II, Naples, Italy
Biostructures and Bioimaging Institute, Consiglio Nazionale Delle Ricerche, Naples, Italy
References: Braeckman, L., De Bacquer, D., Delanghe, J., Claeys, L., De Backer, G., Associations between haptoglobin polymorphism, lipids, lipoproteins and inflammatory variables (1999) Atherosclerosis, 143 (2), pp. 383-388. , DOI 10.1016/S0021-9150(98)00330-X, PII S002191509800330
Buga, G.M., Frank, J.S., Mottino, G.A., Hendizadeh, M., Hakhamian, A., Tillisch, J.H., Reddy, S.T., Fogelman, A.M., D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet (2006) Journal of Lipid Research, 47 (10), pp. 2148-2160. , http://www.jlr.org/cgi/reprint/47/10/2148, DOI 10.1194/jlr.M600214-JLR200
Burstein, M., Scholnick, H.R., Morfin, R., Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions (1970) J Lipid Res, 11, pp. 583-595
Cabana, V.G., Lukens, J.R., Rice, K.S., Hawkins, T.J., Getz, G.S., HDL content and composition in acute phase response in three species: Triglyceride enrichment of HDL a factor in its decrease (1996) J Lipid Res, 37, pp. 2662-2674
Cigliano, L., Pugliese, C.R., Spagnuolo, M.S., Palumbo, R., Abrescia, P., Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (2009) FEBS J, 276, pp. 6158-6171
Cigliano, L., Spagnuolo, M.S., Cuomo, G., Valentini, G., Niglio, A., Abrescia, P., Apolipoprotein A-I-dependent cholesterol esterification in patients with rheumatoid arthritis (2005) Life Sciences, 77 (1), pp. 108-120. , DOI 10.1016/j.lfs.2004.12.023
Coetzee, G.A., Strachan, A.F., Van Der, W.D.R., Serum amyloid A-containing human high density lipoprotein 3. Density, size, and apolipoprotein composition (1986) Journal of Biological Chemistry, 261 (21), pp. 9644-9651
De Bacquer, D., De Backer, G., Langlois, M., Delanghe, J., Kesteloot, H., Kornitzer, M., Haptoglobin polymorphism as a risk factor for coronary heart disease mortality (2001) Atherosclerosis, 157 (1), pp. 161-166. , DOI 10.1016/S0021-9150(00)00690-0, PII S0021915000006900
Delanghe, J., Cambier, B., Langlois, M., De Buyzere, M., Neels, H., De Bacquer, D., Van Cauwelaert, P., Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery (1997) Atherosclerosis, 132 (2), pp. 215-219. , DOI 10.1016/S0021-9150(97)00089-0, PII S0021915097000890
Esteve, E., Ricart, W., Fernández-Real, J.M., Dyslipidemia and inflammation: An evolutionary conserved mechanism (2005) Clin Nutr, 24, pp. 16-31
Furbee Jr., J.W., Francone, O., Parks, J.S., Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT (2001) Journal of Lipid Research, 42 (10), pp. 1626-1635
Gomaraschi, M., Calabresi, L., Rossoni, G., Iametti, S., Franceschini, G., Stonik, J.A., Remaley, A.T., Anti-inflammatory and cardioprotective activities of synthetic high-density lipoprotein containing apolipoprotein A-I mimetic peptides (2008) Journal of Pharmacology and Experimental Therapeutics, 324 (2), pp. 776-783. , http://jpet.aspetjournals.org/cgi/reprint/324/2/776, DOI 10.1124/jpet.107.129411
Khovidhunkit, W., Kim, M.-S., Memon, R.A., Shigenaga, J.K., Moser, A.H., Feingold, K.R., Grunfeld, C., Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host (2004) Journal of Lipid Research, 45 (7), pp. 1169-1196. , DOI 10.1194/jlr.R300019-JLR200
Kontush, A., Chapman, M.J., Functionally defective high-density lipoprotein: A new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis (2006) Pharmacological Reviews, 58 (3), pp. 342-374. , http://pharmrev.aspetjournals.org/cgi/reprint/58/3/342, DOI 10.1124/pr.58.3.1
Kruger, A.L., Peterson, S., Turkseven, S., Kaminski, P.M., Zhang, F.F., Quan, S., Wolin, M.S., Abraham, N.G., D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes (2005) Circulation, 111 (23), pp. 3126-3134. , DOI 10.1161/CIRCULATIONAHA.104.517102
Langlois, M.R., Delanghe, J.R., Biological and clinical significance of haptoglobin polymorphism in humans (1996) Clinical Chemistry, 42 (10), pp. 1589-1600
Lewis, K.E., Kirk, E.A., McDonald, T.O., Wang, S., Wight, T.N., O'Brien, K.D., Chait, A., Increase in serum amyloid A evoked by dietary cholesterol is associated with increased atherosclerosis in mice (2004) Circulation, 110 (5), pp. 540-545. , DOI 10.1161/01.CIR.0000136819.93989.E1
