The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study
The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study(284 views) Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
Depts. Molec. Clin. Endocrinol. O., Federico II University of Naples, 80131 Naples, Italy
Biomorphological Funct. Sci. N., National Council of Research, Federico II University of Naples, 80131 Naples, Italy
Dept. Molec. Clin. Endocrinol. O., Federico II University, via S. Pansini 5, 80131 Napoli, Italy
References: Rosen, T., Bengtsson, B.A., Premature mortality due to cardiovascular disease in hypopituitarism (1990) Lancet, 336, pp. 285-28
Bates, A.S., Vant'Hoff, W., Jones, P.J., Clayton, R.N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Bulöw, B., Hagmar, L., Mikoczy, Z., Nordström, C.H., Erfurth, E.M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol, 46, pp. 75-81. , Oxf
Tomlinson, J.W., Holden, N., Hills, R.K., Wheatley, K., Clayton, R.N., Bates, A.S., Sheppard, M.C., Stewart, P.M., Association between premature mortality and hypopituitarism (2001) Lancet, 357, pp. 425-431. , West Midlands Prospective Hypopituitary Study Group
Beshyah, S.A., Johnston, D.G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol, 50, pp. 1-15. , Oxf
Colao, A., Di Somma, C., Marzullo, P., Lombardi, G., Growth hormone and the heart (2001) Clin Endocrinol, 54, pp. 137-154. , Oxf
Barkan, A.L., Clemmons, D.R., Molitch, M.E., Stewart, P.M., Young Jr., W.F., Growth hormone therapy for hypopituitary adults: Time for re-appraisal (2000) Trends Endocrinol Metab, 11, pp. 238-245
Carroll, P.V., Christ, E.R., Sonksen, P.H., Growth hormone replacement in adults with growth hormone deficiency: Assessment of current knowledge (2000) Trends Endocrinol Metab, 11, pp. 231-238
Bengtsson, B.A., Johannsson, G., Shalet, S.M., Simpson, H., Sonken, P.H., Treatment of growth hormone deficiency in adults (2000) J Clin Endocrinol Metab, 85, pp. 933-942
Colao, A., Cuocolo, A., Di Somma, C., Cerbone, G., Morte, A.M., Pivonello, R., Nicolai, E., Lombardi, G., Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (2000) Clin Endocrinol, 52, pp. 447-455. , Oxf
Amato, G., Carella, C., Fazio, S., La Montagna, G., Cittadini, A., Sabatini, D., Mardano-Mone, C., Bellastella, A., Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses (1993) J Clin Endocrinol Metab, 77, pp. 1671-1676
Merola, B., Cittadini, A., Colao, A., Longobardi, S., Fazio, S., Sabatini, D., Sacca, L., Lombardi, G., Cardiac structural and functional abnormalities in adult patients with GH deficiency (1993) J Clin Endocrinol Metab, 77, pp. 1658-1661
Shulman, D.I., Root, A.W., Diamond, F.B., Bercu, B.B., Martinez, R., Boucek Jr., R.J., Effects of one year of recombinant human growth hormone (GH) therapy on cardiac mass and function in children with classical GH deficiency (2003) J Clin Endocrinol Metab, 88, pp. 4095-4099
Salerno, M., Esposito, V., Spinelli, L., Di Somma, C., Farina, V., Muzzica, S., De Horatio, L.T., Colao, A., Left ventricular mass and function in children with GH deficiency before and during 12 months GH replacement therapy (2004) Clin Endocrinol, 60, pp. 630-636. , Oxf
Cuocolo, A., Nicolai, E., Colao, A., Longobardi, S., Cardei, S., Fazio, S., Merola, B., Salvatore, M., Improved left ventricular function after growth hormone replacement in patients with hypopiruitarism: Assessment with radionuclide angiography (1996) Eur J Nucl Med, 23, pp. 390-394
Ezzat, S., Fear, S., Gaillard, R.C., Gayle, C., Landy, H., Marcovitz, S., Mattioni, T., Svanberg, E., Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults (2002) J Clin Endocrinol Metab, 87, pp. 2725-2733
Ter Maaten, J., De Boer, H., Kamp, O., Stuurman, L., Van Der Veen, E., Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2373-2380
Gibney, J., Wallace, J.D., Spinks, T., Schnorr, L., Ranicar, A., Cuneo, R.C., Lockhart, S., Russell-Jones, D., The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients (1999) J Clin Endocrinol Metab, 84, pp. 2596-2602
Maison, P., Chanson, P., Cardiac effects of growth hormone in adults with growth hormone deficiency: A meta-analysis (2003) Circulation, 108, pp. 2648-2652
Colao, A., Cerbone, G., Pivonello, R., Aimaretti, G., Loche, S., Di Somma, C., Faggiano, A., Lombardi, G., The growth hormone (GH) response to arginine plus GH releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1277-1282
Aimaretti, G., Corneli, G., Razzore, P., Bellone, S., Baffoni, C., Arvat, E., Camanni, F., Ghigo, E., Comparison between insulin-induced hypoglycemia and growth hormone (GH)-releasing hormone + arginine as provocative tests for the diagnosis of GH deficiency in adults (1998) J Clin Endocrinol Metab, 83, pp. 1615-1618
Murray, R.D., Adams, J.E., Shalet, S.M., Adults with partial growth hormone deficiency have an adverse body composition (2004) J Clin Endocrinol Metab, 89, pp. 1586-1591
Ayuk, J., Clayton, R.N., Holder, G., Sheppard, M.C., Stewart, P.M., Bates, A.S., Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly (2004) J Clin Endocrinol Metab, 89, pp. 1613-1617
Gleeson, H.K., Gattamaneni, H.R., Smethurst, L., Brennan, B.M., Shalet, S.M., Reassessment of growth hormone status is required at final height in children treated with growth hormone replacement after radiation therapy (2004) J Clin Endocrinol Metab, 89, pp. 662-666
Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: Summary statement of the Growth Hormone Research Society Workshop on adult growth hormone deficiency (1998) J Clin Endocrinol Metab, 83, pp. 379-381
Biller, B.M.K., Samuels, M.H., Zagar, A., Cook, D.M., Arafah, B.M., Bonert, V., Stavrou, S., Hartman, M.L., Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency (2002) J Clin Endocrinol Metab, 87, pp. 2067-2079
Bates, A. S., Vant'Hoff, W., Jones, P. J., Clayton, R. N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Bul w, B., Hagmar, L., Mikoczy, Z., Nordstr m, C. H., Erfurth, E. M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol, 46, pp. 75-81. , Oxf
Tomlinson, J. W., Holden, N., Hills, R. K., Wheatley, K., Clayton, R. N., Bates, A. S., Sheppard, M. C., Stewart, P. M., Association between premature mortality and hypopituitarism (2001) Lancet, 357, pp. 425-431. , West Midlands Prospective Hypopituitary Study Group
Beshyah, S. A., Johnston, D. G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol, 50, pp. 1-15. , Oxf
Barkan, A. L., Clemmons, D. R., Molitch, M. E., Stewart, P. M., Young Jr., W. F., Growth hormone therapy for hypopituitary adults: Time for re-appraisal (2000) Trends Endocrinol Metab, 11, pp. 238-245
Carroll, P. V., Christ, E. R., Sonksen, P. H., Growth hormone replacement in adults with growth hormone deficiency: Assessment of current knowledge (2000) Trends Endocrinol Metab, 11, pp. 231-238
Bengtsson, B. A., Johannsson, G., Shalet, S. M., Simpson, H., Sonken, P. H., Treatment of growth hormone deficiency in adults (2000) J Clin Endocrinol Metab, 85, pp. 933-942
Shulman, D. I., Root, A. W., Diamond, F. B., Bercu, B. B., Martinez, R., Boucek Jr., R. J., Effects of one year of recombinant human growth hormone (GH) therapy on cardiac mass and function in children with classical GH deficiency (2003) J Clin Endocrinol Metab, 88, pp. 4095-4099
Murray, R. D., Adams, J. E., Shalet, S. M., Adults with partial growth hormone deficiency have an adverse body composition (2004) J Clin Endocrinol Metab, 89, pp. 1586-1591
Gleeson, H. K., Gattamaneni, H. R., Smethurst, L., Brennan, B. M., Shalet, S. M., Reassessment of growth hormone status is required at final height in children treated with growth hormone replacement after radiation therapy (2004) J Clin Endocrinol Metab, 89, pp. 662-666
Biller, B. M. K., Samuels, M. H., Zagar, A., Cook, D. M., Arafah, B. M., Bonert, V., Stavrou, S., Hartman, M. L., Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency (2002) J Clin Endocrinol Metab, 87, pp. 2067-2079
The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study
In 100 patients with, hypopituitarism and 80 sex- and age-matched healthy subjects, we correlated the severity of cardiac impairment to the severity of GH deficiency (GHD). By the GH peak after arginine plus GHBH test (normal > 16.5 μg/liter), the patients were classified as severe GHB (n = 56), partial GHB (n = 27), and non-GHB (n = 17). Compared with controls, decreased left ventricular ejection fraction at rest was found only in severe GHD patients (55.0 ± 8.8 vs. 63.4 ± 4.5%, P < 0.001); decreased left ventricular ejection fraction response on effort in severe (-4.6 ± 17.4 vs. 15.2 ± 9.1%, P < 0.001) and partial GHD patients (3.6 ± 6.6 vs. 14.6 ± 8.3%, P < 0.001); decreased diastolic filling at rest in severe (2.53 ± 0.68 vs. 3.01 ± 0.48 end-diastolic volume per second, P < 0.001) and partial GHD (2.61 ± 0.45 vs. 2.89 ± 0.54 end-diastolic volume per second, P = 0.004) patients; and decreased exercise duration and capacity in all the patient groups. A normal systolic performance on effort was found in 21.4% of severe GHD, 55.6% of partial GHD, all non-GHD, and 93.7% of controls. A normal diastolic filling at rest was found in 57.1% of severe GHD, 74.1% of partial GHD, 76.5% of non-GHD, and 90% of controls. In conclusion, cardiac performance is correlated with the GH status because significant impairment was found in patients with severe and partial GHD but not in non-GHB hypopituitary patients.
The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study
No results.
The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study
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