Description: This activity is focused on developing a software procedure for automated segmentation of brain structures starting from brain CTs and/or MRs. The software must support the manual 3D drawing or importing of a lesion ROI, excluded during segmentation. The software applies also an atlas on the segmentation, both on the Gray Matter and the White Matter and produces an RTP structure file, with contours for each slice and for each ROI. Optionally the software can import an RT dose DICOM file with which it calculates dose-volume histograms. The activity is aimed to develop, test, validate and improve the software and use it on the field for research purposes.