Libby, P., Inflammatory mechanisms: The molecular basis of inflammation and disease (2007) Nutr Rev, 65, pp. S140-S146
Matuszek, M.A., Aristoteli, L.P., Bannon, P.G., Hendel, P.N., Hughes, C.F., Jessup, W., Dean, R.T., Kritharides, L., Haptoglobin elutes from human atherosclerotic coronary arteries - A potential marker of arterial pathology (2003) Atherosclerosis, 168 (2), pp. 389-396. , DOI 10.1016/S0021-9150(03)00150-3
Navab, M., Anantharamaiah, G.M., Reddy, S.T., Hama, S., Hough, G., Frank, J.S., Grijalva, V.R., Fogelman, A.M., Oral small peptides render HDL antiinflammatory in mice and monkeys and reduce atherosclerosis in ApoE null mice (2005) Circulation Research, 97 (6), pp. 524-532. , DOI 10.1161/01.RES.0000181229.69508.2f
O'Brien, K.D., McDonald, T.O., Kunjathoor, V., Eng, K., Knopp, E.A., Lewis, K., Lopez, R., LeBoeuf, R.C., Serum amyloid A and lipoprotein retention in murine models of atherosclerosis (2005) Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (4), pp. 785-790. , DOI 10.1161/01.ATV.0000158383.65277.2b
Parks, J.S., Rudel, L.L., Alteration of high density lipoprotein subfraction distribution with induction of serum amyloid A protein (SAA) in the nonhuman primate (1985) Journal of Lipid Research, 26 (1), pp. 82-91
Peterson, S.J., Husney, D., Kruger, A.L., Olszanecki, R., Ricci, F., Rodella, L.F., Stacchiotti, A., Abraham, N.G., Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats (2007) Journal of Pharmacology and Experimental Therapeutics, 322 (2), pp. 514-520. , http://jpet.aspetjournals.org/cgi/reprint/322/2/514, DOI 10.1124/jpet.107.119479
Porta, A., Cassano, E., Balestrieri, M., Bianco, M., Picone, R., De Stefano, C., Abrescia, P., Haptoglobin transport into human ovarian follicles and its binding to apolipoprotein A-1 (1999) Zygote, 7 (1), pp. 67-77
Posadas, I., Bucci, M., Roviezzo, F., Rossi, A., Parente, L., Sautebin, L., Cirino, G., Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression (2004) British Journal of Pharmacology, 142 (2), pp. 331-338. , DOI 10.1038/sj.bjp.0705650
Rader, D.J., Molecular regulation of HDL metabolism and function: Implications for novel therapies (2006) J Clin Invest, 116, pp. 3090-3100
Rader, D.J., Alexander, E.T., Weibel, G.L., Billheimer, J., Rothblat, G.H., The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis (2009) J Lipid Res, 50, pp. S189-S194
Rader, D.J., Daugherty, A., Translating molecular discoveries into new therapies for atherosclerosis (2008) Nature, 451 (7181), pp. 904-913. , DOI 10.1038/nature06796, PII NATURE06796
Salvatore, A., Cigliano, L., Bucci, E.M., Corpillo, D., Velasco, S., Carlucci, A., Pedone, C., Abrescia, P., Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (2007) Biochemistry, 46 (39), pp. 11158-11168. , DOI 10.1021/bi7006349
Sherman, C.B., Peterson, S.J., Frishman, W.H., Apolipoprotein A-I mimetic peptides: A potential new therapy for the prevention of atherosclerosis (2010) Cardiol Rev, 18, pp. 141-147
Spagnuolo, M.S., Cigliano, L., Abrescia, P., The binding of haptoglobin to apolipoprotein Al: Influence of hemoglobin and concanavalin A (2003) Biological Chemistry, 384 (12), pp. 1593-1596. , DOI 10.1515/BC.2003.176
Subbaiah, P.V., Liu, M., Witt, T.R., Impaired cholesterol esterification in the plasma in patients with breast cancer (1997) Lipids, 32 (2), pp. 157-162. , DOI 10.1007/s11745-997-0020-5
Thomsen, L.L., Ching, L.-M., Baguley, B.C., Evidence for the production of nitric oxide by activated macrophages treated withe the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid (1990) Cancer Research, 50 (21), pp. 6966-6970
Buga, G. M., Frank, J. S., Mottino, G. A., Hendizadeh, M., Hakhamian, A., Tillisch, J. H., Reddy, S. T., Fogelman, A. M., D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet (2006) Journal of Lipid Research, 47 (10), pp. 2148-2160. , http: //www. jlr. org/cgi/reprint/47/10/2148, DOI 10. 1194/jlr. M600214-JLR200
Cabana, V. G., Lukens, J. R., Rice, K. S., Hawkins, T. J., Getz, G. S., HDL content and composition in acute phase response in three species: Triglyceride enrichment of HDL a factor in its decrease (1996) J Lipid Res, 37, pp. 2662-2674
Coetzee, G. A., Strachan, A. F., Van Der, W. D. R., Serum amyloid A-containing human high density lipoprotein 3. Density, size, and apolipoprotein composition (1986) Journal of Biological Chemistry, 261 (21), pp. 9644-9651
Degoma, E. M., Rader, D. J., Novel HDL-directed pharmacotherapeutic strategies (2011) Nat Rev Cardiol, 8, pp. 266-277
Furbee Jr., J. W., Francone, O., Parks, J. S., Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT (2001) Journal of Lipid Research, 42 (10), pp. 1626-1635
Kruger, A. L., Peterson, S., Turkseven, S., Kaminski, P. M., Zhang, F. F., Quan, S., Wolin, M. S., Abraham, N. G., D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes (2005) Circulation, 111 (23), pp. 3126-3134. , DOI 10. 1161/CIRCULATIONAHA. 104. 517102
Langlois, M. R., Delanghe, J. R., Biological and clinical significance of haptoglobin polymorphism in humans (1996) Clinical Chemistry, 42 (10), pp. 1589-1600
Lewis, K. E., Kirk, E. A., McDonald, T. O., Wang, S., Wight, T. N., O'Brien, K. D., Chait, A., Increase in serum amyloid A evoked by dietary cholesterol is associated with increased atherosclerosis in mice (2004) Circulation, 110 (5), pp. 540-545. , DOI 10. 1161/01. CIR. 0000136819. 93989. E1
Matuszek, M. A., Aristoteli, L. P., Bannon, P. G., Hendel, P. N., Hughes, C. F., Jessup, W., Dean, R. T., Kritharides, L., Haptoglobin elutes from human atherosclerotic coronary arteries - A potential marker of arterial pathology (2003) Atherosclerosis, 168 (2), pp. 389-396. , DOI 10. 1016/S0021-9150 (03) 00150-3
O'Brien, K. D., McDonald, T. O., Kunjathoor, V., Eng, K., Knopp, E. A., Lewis, K., Lopez, R., LeBoeuf, R. C., Serum amyloid A and lipoprotein retention in murine models of atherosclerosis (2005) Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (4), pp. 785-790. , DOI 10. 1161/01. ATV. 0000158383. 65277. 2b
Parks, J. S., Rudel, L. L., Alteration of high density lipoprotein subfraction distribution with induction of serum amyloid A protein (SAA) in the nonhuman primate (1985) Journal of Lipid Research, 26 (1), pp. 82-91
Peterson, S. J., Husney, D., Kruger, A. L., Olszanecki, R., Ricci, F., Rodella, L. F., Stacchiotti, A., Abraham, N. G., Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats (2007) Journal of Pharmacology and Experimental Therapeutics, 322 (2), pp. 514-520. , http: //jpet. aspetjournals. org/cgi/reprint/322/2/514, DOI 10. 1124/jpet. 107. 119479
Rader, D. J., Molecular regulation of HDL metabolism and function: Implications for novel therapies (2006) J Clin Invest, 116, pp. 3090-3100
Rader, D. J., Alexander, E. T., Weibel, G. L., Billheimer, J., Rothblat, G. H., The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis (2009) J Lipid Res, 50, pp. S189-S194
Rader, D. J., Daugherty, A., Translating molecular discoveries into new therapies for atherosclerosis (2008) Nature, 451 (7181), pp. 904-913. , DOI 10. 1038/nature06796, PII NATURE06796
Sherman, C. B., Peterson, S. J., Frishman, W. H., Apolipoprotein A-I mimetic peptides: A potential new therapy for the prevention of atherosclerosis (2010) Cardiol Rev, 18, pp. 141-147
Spagnuolo, M. S., Cigliano, L., Abrescia, P., The binding of haptoglobin to apolipoprotein Al: Influence of hemoglobin and concanavalin A (2003) Biological Chemistry, 384 (12), pp. 1593-1596. , DOI 10. 1515/BC. 2003. 176
Subbaiah, P. V., Liu, M., Witt, T. R., Impaired cholesterol esterification in the plasma in patients with breast cancer (1997) Lipids, 32 (2), pp. 157-162. , DOI 10. 1007/s11745-997-0020-5
Thomsen, L. L., Ching, L. -M., Baguley, B. C., Evidence for the production of nitric oxide by activated macrophages treated withe the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid (1990) Cancer Research, 50 (21), pp. 6966-6970
Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(349 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote