In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy (519 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Apr; 39(4): 634-639.
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Paper type: Journal Article,
Impact factor: 3.064, 5-year impact factor: 5.331
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031948219&partnerID=40&md5=4ddf0b5e9e57b0925e62b82575ce8e14
Keywords: Indium-111-Octreotide, Myasthenia Gravis, Somatostatin Receptors, Thymoma, Indium 111, Pentetate Indium, Adult, Article, Cancer Staging, Clinical Article, Clinical Feature, Computer Assisted Tomography, Diagnostic Value, Female, Human, Isotope Labeling, Nuclear Magnetic Resonance Imaging, Priority Journal, Thymus Hyperplasia, Adolescent, Carcinoid Tumor, Differential, Iodine Radioisotopes, Middle Aged, Pentetic Acid, Radiopharmaceuticals, Thymus Neoplasms, Emission-Computed, Single-Photon, X-Ray Computed,
Affiliations:
Via Modigliani 66/68, Aversa (CE), 81031, Italy
References:
Not available.
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Apr; 39(4): 634-639.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.064, 5-year impact factor: 5.331
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031948219&partnerID=40&md5=4ddf0b5e9e57b0925e62b82575ce8e14
Keywords: Indium-111-Octreotide, Myasthenia Gravis, Somatostatin Receptors, Thymoma, Indium 111, Pentetate Indium, Adult, Article, Cancer Staging, Clinical Article, Clinical Feature, Computer Assisted Tomography, Diagnostic Value, Female, Human, Isotope Labeling, Nuclear Magnetic Resonance Imaging, Priority Journal, Thymus Hyperplasia, Adolescent, Carcinoid Tumor, Differential, Iodine Radioisotopes, Middle Aged, Pentetic Acid, Radiopharmaceuticals, Thymus Neoplasms, Emission-Computed, Single-Photon, X-Ray Computed,
Affiliations:
Via Modigliani 66/68, Aversa (CE), 81031, Italy
References:
Not available.
In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy
Many tumors with neuroendocrine characteristics express high amounts of somatostatin receptors that enable in vivo imaging with [111In-DTPA-D- Phe1]-octreotide. In this study, we have analyzed the feasibility in detecting and characterizing thymic masses by somatostatin receptor scintigraphy (SRS). Methods: Eighteen patients (13 women, 5 men, ages 18-78 yr; mean ± s.d. = 42.1 ± 17.6 yr) were enrolled in this study. Eleven patients were studied during diagnosis and seven during routine follow-up. In seven patients, myasthenia gravis was the presenting symptom. SRS was performed within 4 wk after CT and/or MRI. Planar and tomographic images were acquired within 24 hr after the injection of approximately 111 MBq of [111In-DTPA-D-Phe1]-octreotide. The scintigraphic results were categorized according to the histologic findings. Results: Histology diagnosed 10 mixed epithelial/lymphoid thymomas (8 with prevalent epithelial component), 2 thymic carcinomas, 1 thymic carcinoid, 1 lymphangioma and 4 thymic hyperplasias. Two thymoma were Stage I, 3 were Stage II, 2 were Stage III and 5 were Stage IV, as was the thymic carcinoid. Indium-111-DTPA-D- Phe1-octreotide concentrated in primary and/or metastatic sites of thymic tumors, thereby enabling successful external gamma imaging of sites greater than 1.5 cm in size. Tumor-to-lung (T/L) ratios were as high as 7.6-fold (range 1.7-7.6). Untreated thymomas showed higher T/L (4.34 ± 1.57) than treated ones (2.68 ± 1.18). No uptake was detectable in the four patients with benign thymic hyperplasia and the patient with the lymphangioma. Conclusion: Indium-111-DTPA-D-Phe1-octreotide is avidly concentrated within thymic tumors, but it is not concentrated by thymic hyperplasia, which allows differential diagnosis. Thus, in patients with myasthenia gravis, SRS may have a role in characterizing thymic masses, thereby overcoming the limits of cross-sectional imaging modalities.
Many tumors with neuroendocrine characteristics express high amounts of somatostatin receptors that enable in vivo imaging with [111In-DTPA-D- Phe1]-octreotide. In this study, we have analyzed the feasibility in detecting and characterizing thymic masses by somatostatin receptor scintigraphy (SRS). Methods: Eighteen patients (13 women, 5 men, ages 18-78 yr; mean ± s.d. = 42.1 ± 17.6 yr) were enrolled in this study. Eleven patients were studied during diagnosis and seven during routine follow-up. In seven patients, myasthenia gravis was the presenting symptom. SRS was performed within 4 wk after CT and/or MRI. Planar and tomographic images were acquired within 24 hr after the injection of approximately 111 MBq of [111In-DTPA-D-Phe1]-octreotide. The scintigraphic results were categorized according to the histologic findings. Results: Histology diagnosed 10 mixed epithelial/lymphoid thymomas (8 with prevalent epithelial component), 2 thymic carcinomas, 1 thymic carcinoid, 1 lymphangioma and 4 thymic hyperplasias. Two thymoma were Stage I, 3 were Stage II, 2 were Stage III and 5 were Stage IV, as was the thymic carcinoid. Indium-111-DTPA-D- Phe1-octreotide concentrated in primary and/or metastatic sites of thymic tumors, thereby enabling successful external gamma imaging of sites greater than 1.5 cm in size. Tumor-to-lung (T/L) ratios were as high as 7.6-fold (range 1.7-7.6). Untreated thymomas showed higher T/L (4.34 ± 1.57) than treated ones (2.68 ± 1.18). No uptake was detectable in the four patients with benign thymic hyperplasia and the patient with the lymphangioma. Conclusion: Indium-111-DTPA-D-Phe1-octreotide is avidly concentrated within thymic tumors, but it is not concentrated by thymic hyperplasia, which allows differential diagnosis. Thus, in patients with myasthenia gravis, SRS may have a role in characterizing thymic masses, thereby overcoming the limits of cross-sectional imaging modalities.
In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy
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In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
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Q J Nucl Med (ISSN: 1125-0135, 1124-3937), 1995 Dec; 39(4Suppl1): 145-149.
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View Export to BibTeX Export to EndNote
LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
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Impact Factor: 3.491
View Export to BibTeX Export to EndNote
LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW NEOPLASTIC LESIONS EXPRESSING SOMATOSTATIN RECEPTORS USING IN-111 OCTREOTIDE (503 views)
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Impact Factor: 0
View Export to BibTeX Export to EndNote
19 Records (14 excluding Abstracts).
Total impact factor: 43.587 (32.101 excluding Abstracts).
Total 5 year impact factor: 50.684 (36.368 excluding Abstracts).
Total impact factor: 43.587 (32.101 excluding Abstracts).
Total 5 year impact factor: 50.684 (36.368 excluding Abstracts).
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