Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (837 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
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Paper type: Journal Article,
Impact factor: 3.891, 5-year impact factor: 3.959
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857321015&partnerID=40&md5=3fc429396bfbe636c1a7ac63e7aa70a3
Keywords: Antiinflammatory Agent, Apolipoprotein A1, Cholesterol Ester, Haptoglobin, High Density Lipoprotein Cholesterol, Isoenzyme, Nitric Oxide Synthase, Peptide P2a, Prostaglandin E2, Prostaglandin Synthase, Unclassified Drug, Animal Experiment, Animal Model, Antiinflammatory Activity, Article, Cholesterol Blood Level, Cholesterol Esterification, Controlled Study, Drug Effect, Drug Mechanism, Enzyme Linked Immunosorbent Assay, High Performance Liquid Chromatography, In Vivo Study, Mouse, Nonhuman, Paw Edema, Priority Journal, Protein Binding, Protein Blood Level, Protein Expression, Protein Function, Western Blotting, Amino Acid Sequence, Anti-Inflammatory Agents, Cyclooxygenase 2, Dinoprostone, Dose-Response Relationship, Molecular Sequence Data, Phosphatidylcholine-Sterol O-Acyltransferase,
Affiliations:
*** IBB - CNR ***
Department of Experimental Pharmacology, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.
Department of Biological Sciences, University of Naples Federico II, Naples, Italy
Biostructures and Bioimaging Institute, Consiglio Nazionale Delle Ricerche, Naples, Italy
References:
Not available.
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.891, 5-year impact factor: 3.959
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857321015&partnerID=40&md5=3fc429396bfbe636c1a7ac63e7aa70a3
Keywords: Antiinflammatory Agent, Apolipoprotein A1, Cholesterol Ester, Haptoglobin, High Density Lipoprotein Cholesterol, Isoenzyme, Nitric Oxide Synthase, Peptide P2a, Prostaglandin E2, Prostaglandin Synthase, Unclassified Drug, Animal Experiment, Animal Model, Antiinflammatory Activity, Article, Cholesterol Blood Level, Cholesterol Esterification, Controlled Study, Drug Effect, Drug Mechanism, Enzyme Linked Immunosorbent Assay, High Performance Liquid Chromatography, In Vivo Study, Mouse, Nonhuman, Paw Edema, Priority Journal, Protein Binding, Protein Blood Level, Protein Expression, Protein Function, Western Blotting, Amino Acid Sequence, Anti-Inflammatory Agents, Cyclooxygenase 2, Dinoprostone, Dose-Response Relationship, Molecular Sequence Data, Phosphatidylcholine-Sterol O-Acyltransferase,
Affiliations:
*** IBB - CNR ***
Department of Experimental Pharmacology, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy.
Department of Biological Sciences, University of Naples Federico II, Naples, Italy
Biostructures and Bioimaging Institute, Consiglio Nazionale Delle Ricerche, Naples, Italy
References:
Not available.
Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo
The acute-phase protein haptoglobin (Hpt) binds apolipoprotein A-I (ApoA-I) and impairs its action on lecithin-cholesterol acyltransferase, an enzyme that plays a key role in reverse cholesterol transport. We have previously shown that an ApoA-I mimetic peptide, P2a, displaces Hpt from ApoA-I, restoring the enzyme activity in vitro. The aim of this study was to evaluate whether P2a displaces Hpt from ApoA-I in vivo and whether this event leads to anti-inflammatory activity. Mice received subplantar injections of carrageenan. Paw volume was measured before the injection and 2, 4, 6, 24, 48, 72, and 96 h thereafter. At the same time points, concentrations of HDL cholesterol (C) and cholesterol esters (CEs) were measured by high-performance liquid chromatography, and Hpt and ApoA-I plasma levels were evaluated by enzyme-linked immunosorbent assay. Western blotting analysis for nitric-oxide synthase and cyclooxygenase (COX) isoforms was also performed on paw homogenates. CEs significantly decreased in carrageenan-treated mice during edema development and negatively correlated with the Hpt/ApoA-I ratio. P2a administration significantly restored the CE/C ratio. In addition, P2a displayed an anti-inflammatory effect on the late phase of edema with a significant reduction in COX2 expression coupled to an inhibition of prostaglandin E2 synthesis, implying that, in the presence of P2a, CE/C ratio rescue and edema inhibition were strictly related. In conclusion, the P2a effect is due to its binding to Hpt with consequent displacement of ApoA-I that exerts anti-inflammatory activity. Therefore, it is feasible to design drugs that, by enhancing the physiological endogenous protective role of ApoA-I, may be useful in inflammation-based diseases. Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics.
The acute-phase protein haptoglobin (Hpt) binds apolipoprotein A-I (ApoA-I) and impairs its action on lecithin-cholesterol acyltransferase, an enzyme that plays a key role in reverse cholesterol transport. We have previously shown that an ApoA-I mimetic peptide, P2a, displaces Hpt from ApoA-I, restoring the enzyme activity in vitro. The aim of this study was to evaluate whether P2a displaces Hpt from ApoA-I in vivo and whether this event leads to anti-inflammatory activity. Mice received subplantar injections of carrageenan. Paw volume was measured before the injection and 2, 4, 6, 24, 48, 72, and 96 h thereafter. At the same time points, concentrations of HDL cholesterol (C) and cholesterol esters (CEs) were measured by high-performance liquid chromatography, and Hpt and ApoA-I plasma levels were evaluated by enzyme-linked immunosorbent assay. Western blotting analysis for nitric-oxide synthase and cyclooxygenase (COX) isoforms was also performed on paw homogenates. CEs significantly decreased in carrageenan-treated mice during edema development and negatively correlated with the Hpt/ApoA-I ratio. P2a administration significantly restored the CE/C ratio. In addition, P2a displayed an anti-inflammatory effect on the late phase of edema with a significant reduction in COX2 expression coupled to an inhibition of prostaglandin E2 synthesis, implying that, in the presence of P2a, CE/C ratio rescue and edema inhibition were strictly related. In conclusion, the P2a effect is due to its binding to Hpt with consequent displacement of ApoA-I that exerts anti-inflammatory activity. Therefore, it is feasible to design drugs that, by enhancing the physiological endogenous protective role of ApoA-I, may be useful in inflammation-based diseases. Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics.
Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo
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Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo
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Impact Factor: 3.042
View Export to BibTeX Export to EndNote
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Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 28; 4(9): e7191-e7191.
Impact Factor: 4.351
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin Binds The Anti-Atherogenic Protein Apolipoprotein E: Impairment Of The Apolipoprotein E Stimulation On Both The Enzyme Lecithin-Cholesterol Acyl-Transferase Activity And The Cholesterol Uptake By Hepatocytes (590 views)
Febs J, 2009; 276: 6158-6171.
Impact Factor: 3.986
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Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (694 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
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Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (1440 views)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
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Rendina D, De Filippo G, Viceconti R, Soscia E, Sirignano C, Salvatore M, Della Monica M, Scarano G, Mossetti G
* Interleukin (il)-6 And Receptor Activator Of Nuclear Factor (nf)-Kappab Ligand (rankl) Are Increased In The Serum Of A Patient With Primary Pachydermoperiostosis (920 views)
Scand J Rheumatol (ISSN: 0300-9742), 2008 May; 37(3): 225-229.
Impact Factor: 2.345
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Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (732 views)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
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Scarpa R, Cuocolo A, Peluso R, Atteno M, Gisonni P, Iervolino S, Di Minno MND, Nicolai E, Salvatore M, Del Puente A
* Early psoriatic arthritis: the clinical spectrum (711 views)
The Journal Of Rheumatology (ISSN: 0315-162x), 2008 Jan; 35(1): 137-141.
Impact Factor: 3.282
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (1017 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Di Gaetano S, Guglielmi F, Arciello A, Mangione P, Monti M, Pagnozzi D, Raimondi S, Giorgetti S, Orru S, Canale C, Pucci P, Dobson CM, Bellotti V, Piccoli R
* Recombinant amyloidogenic domain of ApoA-I: analysis of its fibrillogenic potential (648 views)
Biochemical And Biophysical Research Communications (ISSN: 0006-291x, 0006-291xprint), 2006 Dec 8; 351(1): 223-228.
Impact Factor: 2.855
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Santamaria F, Montella S, Camera L, Palumbo C, Greco L, Boner AL
* Lung structure abnormalities, but normal lung function in pediatric bronchiectasis (667 views)
Chest (ISSN: 0012-3692), 2006 Sep; 130(2): 480-486.
Impact Factor: 3.924
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Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (525 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (695 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
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Spagnuolo MS, Cigliano L, D'Andrea LD, Pedone C, Abrescia P
* Assignment of the binding site for haptoglobin on apolipoprotein A-I (1008 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Jan 14; 280(2): 1193-1198.
Impact Factor: 5.854
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Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (989 views)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (1095 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (723 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (757 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (941 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
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De Simone G, Galdiero S, Manco G, Lang D, Rossi M, Pedone C
A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase (1167 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Nov 10; 303(5): 761-771.
Impact Factor: 5.388
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (736 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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34 Records (32 excluding Abstracts).
Total impact factor: 118.345 (111.586 excluding Abstracts).
Total 5 year impact factor: 101.208 (94.367 excluding Abstracts).
Total impact factor: 118.345 (111.586 excluding Abstracts).
Total 5 year impact factor: 101.208 (94.367 excluding Abstracts).
837 views. Last view on Sunday 06 April 2025, 20:28:32
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