Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (538 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Comment, Editorial,
Impact factor: 5.217, 5-year impact factor: 4.728
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84879502551&partnerID=40&md5=fee8ebd5cdb69a2ac9a7a0782b3b93f1
Keywords: Amyloid Beta-Peptides Metabolism, Brain Metabolism Radionuclide Imaging, Humans, Positron-Emission Tomography Methods, Amyloid Beta Protein, Florbetaben, Florbetapir F 18, Flutemetamol F 18, Pittsburgh Compound B, Alzheimer Disease, Brain Perfusion, Cerebrospinal Fluid Analysis, Clinical Practice, Cost Effectiveness Analysis, Dementia, Diffuse Lewy Body Disease, Disease Course, Disease Severity, Dopaminergic System, Early Diagnosis, Food And Drug Administration, Health Care Personnel, Medical Society, Mild Cognitive Impairment, Molecular Imaging, Pathogenesis, Positron Emission Tomography, Practice Guideline, Review, Risk Benefit Analysis, Risk Factor,
Affiliations:
*** IBB - CNR ***
Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Nuclear Medicine Department, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain
Clinical Neurophysiology, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
INSERM, Toulouse, France
Institute of Biostructure and Bioimaging, CNR, Naples, Italy
Department of Mental Health Sciences Unit, University College London, London, United Kingdom
Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy
References:
Johnson, K.A., Minoshima, S., Bohnen, N.I., Donohoe, K.J., Foster, N.L., Herscovitch, P., Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association (2013) J Nucl Med, 54, pp. 476-490. , 23359661 10.2967/jnumed.113.120618 1:CAS:528:DC%2BC3sXltV2ks7g%3
Klunk, W.E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D.P., Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B (2004) Ann Neurol, 55, pp. 306-319. , 14991808 10.1002/ana.20009 1:CAS:528:DC%2BD2cXisFKntb8%3D
Kemppainen, N.M., Aalto, S., Wilson, I.A., Någren, K., Helin, S., Brück, A., Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease (2006) Neurology, 67, pp. 1575-1580. , 16971697 10.1212/01.wnl.0000240117.55680.0a 1:STN:280: DC%2BD28nmslagsQ%3D%3D
Edison, P., Archer, H.A., Hinz, R., Hammers, A., Pavese, N., Tai, Y.F., Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study (2007) Neurology, 68, pp. 501-508. , 17065593 10.1212/01.wnl.0000244749.20056.d4 1:STN:280: DC%2BD2s%2FpsFymsA%3D%3D
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Chételat, G., Villemagne, V.L., Bourgeat, P., Pike, K.E., Jones, G., Ames, D., Relationship between atrophy and beta-amyloid deposition in Alzheimer disease (2010) Ann Neurol, 67, pp. 317-324. , 20373343
Santillo, A.F., Gambini, J.P., Lannfelt, L., Långström, B., Ulla-Marja, L., Kilander, L., In vivo imaging of astrocytosis in Alzheimer's disease: An 11C-L-deuteriodeprenyl and PIB PET study (2011) Eur J Nucl Med Mol Imaging, 38, pp. 2202-2208. , 21853308 10.1007/s00259-011-1895-9
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Clark, C.M., Pontecorvo, M.J., Beach, T.G., Bedell, B.J., Coleman, R.E., Doraiswamy, P.M., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-ß plaques: A prospective cohort study (2012) Lancet Neurol, 11, pp. 669-678. , 22749065 10.1016/S1474-4422(12)70142-4 1:CAS:528:DC%2BC38XhtV2gtb3E
Rinne, J.O., Wong, D.F., Wolk, D.A., Leinonen, V., Arnold, S.E., Buckley, C., [18F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid ß detection in living subjects with normal pressure hydrocephalus: Pooled analysis of four studies (2012) Acta Neuropathol, 124, pp. 833-845. , 23053137 10.1007/s00401-012-1051-z 1:CAS:528:DC%2BC38XhslKls7zI
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Villemagne, V.L., Pike, K.E., Chételat, G., Ellis, K.A., Mulligan, R.S., Bourgeat, P., Longitudinal assessment of Aß and cognition in aging and Alzheimer disease (2011) Ann Neurol, 69, pp. 181-192. , 21280088 10.1002/ana.22248 1:CAS:528:DC%2BC3MXisVCisLs%3D
Ossenkoppele, R., Prins, N.D., Pijnenburg, Y.A., Lemstra, A.W., Van Der Flier, W.M., Adriaanse, S.F., Impact of molecular imaging on the diagnostic process in a memory clinic (2012) Alzheimers Dement, , 10.1016/j.jalz.2012.07.003 23164552
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Chételat, G., Alzheimer disease: Aß-independent processes-rethinking preclinical AD (2013) Nat Rev Neurol, , 10.1038/nrneurol.2013.21
Johnson, K. A., Minoshima, S., Bohnen, N. I., Donohoe, K. J., Foster, N. L., Herscovitch, P., Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association (2013) J Nucl Med, 54, pp. 476-490. , 23359661 10. 2967/jnumed. 113. 120618 1: CAS: 528: DC%2BC3sXltV2ks7g%3
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B (2004) Ann Neurol, 55, pp. 306-319. , 14991808 10. 1002/ana. 20009 1: CAS: 528: DC%2BD2cXisFKntb8%3D
Kemppainen, N. M., Aalto, S., Wilson, I. A., N gren, K., Helin, S., Br ck, A., Voxel-based analysis of PET amyloid ligand [11C] PIB uptake in Alzheimer disease (2006) Neurology, 67, pp. 1575-1580. , 16971697 10. 1212/01. wnl. 0000240117. 55680. 0a 1: STN: 280: DC%2BD28nmslagsQ%3D%3D
Gomperts, S. N., Rentz, D. M., Moran, E., Becker, J. A., Locascio, J. J., Klunk, W. E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology, 71, pp. 903-910. , 18794492 10. 1212/01. wnl. 0000326146. 60732. d6 1: STN: 280: DC%2BD1cngs1amtw%3D%3D
Ch telat, G., Villemagne, V. L., Bourgeat, P., Pike, K. E., Jones, G., Ames, D., Relationship between atrophy and beta-amyloid deposition in Alzheimer disease (2010) Ann Neurol, 67, pp. 317-324. , 20373343
Santillo, A. F., Gambini, J. P., Lannfelt, L., L ngstr m, B., Ulla-Marja, L., Kilander, L., In vivo imaging of astrocytosis in Alzheimer's disease: An 11C-L-deuteriodeprenyl and PIB PET study (2011) Eur J Nucl Med Mol Imaging, 38, pp. 2202-2208. , 21853308 10. 1007/s00259-011-1895-9
Bacskai, B. J., Frosch, M. P., Freeman, S. H., Raymond, S. B., Augustinack, J. C., Johnson, K. A., Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report (2007) Arch Neurol, 64, pp. 431-434. , 17353389 10. 1001/archneur. 64. 3. 431
Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Mathis, C. A., Price, J. C., Tsopelas, N. D., Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease (2008) Brain, 131, pp. 1630-1645. , 18339640 10. 1093/brain/awn016
Rowe, C. C., Ackerman, U., Browne, W., Mulligan, R., Pike, K. L., O'Keefe, G., Imaging of amyloid in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism (2008) Lancet Neurol, 7, pp. 129-135. , 18191617 10. 1016/S1474-4422 (08) 70001-2 1: CAS: 528: DC%2BD1cXis1WmsLw%3D
Wong, D. F., Rosenberg, P. B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H. T., In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir F 18) (2010) J Nucl Med, 51, pp. 913-920. , 20501908 10. 2967/jnumed. 109. 069088 1: CAS: 528: DC%2BC3cXosl2ksb4%3D
Clark, C. M., Schneider, J. A., Bedell, B. J., Beach, T. G., Bilker, W. B., Mintun, M. A., Use of florbetapir-PET for imaging beta-amyloid pathology (2011) JAMA, 305, pp. 275-283. , 21245183 10. 1001/jama. 2010. 2008 1: CAS: 528: DC%2BC3MXhtVGrurw%3D
Csel nyi, Z., J nhagen, M. E., Forsberg, A., Halldin, C., Julin, P., Schou, M., Clinical validation of 18F-AZD4694, an amyloid- -specific PET radioligand (2012) J Nucl Med, 53, pp. 415-424. , 22323782 10. 2967/jnumed. 111. 094029
Clark, C. M., Pontecorvo, M. J., Beach, T. G., Bedell, B. J., Coleman, R. E., Doraiswamy, P. M., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid- plaques: A prospective cohort study (2012) Lancet Neurol, 11, pp. 669-678. , 22749065 10. 1016/S1474-4422 (12) 70142-4 1: CAS: 528: DC%2BC38XhtV2gtb3E
Rinne, J. O., Wong, D. F., Wolk, D. A., Leinonen, V., Arnold, S. E., Buckley, C., [18F] Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid detection in living subjects with normal pressure hydrocephalus: Pooled analysis of four studies (2012) Acta Neuropathol, 124, pp. 833-845. , 23053137 10. 1007/s00401-012-1051-z 1: CAS: 528: DC%2BC38XhslKls7zI
Morris, J. C., Price, J. L., Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease (2001) J Mol Neurosci, 17, pp. 101-118. , 11816784 10. 1385/JMN: 17: 2: 101 1: CAS: 528: DC%2BD3MXosVKitrg%3D
Kapucu, O. L., Nobili, F., Varrone, A., Booij, J., Vander Borght, T., N gren, K., EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2093-2102. , 19838703 10. 1007/s00259-009-1266-y 1: CAS: 528: DC%2BD1MXhsVCisb3L
Patel, M. R., Spertus, J. A., Brindis, R. G., Hendel, R. C., Douglas, P. S., Peterson, E. D., ACCF proposed method for evaluating the appropriateness of cardiovascular imaging (2005) J Am Coll Cardiol, 46, pp. 1606-1613. , 16226195 10. 1016/j. jacc. 2005. 08. 030
Fleisher, A. S., Chen, K., Quiroz, Y. T., Jakimovich, L. J., Gomez, M. G., Langois, C. M., Florbetapir PET analysis of amyloid- deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional study (2012) Lancet Neurol, 11, pp. 1057-1065. , 23137949 10. 1016/S1474-4422 (12) 70227-2 1: CAS: 528: DC%2BC38Xhs12gt7%2FO
Villemagne, V. L., Pike, K. E., Ch telat, G., Ellis, K. A., Mulligan, R. S., Bourgeat, P., Longitudinal assessment of A and cognition in aging and Alzheimer disease (2011) Ann Neurol, 69, pp. 181-192. , 21280088 10. 1002/ana. 22248 1: CAS: 528: DC%2BC3MXisVCisLs%3D
Ch telat, G., Alzheimer disease: A -independent processes-rethinking preclinical AD (2013) Nat Rev Neurol, , 10. 1038/nrneurol. 2013. 21
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Comment, Editorial,
Impact factor: 5.217, 5-year impact factor: 4.728
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84879502551&partnerID=40&md5=fee8ebd5cdb69a2ac9a7a0782b3b93f1
Keywords: Amyloid Beta-Peptides Metabolism, Brain Metabolism Radionuclide Imaging, Humans, Positron-Emission Tomography Methods, Amyloid Beta Protein, Florbetaben, Florbetapir F 18, Flutemetamol F 18, Pittsburgh Compound B, Alzheimer Disease, Brain Perfusion, Cerebrospinal Fluid Analysis, Clinical Practice, Cost Effectiveness Analysis, Dementia, Diffuse Lewy Body Disease, Disease Course, Disease Severity, Dopaminergic System, Early Diagnosis, Food And Drug Administration, Health Care Personnel, Medical Society, Mild Cognitive Impairment, Molecular Imaging, Pathogenesis, Positron Emission Tomography, Practice Guideline, Review, Risk Benefit Analysis, Risk Factor,
Affiliations:
*** IBB - CNR ***
Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Nuclear Medicine Department, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain
Clinical Neurophysiology, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
INSERM, Toulouse, France
Institute of Biostructure and Bioimaging, CNR, Naples, Italy
Department of Mental Health Sciences Unit, University College London, London, United Kingdom
Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy
References:
Johnson, K.A., Minoshima, S., Bohnen, N.I., Donohoe, K.J., Foster, N.L., Herscovitch, P., Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association (2013) J Nucl Med, 54, pp. 476-490. , 23359661 10.2967/jnumed.113.120618 1:CAS:528:DC%2BC3sXltV2ks7g%3
Klunk, W.E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D.P., Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B (2004) Ann Neurol, 55, pp. 306-319. , 14991808 10.1002/ana.20009 1:CAS:528:DC%2BD2cXisFKntb8%3D
Kemppainen, N.M., Aalto, S., Wilson, I.A., Någren, K., Helin, S., Brück, A., Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease (2006) Neurology, 67, pp. 1575-1580. , 16971697 10.1212/01.wnl.0000240117.55680.0a 1:STN:280: DC%2BD28nmslagsQ%3D%3D
Edison, P., Archer, H.A., Hinz, R., Hammers, A., Pavese, N., Tai, Y.F., Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study (2007) Neurology, 68, pp. 501-508. , 17065593 10.1212/01.wnl.0000244749.20056.d4 1:STN:280: DC%2BD2s%2FpsFymsA%3D%3D
Edison, P., Rowe, C.C., Rinne, J.O., Ng, S., Ahmed, I., Kemppainen, N., Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography (2008) J Neurol Neurosurg Psychiatry, 79, pp. 1331-1338. , 18653550 10.1136/jnnp.2007.127878 1:STN:280:DC%2BD1cjktFSgsg%3D%3D
Gomperts, S.N., Rentz, D.M., Moran, E., Becker, J.A., Locascio, J.J., Klunk, W.E., Imaging amyloid deposition in Lewy body diseases (2008) Neurology, 71, pp. 903-910. , 18794492 10.1212/01.wnl.0000326146.60732.d6 1:STN:280: DC%2BD1cngs1amtw%3D%3D
Chételat, G., Villemagne, V.L., Bourgeat, P., Pike, K.E., Jones, G., Ames, D., Relationship between atrophy and beta-amyloid deposition in Alzheimer disease (2010) Ann Neurol, 67, pp. 317-324. , 20373343
Santillo, A.F., Gambini, J.P., Lannfelt, L., Långström, B., Ulla-Marja, L., Kilander, L., In vivo imaging of astrocytosis in Alzheimer's disease: An 11C-L-deuteriodeprenyl and PIB PET study (2011) Eur J Nucl Med Mol Imaging, 38, pp. 2202-2208. , 21853308 10.1007/s00259-011-1895-9
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Ikonomovic, M.D., Abrahamson, E.E., Price, J.C., Hamilton, R.L., Mathis, C.A., Paljug, W.R., Early AD pathology in a [C-11]PiB-negative case: A PiB-amyloid imaging, biochemical, and immunohistochemical study (2012) Acta Neuropathol., 123, pp. 433-447. , 22271153 10.1007/s00401-012-0943-2 1:CAS:528:DC%2BC38Xisl2ktbk%3D
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Koole, M., Lewis, D.M., Buckley, C., Nelissen, N., Vandenbulcke, M., Brooks, D.J., Whole-body biodistribution and radiation dosimetry of 18F-GE067: A radioligand for in vivo brain amyloid imaging (2009) J Nucl Med, 50, pp. 818-822. , 19372469 10.2967/jnumed.108.060756 1:CAS:528:DC%2BD1MXmtV2hsrk%3D
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Clark, C.M., Schneider, J.A., Bedell, B.J., Beach, T.G., Bilker, W.B., Mintun, M.A., Use of florbetapir-PET for imaging beta-amyloid pathology (2011) JAMA, 305, pp. 275-283. , 21245183 10.1001/jama.2010.2008 1:CAS:528:DC%2BC3MXhtVGrurw%3D
Barthel, H., Gertz, H.J., Dresel, S., Peters, O., Bartenstein, P., Buerger, K., Cerebral amyloid-ß PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: A multicentre phase 2 diagnostic study (2011) Lancet Neurol, 10, pp. 424-435. , 21481640 10.1016/S1474-4422(11)70077-1 1:CAS:528:DC%2BC3MXlt1Sls7c%3D
Cselényi, Z., Jönhagen, M.E., Forsberg, A., Halldin, C., Julin, P., Schou, M., Clinical validation of 18F-AZD4694, an amyloid-ß-specific PET radioligand (2012) J Nucl Med, 53, pp. 415-424. , 22323782 10.2967/jnumed.111.094029
Clark, C.M., Pontecorvo, M.J., Beach, T.G., Bedell, B.J., Coleman, R.E., Doraiswamy, P.M., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-ß plaques: A prospective cohort study (2012) Lancet Neurol, 11, pp. 669-678. , 22749065 10.1016/S1474-4422(12)70142-4 1:CAS:528:DC%2BC38XhtV2gtb3E
Rinne, J.O., Wong, D.F., Wolk, D.A., Leinonen, V., Arnold, S.E., Buckley, C., [18F]Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid ß detection in living subjects with normal pressure hydrocephalus: Pooled analysis of four studies (2012) Acta Neuropathol, 124, pp. 833-845. , 23053137 10.1007/s00401-012-1051-z 1:CAS:528:DC%2BC38XhslKls7zI
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Kapucu, O.L., Nobili, F., Varrone, A., Booij, J., Vander Borght, T., Någren, K., EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2093-2102. , 19838703 10.1007/s00259-009-1266-y 1:CAS:528:DC%2BD1MXhsVCisb3L
Van Laere, K., Varrone, A., Booij, J., Vander Borght, T., Nobili, F., Kapucu, O.L., EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2 (2010) Eur J Nucl Med Mol Imaging, 37, pp. 434-442. , 19838704 10.1007/s00259-009-1265-z 1:CAS:528:DC%2BC3cXhsVyisL0%3D
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Patel, M.R., Spertus, J.A., Brindis, R.G., Hendel, R.C., Douglas, P.S., Peterson, E.D., ACCF proposed method for evaluating the appropriateness of cardiovascular imaging (2005) J Am Coll Cardiol, 46, pp. 1606-1613. , 16226195 10.1016/j.jacc.2005.08.030
Delbeke, D., Chiti, A., Christian, P., Darcourt, J., Donohoe, K., Flotats, A., SNMMI/EANM guideline for guideline development 6.0 (2012) J Nucl Med Technol, 40, pp. 283-289. , 22743147 10.2967/jnmt.112.108787
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Fleisher, A.S., Chen, K., Quiroz, Y.T., Jakimovich, L.J., Gomez, M.G., Langois, C.M., Florbetapir PET analysis of amyloid-ß deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional study (2012) Lancet Neurol, 11, pp. 1057-1065. , 23137949 10.1016/S1474-4422(12)70227-2 1:CAS:528:DC%2BC38Xhs12gt7%2FO
Villemagne, V.L., Pike, K.E., Chételat, G., Ellis, K.A., Mulligan, R.S., Bourgeat, P., Longitudinal assessment of Aß and cognition in aging and Alzheimer disease (2011) Ann Neurol, 69, pp. 181-192. , 21280088 10.1002/ana.22248 1:CAS:528:DC%2BC3MXisVCisLs%3D
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Grundman, M., Pontecorvo, M.J., Salloway, S.P., Doraiswamy, P.M., Fleisher, A.S., Sadowsky, C.H., Potential impact of amyloid imaging on diagnosis and intended management in patients with progressive cognitive decline (2013) Alzheimer Dis Assoc Disord, 27, pp. 4-15. , 23203162 10.1097/WAD.0b013e318279d02a 1:CAS:528:DC%2BC3sXis12rsLk%3D
Chételat, G., Alzheimer disease: Aß-independent processes-rethinking preclinical AD (2013) Nat Rev Neurol, , 10.1038/nrneurol.2013.21
Johnson, K. A., Minoshima, S., Bohnen, N. I., Donohoe, K. J., Foster, N. L., Herscovitch, P., Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association (2013) J Nucl Med, 54, pp. 476-490. , 23359661 10. 2967/jnumed. 113. 120618 1: CAS: 528: DC%2BC3sXltV2ks7g%3
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Ch telat, G., Villemagne, V. L., Bourgeat, P., Pike, K. E., Jones, G., Ames, D., Relationship between atrophy and beta-amyloid deposition in Alzheimer disease (2010) Ann Neurol, 67, pp. 317-324. , 20373343
Santillo, A. F., Gambini, J. P., Lannfelt, L., L ngstr m, B., Ulla-Marja, L., Kilander, L., In vivo imaging of astrocytosis in Alzheimer's disease: An 11C-L-deuteriodeprenyl and PIB PET study (2011) Eur J Nucl Med Mol Imaging, 38, pp. 2202-2208. , 21853308 10. 1007/s00259-011-1895-9
Bacskai, B. J., Frosch, M. P., Freeman, S. H., Raymond, S. B., Augustinack, J. C., Johnson, K. A., Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report (2007) Arch Neurol, 64, pp. 431-434. , 17353389 10. 1001/archneur. 64. 3. 431
Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Mathis, C. A., Price, J. C., Tsopelas, N. D., Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease (2008) Brain, 131, pp. 1630-1645. , 18339640 10. 1093/brain/awn016
Rowe, C. C., Ackerman, U., Browne, W., Mulligan, R., Pike, K. L., O'Keefe, G., Imaging of amyloid in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism (2008) Lancet Neurol, 7, pp. 129-135. , 18191617 10. 1016/S1474-4422 (08) 70001-2 1: CAS: 528: DC%2BD1cXis1WmsLw%3D
Wong, D. F., Rosenberg, P. B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H. T., In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir F 18) (2010) J Nucl Med, 51, pp. 913-920. , 20501908 10. 2967/jnumed. 109. 069088 1: CAS: 528: DC%2BC3cXosl2ksb4%3D
Clark, C. M., Schneider, J. A., Bedell, B. J., Beach, T. G., Bilker, W. B., Mintun, M. A., Use of florbetapir-PET for imaging beta-amyloid pathology (2011) JAMA, 305, pp. 275-283. , 21245183 10. 1001/jama. 2010. 2008 1: CAS: 528: DC%2BC3MXhtVGrurw%3D
Csel nyi, Z., J nhagen, M. E., Forsberg, A., Halldin, C., Julin, P., Schou, M., Clinical validation of 18F-AZD4694, an amyloid- -specific PET radioligand (2012) J Nucl Med, 53, pp. 415-424. , 22323782 10. 2967/jnumed. 111. 094029
Clark, C. M., Pontecorvo, M. J., Beach, T. G., Bedell, B. J., Coleman, R. E., Doraiswamy, P. M., Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid- plaques: A prospective cohort study (2012) Lancet Neurol, 11, pp. 669-678. , 22749065 10. 1016/S1474-4422 (12) 70142-4 1: CAS: 528: DC%2BC38XhtV2gtb3E
Rinne, J. O., Wong, D. F., Wolk, D. A., Leinonen, V., Arnold, S. E., Buckley, C., [18F] Flutemetamol PET imaging and cortical biopsy histopathology for fibrillar amyloid detection in living subjects with normal pressure hydrocephalus: Pooled analysis of four studies (2012) Acta Neuropathol, 124, pp. 833-845. , 23053137 10. 1007/s00401-012-1051-z 1: CAS: 528: DC%2BC38XhslKls7zI
Morris, J. C., Price, J. L., Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease (2001) J Mol Neurosci, 17, pp. 101-118. , 11816784 10. 1385/JMN: 17: 2: 101 1: CAS: 528: DC%2BD3MXosVKitrg%3D
Kapucu, O. L., Nobili, F., Varrone, A., Booij, J., Vander Borght, T., N gren, K., EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2 (2009) Eur J Nucl Med Mol Imaging, 36, pp. 2093-2102. , 19838703 10. 1007/s00259-009-1266-y 1: CAS: 528: DC%2BD1MXhsVCisb3L
Patel, M. R., Spertus, J. A., Brindis, R. G., Hendel, R. C., Douglas, P. S., Peterson, E. D., ACCF proposed method for evaluating the appropriateness of cardiovascular imaging (2005) J Am Coll Cardiol, 46, pp. 1606-1613. , 16226195 10. 1016/j. jacc. 2005. 08. 030
Fleisher, A. S., Chen, K., Quiroz, Y. T., Jakimovich, L. J., Gomez, M. G., Langois, C. M., Florbetapir PET analysis of amyloid- deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional study (2012) Lancet Neurol, 11, pp. 1057-1065. , 23137949 10. 1016/S1474-4422 (12) 70227-2 1: CAS: 528: DC%2BC38Xhs12gt7%2FO
Villemagne, V. L., Pike, K. E., Ch telat, G., Ellis, K. A., Mulligan, R. S., Bourgeat, P., Longitudinal assessment of A and cognition in aging and Alzheimer disease (2011) Ann Neurol, 69, pp. 181-192. , 21280088 10. 1002/ana. 22248 1: CAS: 528: DC%2BC3MXisVCisLs%3D
Ch telat, G., Alzheimer disease: A -independent processes-rethinking preclinical AD (2013) Nat Rev Neurol, , 10. 1038/nrneurol. 2013. 21
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (572 views)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1088 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (932 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (987 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (455 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (553 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (576 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Storto G, Di Giorgio E, De Renzo A, Pizzuti LM, Cerciello G, Nardelli A, Capacchione D, Castaldi E, Ortosecco G, Pace L
* Assessment of metabolic activity by PET-CT with F-18-FDG in patients with T-cell lymphoma (530 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2010 Oct; 151(2): 195-197.
Impact Factor: 4.942
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (617 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (399 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (676 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (495 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (486 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (910 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (688 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (486 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (388 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (569 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (408 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (496 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (613 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (544 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (545 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (709 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (369 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
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Sciacca MFM, Monaco I, La Rosa C, Milardi D
* The active role of Ca(2+) ions in Abeta-mediated membrane damage (312 views)
Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Apr 5; 54(29): 3629-3631.
Impact Factor: 6.169
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (362 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (538 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E
* Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (727 views) (PDF 197 views)
Aging Cell (ISSN: 1474-9726, 1474-9718linking), 2017 Nov 01; 17(1): N/D-N/D.
Impact Factor: 7.627
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Gargiulo S, Coda AR, Panico M, Gramanzini M, Moresco RM, Chalon S, Pappata S
* Molecular imaging of neuroinflammation in preclinical rodent models using positron emission tomography (307 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 60-75.
Impact Factor: 2.368
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (752 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PLS, Carrotta R
* Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains (363 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2016; 208: 9-16.
Impact Factor: 2.402
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (526 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (773 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Iommelli F, De Rosa V, Gargiulo S, Panico M, Monti M, Greco A, Gramanzini M, Ortosecco G, Fonti R, Brunetti A, Del Vecchio S
* Monitoring Reversal of MET-Mediated Resistance to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Using 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Positron Emission Tomography (513 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2014 Sep 15; 20(18): 4806-4815.
Impact Factor: 8.722
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (560 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (500 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
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Marotta V, Ramundo V, Camera L, Del Prete M, Fonti R, Esposito R, Palmieri G, Salvatore M, Vitale M, Colao A, Faggiano A
* Sorafenib in advanced iodine-refractory differentiated thyroid cancer: Efficacy, safety and exploratory analysis of role of serum thyroglobulin and FDG-PET (456 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2013 May; 78(5): 760-767.
Impact Factor: 3.353
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (697 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (628 views)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
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Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (728 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (456 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (572 views)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1088 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (932 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (987 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (455 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (553 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (748 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (576 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Storto G, Di Giorgio E, De Renzo A, Pizzuti LM, Cerciello G, Nardelli A, Capacchione D, Castaldi E, Ortosecco G, Pace L
* Assessment of metabolic activity by PET-CT with F-18-FDG in patients with T-cell lymphoma (530 views)
Br J Haematol (ISSN: 0007-1048, 0007-1048linking, 1365-2141electronic), 2010 Oct; 151(2): 195-197.
Impact Factor: 4.942
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Pizzuti LM, Lettieri A, Salvatore M
* PET/CT in cancer research: From preclinical to clinical applications (617 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2010 Jul; 5(4): 190-200.
Impact Factor: 4.02
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (399 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (676 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (495 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (486 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (910 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (688 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (486 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (388 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (569 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (408 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (452 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (496 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (613 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (491 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (544 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (797 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (545 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (709 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (369 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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55 Records (54 excluding Abstracts).
Total impact factor: 224.533 (220.441 excluding Abstracts).
Total 5 year impact factor: 227.514 (222.977 excluding Abstracts).
Total impact factor: 224.533 (220.441 excluding Abstracts).
Total 5 year impact factor: 227.514 (222.977 excluding Abstracts).
538 views. Last view on Monday 27 March 2023, 22:01:15
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