Tc-99m sestamibi imaging in the diagnostic assessment of patients with lymphomas: Comparison with clinical and radiological evaluation(294 views) Maurea S, Acampa W, Varrella P, De Rosa V, Fimiani P, Abate G, Salvatore M
Affiliations: Medicine Nucleare, Istituto Nazionale dei Tumori, Univ.̀ Degli Studi Federico II, Napoli, Italy
Radiodiagnostica, Istituto Nazionale Dei Tumori, Univ.̀ Degli Studi Federico II, Napoli, Italy
Ematologia, Istituto Nazionale Dei Tumori, Univ.̀ Degli Studi Federico II, Napoli, Italy
Via Raffaele De Cesare 7, 80132 Napoli, Italy
References: Shiels, R., Stone, J., Ash, D., Priorities for computed tomography and lymphography in the staging and initial management of Hodgkin's disease (1984) Clin Radiol, 35, p. 44
Hopper, K.D., Diehl, L.F., Lesar, M., Barnes, M., Granger, E., Baumann, J., Hodgkin disease: Clinical utility of CT in initial staging and treatment (1988) Radiology, 169, p. 17
Castellino, R.A., Hodgkin disease: Imaging studies and patient management (1988) Radiology, 169, p. 269
Tumeh, S.S., Rosenthal, D.S., Kaplan, W.D., English, R.J., Holman, B.L., Lymphoma: Evaluation with Ga-67 SPECT (1987) Radiology, 164, p. 111
Front, D., Israel, O., Epelbaum, R., Ga-67 SPECT before and after treatment of lymphoma (1990) Radiology, 175, p. 515
Paul, B., Comparison of fluorine-18-2-fluorodeoxyglucose and gallium-67 citrate imaging for detection of lymphoma (1987) J Nucl Med, 28, p. 288
Epstein, A.L., Zimmer, A.M., Spies, S.M., Radioimmunodetection of human B-cell lymphomas with a radiolabeled tumor-specific monoclonal antibody (Lym-1) (1985) Malignant Lymphomas and Hodgkin's Disease: Experimental and Therapeutic Advances, pp. 569-577. , Cavalli F, Bonadonna G, Rozencweig M, eds. Boston, MA: Nihoff
Reubi, J.C., Waser, B., Van Hagen, M., Lamberts, S.M.J., Krenning, E.P., Gebbers, J.O., In vitro and in vivo detection of somatostatin receptors in human malignant lymphomas (1992) Int J Cancer, 50, p. 895
Lipp, R.W., Silly, H., Ranner, G., Dobnig, H., Passath, A., Leb, G., Radiolabeled octreotide for the demonstration of somatostatin receptors in malignant lymphoma and lymphadenopathy (1995) J Nucl Med, 36, p. 13
Sarda, L., Duet, M., Zini, J.M., Indium-111 pentetreotide scintigraphy in malignant lymphoma (1995) Eur J Nucl Med, 22, p. 1105
Okada, R.D., Glover, D., Gaffney, T., Williams, S., Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile (1988) Circulation, 77, p. 491
Carvalho, P.A., Chiu, M.L., Kronauge, J.F., Subcellular distribution and analysis of technetium-99m-MIBI in isolated perfused rat hearts (1992) J Nucl Med, 33, p. 1516
Delmon-Moingeon, L.I., Piwnica-Worms, D., Van den Abbeele, A.D., Holman, B.L., Davison, A., Jones, A.G., Uptake of the cation hexakis (2-methoxyisobutylisonitrile)-technetium-99m by human carcinoma cell lines in vitro (1990) Cancer Research, 50, p. 2198
Chen, L.B., Mitochondrial membrane potential in living cells (1988) Ann Rev Cell Biol, 4, p. 155
Piwnica-Worms, D., Holman, B.L., Noncardiac applications of hexakis-(alkylisonitrile) technetium-99m complexes (1990) J Nucl Med, 31, p. 1166
Abdel-Dayem, H.M., Scott, A.M., Macapinlac, H.A., El-Gazzar, A.H., Larson, S.M., Role of 201-Tl choride and Tc-99m sestamibi in tumor imaging (1994) Nuclear Medicine Annual 1994, pp. 181-234. , Freeman LM, ed. New York, NY: Raven Press
Wang, H., Maurea, S., Mainolfi, C., Tc-99m MIBI scintigraphy in patients with lung cancer: Comparison with CT and fluorine-18 FDG PET imaging (1997) Clin Nucl Med, 22, p. 243
Dimitrakopoulou-Strauss, A., Strauss, L.G., Goldschmidt, H., Lorenz, W.J., Maier-Borst, W., Van Kaick, G., Evaluation of tumour metabolism and multidrug resistance in patients with treated malignant lymphomas (1995) Eur J Nucl Med, 22, p. 434
Ziegels, P., Nocaudie, M., Huglo, D., Deveaux, M., Detourrmignies, L., Wattel, E., Comparision of technetium-99m methoxyisobutylisonitrile and gallium-67 citrate scanning in the assessment of lymphomas (1995) Eur J Nucl Med, 22, p. 126
Maublant, J.C., Zhang, Z., Rapp, M., Oilier, M., Michelot, J., Veyre, A., Vitro uptake of technetium-99m-teboroxime in carcinoma cell lines and normal cells: Comparison with technetium-99msestamibi and thallium-201 (1993) J Nucl Med, 34, p. 1949
Crane, P., Laliberté, R., Heminway, S., Thoolen, M., Orlandi, C., Effect of mitochondrial viability and metabolism on technetium-99m-sestamibi myocardial retention (1993) Eur J Nucl Med, 20, p. 20
Chiu, M.I., Kronauge, J.F., Piwnica-Worms, D., Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutysonitrile) technetium (I) in cultured mouse fibroblasts (1990) J Nucl Med, 31, p. 1646
Waxman, A.D., Eller, D., Ashook, G., Comparison of gallium-67 citrate and thallium-201 scintigraphy in peripheral and intrathoracic lymphoma (1996) J Nucl Med, 37, p. 46
Aktolun, C., Bayhan, H., Kir, M., Clinical experience with Sestamibi imaging in patient with malignant tumors: Preliminary results and comparison with Tl-201 (1992) Clin Nucl Med, 17, p. 171
Maurea, S., Lastoria, S., Klain, M., Celentano, L., Salvatore, M., Non-Hodgkin's lymphoma in a patient with follicular thyroid cancer: The role of Tc-99m methoxy isobutyl isonitrile imaging (1994) J Nucl Biol Med, 38, p. 18
Scott, A.M., Kostakoglu, L., O'Brien, J.P., Straus, D.J., Abdel-Dayem, H.M., Larson, S.M., Comparison of technetium-99m MIBI and thallium-201 chloride uptake in primary thyroid lymphoma (1992) J Nucl Med, 33, p. 1396
Kostakoglu, L., Roistacher, N., Kalaigian, H., Larson, S.M., Abdel-Dayem, H.M., Simultaneous gallium-67 citrate and technetium-99m sestamibi SPECT in a case of myocardial lymphoma: Comparison with echocardiography before and after chemotherapy (1994) Eur J Nucl Med, 21, p. 1013
Matsui, R., Komori, T., Narabayashi, I., Tc-99m sestamibi uptake by malignant lymphoma and slow washout (1995) Clin Nucl Med, 20, p. 352
Hopper, K. D., Diehl, L. F., Lesar, M., Barnes, M., Granger, E., Baumann, J., Hodgkin disease: Clinical utility of CT in initial staging and treatment (1988) Radiology, 169, p. 17
Castellino, R. A., Hodgkin disease: Imaging studies and patient management (1988) Radiology, 169, p. 269
Tumeh, S. S., Rosenthal, D. S., Kaplan, W. D., English, R. J., Holman, B. L., Lymphoma: Evaluation with Ga-67 SPECT (1987) Radiology, 164, p. 111
Epstein, A. L., Zimmer, A. M., Spies, S. M., Radioimmunodetection of human B-cell lymphomas with a radiolabeled tumor-specific monoclonal antibody (Lym-1) (1985) Malignant Lymphomas and Hodgkin's Disease: Experimental and Therapeutic Advances, pp. 569-577. , Cavalli F, Bonadonna G, Rozencweig M, eds. Boston, MA: Nihoff
Reubi, J. C., Waser, B., Van Hagen, M., Lamberts, S. M. J., Krenning, E. P., Gebbers, J. O., In vitro and in vivo detection of somatostatin receptors in human malignant lymphomas (1992) Int J Cancer, 50, p. 895
Lipp, R. W., Silly, H., Ranner, G., Dobnig, H., Passath, A., Leb, G., Radiolabeled octreotide for the demonstration of somatostatin receptors in malignant lymphoma and lymphadenopathy (1995) J Nucl Med, 36, p. 13
