Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis (607 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.576, 5-year impact factor: 4.529
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84861989715&partnerID=40&md5=4929ba240ca0b5376b8689ce12fc8126
Keywords: Angiogenesis, Endothelial Cell, Nitric Oxide, Peptide, Reparative Medicine, Glutaminyllysine, Unclassified Drug, Vasculotropin, Vasculotropin Receptor, Animal Cell, Animal Experiment, Animal Tissue, Apoptosis, Article, Biological Activity, Cell Migration, Cell Proliferation, Cell Survival, Controlled Study, Endothelium Cell, Female, Gene Expression, Human, Human Cell, In Vivo Study, Mouse, Nonhuman, Priority Journal, Protein Expression, Signal Transduction, Vascular Ring, Wound Healing, Amino Acid Sequence, Angiogenesis Inducing Agents, Biomimetic Materials, Cattle, Cell Line, Cultured, Molecular Sequence Data, Neovascularization, Physiologic, Peptide Fragments, Vascular Endothelial Growth Factor A,
Affiliations:
*** IBB - CNR ***
Sezione di Farmacologia, Dipartimento di Biotecnologie, Università degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy
Dipartimento di Scienze Farmaceutiche e Biomediche, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy
Facoltà di Scienze Biotecnologiche, Università di Napoli Federico II, Via Mezzocannone 16, 80134 Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli, Italy
Facolt di Scienze Biotecnologiche, Universit di Napoli Federico II, Via Mezzocannone 16, 80134 Napoli, Italy
References:
Ferrara, N., Gerber, H.-P., LeCouter, J., The biology of VEGF and its receptors (2003) Nature Medicine, 9 (6), pp. 669-676. , DOI 10.1038/nm0603-66
Matsumoto, T., Claesson-Welsh, L., VEGF receptor signal transduction (2001) Sci STKE, pp. re21
Lemmon, M.A., Schlessinger, J., Cell signaling by receptor tyrosine kinases (2010) Cell, 141, pp. 1117-1134
Olsson, A.K., Dimberg, A., Kreuger, J., Claesson-Welsh, L., VEGF receptor signalling - In control of vascular function (2006) Nat Rev Mol Cell Biol, 7, pp. 359-371
Cross, M.J., Dixelius, J., Matsumoto, T., Claesson-Welsh, L., VEGF-receptor signal transduction (2003) Trends in Biochemical Sciences, 28 (9), pp. 488-494. , DOI 10.1016/S0968-0004(03)00193-2, PII S0968000403001932
Holmes, K., Roberts, O.L., Thomas, A.M., Cross, M.J., Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition (2007) Cellular Signalling, 19 (10), pp. 2003-2012. , DOI 10.1016/j.cellsig.2007.05.013, PII S0898656807001532
D'Andrea, L.D., Del Gatto, A., De Rosa, L., Romanelli, A., Pedone, C., Peptides targeting angiogenesis related growth factor receptors (2009) Curr Pharm des, 15, pp. 2414-2429
Folkman, J., Angiogenesis (2006) Annu Rev Med, 57, pp. 1-18
Grothey, A., Galanis, E., Targeting angiogenesis: Progress with anti-VEGF treatment with large molecules (2009) Nat Rev Clin Oncol, 6, pp. 507-518
D'Andrea, L.D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Trimarco, B., Pedone, C., Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (40), pp. 14215-14220. , DOI 10.1073/pnas.0505047102
Soro, S., Orecchia, A., Morbidelli, L., Lacal, P.M., Morea, V., Ballmer-Hofer, K., A proangiogenic peptide derived from vascular endothelial growth factor receptor- 1 acts through alpha5beta1 integrin (2008) Blood, 111, pp. 3479-3488
Diana, D., Basile, A., De Rosa, L., Di Stasi, R., Auriemma, S., Arra, C., Beta-hairpin peptide that targets vascular endothelial growth factor (VEGF) receptors: Design, NMR characterization, and biological activity (2011) J Biol Chem, 286, pp. 41680-41691
Wiesmann, C., Fuh, G., Christinger, H.W., Eigenbrot, C., Wells, J.A., De Vos, A.M., Crystal structure at 1.7 A resolution f VEGF in complex with domain 2 of the Fit-1 receptor (1997) Cell, 91 (5), pp. 695-704
Dudar, G.K., D'Andrea, L.D., Di Stasi, R., Pedone, C., Wallace, J.L., A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (2008) Am J Physiol Gastrointest Liver Physiol, 295, pp. G374-G381
Santulli, G., Ciccarelli, M., Palumbo, G., Campanile, A., Galasso, G., Ziaco, B., In vivo properties of the proangiogenic peptide QK (2009) J Transl Med, 7, p. 4150
Lee, J.S., Wagoner Johnson, A.J., Murphy, W.L., A modular, hydroxyapatite-binding version of vascular endothelial growth factor (2010) Adv Mater, 22, pp. 5494-5498
Leslie-Barbick, J.E., Saik, J.E., Gould, D.J., Dickinson, M.E., West, J.L., The promotion of microvasculature formation in poly(ethylene glycol) diacrylate hydrogels by an immobilized VEGF-mimetic peptide (2011) Biomaterials, 32, pp. 5782-5789
Wang, X., Horii, A., Zhang, S., Designer functionalized self-assembling peptide nanofiber scaffolds for growth, migration, and tubologenesis of human umbilical vein endothelial cells (2008) Soft Matter, 4, pp. 2388-2395
Webber, M.J., Tongers, J., Newcomb, C.J., Marquardt, K.T., Bauersachs, J., Losordo, D.W., Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair (2011) Proc Natl Acad Sci USA, 108, pp. 13438-13443
Diana, D., Ziaco, B., Colombo, G., Scarabelli, G., Romanelli, A., Pedone, C., Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (2008) Chemistry, 14, pp. 4164-4166
Schelling, M.E., Meininger, C.J., Hawker Jr., J.R., Granger, H.J., Venular endothelial cells from bovine heart (1988) Am J Physiol, 254, pp. H1211-H1217
Guedez, L., Rivera, A.M., Salloum, R., Miller, M.L., Diegmueller, J.J., Bungay, P.M., Stetler-Stevenson, W.G., Quantitative assessment of angiogenic responses by the directed in vivo angiogenesis assay (2003) American Journal of Pathology, 162 (5), pp. 1431-1439
Donnini, S., Solito, R., Giachetti, A., Granger, H.J., Ziche, M., Morbidelli, L., Fibroblast growth factor-2 mediates Angiotensin-converting enzyme inhibitor-induced angiogenesis in coronary endothelium (2006) J Pharmacol Exp Ther, 319, pp. 515-522
Finetti, F., Solito, R., Morbidelli, L., Giachetti, A., Ziche, M., Donnini, S., Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1 (2008) J Biol Chem, 283, pp. 2139-2146
Morbidelli, L., Pyriochou, A., Filippi, S., Vasileiadis, I., Roussos, C., Zhou, Z., The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability (2010) Am J Physiol Regul Integr Comp Physiol, 298, pp. R824-R832
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., Zeiher, A.M., Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation (1999) Nature, 399, pp. 601-605
Shen, B.-Q., Lee, D.Y., Gerber, H.-P., Keyt, B.A., Ferrara, N., Zioncheck, T.F., Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro (1998) Journal of Biological Chemistry, 273 (45), pp. 29979-29985. , DOI 10.1074/jbc.273.45.29979
Potente, M., Gerhardt, H., Carmeliet, P., Basic and therapeutic aspects of angiogenesis (2011) Cell, 146, pp. 873-887
Gille, H., Kowalski, J., Li, B., LeCouter, J., Moffat, B., Zioncheck, T.F., Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants (2001) J Biol Chem, 276, pp. 3222-3230
Takahashi, T., Yamaguchi, S., Chida, K., Shibuya, M., A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells (2001) EMBO Journal, 20 (11), pp. 2768-2778. , DOI 10.1093/emboj/20.11.2768
Dayanir, V., Meyer, R.D., Lashkari, K., Rahimi, N., Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation (2001) J Biol Chem, 276, pp. 17686-17692
Fujio, Y., Walsh, K., Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner (1999) J Biol Chem, 274, pp. 16349-16354
Thakker, G.D., Hajjar, D.P., Muller, W.A., Rosengart, T.K., The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling (1999) J Biol Chem, 274, pp. 10002-10007
Fulton, D., Gratton, J.P., McCabe, T.J., Fontana, J., Fujio, Y., Walsh, K., Regulation of endothelium-derived nitric oxide production by the protein kinase Akt (1999) Nature, 399, pp. 597-601
Fukumura, D., Gohongi, T., Kadambi, A., Izumi, Y., Ang, J., Yun, C.-O., Buerk, D.G., Jain, R.K., Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (5), pp. 2604-2609. , DOI 10.1073/pnas.041359198
Ziehe, M., Morbidelli, L., Choudhuri, R., Zhang, H.-T., Donnini, S., Granger, H.J., Bicknell, R., Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis (1997) Journal of Clinical Investigation, 99 (11), pp. 2625-2634
Lee, P.C., Salyapongse, A.N., Bragdon, G.A., Shears II, L.L., Watkins, S.C., Edington, H.D.J., Billiar, T.R., Impaired wound healing and angiogenesis in eNOS-deficient mice (1999) American Journal of Physiology - Heart and Circulatory Physiology, 277 (4), pp. H1600-H1608
Carmeliet, P., VEGF gene therapy: Stimulating angiogenesis or angioma-genesis (2000) Nat Med, 6, pp. 1102-1103
Weis, S.M., Cheresh, D.A., Pathophysiological consequences of VEGF-induced vascular permeability (2005) Nature, 437 (7058), pp. 497-504. , DOI 10.1038/nature03987, PII N03987
Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2 -DeltaDeltaCT method (2001) Methods, 25 (4), pp. 402-408. , DOI 10.1006/meth.2001.1262
Lemmon, M. A., Schlessinger, J., Cell signaling by receptor tyrosine kinases (2010) Cell, 141, pp. 1117-1134
Olsson, A. K., Dimberg, A., Kreuger, J., Claesson-Welsh, L., VEGF receptor signalling - In control of vascular function (2006) Nat Rev Mol Cell Biol, 7, pp. 359-371
Cross, M. J., Dixelius, J., Matsumoto, T., Claesson-Welsh, L., VEGF-receptor signal transduction (2003) Trends in Biochemical Sciences, 28 (9), pp. 488-494. , DOI 10. 1016/S0968-0004 (03) 00193-2, PII S0968000403001932
D'Andrea, L. D., Del Gatto, A., De Rosa, L., Romanelli, A., Pedone, C., Peptides targeting angiogenesis related growth factor receptors (2009) Curr Pharm des, 15, pp. 2414-2429
D'Andrea, L. D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Trimarco, B., Pedone, C., Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (40), pp. 14215-14220. , DOI 10. 1073/pnas. 0505047102
Dudar, G. K., D'Andrea, L. D., Di Stasi, R., Pedone, C., Wallace, J. L., A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (2008) Am J Physiol Gastrointest Liver Physiol, 295, pp. G374-G381
Lee, J. S., Wagoner Johnson, A. J., Murphy, W. L., A modular, hydroxyapatite-binding version of vascular endothelial growth factor (2010) Adv Mater, 22, pp. 5494-5498
Leslie-Barbick, J. E., Saik, J. E., Gould, D. J., Dickinson, M. E., West, J. L., The promotion of microvasculature formation in poly (ethylene glycol) diacrylate hydrogels by an immobilized VEGF-mimetic peptide (2011) Biomaterials, 32, pp. 5782-5789
Webber, M. J., Tongers, J., Newcomb, C. J., Marquardt, K. T., Bauersachs, J., Losordo, D. W., Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair (2011) Proc Natl Acad Sci USA, 108, pp. 13438-13443
Schelling, M. E., Meininger, C. J., Hawker Jr., J. R., Granger, H. J., Venular endothelial cells from bovine heart (1988) Am J Physiol, 254, pp. H1211-H1217
Shen, B. -Q., Lee, D. Y., Gerber, H. -P., Keyt, B. A., Ferrara, N., Zioncheck, T. F., Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro (1998) Journal of Biological Chemistry, 273 (45), pp. 29979-29985. , DOI 10. 1074/jbc. 273. 45. 29979
Thakker, G. D., Hajjar, D. P., Muller, W. A., Rosengart, T. K., The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling (1999) J Biol Chem, 274, pp. 10002-10007
Lee, P. C., Salyapongse, A. N., Bragdon, G. A., Shears II, L. L., Watkins, S. C., Edington, H. D. J., Billiar, T. R., Impaired wound healing and angiogenesis in eNOS-deficient mice (1999) American Journal of Physiology - Heart and Circulatory Physiology, 277 (4), pp. H1600-H1608
Weis, S. M., Cheresh, D. A., Pathophysiological consequences of VEGF-induced vascular permeability (2005) Nature, 437 (7058), pp. 497-504. , DOI 10. 1038/nature03987, PII N03987
Livak, K. J., Schmittgen, T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2 -DeltaDeltaCT method (2001) Methods, 25 (4), pp. 402-408. , DOI 10. 1006/meth. 2001. 1262
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2012 Sep 1; 84(3): 303-311.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.576, 5-year impact factor: 4.529
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84861989715&partnerID=40&md5=4929ba240ca0b5376b8689ce12fc8126
Keywords: Angiogenesis, Endothelial Cell, Nitric Oxide, Peptide, Reparative Medicine, Glutaminyllysine, Unclassified Drug, Vasculotropin, Vasculotropin Receptor, Animal Cell, Animal Experiment, Animal Tissue, Apoptosis, Article, Biological Activity, Cell Migration, Cell Proliferation, Cell Survival, Controlled Study, Endothelium Cell, Female, Gene Expression, Human, Human Cell, In Vivo Study, Mouse, Nonhuman, Priority Journal, Protein Expression, Signal Transduction, Vascular Ring, Wound Healing, Amino Acid Sequence, Angiogenesis Inducing Agents, Biomimetic Materials, Cattle, Cell Line, Cultured, Molecular Sequence Data, Neovascularization, Physiologic, Peptide Fragments, Vascular Endothelial Growth Factor A,
Affiliations:
*** IBB - CNR ***
Sezione di Farmacologia, Dipartimento di Biotecnologie, Università degli Studi di Siena, Via A. Moro 2, 53100 Siena, Italy
Dipartimento di Scienze Farmaceutiche e Biomediche, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy
Facoltà di Scienze Biotecnologiche, Università di Napoli Federico II, Via Mezzocannone 16, 80134 Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli, Italy
Facolt di Scienze Biotecnologiche, Universit di Napoli Federico II, Via Mezzocannone 16, 80134 Napoli, Italy
References:
Ferrara, N., Gerber, H.-P., LeCouter, J., The biology of VEGF and its receptors (2003) Nature Medicine, 9 (6), pp. 669-676. , DOI 10.1038/nm0603-66
Matsumoto, T., Claesson-Welsh, L., VEGF receptor signal transduction (2001) Sci STKE, pp. re21
Lemmon, M.A., Schlessinger, J., Cell signaling by receptor tyrosine kinases (2010) Cell, 141, pp. 1117-1134
Olsson, A.K., Dimberg, A., Kreuger, J., Claesson-Welsh, L., VEGF receptor signalling - In control of vascular function (2006) Nat Rev Mol Cell Biol, 7, pp. 359-371
Cross, M.J., Dixelius, J., Matsumoto, T., Claesson-Welsh, L., VEGF-receptor signal transduction (2003) Trends in Biochemical Sciences, 28 (9), pp. 488-494. , DOI 10.1016/S0968-0004(03)00193-2, PII S0968000403001932
Holmes, K., Roberts, O.L., Thomas, A.M., Cross, M.J., Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition (2007) Cellular Signalling, 19 (10), pp. 2003-2012. , DOI 10.1016/j.cellsig.2007.05.013, PII S0898656807001532
D'Andrea, L.D., Del Gatto, A., De Rosa, L., Romanelli, A., Pedone, C., Peptides targeting angiogenesis related growth factor receptors (2009) Curr Pharm des, 15, pp. 2414-2429
Folkman, J., Angiogenesis (2006) Annu Rev Med, 57, pp. 1-18
Grothey, A., Galanis, E., Targeting angiogenesis: Progress with anti-VEGF treatment with large molecules (2009) Nat Rev Clin Oncol, 6, pp. 507-518
D'Andrea, L.D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Trimarco, B., Pedone, C., Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (40), pp. 14215-14220. , DOI 10.1073/pnas.0505047102
Soro, S., Orecchia, A., Morbidelli, L., Lacal, P.M., Morea, V., Ballmer-Hofer, K., A proangiogenic peptide derived from vascular endothelial growth factor receptor- 1 acts through alpha5beta1 integrin (2008) Blood, 111, pp. 3479-3488
Diana, D., Basile, A., De Rosa, L., Di Stasi, R., Auriemma, S., Arra, C., Beta-hairpin peptide that targets vascular endothelial growth factor (VEGF) receptors: Design, NMR characterization, and biological activity (2011) J Biol Chem, 286, pp. 41680-41691
Wiesmann, C., Fuh, G., Christinger, H.W., Eigenbrot, C., Wells, J.A., De Vos, A.M., Crystal structure at 1.7 A resolution f VEGF in complex with domain 2 of the Fit-1 receptor (1997) Cell, 91 (5), pp. 695-704
Dudar, G.K., D'Andrea, L.D., Di Stasi, R., Pedone, C., Wallace, J.L., A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (2008) Am J Physiol Gastrointest Liver Physiol, 295, pp. G374-G381
Santulli, G., Ciccarelli, M., Palumbo, G., Campanile, A., Galasso, G., Ziaco, B., In vivo properties of the proangiogenic peptide QK (2009) J Transl Med, 7, p. 4150
Lee, J.S., Wagoner Johnson, A.J., Murphy, W.L., A modular, hydroxyapatite-binding version of vascular endothelial growth factor (2010) Adv Mater, 22, pp. 5494-5498
Leslie-Barbick, J.E., Saik, J.E., Gould, D.J., Dickinson, M.E., West, J.L., The promotion of microvasculature formation in poly(ethylene glycol) diacrylate hydrogels by an immobilized VEGF-mimetic peptide (2011) Biomaterials, 32, pp. 5782-5789
Wang, X., Horii, A., Zhang, S., Designer functionalized self-assembling peptide nanofiber scaffolds for growth, migration, and tubologenesis of human umbilical vein endothelial cells (2008) Soft Matter, 4, pp. 2388-2395
Webber, M.J., Tongers, J., Newcomb, C.J., Marquardt, K.T., Bauersachs, J., Losordo, D.W., Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair (2011) Proc Natl Acad Sci USA, 108, pp. 13438-13443
Diana, D., Ziaco, B., Colombo, G., Scarabelli, G., Romanelli, A., Pedone, C., Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (2008) Chemistry, 14, pp. 4164-4166
Schelling, M.E., Meininger, C.J., Hawker Jr., J.R., Granger, H.J., Venular endothelial cells from bovine heart (1988) Am J Physiol, 254, pp. H1211-H1217
Guedez, L., Rivera, A.M., Salloum, R., Miller, M.L., Diegmueller, J.J., Bungay, P.M., Stetler-Stevenson, W.G., Quantitative assessment of angiogenic responses by the directed in vivo angiogenesis assay (2003) American Journal of Pathology, 162 (5), pp. 1431-1439
Donnini, S., Solito, R., Giachetti, A., Granger, H.J., Ziche, M., Morbidelli, L., Fibroblast growth factor-2 mediates Angiotensin-converting enzyme inhibitor-induced angiogenesis in coronary endothelium (2006) J Pharmacol Exp Ther, 319, pp. 515-522
Finetti, F., Solito, R., Morbidelli, L., Giachetti, A., Ziche, M., Donnini, S., Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1 (2008) J Biol Chem, 283, pp. 2139-2146
Morbidelli, L., Pyriochou, A., Filippi, S., Vasileiadis, I., Roussos, C., Zhou, Z., The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability (2010) Am J Physiol Regul Integr Comp Physiol, 298, pp. R824-R832
Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., Zeiher, A.M., Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation (1999) Nature, 399, pp. 601-605
Shen, B.-Q., Lee, D.Y., Gerber, H.-P., Keyt, B.A., Ferrara, N., Zioncheck, T.F., Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro (1998) Journal of Biological Chemistry, 273 (45), pp. 29979-29985. , DOI 10.1074/jbc.273.45.29979
Potente, M., Gerhardt, H., Carmeliet, P., Basic and therapeutic aspects of angiogenesis (2011) Cell, 146, pp. 873-887
Gille, H., Kowalski, J., Li, B., LeCouter, J., Moffat, B., Zioncheck, T.F., Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants (2001) J Biol Chem, 276, pp. 3222-3230
Takahashi, T., Yamaguchi, S., Chida, K., Shibuya, M., A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells (2001) EMBO Journal, 20 (11), pp. 2768-2778. , DOI 10.1093/emboj/20.11.2768
Dayanir, V., Meyer, R.D., Lashkari, K., Rahimi, N., Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation (2001) J Biol Chem, 276, pp. 17686-17692
Fujio, Y., Walsh, K., Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner (1999) J Biol Chem, 274, pp. 16349-16354
Thakker, G.D., Hajjar, D.P., Muller, W.A., Rosengart, T.K., The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling (1999) J Biol Chem, 274, pp. 10002-10007
Fulton, D., Gratton, J.P., McCabe, T.J., Fontana, J., Fujio, Y., Walsh, K., Regulation of endothelium-derived nitric oxide production by the protein kinase Akt (1999) Nature, 399, pp. 597-601
Fukumura, D., Gohongi, T., Kadambi, A., Izumi, Y., Ang, J., Yun, C.-O., Buerk, D.G., Jain, R.K., Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (5), pp. 2604-2609. , DOI 10.1073/pnas.041359198
Ziehe, M., Morbidelli, L., Choudhuri, R., Zhang, H.-T., Donnini, S., Granger, H.J., Bicknell, R., Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis (1997) Journal of Clinical Investigation, 99 (11), pp. 2625-2634
Lee, P.C., Salyapongse, A.N., Bragdon, G.A., Shears II, L.L., Watkins, S.C., Edington, H.D.J., Billiar, T.R., Impaired wound healing and angiogenesis in eNOS-deficient mice (1999) American Journal of Physiology - Heart and Circulatory Physiology, 277 (4), pp. H1600-H1608
Carmeliet, P., VEGF gene therapy: Stimulating angiogenesis or angioma-genesis (2000) Nat Med, 6, pp. 1102-1103
Weis, S.M., Cheresh, D.A., Pathophysiological consequences of VEGF-induced vascular permeability (2005) Nature, 437 (7058), pp. 497-504. , DOI 10.1038/nature03987, PII N03987
Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2 -DeltaDeltaCT method (2001) Methods, 25 (4), pp. 402-408. , DOI 10.1006/meth.2001.1262
Lemmon, M. A., Schlessinger, J., Cell signaling by receptor tyrosine kinases (2010) Cell, 141, pp. 1117-1134
Olsson, A. K., Dimberg, A., Kreuger, J., Claesson-Welsh, L., VEGF receptor signalling - In control of vascular function (2006) Nat Rev Mol Cell Biol, 7, pp. 359-371
Cross, M. J., Dixelius, J., Matsumoto, T., Claesson-Welsh, L., VEGF-receptor signal transduction (2003) Trends in Biochemical Sciences, 28 (9), pp. 488-494. , DOI 10. 1016/S0968-0004 (03) 00193-2, PII S0968000403001932
D'Andrea, L. D., Del Gatto, A., De Rosa, L., Romanelli, A., Pedone, C., Peptides targeting angiogenesis related growth factor receptors (2009) Curr Pharm des, 15, pp. 2414-2429
D'Andrea, L. D., Iaccarino, G., Fattorusso, R., Sorriento, D., Carannante, C., Capasso, D., Trimarco, B., Pedone, C., Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (40), pp. 14215-14220. , DOI 10. 1073/pnas. 0505047102
Dudar, G. K., D'Andrea, L. D., Di Stasi, R., Pedone, C., Wallace, J. L., A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (2008) Am J Physiol Gastrointest Liver Physiol, 295, pp. G374-G381
Lee, J. S., Wagoner Johnson, A. J., Murphy, W. L., A modular, hydroxyapatite-binding version of vascular endothelial growth factor (2010) Adv Mater, 22, pp. 5494-5498
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Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis
Vascular endothelial growth factor (VEGF) is the main regulator of physiological and pathological angiogenesis. Low molecular weight molecules able to stimulate angiogenesis have interesting medical application for example in regenerative medicine, but at present none has reached the clinic. We reported that a VEGF mimetic helical peptide, QK, designed on the VEGF helix sequence 17-25, is able to bind and activate the VEGF receptors, producing angiogenesis. In this study we evaluate the pharmacological properties of peptide QK with the aim to propose it as a VEGF-mimetic drug to be employed in reparative angiogenesis. We show that the peptide QK is able to recapitulate all the biological activities of VEGF in vivo and on endothelial cells. In experiments evaluating sprouting from aortic ring and vessel formation in an in vivo angiogenesis model, the peptide QK showed biological effects comparable with VEGF. At endothelial level, the peptide up-regulates VEGF receptor expression, activates intracellular pathways depending on VEGFR2, and consistently it induces endothelial cell proliferation, survival and migration. When added to angiogenic factors (VEGF and/or FGF-2), QK produces an improved biological action, which resulted in reduced apoptosis and accelerated in vitro wound healing. The VEGF-like activity of the short peptide QK, characterized by lower cost of production and easier handling compared to the native glycoprotein, suggests that it is an attractive candidate to be further developed for application in therapeutic angiogenesis.(C) 2012 Elsevier Inc. All rights reserved.
Vascular endothelial growth factor (VEGF) is the main regulator of physiological and pathological angiogenesis. Low molecular weight molecules able to stimulate angiogenesis have interesting medical application for example in regenerative medicine, but at present none has reached the clinic. We reported that a VEGF mimetic helical peptide, QK, designed on the VEGF helix sequence 17-25, is able to bind and activate the VEGF receptors, producing angiogenesis. In this study we evaluate the pharmacological properties of peptide QK with the aim to propose it as a VEGF-mimetic drug to be employed in reparative angiogenesis. We show that the peptide QK is able to recapitulate all the biological activities of VEGF in vivo and on endothelial cells. In experiments evaluating sprouting from aortic ring and vessel formation in an in vivo angiogenesis model, the peptide QK showed biological effects comparable with VEGF. At endothelial level, the peptide up-regulates VEGF receptor expression, activates intracellular pathways depending on VEGFR2, and consistently it induces endothelial cell proliferation, survival and migration. When added to angiogenic factors (VEGF and/or FGF-2), QK produces an improved biological action, which resulted in reduced apoptosis and accelerated in vitro wound healing. The VEGF-like activity of the short peptide QK, characterized by lower cost of production and easier handling compared to the native glycoprotein, suggests that it is an attractive candidate to be further developed for application in therapeutic angiogenesis.(C) 2012 Elsevier Inc. All rights reserved.
Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis
Functional and pharmacological characterization of a VEGF mimetic peptide on reparative angiogenesis
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (558 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (482 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
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Impact Factor: 2.608
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
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Impact Factor: 1.95
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D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
* Bioinorganic aspects of angiogenesis (543 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
Impact Factor: 3.647
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (621 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* VEGFR1(D2) in drug discovery: Expression and molecular characterization (352 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010; 94(6): 800-809.
Impact Factor: 2.572
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1091 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14589 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
* In vivo properties of the proangiogenic peptide QK (417 views)
J Transl Med (ISSN: 1479-5876, 1479-5876electronic, 1479-5876linking), 2009 Jun 8; 7: 41-41.
Impact Factor: 3.407
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
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Impact Factor: 9.432
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Bonomo RP, Di Natale G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies (426 views)
Dalton T (ISSN: 1477-9226, 1477-7922, 1477-9234), 2009 Apr 14; (14): 2637-2646.
Impact Factor: 2.908
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (466 views)
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Impact Factor: 6.069
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (615 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (309 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (908 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (351 views)
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Impact Factor: 1.654
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Di Stasi R, Capasso D, Diana D, Fattorusso R, Pedone C, D'Andrea LD
* Vascular Endothelial Growth Factor (VEGF) and its receptors: key regulators of angiogenesis (290 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (463 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
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Impact Factor: 9.38
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Costantino V, De Rosa C, Fattorusso E, Imperatore C, Mangoni A, Irace C, Maffettone C, Capasso D, Malorni L, Palumbo R, Pedone C
* Oreacerebrosides: Bioactive cerebrosides with a triunsaturated sphingoid base from the sea star Oreaster reticulatus (262 views)
Eur J Org Chem (ISSN: 1434-193x), 2007 Nov; (31): 5277-5283.
Impact Factor: 2.914
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (991 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (703 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (729 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (840 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (582 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
* Engineering Peptides In Angiogenesis (418 views)
Biopolymers, 2006; 0: 215-216.
Impact Factor: 2.288
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (657 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (441 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (465 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Bonomo RP, Castronovo BM, Santoro AM
* A Spectroscopic Investigation Of The Interaction Between Nitrogen Monoxide And Copper Sites Of The Fungal Laccase From Rigidoporus Lignosus (288 views)
Dalton Trans, 2004 Jan 7; N/D: 104-112.
Impact Factor: 4.097
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
* Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (334 views)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (570 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (457 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (760 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB
Antioxidant effects of nitric oxide (351 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 1998; 301: 413-424.
Impact Factor: 2.823
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (502 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
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Wink DA, Cook JA, Kim SY, Vodovotz Y, Pacelli R, Krishna MC, Russo A, Mitchell JB, Jourd'heuil D, Miles AM, Grisham MB
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates (420 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1997 Apr 25; 272(17): 11147-11151.
Impact Factor: 6.963
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Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin (483 views)
Nitric Oxide Biology And Chemistry (ISSN: 1089-8603), 1997 Feb; 1(1): 88-94.
Impact Factor: 2.151
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (699 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
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Cook JA, Kim SY, Teague D, Krishna MC, Pacelli R, Mitchell JB, Vodovotz Y, Nims RW, Christodoulou D, Miles AM, Grisham MB, Wink DA
Convenient colorimetric and fluorometric assays for S-nitrosothiols (567 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 Jul 1; 238(2): 150-158.
Impact Factor: 2.017
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Pacelli R, Taira J, Cook JA, Wink DA, Krishna MC
Hydroxyurea reacts with heme proteins to generate nitric oxide [6] (363 views)
Lancet (ISSN: 0140-6736), 1996 Mar 30; 347(9005): 900-900.
Impact Factor: 16.135
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (816 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Wink DA, Grisham MB, Miles AM, Nims RW, Krishna MC, Pacelli R, Teague D, Poore CM, Cook JA, Ford PC
Determination of selectivity of reactive nitrogen oxide species for various substrates (367 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic, 0076-6879linking), 1996; 268: 120-130.
Impact Factor: 2.435
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (544 views)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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Miles AM, Gibson MF, Kirshina M, Cook JC, Pacelli R, Wink D, Grisham MB
Effects of superoxide on nitric oxide-dependent n-nitrosation reactions (292 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 1995 Oct; 23(4): 379-390.
Impact Factor: 2.361
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Vinci C, Caltabiano V, Santoro AM, Rabuazzo AM, Buscema M, Purrello R, Rizzarelli E, Vigneri R, Purrello F
Copper Addition Prevents The Inhibitory Effects Of Interleukin 1-Beta On Rat Pancreatic Islets (442 views)
Diabetologia, 1995 Jan; 38(1): 39-45.
Impact Factor: 0
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* Liver Sinusoidal Endothelial Cells at the Crossroad of Iron Overload and Liver Fibrosis (25 views)
Antioxid Redox Signal (ISSN: 1523-0864linking, 1557-7716), 2021 Aug 20; 35(6): 474-486.
Impact Factor: 7.04
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Miro C, Nappi A, Cicatiello AG, Di Cicco E, Sagliocchi S, Murolo M, Belli V, Troiani T, Albanese S, Amiranda S, Zavacki AM, Stornaiuolo M, Mancini M, Salvatore D, Dentice M
* Thyroid Hormone Enhances Angiogenesis and the Warburg Effect in Squamous Cell Carcinomas (12 views)
Cancers (ISSN: 2072-6694linking), 2021 Jun 1; 13(11): N/D-N/D.
Impact Factor: 6.126
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Capasso D, Del Gatto A, Comegna D, Russo L, Fattorusso R, Saviano M, Di Gaetano S, Zaccaro L
* Selective Targeting of αvβ5 Integrin in HepG2 Cell Line by RGDechi15D Peptide (108 views)
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Impact Factor: 3.267
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Nawaz MI, Rezzola S, Tobia C, Coltrini D, Belleri M, Mitola S, Corsini M, Sandomenico A, Caporale A, Ruvo M, Presta M
* D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor (71 views)
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Impact Factor: 9.78
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Zaichko K, Zaichko N, Maievskyi O, Korotkyi O, Falalyeyeva T, Fagoonee S, Pellicano R, Abenavoli L, Stanislavchuk M
* Circadian Rhythms of Endothelial Nitric Oxide Synthase and Toll-like Receptors 2 Production in Females with Rheumatoid Arthritis Depending on NOS3 Gene Polymorphism (44 views)
Rev Recent Clin Trials (ISSN: 1574-8871linking), 2020; 15(2): 145-151.
Impact Factor: 0.95
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Di Stasi R, Diana D, De Rosa L, Fattorusso R, D'Andrea LD
* Biochemical and Conformational Characterization of Recombinant VEGFR2 Domain "7" (226 views)
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Nov; 61(11): 860-872.
Impact Factor: 2.275
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Cimmino I, Margheri F, Prisco F, Perruolo G, D'Esposito V, Laurenzana A, Fibbi G, Paciello O, Doti N, Ruvo M, Miele C, Beguinot F, Formisano P, Oriente F
* Prep1 regulates angiogenesis through a PGC-1alpha-mediated mechanism (219 views)
Faseb J (ISSN: 0892-6638linking), 2019 Oct 15; 33(12): 13893-13904.
Impact Factor: 5.391
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Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Biodegradable nanoparticles exposing a short anti-FLT1 peptide as antiangiogenic platform to complement docetaxel anticancer activity (215 views)
Mater Sci Eng C Mater Biol Appl (ISSN: 0928-4931linking), 2019 Sep; 102: 876-886.
Impact Factor: 5.08
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Wang L, Coric P, Broussy S, Di Stasi R, Zhou L, D'Andrea LD, Ji L, Vidal M, Bouaziz S, Liu WQ
* Structural studies of the binding of an antagonistic cyclic peptide to the VEGFR1 domain "2" (224 views)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2019 May 1; 169: 65-75.
Impact Factor: 2.882
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Caporale A, Martin AD, Capasso D, Foca G, Sandomenico A, D'Andrea LD, Grieco P, Ruvo M, Doti N
* Short PlGF-derived peptides bind VEGFR-1 and VEGFR-2 in vitro and on the surface of endothelial cells (298 views)
J Pept Sci (ISSN: 1075-2617linking, 1099-1387electronic), 2019 May; 25 (5 ): e3146-e3146.
Impact Factor: 1.807
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Di Stasi R, De Rosa L, Diana D, Fattorusso R, D'Andrea LD
* Human Recombinant VEGFR2D4 Biochemical Characterization to Investigate Novel Anti-VEGFR2D4 Antibodies for Allosteric Targeting of VEGFR2 (287 views)
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Apr 26; 61(7): 513-520.
Impact Factor: 2.275
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De Simone G
* Targeted treatment of anaerobic cancer. Patent evaluation of US2016279084 and US2017056350 (225 views)
Expert Opin Ther Pat (ISSN: 1744-7674electronic, 1354-3776linking), 2019 Jan; 29(1): 1-6.
Impact Factor: 3.699
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De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (481 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
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Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (338 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(44): 11461-11466.
Impact Factor: 5.16
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Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E
* Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis (201 views)
Cell Death Differ (ISSN: 1350-9047, 1476-5403electronic), 2017 Dec 11; N/D: N/D-N/D.
Impact Factor: 8
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Crich SG, Terreno E, Aime S
* Nano-sized and other improved reporters for magnetic resonance imaging of angiogenesis (253 views)
Adv Drug Deliver Rev (ISSN: 0169-409x), 2017 Sep 15; 119: 61-72.
Impact Factor: 13.66
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Filippi M, Catanzaro V, Patrucco D, Botta M, Tei L, Terreno E
* First in vivo MRI study on theranostic dendrimersomes (280 views)
J Control Release (ISSN: 0168-3659), 2017 Feb 28; 248: 45-52.
Impact Factor: 7.877
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Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S
* Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging (263 views)
Gastric Cancer (ISSN: 1436-3291, 1436-3291linking), 2016 Dec 19; 20(4): 629-639.
Impact Factor: 5.454
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La Mendola D, Arnesano F, Hansson O, Giacomelli C, Calo V, Mangini V, Magrì A, Bellia F, Trincavelli ML, Martini C, Natile G, Rizzarelli E
* Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity (407 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2016 Jan 20; 8(1): 118-124.
Impact Factor: 3.975
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Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (308 views)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
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Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, Sandomenico A, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Ambati BK, Leusen JH, Langdon WY, Clark MR, Armour KL, Bruhns P, Verbeek JS, Gelfand BD, De Falco S, Ambati J
* Human IgG1 antibodies suppress angiogenesis in a target-independent manner (557 views)
Signal Transduct Target Ther (ISSN: 2059-3635print), 2016; 1: N/D-N/D.
Impact Factor: 0
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Di Stasi R, De Rosa L, Romanelli A, D'Andrea LD
* Peptides Interacting with Growth Factor Receptors Regulating Angiogenesis (350 views)
Frontiers In Medicinal Chemistry, 2016; 9: 103-160.
