Affiliations: Diagnostic Imaging Department, CNR, Univ. di Napoli Federico II, 80131 Napoli, Italy
Clin. and Exp. Medicine Department, University Federico II, 80131 Napoli, Italy
Fond. Pascale, 80131 Napoli, Italy
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Wisnieski, H. M., Wegiel, J., Neuropathology of Alzheimer's disease (1995) Neuroimaging Clin North Am, 5, pp. 45-57
Davis, P. C., Gray, L., Albert, M., The consortium to establish a registry for Alzheimer's disease (CERAD). Part III. Reliability of a standardized MRI evaluation of Alzheimer's disease (1992) Neurology, 42, pp. 1676-1680
Evans, W. A., An encephalographic ratio for estimating ventricular enlargement and cerebral atrophy (1942) Arch Neurol Psych, 47, pp. 931-937
Clarke, L. P., Velthuizen, R. P., Camacho, M. A., MRI segmentation methods and applications (1995) Magn Reson Imaging, 13, pp. 343-368
(1994) Quick Reference to the Diagnostic Criteria from DSM-IV, , Washington, DC: American Psychiatry Association
Folstein, M. F., Folstein, S. E., McHugh, P. R. J., Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician (1975) Psychol Res, 12, pp. 189-198
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Deleo, J. M., Schwartz, M., Creasey, H., Cutler, N., Rapoport, S. I., Computer assisted categorization of brain computerized tomography (1985) Comput Biomed Res, 18, pp. 79-88
Ortendhal, D. A., Hykton, N., Kaufman, B., Analytic tools for magnetic resonance imaging (1984) Radiology, 153, pp. 479-488
Tanabe, J. L., Amend, D., Schuff, N., Tissue segmentation of the brain in Alzheimer disease (1997) AJNR, 18, pp. 115-123
Sullivan, E. V., Shear, P. K., Mathalon, D. H., Greater abnormalities of brain cerebrospinal fluid volumes in younger than in older patients with Alzheimer's disease (1993) Arch Neurol, 50, pp. 359-373
Woo, J. I., Kim, J. H., Lee, J. H., Age of onset and brain atrophy in Alzheimer's disease (1997) Int Psychogeriatr, 9, pp. 183-196
Fox, N. C., Freeborough, P. A., Brain atrophy progression measured from registered serial MRI: Validation and application to Alzheimer's disease (1997) J Magn Reson Imaging, 7, pp. 1069-1075
Bigler, E. D., Hubler, D. W., Cullum, C. M., Turkheimer, E., Intellectual and memory impairment in dementia. Computerized axial tomography volume correlations (1985) J Nerv Ment Dis, 173, pp. 347-352
George, A. E., De Leon, M. J., Rosenbloom, S., Ventricular volume and cognitive deficit: A computed tomographic study (1983) Radiology, 149, pp. 493-498
Murphy, D. G., Decarli, C. D., Daly, E., Volumetric magnetic resonance imaging in men with dementia of the Azheimer type: Correlation with disease severity (1993) Biol Psych, 34, pp. 612-621
Stout, J. C., Jernigan, T. L., Archibald, S. L., Salmon, D. P., Association of dementia severity with cortical gray matter and abnormal white matter volumes in dementia of the Alzheimer type (1996) Arch Neurol, 53, pp. 742-749
Jobst, K. A., Smith, A. D., Szatmari, M., Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography (1992) Lancet, 340, pp. 1179-1183
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Frisoni, G. B., Beltramello, A., Weiss, C., Geroldi, C., Bianchetti, A., Trabucchi, M., Usefulness of simple measures of temporal lobe atrophy in probable Alzheimer's disease (1996) Dementia, 7, pp. 15-22
Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies
In 16 patients with probable Alzheimer's disease (AD; NINDS criteria, age range 56-78 years), gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) absolute and fractional volumes were measured with an unsupervised multiparametric post-processing segmentation method based on estimates of relaxation rates R1, R2 (R1 = 1/T1; R2 = 1/T2) and proton density [N(H)] from conventional spin-echo studies (Alfano et al. Magn. Reson. Med. 1997;37:84-93). Global brain atrophy, and GM and WM fractions significantly correlated with Mini-Mental Status Examination and Blessed Dementia Scale scores. Compared with normals, brain compartments in AD patients showed decreased GM (-6.84 ± 1.58%) and WM fractions (-9.79 ± 2.47%) and increased CSF fractions (+58.80 ± 10.37%). Changes were more evident in early-onset AD patients. In AD, measurement of global brain atrophy obtained by a computerized procedure based on routine magnetic resonance studies could complement the information provided by neuropsychological tests for the assessment of disease severity. (C) 2000 Wiley-Liss, Inc.
Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies
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Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(694 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote