Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients (390 views visite)
Diabetes Care (ISSN: 1935-5548, 0149-5992, 1935-5548electronic), 2012 Jul; 35(7): 1429-1435.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Randomized Controlled Trial, Research Support, Non-U. S. Gov'T
Impact factor: 7.735, 5-year impact factor Impact factor a 5 anni: 7.555
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862885081&partnerID=40&md5=fe7808f7fdab090d4d2f442a45206d3a
Keywords Parole chiave: Metformin, Monounsaturated Fatty Acid, Adult, Aerobic Exercise, Aged, Article, Blood Glucose Monitoring, Body Weight, Caloric Intake, Carbohydrate Diet, Clinical Article, Controlled Study, Diet Therapy, Fat Content, Fat Intake, Fatty Liver, Female, Glycemic Index, High Fiber Diet, Human, Lipid Diet, Non Insulin Dependent Diabetes Mellitus, Parallel Design, Physical Activity, Qualitative Analysis, Randomized Controlled Trial, Reference Value, Risk Reduction, Treatment Duration, Treatment Response, Weight Reduction, Type 2, Middle Aged, Type 2 Blood Diet Therapy, Fats Analysis, Monounsaturated Administration, Dosage, Fatty Liver Prevention, Liver Metabolism, Metformin Therapeutic Use
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
Department of Biomorphological and Functional Science, Federico II University, Naples, Italy
References Riferimenti:
Bozzetto, L., Prinster, A., Mancini, M., Liver fat in obesity: Role of type 2 diabetes mellitus and adipose tissue distribution (2011) Eur J Clin Invest, 41, pp. 39-4
Kotronen, A., Juurinen, L., Hakkarainen, A., Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects (2008) Diabetes Care, 31, pp. 165-169
Powell, E.E., Cooksley, W.G.E., Hanson, R., Searle, J., Halliday, J.W., Powell, L.W., The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years (1990) Hepatology, 11 (1), pp. 74-80
Targher, G., Bertolini, L., Poli, F., Rodella, S., Scala, L., Tessari, R., Zenari, L., Falezza, G., Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients (2005) Diabetes, 54 (12), pp. 3541-3546. , http://diabetes.diabetesjournals.org/cgi/reprint/54/12/3541, DOI 10.2337/diabetes.54.12.3541
Adiels, M., Taskinen, M.-R., Boren, J., Fatty liver, insulin resistance, and dyslipidemia (2008) Current Diabetes Reports, 8 (1), pp. 60-64. , DOI 10.1007/s11892-008-0011-4
Kotronen, A., Seppala-Lindroos, A., Bergholm, R., Yki-Jarvinen, H., Tissue specificity of insulin resistance in humans: Fat in the liver rather than muscle is associated with features of the metabolic syndrome (2008) Diabetologia, 51 (1), pp. 130-138. , DOI 10.1007/s00125-007-0867-x
Kelley, D.E., Kuller, L.H., McKolanis, T.M., Harper, P., Mancino, J., Kalhan, S., Effects of Moderate Weight Loss and Orlistat on Insulin Resistance, Regional Adiposity, and Fatty Acids in Type 2 Diabetes (2004) Diabetes Care, 27 (1), pp. 33-40. , DOI 10.2337/diacare.27.1.33
Bantle, J.P., Wylie-Rosett, J., Albright, A.L., Nutrition recommendations and interventions for diabetes: A position statement of the American Diabetes Association (2008) Diabetes Care, 31 (SUPPL. 1), pp. S61-S78. , American Diabetes Association
Marwick, T.H., Hordern, M.D., Miller, T., Exercise training for type 2 diabetes mellitus: Impact on cardiovascular risk: A scientific statement from the American Heart Association (2009) Circulation, 119, pp. 3244-3262. , Council on Clinical Cardiology, American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee
Council on Cardiovascular Disease in the Young
Council on Nutrition, Physical Activity, and Metabolism
Interdisciplinary Council on Quality of Care and Outcomes Research
Vitola, B.E., Deivanayagam, S., Stein, R.I., Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents (2009) Obesity, 17, pp. 1744-1748. , (Silver Spring)
Huang, M.A., Greenson, J.K., Chao, C., Anderson, L., Peterman, D., Jacobson, J., Emick, D., Conjeevaram, H.S., One-year intense nutritional counseling results in histological improvement in patients with nonalcoholic steatohepatitis: A pilot study (2005) American Journal of Gastroenterology, 100 (5), pp. 1072-1081. , DOI 10.1111/j.1572-0241.2005.41334.x
Westerbacka, J., Lammi, K., Hakkinen, A.-M., Rissanen, A., Salminen, I., Aro, A., Yki-Jarvinen, H., Dietary fat content modifies liver fat in overweight nondiabetic subjects (2005) Journal of Clinical Endocrinology and Metabolism, 90 (5), pp. 2804-2809. , DOI 10.1210/jc.2004-1983
Allard, J.P., Aghdassi, E., Mohammed, S., Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study (2008) J Hepatol, 48, pp. 300-307
Gerhard, G.T., Ahmann, A., Meeuws, K., McMurry, M.P., Duell, P.B., Connor, W.E., Effects of a low-fat diet compared with those of a high-monounsaturated fat diet on body weight, plasma lipids and lipoproteins, and glycemic control in type 2 diabetes (2004) American Journal of Clinical Nutrition, 80 (3), pp. 668-673
Valtueña, S., Pellegrini, N., Ardigò, D., Dietary glycemic index and liver steatosis (2006) Am J Clin Nutr, 84, pp. 136-142. , quiz 268-269
Zelber-Sagi, S., Ratziu, V., Oren, R., Nutrition and physical activity in NAFLD: An overview of the epidemiological evidence (2011) World J Gastroenterol, 17, pp. 3377-3389
Tamura, Y., Tanaka, Y., Sato, F., Jong, B.C., Watada, H., Niwa, M., Kinoshita, J., Kawamori, R., Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients (2005) Journal of Clinical Endocrinology and Metabolism, 90 (6), pp. 3191-3196. , http://jcem.endojournals.org/cgi/reprint/90/6/3191, DOI 10.1210/jc.2004-1959
Johnson, N.A., Sachinwalla, T., Walton, D.W., Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss (2009) Hepatology, 50, pp. 1105-1112
Hallsworth, K., Fattakhova, G., Hollingsworth, K.G., Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss (2011) Gut, 60, pp. 1278-1283
Carnovale, E., Marletta, L., Miuccio, F., (1995) Tabelle di Composizione degli Alimenti, , Roma, Istituto Nazionale della Nutrizione
Richardson, M.T., Ainsworth, B.E., Jacobs Jr., D.R., Leon, A.S., Validation of theStanford 7-Day Recall to assess habitual physical activity (2001) Annals of Epidemiology, 11 (2), pp. 145-153. , DOI 10.1016/S1047-2797(00)00190-3, PII S1047279700001903
Provencher, S.W., Automatic quantitation of localized in vivo 1H spectra with LCModel (2001) NMR in Biomedicine, 14 (4), pp. 260-264. , DOI 10.1002/nbm.698
Longo, R., Pollesello, P., Ricci, C., Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis (1995) J Magn Reson Imaging, 5, pp. 281-285
Longo, R., Ricci, C., Masutti, F., Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography (1993) Invest Radiol, 28, pp. 297-302
Carlson, K., Lipoprotein fractionation (1973) J Clin Pathol Suppl (Assoc Clin Pathol), 5, pp. 32-37
Ferramosca, A., Savy, V., Zara, V., Olive oil increases the hepatic triacylglycerol content in mice by a distinct influence on the synthesis and oxidation of fatty acids (2008) Bioscience, Biotechnology and Biochemistry, 72 (1), pp. 62-69. , http://www.jstage.jst.go.jp/article/bbb/72/1/62/_pdf, DOI 10.1271/bbb.70369
Hussein, O., Grosovski, M., Lasri, E., Svalb, S., Ravid, U., Assy, N., Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats (2007) World Journal of Gastroenterology, 13 (3), pp. 361-368
DeLany, J.P., Windhauser, M.M., Champagne, C.M., Bray, G.A., Differential oxidation of individual dietary fatty acids in humans (2000) Am J Clin Nutr, 72, pp. 905-911
Rivellese, A.A., Giacco, R., Annuzzi, G., De Natale, C., Patti, L., Di, M.L., Minerva, V., Riccardi, G., Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes (2008) Clinical Nutrition, 27 (1), pp. 133-141. , DOI 10.1016/j.clnu.2007.07.005, PII S0261561407001264
Bessesen, D.H., Vensor, S.H., Jackman, M.R., Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed lean rats (2000) American Journal of Physiology - Endocrinology and Metabolism, 278 (6), pp. E1124-E1132
Kolak, M., Westerbacka, J., Velagapudi, V.R., Wagsater, D., Yetukuri, L., Makkonen, J., Rissanen, A., Yki-Jarvinen, H., Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity (2007) Diabetes, 56 (8), pp. 1960-1968. , http://diabetes.diabetesjournals.org/cgi/reprint/56/8/1960, DOI 10.2337/db07-0111
Sanyal, A.J., Chalasani, N., Kowdley, K.V., Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis (2010) N Engl J Med, 362, pp. 1675-1685. , NASH CRN
Lavine, J.E., Schwimmer, J.B., Van Natta, M.L., Effect of vitamin e or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial (2011) JAMA, 305, pp. 1659-1668. , Nonalcoholic Steatohepatitis Clinical Research Network
Scribner, K.B., Pawlak, D.B., Ludwig, D.S., Hepatic steatosis and increased adiposity in mice consuming rapidly vs. slowly absorbed carbohydrate (2007) Obesity, 15 (9), pp. 2190-2199. , DOI 10.1038/oby.2007.260
Parks, E.J., Krauss, R.M., Christiansen, M.P., Neese, R.A., Hellerstein, M.K., Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance (1999) Journal of Clinical Investigation, 104 (8), pp. 1087-1096
Hudgins, L.C., Seidman, C.E., Diakun, J., Hirsch, J., Human fatty acid synthesis is reduced after the substitution of dietary starch for sugar (1998) American Journal of Clinical Nutrition, 67 (4), pp. 631-639
Musso, G., Gambino, R., Cassader, M., Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: Mechanisms and implications for metabolic disorders (2010) Curr Opin Lipidol, 21, pp. 76-83
Yasari, S., Prud'Homme, D., Tesson, F., Effects of exercise training on molecular markers of lipogenesis and lipid partitioning in fructose-induced liver fat accumulation (2011) J Nutr Metab, , 10 August [Epub ahead of print]
Burns, N., Finucane, F.M., Hatunic, M., Gilman, M., Murphy, M., Gasparro, D., Mari, A., Nolan, J.J., Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training (2007) Diabetologia, 50 (7), pp. 1500-1508. , DOI 10.1007/s00125-007-0655-7
Poirier, P., Tremblay, A., Broderick, T., Catellier, C., Tancrede, G., Nadeau, A., Impact of moderate aerobic exercise training on insulin sensitivity in type 2 diabetic men treated with oral hypoglycemic agents: Is insulin sensitivity enhanced only in nonobese subjects? (2002) Medical Science Monitor, 8 (2), pp. CR59-CR65
Powell, E. E., Cooksley, W. G. E., Hanson, R., Searle, J., Halliday, J. W., Powell, L. W., The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years (1990) Hepatology, 11 (1), pp. 74-80
Kelley, D. E., Kuller, L. H., McKolanis, T. M., Harper, P., Mancino, J., Kalhan, S., Effects of Moderate Weight Loss and Orlistat on Insulin Resistance, Regional Adiposity, and Fatty Acids in Type 2 Diabetes (2004) Diabetes Care, 27 (1), pp. 33-40. , DOI 10. 2337/diacare. 27. 1. 33
Bantle, J. P., Wylie-Rosett, J., Albright, A. L., Nutrition recommendations and interventions for diabetes: A position statement of the American Diabetes Association (2008) Diabetes Care, 31 (SUPPL. 1), pp. S61-S78. , American Diabetes Association
Marwick, T. H., Hordern, M. D., Miller, T., Exercise training for type 2 diabetes mellitus: Impact on cardiovascular risk: A scientific statement from the American Heart Association (2009) Circulation, 119, pp. 3244-3262. , Council on Clinical Cardiology, American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee
Vitola, B. E., Deivanayagam, S., Stein, R. I., Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents (2009) Obesity, 17, pp. 1744-1748. , (Silver Spring)
Huang, M. A., Greenson, J. K., Chao, C., Anderson, L., Peterman, D., Jacobson, J., Emick, D., Conjeevaram, H. S., One-year intense nutritional counseling results in histological improvement in patients with nonalcoholic steatohepatitis: A pilot study (2005) American Journal of Gastroenterology, 100 (5), pp. 1072-1081. , DOI 10. 1111/j. 1572-0241. 2005. 41334. x
Allard, J. P., Aghdassi, E., Mohammed, S., Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study (2008) J Hepatol, 48, pp. 300-307
Gerhard, G. T., Ahmann, A., Meeuws, K., McMurry, M. P., Duell, P. B., Connor, W. E., Effects of a low-fat diet compared with those of a high-monounsaturated fat diet on body weight, plasma lipids and lipoproteins, and glycemic control in type 2 diabetes (2004) American Journal of Clinical Nutrition, 80 (3), pp. 668-673
Valtue a, S., Pellegrini, N., Ardig, D., Dietary glycemic index and liver steatosis (2006) Am J Clin Nutr, 84, pp. 136-142. , quiz 268-269
Johnson, N. A., Sachinwalla, T., Walton, D. W., Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss (2009) Hepatology, 50, pp. 1105-1112
Richardson, M. T., Ainsworth, B. E., Jacobs Jr., D. R., Leon, A. S., Validation of theStanford 7-Day Recall to assess habitual physical activity (2001) Annals of Epidemiology, 11 (2), pp. 145-153. , DOI 10. 1016/S1047-2797 (00) 00190-3, PII S1047279700001903
Provencher, S. W., Automatic quantitation of localized in vivo 1H spectra with LCModel (2001) NMR in Biomedicine, 14 (4), pp. 260-264. , DOI 10. 1002/nbm. 698
DeLany, J. P., Windhauser, M. M., Champagne, C. M., Bray, G. A., Differential oxidation of individual dietary fatty acids in humans (2000) Am J Clin Nutr, 72, pp. 905-911
Rivellese, A. A., Giacco, R., Annuzzi, G., De Natale, C., Patti, L., Di, M. L., Minerva, V., Riccardi, G., Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes (2008) Clinical Nutrition, 27 (1), pp. 133-141. , DOI 10. 1016/j. clnu. 2007. 07. 005, PII S0261561407001264
Bessesen, D. H., Vensor, S. H., Jackman, M. R., Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed lean rats (2000) American Journal of Physiology - Endocrinology and Metabolism, 278 (6), pp. E1124-E1132
Sanyal, A. J., Chalasani, N., Kowdley, K. V., Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis (2010) N Engl J Med, 362, pp. 1675-1685. , NASH CRN
Lavine, J. E., Schwimmer, J. B., Van Natta, M. L., Effect of vitamin e or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial (2011) JAMA, 305, pp. 1659-1668. , Nonalcoholic Steatohepatitis Clinical Research Network
Scribner, K. B., Pawlak, D. B., Ludwig, D. S., Hepatic steatosis and increased adiposity in mice consuming rapidly vs. slowly absorbed carbohydrate (2007) Obesity, 15 (9), pp. 2190-2199. , DOI 10. 1038/oby. 2007. 260
Parks, E. J., Krauss, R. M., Christiansen, M. P., Neese, R. A., Hellerstein, M. K., Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance (1999) Journal of Clinical Investigation, 104 (8), pp. 1087-1096
Hudgins, L. C., Seidman, C. E., Diakun, J., Hirsch, J., Human fatty acid synthesis is reduced after the substitution of dietary starch for sugar (1998) American Journal of Clinical Nutrition, 67 (4), pp. 631-639
Diabetes Care (ISSN: 1935-5548, 0149-5992, 1935-5548electronic), 2012 Jul; 35(7): 1429-1435.
Export to Esporta in BibTeX Export to Esporta in EndNote
Paper type Tipo di articolo: Journal Article, Randomized Controlled Trial, Research Support, Non-U. S. Gov'T
Impact factor: 7.735, 5-year impact factor Impact factor a 5 anni: 7.555
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862885081&partnerID=40&md5=fe7808f7fdab090d4d2f442a45206d3a
Keywords Parole chiave: Metformin, Monounsaturated Fatty Acid, Adult, Aerobic Exercise, Aged, Article, Blood Glucose Monitoring, Body Weight, Caloric Intake, Carbohydrate Diet, Clinical Article, Controlled Study, Diet Therapy, Fat Content, Fat Intake, Fatty Liver, Female, Glycemic Index, High Fiber Diet, Human, Lipid Diet, Non Insulin Dependent Diabetes Mellitus, Parallel Design, Physical Activity, Qualitative Analysis, Randomized Controlled Trial, Reference Value, Risk Reduction, Treatment Duration, Treatment Response, Weight Reduction, Type 2, Middle Aged, Type 2 Blood Diet Therapy, Fats Analysis, Monounsaturated Administration, Dosage, Fatty Liver Prevention, Liver Metabolism, Metformin Therapeutic Use
Affiliations Affiliazioni:
*** IBB - CNR ***
Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
Biostructure and Bioimaging Institute, National Research Council, Naples, Italy
Department of Biomorphological and Functional Science, Federico II University, Naples, Italy
References Riferimenti:
Bozzetto, L., Prinster, A., Mancini, M., Liver fat in obesity: Role of type 2 diabetes mellitus and adipose tissue distribution (2011) Eur J Clin Invest, 41, pp. 39-4
Kotronen, A., Juurinen, L., Hakkarainen, A., Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects (2008) Diabetes Care, 31, pp. 165-169
Powell, E.E., Cooksley, W.G.E., Hanson, R., Searle, J., Halliday, J.W., Powell, L.W., The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years (1990) Hepatology, 11 (1), pp. 74-80
Targher, G., Bertolini, L., Poli, F., Rodella, S., Scala, L., Tessari, R., Zenari, L., Falezza, G., Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients (2005) Diabetes, 54 (12), pp. 3541-3546. , http://diabetes.diabetesjournals.org/cgi/reprint/54/12/3541, DOI 10.2337/diabetes.54.12.3541
Adiels, M., Taskinen, M.-R., Boren, J., Fatty liver, insulin resistance, and dyslipidemia (2008) Current Diabetes Reports, 8 (1), pp. 60-64. , DOI 10.1007/s11892-008-0011-4
Kotronen, A., Seppala-Lindroos, A., Bergholm, R., Yki-Jarvinen, H., Tissue specificity of insulin resistance in humans: Fat in the liver rather than muscle is associated with features of the metabolic syndrome (2008) Diabetologia, 51 (1), pp. 130-138. , DOI 10.1007/s00125-007-0867-x
Kelley, D.E., Kuller, L.H., McKolanis, T.M., Harper, P., Mancino, J., Kalhan, S., Effects of Moderate Weight Loss and Orlistat on Insulin Resistance, Regional Adiposity, and Fatty Acids in Type 2 Diabetes (2004) Diabetes Care, 27 (1), pp. 33-40. , DOI 10.2337/diacare.27.1.33
Bantle, J.P., Wylie-Rosett, J., Albright, A.L., Nutrition recommendations and interventions for diabetes: A position statement of the American Diabetes Association (2008) Diabetes Care, 31 (SUPPL. 1), pp. S61-S78. , American Diabetes Association
Marwick, T.H., Hordern, M.D., Miller, T., Exercise training for type 2 diabetes mellitus: Impact on cardiovascular risk: A scientific statement from the American Heart Association (2009) Circulation, 119, pp. 3244-3262. , Council on Clinical Cardiology, American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee
Council on Cardiovascular Disease in the Young
Council on Nutrition, Physical Activity, and Metabolism
Interdisciplinary Council on Quality of Care and Outcomes Research
Vitola, B.E., Deivanayagam, S., Stein, R.I., Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents (2009) Obesity, 17, pp. 1744-1748. , (Silver Spring)
Huang, M.A., Greenson, J.K., Chao, C., Anderson, L., Peterman, D., Jacobson, J., Emick, D., Conjeevaram, H.S., One-year intense nutritional counseling results in histological improvement in patients with nonalcoholic steatohepatitis: A pilot study (2005) American Journal of Gastroenterology, 100 (5), pp. 1072-1081. , DOI 10.1111/j.1572-0241.2005.41334.x
Westerbacka, J., Lammi, K., Hakkinen, A.-M., Rissanen, A., Salminen, I., Aro, A., Yki-Jarvinen, H., Dietary fat content modifies liver fat in overweight nondiabetic subjects (2005) Journal of Clinical Endocrinology and Metabolism, 90 (5), pp. 2804-2809. , DOI 10.1210/jc.2004-1983
Allard, J.P., Aghdassi, E., Mohammed, S., Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study (2008) J Hepatol, 48, pp. 300-307
Gerhard, G.T., Ahmann, A., Meeuws, K., McMurry, M.P., Duell, P.B., Connor, W.E., Effects of a low-fat diet compared with those of a high-monounsaturated fat diet on body weight, plasma lipids and lipoproteins, and glycemic control in type 2 diabetes (2004) American Journal of Clinical Nutrition, 80 (3), pp. 668-673
Valtueña, S., Pellegrini, N., Ardigò, D., Dietary glycemic index and liver steatosis (2006) Am J Clin Nutr, 84, pp. 136-142. , quiz 268-269
Zelber-Sagi, S., Ratziu, V., Oren, R., Nutrition and physical activity in NAFLD: An overview of the epidemiological evidence (2011) World J Gastroenterol, 17, pp. 3377-3389
Tamura, Y., Tanaka, Y., Sato, F., Jong, B.C., Watada, H., Niwa, M., Kinoshita, J., Kawamori, R., Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients (2005) Journal of Clinical Endocrinology and Metabolism, 90 (6), pp. 3191-3196. , http://jcem.endojournals.org/cgi/reprint/90/6/3191, DOI 10.1210/jc.2004-1959
Johnson, N.A., Sachinwalla, T., Walton, D.W., Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss (2009) Hepatology, 50, pp. 1105-1112
Hallsworth, K., Fattakhova, G., Hollingsworth, K.G., Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss (2011) Gut, 60, pp. 1278-1283
Carnovale, E., Marletta, L., Miuccio, F., (1995) Tabelle di Composizione degli Alimenti, , Roma, Istituto Nazionale della Nutrizione
Richardson, M.T., Ainsworth, B.E., Jacobs Jr., D.R., Leon, A.S., Validation of theStanford 7-Day Recall to assess habitual physical activity (2001) Annals of Epidemiology, 11 (2), pp. 145-153. , DOI 10.1016/S1047-2797(00)00190-3, PII S1047279700001903
Provencher, S.W., Automatic quantitation of localized in vivo 1H spectra with LCModel (2001) NMR in Biomedicine, 14 (4), pp. 260-264. , DOI 10.1002/nbm.698
Longo, R., Pollesello, P., Ricci, C., Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis (1995) J Magn Reson Imaging, 5, pp. 281-285
Longo, R., Ricci, C., Masutti, F., Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography (1993) Invest Radiol, 28, pp. 297-302
Carlson, K., Lipoprotein fractionation (1973) J Clin Pathol Suppl (Assoc Clin Pathol), 5, pp. 32-37
Ferramosca, A., Savy, V., Zara, V., Olive oil increases the hepatic triacylglycerol content in mice by a distinct influence on the synthesis and oxidation of fatty acids (2008) Bioscience, Biotechnology and Biochemistry, 72 (1), pp. 62-69. , http://www.jstage.jst.go.jp/article/bbb/72/1/62/_pdf, DOI 10.1271/bbb.70369
Hussein, O., Grosovski, M., Lasri, E., Svalb, S., Ravid, U., Assy, N., Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats (2007) World Journal of Gastroenterology, 13 (3), pp. 361-368
DeLany, J.P., Windhauser, M.M., Champagne, C.M., Bray, G.A., Differential oxidation of individual dietary fatty acids in humans (2000) Am J Clin Nutr, 72, pp. 905-911
Rivellese, A.A., Giacco, R., Annuzzi, G., De Natale, C., Patti, L., Di, M.L., Minerva, V., Riccardi, G., Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes (2008) Clinical Nutrition, 27 (1), pp. 133-141. , DOI 10.1016/j.clnu.2007.07.005, PII S0261561407001264
Bessesen, D.H., Vensor, S.H., Jackman, M.R., Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed lean rats (2000) American Journal of Physiology - Endocrinology and Metabolism, 278 (6), pp. E1124-E1132
Kolak, M., Westerbacka, J., Velagapudi, V.R., Wagsater, D., Yetukuri, L., Makkonen, J., Rissanen, A., Yki-Jarvinen, H., Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity (2007) Diabetes, 56 (8), pp. 1960-1968. , http://diabetes.diabetesjournals.org/cgi/reprint/56/8/1960, DOI 10.2337/db07-0111
Sanyal, A.J., Chalasani, N., Kowdley, K.V., Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis (2010) N Engl J Med, 362, pp. 1675-1685. , NASH CRN
Lavine, J.E., Schwimmer, J.B., Van Natta, M.L., Effect of vitamin e or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial (2011) JAMA, 305, pp. 1659-1668. , Nonalcoholic Steatohepatitis Clinical Research Network
Scribner, K.B., Pawlak, D.B., Ludwig, D.S., Hepatic steatosis and increased adiposity in mice consuming rapidly vs. slowly absorbed carbohydrate (2007) Obesity, 15 (9), pp. 2190-2199. , DOI 10.1038/oby.2007.260
Parks, E.J., Krauss, R.M., Christiansen, M.P., Neese, R.A., Hellerstein, M.K., Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance (1999) Journal of Clinical Investigation, 104 (8), pp. 1087-1096
Hudgins, L.C., Seidman, C.E., Diakun, J., Hirsch, J., Human fatty acid synthesis is reduced after the substitution of dietary starch for sugar (1998) American Journal of Clinical Nutrition, 67 (4), pp. 631-639
Musso, G., Gambino, R., Cassader, M., Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: Mechanisms and implications for metabolic disorders (2010) Curr Opin Lipidol, 21, pp. 76-83
Yasari, S., Prud'Homme, D., Tesson, F., Effects of exercise training on molecular markers of lipogenesis and lipid partitioning in fructose-induced liver fat accumulation (2011) J Nutr Metab, , 10 August [Epub ahead of print]
Burns, N., Finucane, F.M., Hatunic, M., Gilman, M., Murphy, M., Gasparro, D., Mari, A., Nolan, J.J., Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training (2007) Diabetologia, 50 (7), pp. 1500-1508. , DOI 10.1007/s00125-007-0655-7
Poirier, P., Tremblay, A., Broderick, T., Catellier, C., Tancrede, G., Nadeau, A., Impact of moderate aerobic exercise training on insulin sensitivity in type 2 diabetic men treated with oral hypoglycemic agents: Is insulin sensitivity enhanced only in nonobese subjects? (2002) Medical Science Monitor, 8 (2), pp. CR59-CR65
Powell, E. E., Cooksley, W. G. E., Hanson, R., Searle, J., Halliday, J. W., Powell, L. W., The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years (1990) Hepatology, 11 (1), pp. 74-80
Kelley, D. E., Kuller, L. H., McKolanis, T. M., Harper, P., Mancino, J., Kalhan, S., Effects of Moderate Weight Loss and Orlistat on Insulin Resistance, Regional Adiposity, and Fatty Acids in Type 2 Diabetes (2004) Diabetes Care, 27 (1), pp. 33-40. , DOI 10. 2337/diacare. 27. 1. 33
Bantle, J. P., Wylie-Rosett, J., Albright, A. L., Nutrition recommendations and interventions for diabetes: A position statement of the American Diabetes Association (2008) Diabetes Care, 31 (SUPPL. 1), pp. S61-S78. , American Diabetes Association
Marwick, T. H., Hordern, M. D., Miller, T., Exercise training for type 2 diabetes mellitus: Impact on cardiovascular risk: A scientific statement from the American Heart Association (2009) Circulation, 119, pp. 3244-3262. , Council on Clinical Cardiology, American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee
Vitola, B. E., Deivanayagam, S., Stein, R. I., Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents (2009) Obesity, 17, pp. 1744-1748. , (Silver Spring)
Huang, M. A., Greenson, J. K., Chao, C., Anderson, L., Peterman, D., Jacobson, J., Emick, D., Conjeevaram, H. S., One-year intense nutritional counseling results in histological improvement in patients with nonalcoholic steatohepatitis: A pilot study (2005) American Journal of Gastroenterology, 100 (5), pp. 1072-1081. , DOI 10. 1111/j. 1572-0241. 2005. 41334. x
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Gerhard, G. T., Ahmann, A., Meeuws, K., McMurry, M. P., Duell, P. B., Connor, W. E., Effects of a low-fat diet compared with those of a high-monounsaturated fat diet on body weight, plasma lipids and lipoproteins, and glycemic control in type 2 diabetes (2004) American Journal of Clinical Nutrition, 80 (3), pp. 668-673
Valtue a, S., Pellegrini, N., Ardig, D., Dietary glycemic index and liver steatosis (2006) Am J Clin Nutr, 84, pp. 136-142. , quiz 268-269
Johnson, N. A., Sachinwalla, T., Walton, D. W., Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss (2009) Hepatology, 50, pp. 1105-1112
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Rivellese, A. A., Giacco, R., Annuzzi, G., De Natale, C., Patti, L., Di, M. L., Minerva, V., Riccardi, G., Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes (2008) Clinical Nutrition, 27 (1), pp. 133-141. , DOI 10. 1016/j. clnu. 2007. 07. 005, PII S0261561407001264
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Sanyal, A. J., Chalasani, N., Kowdley, K. V., Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis (2010) N Engl J Med, 362, pp. 1675-1685. , NASH CRN
Lavine, J. E., Schwimmer, J. B., Van Natta, M. L., Effect of vitamin e or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial (2011) JAMA, 305, pp. 1659-1668. , Nonalcoholic Steatohepatitis Clinical Research Network
Scribner, K. B., Pawlak, D. B., Ludwig, D. S., Hepatic steatosis and increased adiposity in mice consuming rapidly vs. slowly absorbed carbohydrate (2007) Obesity, 15 (9), pp. 2190-2199. , DOI 10. 1038/oby. 2007. 260
Parks, E. J., Krauss, R. M., Christiansen, M. P., Neese, R. A., Hellerstein, M. K., Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance (1999) Journal of Clinical Investigation, 104 (8), pp. 1087-1096
Hudgins, L. C., Seidman, C. E., Diakun, J., Hirsch, J., Human fatty acid synthesis is reduced after the substitution of dietary starch for sugar (1998) American Journal of Clinical Nutrition, 67 (4), pp. 631-639
Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients
OBJECTIVE - To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - With use of a factorial 2 x 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plusmetformin treatmentwere assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high- fiber/low- glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by 1H NMR. RESULTS - Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29%) and MUFA+Ex (-25%) groups than in CHO/fiber (-4%) and CHO/fiber+Ex groups (-6%). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712). CONCLUSIONS - An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes. © 2012 by the American Diabetes Association.
OBJECTIVE - To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS - With use of a factorial 2 x 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plusmetformin treatmentwere assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high- fiber/low- glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by 1H NMR. RESULTS - Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29%) and MUFA+Ex (-25%) groups than in CHO/fiber (-4%) and CHO/fiber+Ex groups (-6%). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712). CONCLUSIONS - An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes. © 2012 by the American Diabetes Association.
Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients
Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients
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Bozzetto L, Polito R, Nigro E, Prinster A, Della Pepa G, Costabile G, Vetrani C, Vitale M, Daniele A, Rivellese AA, Annuzzi G
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Impact Factor: 3.086
Dettagli Esporta in BibTeX Esporta in EndNote
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Impact Factor: 3.639
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Impact Factor: 3.731
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Impact Factor: 3.438
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Impact Factor: 2.26
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
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Dettagli Esporta in BibTeX Esporta in EndNote
Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
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Impact Factor: 3.658
Dettagli Esporta in BibTeX Esporta in EndNote
Ferrara LA, Marotta T, Mainenti G, Borrelli R, Mancini M, Soro S
Resting blood pressure and cardiovascular response to sympathetic stimulation in adolescents (256 visite)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic), 1992 Sep; 36(2): 197-201.
Impact Factor: 0.61
Dettagli Esporta in BibTeX Esporta in EndNote
Ferrara LA, Mancini M, De Simone GD, Turco S, Iovine C, Marotta T, Mainenti G, Mancini M
Responses of serum insulin and blood pressure to cold and handgrip in obese patients (302 visite)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic), 1991 Sep; 32(3): 353-359.
Impact Factor: 0.61
Dettagli Esporta in BibTeX Esporta in EndNote
Ferrara LA, Soro S, Mainenti G, Mancini M, Pisanti N, Borrelli R, Moscato TS
Body weight and cardiovascular response to sympathetic stimulation in childhood (502 visite)
Int J Obes (ISSN: 0307-0565), 1989; 13(3): 271-277.
Impact Factor: 2.476
Dettagli Esporta in BibTeX Esporta in EndNote
Alberghina M, Brogna A, Mangiameli A, Marletta F, Rizzarelli E, Sammartano S
Copper(II) complexes of aminoacids: Gastric acid antisecretory activity in rats (2033 visite)
Farmaco Ed Sci, 1982 Dec; 37(12): 805-814.
Impact Factor: 0
Dettagli Esporta in BibTeX Esporta in EndNote
17 Records (17 escludendo Abstract e Conferenze).
Impact factor totale: 53.04 (53.04 escludendo Abstract e Conferenze).
Impact factor a 5 anni totale: 58.189 (58.189 escludendo Abstract e Conferenze).
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