Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (469 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.377, 5-year impact factor: 3.168
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84858225733&partnerID=40&md5=4c43215e7bb5c0f8a340ea46e85d7dbf
Keywords: Ankyrin, Binding Modes, Binding Studies, Cancer Cells, Isothermal Titration Calorimetry, Micromolar Range, Molecular Modeling Studies, Nmr Chemical Shift Perturbations, Receptor Endocytosis, Solution Structures, Structural Elements, Therapeutic Compounds, Topology Characteristics, Binding Energy, Molecular Biology, Ephrin Receptor A2, Phosphatase, Protein Odin, Protein Ship2, Unclassified Drug, Amino Acid Sequence, Article, Binding Kinetics, Carbon Nuclear Magnetic Resonance, Heteronuclear Single Quantum Coherence, Molecular Docking, Molecular Interaction, Nitrogen Nuclear Magnetic Resonance, Nuclear Overhauser Effect, Priority Journal, Protein Domain, Protein Structure, Receptor Binding, Sterile Alpha Motif Domain, Surface Plasmon Resonance, Adaptor Proteins, Signal Transducing, Humans, Multiprotein Complexes, Biomolecular, Protein Interaction Domains And Motifs, Recombinant Proteins, Thermodynamics,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, University of Naples Federico II, Naples, Italy
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPEB), Naples, Italy
Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy
Sanford-Burnham Medical Research Institute, San Diego, CA 92037, United States
References:
Pasquale, E.B., Eph receptors and ephrins in cancer: Bidirectional signalling and beyond (2010) Nat. Rev. Cancer, 10, pp. 165-18
Surawska, H., Ma, P.C., Salgia, R., The role of ephrins and Eph receptors in cancer (2004) Cytokine and Growth Factor Reviews, 15 (6), pp. 419-433. , DOI 10.1016/j.cytogfr.2004.09.002, PII S1359610104000760
Koolpe, M., Dail, M., Pasquale, E.B., An ephrin mimetic peptide that selectively targets the EphA2 receptor (2002) Journal of Biological Chemistry, 277 (49), pp. 46974-46979. , DOI 10.1074/jbc.M208495200
Cooper, M.A., Son, A.I., Komlos, D., Sun, Y., Kleiman, N.J., Zhou, R., Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract (2008) Proc. Natl. Acad. Sci. U.S.A., 105, pp. 16620-16625
Jun, G., Guo, H., Klein, B.E., Klein, R., Wang, J.J., Mitchell, P., Miao, H., Wang, B., EPHA2 is associated with age-related cortical cataract in mice and humans (2009) PLoS Genet., 5, p. 1000584
Zhang, T., Hua, R., Xiao, W., Burdon, K.P., Bhattacharya, S.S., Craig, J.E., Shang, D., Zhang, X., Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract (2009) Hum. Mutat., 30, pp. 603-E611
Lupberger, J., Zeisel, M.B., Xiao, F., Thumann, C., Fofana, I., Zona, L., Davis, C., Baumert, T.F., EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy (2011) Nat. Med., 17, pp. 589-595
Zhuang, G., Hunter, S., Hwang, Y., Chen, J., Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-kinase-dependent Rac1 activation (2007) Journal of Biological Chemistry, 282 (4), pp. 2683-2694. , http://www.jbc.org/cgi/reprint/282/4/2683, DOI 10.1074/jbc.M608509200
Kim, J., Lee, H., Kim, Y., Yoo, S., Park, E., Park, S., The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors (2010) Mol. Cell. Biol., 30, pp. 1582-1592
Kim, C.A., Bowie, J.U., SAM domains: Uniform structure, diversity of function (2003) Trends in Biochemical Sciences, 28 (12), pp. 625-628. , DOI 10.1016/j.tibs.2003.11.001
Meruelo, A.D., Bowie, J.U., Identifying polymer-forming SAM domains (2009) Proteins, 74, pp. 1-5
Leone, M., Cellitti, J., Pellecchia, M., NMR studies of a heterotypic Sam-Sam domain association: The interaction between the lipid phosphatase Ship2 and the EphA2 receptor (2008) Biochemistry, 47, pp. 12721-12728
Rajakulendran, T., Sahmi, M., Kurinov, I., Tyers, M., Therrien, M., Sicheri, F., CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling (2008) Proceedings of the National Academy of Sciences of the United States of America, 105 (8), pp. 2836-2841. , http://www.pnas.org/cgi/reprint/105/8/2836, DOI 10.1073/pnas.0709705105
Ramachander, R., Bowie, J.U., SAM domains can utilize similar surfaces for the formation of polymers and closed oligomers (2004) Journal of Molecular Biology, 342 (5), pp. 1353-1358. , DOI 10.1016/j.jmb.2004.08.011, PII S0022283604009787
Wei, Z., Zheng, S., Spangler, S.A., Yu, C., Hoogenraad, C.C., Zhang, M., Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures (2011) Mol. Cell, 43, pp. 586-598
Emaduddin, M., Edelmann, M.J., Kessler, B.M., Feller, S.M., Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells (2008) Cell Commun. Signaling, 6, p. 7
Ghersi, E., Vito, P., Lopez, P., Abdallah, M., D'Adamio, L., The intracellular localization of amyloid β protein precursor (AβPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AβPP and alternative splicing (2004) Journal of Alzheimer's Disease, 6 (1), pp. 67-78
Neri, D., Szyperski, T., Otting, G., Senn, H., Wuthrich, K., Stereospecific nuclear magnetic resonance assignments of the methyl groups of valine and leucine in the DNA-binding domain of the 434 repressor by biosynthetically directed fractional 13C labeling (1989) Biochemistry, 28 (19), pp. 7510-7516
Grzesiek, S., Bax, A., Amino acid type determination in the sequential assignment procedure of uniformly 13C/ 15N-enriched proteins (1993) J. Biomol. NMR, 3, pp. 185-204
Bartels, C., Xia, T., Billeter, M., Güntert, P., Wüthrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J. Biomol. NMR, 6, pp. 1-10
Kay, L.E., Torchia, D.A., Bax, A., Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: Application to staphylococcal nuclease (1989) Biochemistry, 28 (23), pp. 8972-8979
Morris, K., Johnson, C.S., Diffusion-ordered two-dimensional nuclear magnetic resonance spectroscopy (1992) J. Am. Chem. Soc., 114, pp. 3139-3141
Price, W.S., Pulsed-Field Gradient Nuclear Magnetic Resonance as a Tool for Studying Translational Diffusion: Part I. Basic Theory (1997) Concepts in Magnetic Resonance, 9 (5), pp. 299-336. , DOI 10.1002/(SICI)1099-0534(1997)9:5<299::AID-CMR2> 3.0.CO
Talluri, S., Wagner, G., An optimized 3D NOESY-HSQC (1996) Journal of Magnetic Resonance - Series B, 112 (2), pp. 200-205
Kumar, A., Ernst, R.R., Wuthrich, K., A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules (1980) Biochem. Biophys. Res. Commun., 95, pp. 1-6
Herrmann, T., Guntert, P., Wuthrich, K., Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA (2002) Journal of Molecular Biology, 319 (1), pp. 209-227. , DOI 10.1016/S0022-2836(02)00241-3
Koradi, R., Billeter, M., Wuthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graphics, 14, pp. 29-32. , 51-55
Sanner, M.F., Olson, A.J., Spehner, J.C., Reduced surface: An efficient way to compute molecular surfaces (1996) Biopolymers, 38, pp. 305-320
Johnsson, B., Lofas, S., Lindquist, G., Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors (1991) Anal. Biochem., 198, pp. 268-277
Rich, R.L., Myszka, D.G., BIACORE J: A new platform for routine biomolecular interaction analysis (2001) Journal of Molecular Recognition, 14 (4), pp. 223-228. , DOI 10.1002/jmr.535
De Vries, S.J., Van Dijk, M., Bonvin, A.M., The HADDOCK web server for data-driven biomolecular docking (2010) Nat. Protoc., 5, pp. 883-897
Van Dijk, A.D.J., Bonvin, A.M.J.J., Solvated docking: Introducing water into the modelling of biomolecular complexes (2006) Bioinformatics, 22 (19), pp. 2340-2347. , DOI 10.1093/bioinformatics/btl395
Kurabi, A., Brener, S., Mobli, M., Kwan, J.J., Donaldson, L.W., A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import (2009) J. Mol. Biol., 392, pp. 1168-1177
Pellecchia, M., Solution nuclear magnetic resonance spectroscopy techniques for probing intermolecular interactions (2005) Chemistry and Biology, 12 (9), pp. 961-971. , DOI 10.1016/j.chembiol.2005.08.013, PII S1074552105002693
Farmer II, B.T., Constantine, K.L., Goldfarb, V., Friedrichs, M.S., Wittekind, M., Yanchunas Jr., J., Robertson, J.G., Mueller, L., Localizing the NADP + binding site on the murb enzyme by NMR (1996) Nature Structural Biology, 3 (12), pp. 995-997. , DOI 10.1038/nsb1296-995
Stafford, R.L., Hinde, E., Knight, M.J., Pennella, M.A., Ear, J., Digman, M.A., Gratton, E., Bowie, J.U., Tandem SAM Domain Structure of Human Caskin1: A Presynaptic, Self-Assembling Scaffold for CASK (2011) Structure, 19, pp. 1826-1836
Dominguez, C., Boelens, R., Bonvin, A.M.J.J., HADDOCK: A protein-protein docking approach based on biochemical or biophysical information (2003) Journal of the American Chemical Society, 125 (7), pp. 1731-1737. , DOI 10.1021/ja026939x
Zhuang, G., Brantley-Sieders, D.M., Vaught, D., Yu, J., Xie, L., Wells, S., Jackson, D., Chen, J., Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy (2010) Cancer Res., 70, pp. 299-308
Thanos, C.D., Faham, S., Goodwill, K.E., Cascio, D., Phillips, M., Bowie, J.U., Monomeric structure of the human EphB2 sterile α motif domain (1999) J. Biol. Chem., 274, pp. 37301-37306
Wilkins, D.K., Grimshaw, S.B., Receveur, V., Dobson, C.M., Jones, J.A., Smith, L.J., Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques (1999) Biochemistry, 38, pp. 16424-16431
Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., Lipman, D.J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs (1997) Nucleic Acids Research, 25 (17), pp. 3389-3402. , DOI 10.1093/nar/25.17.3389
Kim, C.A., Gingery, M., Pilpa, R.M., Bowie, J.U., The SAM domain of polyhomeotic forms a helical polymer (2002) Nature Structural Biology, 9 (6), pp. 453-457. , DOI 10.1038/nsb802
Lee, H.J., Hota, P.K., Chugha, P., Guo, H., Miao, H., Zhang, L., Kim, S.J., Buck, M., NMR Structure of a Heterodimeric SAM:SAM Complex: Characterization and Manipulation of EphA2 Binding Reveal New Cellular Functions of SHIP2 (2012) Structure, 20, pp. 41-55
Shiels, A., Bennett, T.M., Knopf, H.L., Maraini, G., Li, A., Jiao, X., Hejtmancik, J.F., The EPHA2 gene is associated with cataracts linked to chromosome 1p (2008) Mol. Vision, 14, pp. 2042-2055
Laskowski, R.A., Rullmann, J.A.C., MacArthur, M.W., Kaptein, R., Thornton, J.M., AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR (1996) Journal of Biomolecular NMR, 8 (4), pp. 477-486
Pasquale, E. B., Eph receptors and ephrins in cancer: Bidirectional signalling and beyond (2010) Nat. Rev. Cancer, 10, pp. 165-18
Cooper, M. A., Son, A. I., Komlos, D., Sun, Y., Kleiman, N. J., Zhou, R., Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract (2008) Proc. Natl. Acad. Sci. U. S. A., 105, pp. 16620-16625
Kim, C. A., Bowie, J. U., SAM domains: Uniform structure, diversity of function (2003) Trends in Biochemical Sciences, 28 (12), pp. 625-628. , DOI 10. 1016/j. tibs. 2003. 11. 001
Meruelo, A. D., Bowie, J. U., Identifying polymer-forming SAM domains (2009) Proteins, 74, pp. 1-5
Kay, L. E., Torchia, D. A., Bax, A., Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: Application to staphylococcal nuclease (1989) Biochemistry, 28 (23), pp. 8972-8979
Price, W. S., Pulsed-Field Gradient Nuclear Magnetic Resonance as a Tool for Studying Translational Diffusion: Part I. Basic Theory (1997) Concepts in Magnetic Resonance, 9 (5), pp. 299-336. , DOI 10. 1002/ (SICI) 1099-0534 (1997) 9: 5<299:: AID-CMR2> 3. 0. CO
Sanner, M. F., Olson, A. J., Spehner, J. C., Reduced surface: An efficient way to compute molecular surfaces (1996) Biopolymers, 38, pp. 305-320
Rich, R. L., Myszka, D. G., BIACORE J: A new platform for routine biomolecular interaction analysis (2001) Journal of Molecular Recognition, 14 (4), pp. 223-228. , DOI 10. 1002/jmr. 535
De Vries, S. J., Van Dijk, M., Bonvin, A. M., The HADDOCK web server for data-driven biomolecular docking (2010) Nat. Protoc., 5, pp. 883-897
Van Dijk, A. D. J., Bonvin, A. M. J. J., Solvated docking: Introducing water into the modelling of biomolecular complexes (2006) Bioinformatics, 22 (19), pp. 2340-2347. , DOI 10. 1093/bioinformatics/btl395
Farmer II, B. T., Constantine, K. L., Goldfarb, V., Friedrichs, M. S., Wittekind, M., Yanchunas Jr., J., Robertson, J. G., Mueller, L., Localizing the NADP + binding site on the murb enzyme by NMR (1996) Nature Structural Biology, 3 (12), pp. 995-997. , DOI 10. 1038/nsb1296-995
Stafford, R. L., Hinde, E., Knight, M. J., Pennella, M. A., Ear, J., Digman, M. A., Gratton, E., Bowie, J. U., Tandem SAM Domain Structure of Human Caskin1: A Presynaptic, Self-Assembling Scaffold for CASK (2011) Structure, 19, pp. 1826-1836
Thanos, C. D., Faham, S., Goodwill, K. E., Cascio, D., Phillips, M., Bowie, J. U., Monomeric structure of the human EphB2 sterile motif domain (1999) J. Biol. Chem., 274, pp. 37301-37306
Wilkins, D. K., Grimshaw, S. B., Receveur, V., Dobson, C. M., Jones, J. A., Smith, L. J., Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques (1999) Biochemistry, 38, pp. 16424-16431
Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., Lipman, D. J., Gapped BLAST and PSI-BLAST: A new generation of protein database search programs (1997) Nucleic Acids Research, 25 (17), pp. 3389-3402. , DOI 10. 1093/nar/25. 17. 3389
Kim, C. A., Gingery, M., Pilpa, R. M., Bowie, J. U., The SAM domain of polyhomeotic forms a helical polymer (2002) Nature Structural Biology, 9 (6), pp. 453-457. , DOI 10. 1038/nsb802
Lee, H. J., Hota, P. K., Chugha, P., Guo, H., Miao, H., Zhang, L., Kim, S. J., Buck, M., NMR Structure of a Heterodimeric SAM: SAM Complex: Characterization and Manipulation of EphA2 Binding Reveal New Cellular Functions of SHIP2 (2012) Structure, 20, pp. 41-55
Laskowski, R. A., Rullmann, J. A. C., MacArthur, M. W., Kaptein, R., Thornton, J. M., AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR (1996) Journal of Biomolecular NMR, 8 (4), pp. 477-486
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.377, 5-year impact factor: 3.168
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84858225733&partnerID=40&md5=4c43215e7bb5c0f8a340ea46e85d7dbf
Keywords: Ankyrin, Binding Modes, Binding Studies, Cancer Cells, Isothermal Titration Calorimetry, Micromolar Range, Molecular Modeling Studies, Nmr Chemical Shift Perturbations, Receptor Endocytosis, Solution Structures, Structural Elements, Therapeutic Compounds, Topology Characteristics, Binding Energy, Molecular Biology, Ephrin Receptor A2, Phosphatase, Protein Odin, Protein Ship2, Unclassified Drug, Amino Acid Sequence, Article, Binding Kinetics, Carbon Nuclear Magnetic Resonance, Heteronuclear Single Quantum Coherence, Molecular Docking, Molecular Interaction, Nitrogen Nuclear Magnetic Resonance, Nuclear Overhauser Effect, Priority Journal, Protein Domain, Protein Structure, Receptor Binding, Sterile Alpha Motif Domain, Surface Plasmon Resonance, Adaptor Proteins, Signal Transducing, Humans, Multiprotein Complexes, Biomolecular, Protein Interaction Domains And Motifs, Recombinant Proteins, Thermodynamics,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, University of Naples Federico II, Naples, Italy
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPEB), Naples, Italy
Institute of Biostructures and Bioimaging, National Research Council, Naples, Italy
Sanford-Burnham Medical Research Institute, San Diego, CA 92037, United States
References:
Pasquale, E.B., Eph receptors and ephrins in cancer: Bidirectional signalling and beyond (2010) Nat. Rev. Cancer, 10, pp. 165-18
Surawska, H., Ma, P.C., Salgia, R., The role of ephrins and Eph receptors in cancer (2004) Cytokine and Growth Factor Reviews, 15 (6), pp. 419-433. , DOI 10.1016/j.cytogfr.2004.09.002, PII S1359610104000760
Koolpe, M., Dail, M., Pasquale, E.B., An ephrin mimetic peptide that selectively targets the EphA2 receptor (2002) Journal of Biological Chemistry, 277 (49), pp. 46974-46979. , DOI 10.1074/jbc.M208495200
Cooper, M.A., Son, A.I., Komlos, D., Sun, Y., Kleiman, N.J., Zhou, R., Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract (2008) Proc. Natl. Acad. Sci. U.S.A., 105, pp. 16620-16625
Jun, G., Guo, H., Klein, B.E., Klein, R., Wang, J.J., Mitchell, P., Miao, H., Wang, B., EPHA2 is associated with age-related cortical cataract in mice and humans (2009) PLoS Genet., 5, p. 1000584
Zhang, T., Hua, R., Xiao, W., Burdon, K.P., Bhattacharya, S.S., Craig, J.E., Shang, D., Zhang, X., Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract (2009) Hum. Mutat., 30, pp. 603-E611
Lupberger, J., Zeisel, M.B., Xiao, F., Thumann, C., Fofana, I., Zona, L., Davis, C., Baumert, T.F., EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy (2011) Nat. Med., 17, pp. 589-595
Zhuang, G., Hunter, S., Hwang, Y., Chen, J., Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-kinase-dependent Rac1 activation (2007) Journal of Biological Chemistry, 282 (4), pp. 2683-2694. , http://www.jbc.org/cgi/reprint/282/4/2683, DOI 10.1074/jbc.M608509200
Kim, J., Lee, H., Kim, Y., Yoo, S., Park, E., Park, S., The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors (2010) Mol. Cell. Biol., 30, pp. 1582-1592
Kim, C.A., Bowie, J.U., SAM domains: Uniform structure, diversity of function (2003) Trends in Biochemical Sciences, 28 (12), pp. 625-628. , DOI 10.1016/j.tibs.2003.11.001
Meruelo, A.D., Bowie, J.U., Identifying polymer-forming SAM domains (2009) Proteins, 74, pp. 1-5
Leone, M., Cellitti, J., Pellecchia, M., NMR studies of a heterotypic Sam-Sam domain association: The interaction between the lipid phosphatase Ship2 and the EphA2 receptor (2008) Biochemistry, 47, pp. 12721-12728
Rajakulendran, T., Sahmi, M., Kurinov, I., Tyers, M., Therrien, M., Sicheri, F., CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling (2008) Proceedings of the National Academy of Sciences of the United States of America, 105 (8), pp. 2836-2841. , http://www.pnas.org/cgi/reprint/105/8/2836, DOI 10.1073/pnas.0709705105
Ramachander, R., Bowie, J.U., SAM domains can utilize similar surfaces for the formation of polymers and closed oligomers (2004) Journal of Molecular Biology, 342 (5), pp. 1353-1358. , DOI 10.1016/j.jmb.2004.08.011, PII S0022283604009787
Wei, Z., Zheng, S., Spangler, S.A., Yu, C., Hoogenraad, C.C., Zhang, M., Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures (2011) Mol. Cell, 43, pp. 586-598
Emaduddin, M., Edelmann, M.J., Kessler, B.M., Feller, S.M., Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells (2008) Cell Commun. Signaling, 6, p. 7
Ghersi, E., Vito, P., Lopez, P., Abdallah, M., D'Adamio, L., The intracellular localization of amyloid β protein precursor (AβPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AβPP and alternative splicing (2004) Journal of Alzheimer's Disease, 6 (1), pp. 67-78
Neri, D., Szyperski, T., Otting, G., Senn, H., Wuthrich, K., Stereospecific nuclear magnetic resonance assignments of the methyl groups of valine and leucine in the DNA-binding domain of the 434 repressor by biosynthetically directed fractional 13C labeling (1989) Biochemistry, 28 (19), pp. 7510-7516
Grzesiek, S., Bax, A., Amino acid type determination in the sequential assignment procedure of uniformly 13C/ 15N-enriched proteins (1993) J. Biomol. NMR, 3, pp. 185-204
Bartels, C., Xia, T., Billeter, M., Güntert, P., Wüthrich, K., The program XEASY for computer-supported NMR spectral analysis of biological macromolecules (1995) J. Biomol. NMR, 6, pp. 1-10
Kay, L.E., Torchia, D.A., Bax, A., Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: Application to staphylococcal nuclease (1989) Biochemistry, 28 (23), pp. 8972-8979
Morris, K., Johnson, C.S., Diffusion-ordered two-dimensional nuclear magnetic resonance spectroscopy (1992) J. Am. Chem. Soc., 114, pp. 3139-3141
Price, W.S., Pulsed-Field Gradient Nuclear Magnetic Resonance as a Tool for Studying Translational Diffusion: Part I. Basic Theory (1997) Concepts in Magnetic Resonance, 9 (5), pp. 299-336. , DOI 10.1002/(SICI)1099-0534(1997)9:5<299::AID-CMR2> 3.0.CO
Talluri, S., Wagner, G., An optimized 3D NOESY-HSQC (1996) Journal of Magnetic Resonance - Series B, 112 (2), pp. 200-205
Kumar, A., Ernst, R.R., Wuthrich, K., A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules (1980) Biochem. Biophys. Res. Commun., 95, pp. 1-6
Herrmann, T., Guntert, P., Wuthrich, K., Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA (2002) Journal of Molecular Biology, 319 (1), pp. 209-227. , DOI 10.1016/S0022-2836(02)00241-3
Koradi, R., Billeter, M., Wuthrich, K., MOLMOL: A program for display and analysis of macromolecular structures (1996) J. Mol. Graphics, 14, pp. 29-32. , 51-55
Sanner, M.F., Olson, A.J., Spehner, J.C., Reduced surface: An efficient way to compute molecular surfaces (1996) Biopolymers, 38, pp. 305-320
Johnsson, B., Lofas, S., Lindquist, G., Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors (1991) Anal. Biochem., 198, pp. 268-277
Rich, R.L., Myszka, D.G., BIACORE J: A new platform for routine biomolecular interaction analysis (2001) Journal of Molecular Recognition, 14 (4), pp. 223-228. , DOI 10.1002/jmr.535
De Vries, S.J., Van Dijk, M., Bonvin, A.M., The HADDOCK web server for data-driven biomolecular docking (2010) Nat. Protoc., 5, pp. 883-897
Van Dijk, A.D.J., Bonvin, A.M.J.J., Solvated docking: Introducing water into the modelling of biomolecular complexes (2006) Bioinformatics, 22 (19), pp. 2340-2347. , DOI 10.1093/bioinformatics/btl395
Kurabi, A., Brener, S., Mobli, M., Kwan, J.J., Donaldson, L.W., A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import (2009) J. Mol. Biol., 392, pp. 1168-1177
Pellecchia, M., Solution nuclear magnetic resonance spectroscopy techniques for probing intermolecular interactions (2005) Chemistry and Biology, 12 (9), pp. 961-971. , DOI 10.1016/j.chembiol.2005.08.013, PII S1074552105002693
Farmer II, B.T., Constantine, K.L., Goldfarb, V., Friedrichs, M.S., Wittekind, M., Yanchunas Jr., J., Robertson, J.G., Mueller, L., Localizing the NADP + binding site on the murb enzyme by NMR (1996) Nature Structural Biology, 3 (12), pp. 995-997. , DOI 10.1038/nsb1296-995
Stafford, R.L., Hinde, E., Knight, M.J., Pennella, M.A., Ear, J., Digman, M.A., Gratton, E., Bowie, J.U., Tandem SAM Domain Structure of Human Caskin1: A Presynaptic, Self-Assembling Scaffold for CASK (2011) Structure, 19, pp. 1826-1836
Dominguez, C., Boelens, R., Bonvin, A.M.J.J., HADDOCK: A protein-protein docking approach based on biochemical or biophysical information (2003) Journal of the American Chemical Society, 125 (7), pp. 1731-1737. , DOI 10.1021/ja026939x
Zhuang, G., Brantley-Sieders, D.M., Vaught, D., Yu, J., Xie, L., Wells, S., Jackson, D., Chen, J., Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy (2010) Cancer Res., 70, pp. 299-308
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Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor
The EphA2 receptor plays key roles in many physiological and pathological events, including cancer. The process of receptor endocytosis and the consequent degradation have attracted attention as possible means of overcoming the negative outcomes of EphA2 in cancer cells and decreasing tumor malignancy. A recent study indicates that Sam (sterile alpha motif) domains of Odin, a member of the ANKS (ankyrin repeat and sterile alpha motif domain-containing) family of proteins, are important for the regulation of EphA2 endocytosis. Odin contains two tandem Sam domains (Odin-Sam1 and -Sam2). Herein, we report on the nuclear magnetic resonance (NMR) solution structure of Odin-Sam1; through a variety of assays (employing NMR, surface plasmon resonance, and isothermal titration calorimetry techniques), we clearly demonstrate that Odin-Sam1 binds to the Sam domain of EphA2 in the low micromolar range. NMR chemical shift perturbation experiments and molecular modeling studies point out that the two Sam domains interact with a head-to-tail topology characteristic of several Sam-Sam complexes. This binding mode is similar to that we have previously proposed for the association between the Sam domains of the lipid phosphatase Ship2 and EphA2. This work further validates structural elements relevant for the heterotypic Sam-Sam interactions of EphA2 and provides novel insights for the design of potential therapeutic compounds that can modulate receptor endocytosis.
The EphA2 receptor plays key roles in many physiological and pathological events, including cancer. The process of receptor endocytosis and the consequent degradation have attracted attention as possible means of overcoming the negative outcomes of EphA2 in cancer cells and decreasing tumor malignancy. A recent study indicates that Sam (sterile alpha motif) domains of Odin, a member of the ANKS (ankyrin repeat and sterile alpha motif domain-containing) family of proteins, are important for the regulation of EphA2 endocytosis. Odin contains two tandem Sam domains (Odin-Sam1 and -Sam2). Herein, we report on the nuclear magnetic resonance (NMR) solution structure of Odin-Sam1; through a variety of assays (employing NMR, surface plasmon resonance, and isothermal titration calorimetry techniques), we clearly demonstrate that Odin-Sam1 binds to the Sam domain of EphA2 in the low micromolar range. NMR chemical shift perturbation experiments and molecular modeling studies point out that the two Sam domains interact with a head-to-tail topology characteristic of several Sam-Sam complexes. This binding mode is similar to that we have previously proposed for the association between the Sam domains of the lipid phosphatase Ship2 and EphA2. This work further validates structural elements relevant for the heterotypic Sam-Sam interactions of EphA2 and provides novel insights for the design of potential therapeutic compounds that can modulate receptor endocytosis.
Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor
Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor
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* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (581 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Roviello GN, Musumeci D, De Cristofaro A, Capasso D, Di Gaetano S, Bucci EM, Pedone C
* Alternate dab-aegPNAs: synthesis, nucleic acid binding studies and biological activity (526 views)
Mol Biosyst (ISSN: 1742-2051, 1742-206x, 1742-2051electronic), 2010 Jan; 6(1): 199-205.
Impact Factor: 3.825
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Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (494 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
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Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (435 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (420 views)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (430 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (512 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Sommella I, Potena A, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing breast cancer cells during treatment with gefitinib, a selective tyrosine kinase inhibitor (381 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
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Zannetti A, Del Vecchio S, Fonti R, Iommelli F, Sommella J, Potena A, Salvatore M
* Gefitinib, A Selective, Tyrosine Kinase Inhibitor Increases 99mtc-Mibi Uptake In Bcl-2 Overexpressing Breast Cancer Cells (380 views)
Mol Immunol, 2005; 4: 355-355.
Impact Factor: 3.003
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
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Impact Factor: 3.992
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Pappalardo G, Impellizzeri G, Bonomo RP, Campagna T, Grasso G, Saita MG
* Copper(II) and nickel(II) binding modes in a histidine-containing model dodecapeptide (331 views)
New J Chem (ISSN: 1144-0546), 2002; 26(5): 593-600.
Impact Factor: 2.06
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Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (372 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Aloj L, Del Vecchio S, Zannetti A, Caracò C, Salvatore M
* 99mTc-MIBI uptake is reduced in Bcl-2 overexpressing MCF-7 breast cancer cells (357 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (504 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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* Selective Photo-Assisted Eradication of Triple-Negative Breast Cancer Cells through Aptamer Decoration of Doped Conjugated Polymer Nanoparticles (15 views)
Pharmaceutics (ISSN: 1999-4923linking), 2022 Mar 12; 14(3): N/D-N/D.
Impact Factor: 6.321
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Pramanik A, Xu Z, Shamsuddin SH, Khaled YS, Ingram N, Maisey T, Tomlinson D, Coletta PL, Jayne D, Hughes TA, Tyler AII, Millner PA
Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using In Vitro and In Vivo Models (3 views)
Acs Appl Mater Interfaces (ISSN: 1944-8252electronic), 2022 Mar 09; 14 (9 ): 11078-11091.
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Manco M, Ala U, Cantarella D, Tolosano E, Medico E, Altruda F, Fagoonee S
* The RNA-Binding Protein ESRP1 Modulates the Expression of RAC1b in Colorectal Cancer Cells (4 views)
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Impact Factor: 6.126
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Susana F, Fagoonee S, Alessandro S, Valentina G, Chiara R, Marco P, Fiorella A, Danilo D
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Impact Factor: 5.339
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Monti A, Sturlese M, Caporale A, Roger JA, Mascanzoni F, Ruvo M, Doti N
* Design, synthesis, structural analysis and biochemical studies of stapled AIF(370-394) analogues as ligand of CypA (87 views)
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Impact Factor: 3.422
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Riccardi C, Capasso D, Coppola A, Platella C, Montesarchio D, Di Gaetano S, Roviello GN, Musumeci D
* Synthesis, Antiproliferative Activity, and DNA Binding Studies of Nucleoamino Acid-Containing Pt(II) Complexes (150 views)
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Impact Factor: 4.421
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Capasso D, Borbone N, Terracciano M, Di Gaetano S, Piccialli V
* Antiproliferative Activity of Mycalin A and Its Analogues on Human Skin Melanoma and Human Cervical Cancer Cells (87 views)
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Impact Factor: 4.379
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Squeglia F, Maciejewska B, Łątka A, Ruggiero A, Briers Y, Drulis-kawa Z, Berisio R
* Structural and Functional Studies of a Klebsiella Phage Capsule Depolymerase Tailspike: Mechanistic Insights into Capsular Degradation (98 views)
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Impact Factor: 4.86
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Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
* Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)- complexes with an L-alanyl-based ligand (261 views)
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Impact Factor: 3.224
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Ala U, Manco M, Mandili G, Tolosano E, Novelli F, Provero P, Altruda F, Fagoonee S
* Proteomics-Based Evidence for a Pro-Oncogenic Role of ESRP1 in Human Colorectal Cancer Cells (128 views)
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Impact Factor: 2.598
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Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
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Impact Factor: 3.345
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Russi S, Verma HK, Laurino S, Mazzone P, Storto G, Nardelli A, Zoppoli P, Calice G, La Rocca F, Sgambato A, Lucci V, Falco G, Ruggieri V
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Impact Factor: 4.183
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D'Amora A, Cucciolito M, E , Iannitti R, Morelli G, Palumbo R, Ruffo F, Tesauro D
* Pyridine Ruthenium(III) complexes entrapped in liposomes with enhanced cytotoxic properties in PC-3 prostate cancer cells (156 views)
Journal Of Drug Delivery Science And Technology, 2019; 51: 552-558.
Impact Factor: 2.606
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Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
* Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (1084 views)
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Impact Factor: 5.207
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Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A
* Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (328 views)
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Impact Factor: 2.507
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Avitabile C, D'Andrea LD, Saviano M, Olivieri M, Cimmino A, Romanelli A
* Binding studies of antimicrobial peptides to Escherichia coli cells (389 views)
Biochem Bioph Res Co (ISSN: 0006-291x), 2016 Sep 09; 478(1): 149-153.
Impact Factor: 2.466
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Soprano M, Sorriento D, Rusciano MR, Maione AS, Limite G, Forestieri P, D'Angelo D, D'Alessio M, Campiglia P, Formisano P, Iaccarino G, Bianco R, Illario M
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Impact Factor: 2.806
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Roviello GN, Musumeci D
* Synthetic approaches to nucleopeptides containing all the four nucleobases, and nucleic acid-binding studies on a mixed-sequence nucleo-oligolysine (435 views)
Rsc Adv (ISSN: 2046-2069), 2016 Jun; 6: 63578-63585.
Impact Factor: 3.108
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Langella E, D'Ambrosio K, D'Ascenzio M, Carradori S, Monti SM, Supuran CT, De Simone G
* A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases (336 views)
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Impact Factor: 5.317
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Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PLS, Carrotta R
* Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains (367 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2016; 208: 9-16.
Impact Factor: 2.402
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Roviello GN, Roviello V, Autiero I, Saviano M
* Solid phase synthesis of TyrT, a thymine-tyrosine conjugate with poly(A) RNA-binding ability (505 views)
Rsc Adv (ISSN: 2046-2069), 2016; 6(33): 27607-27613.
Impact Factor: 3.108
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Smaldone G, Pirone L, Balasco N, Di Gaetano S, Pedone E, Vitagliano L
* Cullin 3 recognition is not a universal property among KCTD proteins (581 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 May 14; 10(5): e0126808-e0126808.
Impact Factor: 3.057
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Pietropaolo A, Satriano C, Strano G, La Mendola D, Rizzarelli E
* Different zinc(II) complex species and binding modes at Aβ N-terminus drive distinct long range cross-talks in the Aβ monomers (416 views)
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Impact Factor: 3.205
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
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Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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Morra F, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A
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Int J Cancer (ISSN: 0020-7136), 2015; 136(9): 2146-2157.
Impact Factor: 5.531
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Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (370 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
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Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G
* Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis (475 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014 Jul; 101(7): 712-719.
Impact Factor: 2.385
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Basile L, Pappalardo M, Guccione S, Milardi D, Ramsay RR
* Computational comparison of imidazoline association with the I2 binding site in human monoamine oxidases (358 views)
J Chem Inf Model (ISSN: 1549-9596), 2014 Apr 28; 54(4): 1200-1207.
Impact Factor: 3.738
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Palmieri M, Russo L, Malgieri G, Esposito S, Baglivo I, Rivellino A, Farina B, de Paola I, Zaccaro L, Milardi D, Isernia C, Pedone PV, Fattorusso R
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J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 30-36.
Impact Factor: 3.444
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Contursi P, Farina B, Pirone L, Fusco S, Russo L, Bartolucci S, Fattorusso R, Pedone E
* Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family (384 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962), 2014; 42(9): 5993-6011.
Impact Factor: 9.112
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Di Natale G, Osz K, Kállay C, Pappalardo G, Sanna D, Impellizzeri G, Sóvágó I, Rizzarelli E
* Affinity, speciation, and molecular features of copper(II) complexes with a prion tetraoctarepeat domain in aqueous solution: insights into old and new results (422 views)
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Impact Factor: 5.696
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Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (402 views)
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Impact Factor: 2.92
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (410 views)
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Impact Factor: 2.768
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Arena G, La Mendola D, Pappalardo G, Sovago I, Rizzarelli E
* Interactions of Cu 2+ with prion family peptide fragments: Considerations on affinity, speciation and coordination (489 views)
Coord Chem Rev (ISSN: 0010-8545), 2012 Oct; 256(19-20): 2202-2218.
Impact Factor: 11.016
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Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
* Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (462 views)
Chem Rev (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
Impact Factor: 41.298
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Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (447 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (518 views)
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Impact Factor: 6.044
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De Rosa V, Erkekoǧlu P, Forestier A, Favier A, Hincal F, Diamond AM, Douki T, Rachidi W
* Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells (848 views)
Free Radic Res Free Radical Research (ISSN: 1071-5762), 2012; 46(2): 105-115.
Impact Factor: 3.279
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (383 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (560 views)
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Impact Factor: 5.925
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Bonaccorso C, Sgarlata C, Grasso G, Zito V, Sciotto D, Arena G
* A gemini guest triggers the self-assembly of a calixarene capsule in water at neutral pH (275 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011; 47(21): 6117-6119.
Impact Factor: 6.169
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Di Fiore A, Monti SM, Innocenti A, Winum J-Y, De Simone G, Supuran CT
* Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV (352 views)
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Impact Factor: 2.661
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (581 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Roviello GN, Musumeci D, De Cristofaro A, Capasso D, Di Gaetano S, Bucci EM, Pedone C
* Alternate dab-aegPNAs: synthesis, nucleic acid binding studies and biological activity (526 views)
Mol Biosyst (ISSN: 1742-2051, 1742-206x, 1742-2051electronic), 2010 Jan; 6(1): 199-205.
Impact Factor: 3.825
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Roviello GN, Musumeci D, Pedone C, Bucci EM
* Synthesis, Characterization And Hybridization Studies Of An Alternate Nucleo-Epsilon/Gamma-Peptide: Complexes Formation With Natural Nucleic Acids (494 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Jan; 38(1): 103-111.
Impact Factor: 4.106
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Roviello GN, Musumeci D, Castiglione M, Bucci EM, Pedone C, Benedetti E
* Solid Phase Synthesis And Rna-Binding Studies Of A Serum-Resistant Nucleo-Epsilon-Peptide (435 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 155-160.
Impact Factor: 1.807
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Malaguarnera R, Vella V, Pandini G, Sanfilippo M, Pezzino V, Vigneri R, Frasca F
* TAp73α increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation (420 views)
Mol Cancer Res (ISSN: 1541-7786), 2008; 6(1): 64-77.
Impact Factor: 4.533
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, Pedone C
* Dabpna: Design, Synthesis And Nucleic Acids Binding Studies (430 views)
Nucleosides Nucleotides Nucleic Acids (ISSN: 1525-7770), 2007; 26(10-12): 1307-1310.
Impact Factor: 0.723
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (512 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Sommella I, Potena A, Salvatore M
* 99mTc-MIBI uptake in Bcl-2 overexpressing breast cancer cells during treatment with gefitinib, a selective tyrosine kinase inhibitor (381 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
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Zannetti A, Del Vecchio S, Fonti R, Iommelli F, Sommella J, Potena A, Salvatore M
* Gefitinib, A Selective, Tyrosine Kinase Inhibitor Increases 99mtc-Mibi Uptake In Bcl-2 Overexpressing Breast Cancer Cells (380 views)
Mol Immunol, 2005; 4: 355-355.
Impact Factor: 3.003
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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Pappalardo G, Impellizzeri G, Bonomo RP, Campagna T, Grasso G, Saita MG
* Copper(II) and nickel(II) binding modes in a histidine-containing model dodecapeptide (331 views)
New J Chem (ISSN: 1144-0546), 2002; 26(5): 593-600.
Impact Factor: 2.06
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Aloj L, Zannetti A, Caraco C, Fonti R, Del Vecchio S, Salvatore M
* 99mTc-MIBI uptake in breast cancer cells during early phases of apoptosis induction with Staurosporine (372 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Aloj L, Del Vecchio S, Zannetti A, Caracò C, Salvatore M
* 99mTc-MIBI uptake is reduced in Bcl-2 overexpressing MCF-7 breast cancer cells (357 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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Bonomo RP, Imperllizzeri G, Pappalardo G, Rizzarelli E, Tabbì G
Copper(II) binding modes in the prion octapeptide PHGGGWGQ: A spectroscopic and voltammetric study (504 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2000 Nov 17; 6(22): 4195-4202.
Impact Factor: 4.698
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57 Records (52 excluding Abstracts).
Total impact factor: 281.563 (261.705 excluding Abstracts).
Total 5 year impact factor: 273.555 (250.43 excluding Abstracts).
Total impact factor: 281.563 (261.705 excluding Abstracts).
Total 5 year impact factor: 273.555 (250.43 excluding Abstracts).
469 views. Last view on Friday 19 May 2023, 20:34:54
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