Okada, R. D., Glover, D., Gaffney, T., Williams, S., Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile (1988) Circulation, 77, p. 491
Carvalho, P. A., Chiu, M. L., Kronauge, J. F., Subcellular distribution and analysis of technetium-99m-MIBI in isolated perfused rat hearts (1992) J Nucl Med, 33, p. 1516
Chen, L. B., Mitochondrial membrane potential in living cells (1988) Ann Rev Cell Biol, 4, p. 155
Abdel-Dayem, H. M., Scott, A. M., Macapinlac, H. A., El-Gazzar, A. H., Larson, S. M., Role of 201-Tl choride and Tc-99m sestamibi in tumor imaging (1994) Nuclear Medicine Annual 1994, pp. 181-234. , Freeman LM, ed. New York, NY: Raven Press
Maublant, J. C., Zhang, Z., Rapp, M., Oilier, M., Michelot, J., Veyre, A., Vitro uptake of technetium-99m-teboroxime in carcinoma cell lines and normal cells: Comparison with technetium-99msestamibi and thallium-201 (1993) J Nucl Med, 34, p. 1949
Chiu, M. I., Kronauge, J. F., Piwnica-Worms, D., Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutysonitrile) technetium (I) in cultured mouse fibroblasts (1990) J Nucl Med, 31, p. 1646
Waxman, A. D., Eller, D., Ashook, G., Comparison of gallium-67 citrate and thallium-201 scintigraphy in peripheral and intrathoracic lymphoma (1996) J Nucl Med, 37, p. 46
Scott, A. M., Kostakoglu, L., O'Brien, J. P., Straus, D. J., Abdel-Dayem, H. M., Larson, S. M., Comparison of technetium-99m MIBI and thallium-201 chloride uptake in primary thyroid lymphoma (1992) J Nucl Med, 33, p. 1396
Tc-99m sestamibi imaging in the diagnostic assessment of patients with lymphomas: Comparison with clinical and radiological evaluation
Tc-99m MIBI imaging has been used in nuclear oncology, but its role in detecting lymphomas has not been widely investigated. In this study, 31 patients with lymphomas (20 non-Hodgkin's and 11 Hodgkin's) underwent Tc-99m MIBI whole-body imaging. A total of 74 tumor lesions were detected in 25 patients, while the remaining 8 patients were disease-free. The diagnostic accuracy of MIBI imaging for lesion detection was 85%. A total of 11 unknown tumor lesions in 3 patients were discovered on MIBI scans. Tumor size was significantly (p = 0.01) higher in lesions with increased MIBI uptake (3.5 ± 2.0 cm) compared with those with no uptake (1.8 ± 1.0 cm). No false positive MIBI findings were observed. The accuracy of MIBI scintigraphy in patients with Hodgkin's disease was lower (72%) compared to that of patients with non- Hodgkin's lymphomas (94%). However, this difference was not related to tumor type, but to lesion size. In fact, tumor size was significantly (p = 0.02) lower in lesions of patients with Hodgkin's disease (2.5 ± 1.3 cm) compared to those of patients with non-Hodgkin's lymphomas (3.7 ± 2.2 cm). MIBI imaging may be useful in patients with lymphomas for detecting tumor lesions and, hence, may be considered an alternative to gallium scanning, providing better imaging quality. However, the intense Sestamibi activity in the lower chest and abdomen as well as tumor size may limit the diagnostic sensitivity of this radionuclide technique in patients with lymphomas.
Tc-99m sestamibi imaging in the diagnostic assessment of patients with lymphomas: Comparison with clinical and radiological evaluation
No results.
Tc-99m sestamibi imaging in the diagnostic assessment of patients with lymphomas: Comparison with clinical and radiological evaluation
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(731 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote