Exercise-test Tc-99m tetrofosmin SPECT in patients with chronic ischemic left ventricular dysfunction: direct comparison with Ti-201 reinjection(300 views) Nicolai E, Cuocolo A, Acampa W, Varrone A, Pace L, Salvatore M
Affiliations: Ctr. per la Med. Nucleare del CNR, Università Federico II, Via Pansini, 5, 80131, Napoli, Italy
Nuclear Medicine Center of the National Council of Research (CNR), Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy.,
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Kelly, D. J., Forster, A. M., Higley, B., Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging (1993) J Nucl Med, 34, pp. 222-22
Nakajima, B. S., Taki, J., Shuke, N., Bunko, H., Takata, S., Hisada, K., Myocardial perfusion imaging and dynamic analysis with technetium-99m-tetrofosmin (1993) J Nucl Med, 34, pp. 1478-1484
Shiller, N. B., Shah, P. M., Crawford, M., American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-dimensional Echocardiograms: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography (1989) J Am Soc Echo, 2, pp. 358-367
Volpe, M., Rao, M. A. E., Cuocolo, A., Radionuclide monitoring of cardiac adaptations to volume loading in patients with dilated cardiomyopathy and mild heart failure (1995) Circulation, 92, pp. 2511-2518
Dahlberg, S. T., Gilmore, M. P., Leppo, J. A., Effects of coronary blood flow on the "uptake" of tetrofosmin in isolated rabbit heart (1992) J Nucl Med, 33, p. 846
Koplan, B. A., Belier, G. A., Ruiz, M., Yang, J. Y., Watson, D. D., Glover, D. K., Comparison between thallium-201 and technetium-99m-tetrofosmin uptake with sustained low flow and profound systolic dysfunction (1996) J Nucl Med, 37, pp. 1398-1402
Galassi, A. R., Tamburino, C., Grassi, R., Comparison of technetium-99m tetrofosmin and thallium-201 single photon emission computed tomographic imaging for the assessment of viable myocardium in patients with left ventricular dysfunction (1998) J Nucl Cardiol, 5, pp. 56-63
Udelson, J. E., Coleman, P. S., Metherall, J., Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with Tl-201 and Tc-99m sestamibi (1994) Circulation, 89, pp. 2552-2561
Plats, E. A., North, T. L., Pickett, R. D., Kelly, J. D., Mechanism of uptake of technetium-tetrofosmin - I: Uptake into isolated adult rat ventricular myocytes and subcellular localization (1995) J Nucl Cardiol, 2, pp. 317-326
Youn s, A., Songadele, J. A., Maublant, J., Platts, E., Pickett, R., Veyre, A., Mechanism of uptake of technetium-tetrofosmin. II: Uptake into isolated adult rat ventricular myocytes and subcellular localization (1995) J Nucl Cardiol, 2, pp. 327-333
Rocco, T. P., Dilsizian, V., McKusick, K. A., Fishman, A. J., Boucher, C. A., Strauss, H. W., Comparison of thallium redistribution with rest "reinjection" imaging for the detection of viable myocardium (1990) Am J Cardiol, 66, pp. 158-163
Bonow, R. O., Dilsizian, V., Cuocolo, A., Bacharach, S. L., Identification of viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction. Comparison of thallium scintigraphy with reinjection and PET imaging with 18-F-fluorodeoxiglucose (1991) Circulation, 83, pp. 26-37
Exercise-test Tc-99m tetrofosmin SPECT in patients with chronic ischemic left ventricular dysfunction: direct comparison with Ti-201 reinjection
BACKGROUND: This study was designed to compare the results of exercise-rest technetium-99m tetrofosmin single photon emission computed tomography (SPECT) with those of thallium-201 reinjection at rest after exercise-redistribution imaging in the same patients with chronic ischemic left ventricular (LV) dysfunction. METHODS: Within 1 week, 33 patients with chronic myocardial infarction and LV dysfunction underwent exercise-rest tetrofosmin SPECT and Tl-201 reinjection at rest after exercise-redistribution imaging. In each patient, regional tetrofosmin and Tl-201 activity was quantitatively measured in 22 myocardial segments. Regional LV function was assessed in corresponding segments by echocardiography. RESULTS: Agreement in the evaluation of regional perfusion status between tetrofosmin and Tl-201 imaging was observed in 78% of the 726 total segments, with a kappa value of 0.61. In segments with normal function at echocardiography (n = 436), no difference between Tl-201 and tetrofosmin uptake was observed. In hypokinetic segments (n = 138), exercise tetrofosmin uptake was lower (P < .01) as compared with exercise Tl-201 activity, whereas no difference was observed between tetrofosmin uptake at rest as compared with Tl-201 activity on redistribution and reinjection images. In segments with severe functional impairment (akinetic or dyskinetic, n = 152), tetrofosmin uptake on exercise images was reduced (P < .01) as compared with exercise Tl-201 activity; furthermore, tetrofosmin uptake at rest was lower (P < .01) as compared with Tl-201 activity on both redistribution and reinjection images. In these segments, concordance in the detection of myocardial viability between tetrofosmin and Tl-201 imaging was observed in 138 (91%) of the 152 segments, with a kappa value of 0.77. CONCLUSIONS: In patients with chronic coronary artery disease and LV dysfunction quantitative exercise-rest tetrofosmin and Tl-201 reinjection SPECT provide similar information in the assessment of perfusion status and in the detection of myocardial viability.
Exercise-test Tc-99m tetrofosmin SPECT in patients with chronic ischemic left ventricular dysfunction: direct comparison with Ti-201 reinjection
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(694 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote