Contact person: Stefania De Luca, stefania.deluca
cnr.itActors: Stefania De Luca, stefania.deluca
cnr.it, Our research activity concerns several topics. One of our major interest is the modification of natural biopolymers and their characterization via chemical-physic characterizations. We are particularly skilled in synthetic procedures performed under solvent free conditions and with micro waves irradiation. These techniques are particularly suitable for developing environmentally sustainable and energy-efficient synthetic process to prepare biopolymer-based nano-sized material to be employed as drug delivery carrier systems. We are also focused on the development of chemoselective, convenient and mild synthetic strategy to modify the cysteine sulfhydryl group of peptide sequences in order to introduce different functionalities, such as carbohydrate moieties. It uses only activated molecular sieves to selectively promote the S- alkylation in presence of other peptide nucleophilic groups.Recently, this methodology has been employed to introduce lanthionine derivatives in peptide sequences. It consisted in a post-synthetic cysteineS-alkylation reaction performed on cyclic sulfamidates and allowed the preparation of different lanthipeptides. In addition, our skills are employed for the design, synthesis and biological evaluation of new peptide analogues endowed with a good binding affinity toward biological targets involved in cancer illnesses, such as the CXCR4 and HER2 receptors. They are supposed to be used as therapeutic agents, if able to modulate the receptor target functional roles, or to be used as diagnostic markers.
A Late-Stage Synthetic Approach to Lanthionine-Containing Peptides via S-Alkylation on Cyclic Sulfamidates Promoted by Molecular Sieves;
Chemoselective Glycosylation of Peptides through S-Alkylation Reaction:
The Cysteine S-Alkylation Reaction as a Synthetic Method to Covalently Modify Peptide Sequences;
Eco-friendly microwave-assisted protocol to prepare hyaluronan-fatty acid conjugates and to induce their self-assembly process;
A biocompatible process to prepare hyaluronan-based material able to self-assemble into stable nano-particles;
Physical and Water Sorption Properties of Chemically Modified Pectin with an Environmentally Friendly Process;
Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe;
Structural identification of an HER2 receptor model binding pocket to optimize lead compounds: a combined experimental and computational approach;
Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach.
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