Description: The Chromatin Assembly Factor 1 is a heterotrimeric complex responsible for the nucleosome assembly during DNA replication and DNA repair. It consists of three subunits named according to their molecular weight: P150, P60, and P48. There is great interest towards these components, with particular regards to P150 which was recently considered as a tumor-associated protein due to its overexpression in many malignancies and P60 which is a marker for poor prognosis in many human malignancies. Despite their importance, structural and functional studies targeting P150 and P60 are still limited and only scarce information about these subunits are available. Insights into the biochemical, structural and functional features of this subunit are currently underway by means of different tools. Results can help to better understand the molecular mechanism of the nucleosome assembly and to correlate its features to human cancer.
Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events