Description: Monoclonal Antibodies (MAbs) represent a class of molecules with high specificity and affinity for the target. MAbs can be raised against virtually any antigen, provided they are sufficiently immunogenic and sufficiently large to be recognized by the immune system. We are developing MAbs against several protein antigens which are recognized as biomarkers for several cancer as well as other important diseases. Among the others we have developed MAbs against Cripto and Nodal, two main players of the activin receptor complex signaling. They are largely overexpressed in several types of cancers and their detection in tissues and in biological fluids is of utmost importance for diagnostic and prognostic purposes. Furthermore, the screening of clones using specific mutated antigens, has allowed the selection of MAbs having neutralizing activity for their respective receptors
Monoclonal Antibodies for therapeutic and diagnostic applications