Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction
Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction(454 views) Petretta M, Cuocolo A, Nicolai E, Acampa W, Salvatore M, Bonaduce D
Affiliations: Inst. Int. Med., Cardiol. Heart S., Nucl. Med. Ctr. Natl. Cncl. of Res., University Federico II, Naples, Italy
Ctro. Per la Med. Nucleare del CNR, Università Federico II, Via Pansini, 5 - 80131 Napoli, Italy
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Bonow, R. O., The hibernating myocardium: Implications for management of congestive heart failure (1995) Am J Cardiol, 75, pp. 17A-25A
Brundage, B. H., Massie, B. M., Botvinick, E. H., Improved regional ventricular function after successful surgical revascularization (1984) J Am Coll Cardiol, 3, pp. 902-908
Galassi, A. R., Centamore, G., Fiscella, A., Comparison of rest-redistribution thallium imaging and reinjection after stress-redistribution for the assessment of myocardial viability in patients with left ventricular dysfunction secondary to coronary artery disease (1995) Am J Cardiol, 75, pp. 436-442
Madsen, B. K., Egeblad, H., H jberg, S., Prognostic value of echocardiographic compared to other clinical findings (1995) Cardiology, 86, pp. 157-162
Bhatnagar, S. K., Moussa, M. A. A., Al-Yusuf, A. R., The role of prehospital discharge two-dimensional echocardiography in determining the prognosis of survivors of first myocardial infarction (1985) Am Heart J, 109, pp. 472-477
Katz, A. S., Harrigan, P., Parisi, A. F., The value and promise of echocardiography in acute myocardial infarction and coronary artery disease (1992) Clin Cardiol, 15, pp. 401-410
Shiller, N. B., Shah, P. M., Crawford, M., American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-dimensional Echocardiograms: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography (1989) J Am Soc Echocardiogr, 2, pp. 358-367
Norusis, M. J., (1993) SPSS for Windows: Advanced Statistics, Release 6. 0, pp. 259-312. , Chicago, Illinois: SPSS Inc
Cox, D. R., Regression models and life table (1972) J R Stat Soc B, 34, pp. 187-220
Pagley, P. R., Beller, G. A., Watson, D. D., Gimple, L. W., Ragosta, M., Improved outcome after coronary bypass surgery in patients with ischemic cardiomyopathy and residual myocardial viability (1997) Circulation, 96, pp. 793-800
Bax, J. J., Cornel, J. H., Visser, F. C., Prediction of recovery of myocardial dysfunction after revascularization. Comparison of fluorine-18 fluorodeoxyglucose/thallium-201 SPECT, thallium-201 stress-reinjection SPECT and dobutamine echocardiography (1996) J Am Coll Cardiol, 28, pp. 558-564
Marinho, N. V. S., Keogh, B. E., Costa, D. C., Lammerstma, A. A., Ell, P. J., Camici, P. G., Pathophysiology of chronic left ventricular dysfunction. New insights from the measurement of absolute myocardial blood flow and glucose utilization (1996) Circulation, 93, pp. 737-744
Vanoverschelde, J. -L. J., Wijns, W., Depre, C., Mechanisms of chronic regional postischemic dysfunction in humans: New insights from the study of noninfarcted collateral-dependent myocardium (1993) Circulation, 87, pp. 1513-1523
Dakik, H. A., Mahmarian, J. J., Kimball, K. T., Koutelou, M. G., Medrano, R., Verani, M., Prognostic value of exercise Tl-201 tomography in patients treated with thrombolytic therapy during acute myocardial infarction (1996) Circulation, 94, pp. 2735-2742
Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction
Background. This study evaluated the prognostic value of combined assessment of left ventricular (LV) function and regional myocardial thallium activity in patients with nonrecent myocardial infarction and LV dysfunction. Methods and Results. Eighty-two patients with previous myocardial infarction (> 8 weeks) and echocardiographic evidence of LV dysfunction underwent thallium-201 rest-redistribution tomography and cardiac catheterization. During the follow-up period (mean 25 months) there were 18 cardiac events (14 deaths and 4 nonfatal myocardial infarctions). Multivariate Cox regression analysis on clinical, angiographic, and thallium variables showed that the number of echocardiographic dysfunctional segments with preserved thallium uptake (≤ 50% of peak activity; chi-square 11.03; p < 0.005) and age (chi-square 8.12, p < 0.01) were predictive of poor outcome. At incremental analysis, combined echocardiographic and thallium data provided significant additional information to clinical, thallium, and LV functional data, increasing global chi-square value from 22.4 to 31.5 (p < 0.01). Similarly, combined data gave additional information after considering clinical, echocardiographic, and LV functional data, increasing global chi-square from 17.8 to 22.3 (p < 0.05). Differently, the number of diseased vessels at coronary angiography did not add further prognostic information. Conclusions. In patients with previous myocardial infarction and chronic LV dysfunction, the combination of echocardiographic and thallium rest-redistribution imaging data gives prognostic information incremental to those of clinical and LV functional data and to those of each technique considered separately.
Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction
Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction
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