New synthetic molecules for active targeting of multifunctional theranostic nanosystems
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New synthetic molecules for active targeting of multifunctional theranostic nanosystems
Research areas: Small molecules and peptides/modified peptides for diagnostic, therapeutic and biotechnological applications, Small molecules and modified peptides as drug delivery systems, 

Keywords: Design, synthesis, peptides, thio glycosides, integrins, asialoglycoprotein receptor, nanoparticles, integrated multifunctionality, theranostic

Contact person: Laura Zaccaro, lzaccarounina.it

Actors: Laura Zaccaro, lzaccarounina.it, Annarita Del Gatto, annarita.delgattocnr.it,

Description:
Active targeting based on the ligand-target affinity is a common strategy to enhance the binding and the uptake of theranostic nanosystems  into tumoral tissues and microenviroment.
Peptides are widely employed as targeting ligands for their several advantages including the capability to selectively recognize specific diseases markers, and to be easily manipulated for achieving the decoration of smart nanosystem surface. Carbohydrates can also potentially be considered good candidates although the low resistance to glycosidases and the low protein affinity narrow their use as native compounds. Recently we focused on developing novel peptides and carbohydrates for the decoration of nanoparticles (i.e TiO2/Fe2O3, SPION/Au heterostructures), prepared at IBCF-CNR and University of Bari, with integrated multifunctionality for theranostic applications. Both chimeric peptides, displaying motifs for efficient integrins targeting and surface capping function, and thio-glycosides, featuring the sulfur atom at anomeric position for improving glycosidase stability and asialoglycoprotein receptor specific targeting, were designed. These molecules are chemically synthesized and characterized by means of spectroscopic and biological techniques.

Selected papers:

-     Siciliano, G. et al. Gold-Speckled SPION@SiO2 Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications. CHEM EUR J 2020, 26, 11048. doi: 10.1002/chem.202002142

-  Depalo, N. et al. NIR emitting nanoprobes based on cyclic RGD motif conjugated PbS quantum dots for integrin-targeted optical bioimaging. ACS Appl Mater Interfaces 2017, 9, 43113. doi: 10.1021/acsami.7b14155

-     Valente, G. et al. Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures. NANO RESEARCH 2016, 9, 644. doi: 10.1007/s12274-015-0944-2

-  Di Pietro, P. et al. Silver nanoparticles functionalized with a fluorescent cyclic RGD peptide: a versatile integrin targeting platform for cells and bacteria. RSC ADVANCES 2016, 6, 112381. doi: 10.1039/c6ra21568h

New synthetic molecules for active targeting of multifunctional theranostic nanosystems
▼    Targeted Drug Delivery by integrin avb3 antagonist
▼    MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles
▼    Development of integrin subtypes selective ligands: from a first rationally designed peptide to a wide range of molecules
▼    Multispecific Human Albumin Nanoparticles (NP-HSA) decorated with multiple molecular cues for the specific and controlled delivery of cytotoxic agents
▼    Monoclonal Antibodies and recombinant fragments for therapeutic and diagnostic applications
New synthetic molecules for active targeting of multifunctional theranostic nanosystems
Search related bibliography on PubMed

Last modified by Marco Comerci on Monday 30 November 2020, 17:50:48
365 views. Last view on Wednesday 10 December 2025, 9:06:00