Impact Factor: 0
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Grasso G, Santoro AM, Magrì A, La Mendola D, Tomasello MF, Zimbone S, Rizzarelli E
* The Inorganic Perspective of VEGF: Interactions of Cu2 + with Peptides Encompassing a Recognition Domain of the VEGF Receptor (433 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016; 159: 149-158.
Impact Factor: 3.348
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Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (424 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
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Ciccarelli M, Rusciano MR, Sorriento D, Maione AS, Soprano M, Iaccarino G, Illario M
* Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis (237 views)
Journal Of Cancer Therapy (ISSN: 2151-1934), 2015 Feb 11; 6: 199-212.
Impact Factor: 0.56
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Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
* Functional Binding Surface Of A Beta-Hairpin Vegf Receptor Targeting Peptide Determined By Nmr Spectroscopy In Living Cells (445 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 2; 21(1): 91-95.
Impact Factor: 5.771
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Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
* Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment (488 views)
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Impact Factor: 1.98
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Cicatiello V, Apicella I, Tudisco L, Tarallo V, Formisano L, Sandomenico A, Kim Y, Bastos-Carvalho A, Orlandi A, Ambati J, Ruvo M, Bianco R, de Falco S
* Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models (455 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic, 1949-2553linking), 2015; 6(12): 10563-10576.
Impact Factor: 5.008
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Ciccarelli M, Sorriento D, Iaccarino G
The Adrenergic System in Vascular Endothelial Cells (188 views)
The Cardiovascular Adrenergic System, 2015; Chapter3: 25-44.
Impact Factor: 0
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Carriero MV, Bifulco K, Minopoli M, Lista L, Maglio O, Mele L, Di Carluccio G, De Rosa M, Pavone V
* UPARANT: a urokinase receptor-derived peptide inhibitor of VEGF-driven angiogenesis with enhanced stability and in vitro and in vivo potency (467 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic), 2014 May; 13(5): 1092-1104.
Impact Factor: 5.683
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (846 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
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Ciccarelli M, Rusciano MR, Sorriento D, Basilicata MF, Santulli G, Campiglia P, Bertamino A, De Luca N, Trimarco B, Iaccarino G, Illario M
* CaMKII protects MKP-1 from proteasome degradation in endothelial cells (259 views)
Cell Signal (ISSN: 0898-6568), 2014; 26(10): 2167-2174.
Impact Factor: 4.315
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De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (510 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
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Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
* Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice (483 views)
Bmc Med Imaging (ISSN: 1471-2342, 1471-2342electronic), 2013 Sep 12; 13(1): 31-31.
Impact Factor: 0.983
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Alcides Petruk A, Vergara A, Estrin D, Merlino A
* Molecular basis of the NO trans influence in quaternary T-state human hemoglobin: A computational study (414 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013 Sep 2; 587(15): 2393-2398.
Impact Factor: 3.341
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Diana D, Di Stasi R, De Rosa L, Isernia C, D'Andrea LD, Fattorusso R
* Structural investigation of the VEGF receptor interaction with a helical antagonist peptide (415 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 214-219.
Impact Factor: 1.862
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Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (447 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (425 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FSN, Pompidor G, Mazzarella L, Vergara A
* Selective X-ray-induced NO photodissociation in haemoglobin crystals: evidence from a Raman-assisted crystallographic study (339 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Jan; 69: 137-140.
Impact Factor: 7.232
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
* Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species (605 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (473 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
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Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (556 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
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Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (488 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
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Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (370 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
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La Mendola D, Magrì A, Santoro AM, Nicoletti VG, Rizzarelli E
* Copper(II) interaction with peptide fragments of histidine-proline-rich glycoprotein: Speciation, stability and binding details (409 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 59-69.
Impact Factor: 3.197
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (447 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G
* Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo (424 views)
Hypertensionhypertension (ISSN: 0194-911x), 2012; 60(1): 129-136.
Impact Factor: 6.873
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Satriano C, Fragalà ME, Forte G, Santoro AM, La Mendola D, Kasemo B
* Surface adsorption of fibronectin-derived peptide fragments: The influence of electrostatics and hydrophobicity for endothelial cells adhesion (307 views)
Soft Matter (ISSN: 1744-683x), 2012; 8(1): 53-56.
Impact Factor: 3.909
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S
* Administration of carnosine in the treatment of acute spinal cord injury (656 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2011 Nov 15; 82(10): 1478-1489.
Impact Factor: 4.705
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Ruvo M, Sandomenico A, Tudisco L, De Falco S
* Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (532 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Impact Factor: 4.859
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (558 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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Ciccarelli M, Sorriento D, Cipolletta E, Santulli G, Fusco A, Zhou R-H, Eckhart AD, Peppel K, Koch WJ, Trimarco B, Iaccarino G
* Impaired neoangiogenesis in β2-adrenoceptor gene-deficient mice: Restoration by intravascular human β2-adrenoceptor gene transfer and role of NFkB and CREB transcription factors (370 views)
Br J Pharmacol British Journal Of Pharmacology (ISSN: 0007-1188), 2011; 162(3): 712-721.
Impact Factor: 4.409
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Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (482 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
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Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
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La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (448 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (445 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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D'Andrea LD, Romanelli A, Di Stasi R, Pedone C
* Bioinorganic aspects of angiogenesis (543 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Sep 7; 39(33): 7625-7636.
Impact Factor: 3.647
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (621 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Di Stasi R, Diana D, Capasso D, Palumbo R, Romanelli A, Pedone C, Fattorusso R, D'Andrea LD
* VEGFR1(D2) in drug discovery: Expression and molecular characterization (352 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010; 94(6): 800-809.
Impact Factor: 2.572
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Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1091 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14589 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Santulli G, Ciccarelli M, Palumbo G, Campanile A, Galasso G, Ziaco B, Altobelli GG, Cimini V, Piscione F, D'Andrea LD, Pedone C, Trimarco B, Iaccarino G
* In vivo properties of the proangiogenic peptide QK (417 views)
J Transl Med (ISSN: 1479-5876, 1479-5876electronic, 1479-5876linking), 2009 Jun 8; 7: 41-41.
Impact Factor: 3.407
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Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
* Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth (421 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Apr 28; 106(17): 7137-7142.
Impact Factor: 9.432
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Bonomo RP, Di Natale G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies (426 views)
Dalton T (ISSN: 1477-9226, 1477-7922, 1477-9234), 2009 Apr 14; (14): 2637-2646.
Impact Factor: 2.908
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (466 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (615 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Bonomo RP, Pappalardo G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Studies of nitric oxide interaction with mono- and dinuclear copper(II) complexes of prion protein bis-octarepeat fragments (309 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2008 Sep 7; (29): 3805-3816.
Impact Factor: 3.58
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (908 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (351 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Di Stasi R, Capasso D, Diana D, Fattorusso R, Pedone C, D'Andrea LD
* Vascular Endothelial Growth Factor (VEGF) and its receptors: key regulators of angiogenesis (290 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (463 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
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Costantino V, De Rosa C, Fattorusso E, Imperatore C, Mangoni A, Irace C, Maffettone C, Capasso D, Malorni L, Palumbo R, Pedone C
* Oreacerebrosides: Bioactive cerebrosides with a triunsaturated sphingoid base from the sea star Oreaster reticulatus (262 views)
Eur J Org Chem (ISSN: 1434-193x), 2007 Nov; (31): 5277-5283.
Impact Factor: 2.914
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Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (991 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (703 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (729 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (840 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (582 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
* Engineering Peptides In Angiogenesis (418 views)
Biopolymers, 2006; 0: 215-216.
Impact Factor: 2.288
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D'Andrea LD, Iaccarino G, Fattorusso R, Sorriento D, Carannante C, Capasso D, Trimarco B, Pedone C
* Targeting angiogenesis: Structural characterization and biological properties of a de novo engineered VEGF mimicking peptide (657 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2005 Oct 4; 102(40): 14215-14220.
Impact Factor: 10.231
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (441 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (465 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
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Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, Cipolletta E, Cerullo V, Cimini V, Altobelli GG, Piscione F, Priante O, Pastore L, Chiariello M, Salvatore F, Koch WJ, Trimarco B
* Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression: A novel role for the endothelial adrenergic system (380 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic), 2005; 97(11): 1182-1189.
Impact Factor: 9.408
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Bonomo RP, Castronovo BM, Santoro AM
* A Spectroscopic Investigation Of The Interaction Between Nitrogen Monoxide And Copper Sites Of The Fungal Laccase From Rigidoporus Lignosus (288 views)
Dalton Trans, 2004 Jan 7; N/D: 104-112.
Impact Factor: 4.097
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Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
* AKT participates in endothelial dysfunction in hypertension (356 views)
Circulationcirculation (ISSN: 0009-7322), 2004; 109(21): 2587-2593.
Impact Factor: 12.563
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Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
* Exercise restores β-adrenergic vasorelaxation in aged rat carotid arteries (334 views)
Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
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Esposito G, Ligresti A, Izzo AA, Bisogno T, Ruvo M, Di Rosa M, Di Marzo V, Iuvone T
* The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity: Mechanism and regulation (570 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2002 Dec 27; 277(52): 50348-50354.
Impact Factor: 6.696
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Salvatore M, Fonti R
* New frontiers of nuclear medicine (457 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S60-S60.
Impact Factor: 0.267
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Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (760 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
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Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB
Antioxidant effects of nitric oxide (351 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 1998; 301: 413-424.
Impact Factor: 2.823
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Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA
Nitric oxide enhancement of melphalan-induced cytotoxicity (502 views)
Br J Cancer (ISSN: 0007-0920, 0007-0920print, 0007-0920linking), 1997 Sep; 76(3): 325-334.
Impact Factor: 2.938
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Wink DA, Cook JA, Kim SY, Vodovotz Y, Pacelli R, Krishna MC, Russo A, Mitchell JB, Jourd'heuil D, Miles AM, Grisham MB
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates (420 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1997 Apr 25; 272(17): 11147-11151.
Impact Factor: 6.963
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Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, DeGraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin (483 views)
Nitric Oxide Biology And Chemistry (ISSN: 1089-8603), 1997 Feb; 1(1): 88-94.
Impact Factor: 2.151
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (699 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
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Cook JA, Kim SY, Teague D, Krishna MC, Pacelli R, Mitchell JB, Vodovotz Y, Nims RW, Christodoulou D, Miles AM, Grisham MB, Wink DA
Convenient colorimetric and fluorometric assays for S-nitrosothiols (567 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 Jul 1; 238(2): 150-158.
Impact Factor: 2.017
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Pacelli R, Taira J, Cook JA, Wink DA, Krishna MC
Hydroxyurea reacts with heme proteins to generate nitric oxide [6] (363 views)
Lancet (ISSN: 0140-6736), 1996 Mar 30; 347(9005): 900-900.
Impact Factor: 16.135
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Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms (816 views)
Current Topics In Cellular Regulation (ISSN: 0070-2137), 1996; 34: 159-187.
Impact Factor: 4.375
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Wink DA, Grisham MB, Miles AM, Nims RW, Krishna MC, Pacelli R, Teague D, Poore CM, Cook JA, Ford PC
Determination of selectivity of reactive nitrogen oxide species for various substrates (367 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic, 0076-6879linking), 1996; 268: 120-130.
Impact Factor: 2.435
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Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB
Nitric oxide (NO) protects against cellular damage by reactive oxygen species (544 views)
Toxicology Letters (ISSN: 0378-4274), 1995 Dec; 82-3: 221-226.
Impact Factor: 1.128
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Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB
NITRIC-OXIDE POTENTIATES HYDROGEN PEROXIDE-INDUCED KILLING OF ESCHERICHIA-COLI (428 views)
Journal Of Experimental Medicine (ISSN: 0022-1007), 1995 Nov 1; 182(5): 1469-1479.
Impact Factor: 14.384
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Miles AM, Gibson MF, Kirshina M, Cook JC, Pacelli R, Wink D, Grisham MB
Effects of superoxide on nitric oxide-dependent n-nitrosation reactions (292 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 1995 Oct; 23(4): 379-390.
Impact Factor: 2.361
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Vinci C, Caltabiano V, Santoro AM, Rabuazzo AM, Buscema M, Purrello R, Rizzarelli E, Vigneri R, Purrello F
Copper Addition Prevents The Inhibitory Effects Of Interleukin 1-Beta On Rat Pancreatic Islets (442 views)
Diabetologia, 1995 Jan; 38(1): 39-45.
Impact Factor: 0
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111 Records (106 excluding Abstracts).
Total impact factor: 501.264 (477.34 excluding Abstracts).
Total 5 year impact factor: 506.369 (473.277 excluding Abstracts).
Total impact factor: 501.264 (477.34 excluding Abstracts).
Total 5 year impact factor: 506.369 (473.277 excluding Abstracts).
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