TheWorld Health Organisation has identified antimicrobial resistance (AMR) as oneof the three greatest threats to mankind. There is an urgent need to traininnovative ESRs in the development of new vaccines against AMR infections.BactiVax will tackle the societal challenge caused by the emergence of AMRpathogens and have significant impact on pathogens causing chronic,life-threatening respiratory and/or systemic infections. BactiVax training willcover critical areas of vaccinology from early antigen discovery tooptimisation of host response and delivery of vaccine antigens. It will alsoencompass the increasing problem of vaccine hesitancy in its public engagement.The specific research objectives at CNR-IBB are the production andcharacterization at a molecular level of novel protective vaccine antigensagainst target pathogens and their improvement in terms of host response usinga structural vaccinology approach [1-4]. BactiVax (anti-Bacterial Innovative Vaccines) è una rete di formazione europea finanziata dall'UE, Marie Skłodowska-Curie Actions, che fornirà una formazione di alto livello in ambito vaccinale a 15 giovani ricercatori e fornirà loro un’ampia gamma di competenze trasferibili all'interno del mondo accademico e industriale (https://www.bactivax.eu/management-team/).
 Moreira M,Ruggiero A, Esposito L, Choi HG, Kim HJ, Berisio R. Structural features ofHtpGMtb and HtpG-ESAT6Mtb vaccine antigens against tuberculosis: Moleculardeterminants of antigenic synergy and cytotoxicity modulation. Int J BiolMacromol. 2020 May 4;158:305-317.
 De MaioF, Berisio R, Manganelli R, Delogu G. PE_PGRS proteins of Mycobacteriumtuberculosis: A specialized molecular task force at the forefront ofhost-pathogen interaction.
 Dennehy R, Romano M, Ruggiero A, Mohamed YF,Dignam SL, Mujica Troncoso C, Callaghan M, Valvano MA, Berisio R, McClean S.The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involvedin epithelial cell attachment and elicitation of inflammation. Cell Microbiol.2017 19(5).
|▼ Generation of innovative scaffolds by manipulating hyperstable proteins Design di scaffold innovativi mediante l’ingegnerizzazione di proteine termostabili|
|▼ Cell wall recognition events for biosensors development Riconoscimento delle pareti cellulari batteriche per lo sviluppo di biosensori|