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NameLaura Zaccaro
AreaResearch&Development
PositionSenior Researcher
Work siteNaples - Castellino
AddressVia Pietro Castellino 111, 80131 Naples - Italy
E-maillzaccarounina.it
▼    Hematologic Diseases
▼    Structure-based design of artificial activators that reactivate gene expression in vivo
▼    Cancer Diseases
▼    Gadd45 beta and its implication in chronic inflammation
▼    Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
▼    Monoclonal Antibodies for therapeutic and diagnostic applications
▼    Targeted Drug Delivery by integrin avb3 antagonist
▼    Chemical protein synthesis and modification for biomedical applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Imaging Tumor Acidosis
▼    Bioactive peptide-membrane assemblies
No results.
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Clinical Oncology
▼    Translational Molecular Imaging in Cancer
▼    Molecular imaging for personalized therapy in oncology
▼    Modeling radiation induced normal tissue effects
▼    Evaluation of new molecular probes by preclinical imaging
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Brain segmentation for radiation oncology application
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Drug discovery by mirror-image phage display
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Macromolecules for biomedical and biotechnological applications
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    A multi-targeting approach to fight COVID-19
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Chemical protein synthesis and modification for biomedical applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Generation of innovative scaffolds by manipulating hyperstable proteins
▼    The fine structure of proteins as a new tool for protein structure validation, quality assessment, and prediction
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
▼    Plant polypeptides as natural enhancers of biostimulation
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Protein-based biotherapeutics
▼    Understanding SARS-CoV-2 interaction with its host of for therapeutic applications
▼    Structure and function of proteins involved in physio-pathologic processes
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    A multi-targeting approach to fight COVID-19
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Carbonic Anhydrase family as target for rational drug design
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Chemical protein synthesis and modification for biomedical applications
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Structural characterization of the porphyrins/proteasome interaction
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Drug discovery by mirror-image phage display
▼    Analysis of Sam domain druggability through computational and experimental studies
▼    Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
▼    Targeting Of Protein-Protein Interactions For Therapeutic Purposes
▼    Small molecules and peptides/modified peptides for diagnostic, therapeutic and biotechnological applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    New peptide–based molecules as NGF mimetics in the therapy of neurological dysfunctions
▼    Peptide-based molecules for αvβ3 integrin modulation in Th17 cells-dependent demyelinating diseases
▼    Development of integrin subtypes selective ligands: from a first rationally designed peptide to a wide range of molecules
▼    Design of New FSHR-Specific Peptides for therapeutic and diagnostic applications
▼    New synthetic molecules for active targeting of multifunctional theranostic nanosystems
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    A multi-targeting approach to fight COVID-19
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Drug discovery by mirror-image phage display
▼    Peptides of therapeutic interest with antimicrobial and/ or antitumoral activity
▼    Analysis of Sam domain druggability through computational and experimental studies
▼    Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Plant polypeptides as natural enhancers of biostimulation
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Design and screening of molecular repertoires as a source for new bioactive compounds
▼    Targeting Of Protein-Protein Interactions For Therapeutic Purposes
▼    Small molecules and modified peptides as drug delivery systems
▼    Development of integrin subtypes selective ligands: from a first rationally designed peptide to a wide range of molecules
▼    New synthetic molecules for active targeting of multifunctional theranostic nanosystems
▼    Structure-based design of artificial activators that reactivate gene expression in vivo
▼    Targeted Drug Delivery by integrin avb3 antagonist
▼    A multi-targeting approach to fight COVID-19
▼    New synthetic molecules for active targeting of multifunctional theranostic nanosystems
▼    Development of integrin subtypes selective ligands: from a first rationally designed peptide to a wide range of molecules
▼    Design of New FSHR-Specific Peptides for therapeutic and diagnostic applications
▼    Peptide-based molecules for αvβ3 integrin modulation in Th17 cells-dependent demyelinating diseases
▼    New peptide–based molecules as NGF mimetics in the therapy of neurological dysfunctions

Born in Naples on 4th May 1968. 1991: Degree in Pharmacy summa cum laude at University of Naples Federico II (Italy). 1994: Postgraduate specialisation summa cum laude in Pharmaceutical Chemistry at University of Naples Federico II. 1992-1995 CNR Fellowships at the Centre of Biocrystallography, Naples. 1995-1996: Fellowship at Department of Chemistry at University of Naples Federico II. 1996-2000: Research assistent at Biotechnology Faculty of University of Naples Federico II. From 2001 to present day: Researcher at Biostructure and Bioimaging Institute-CNR, Naples. 2001-2002: External Scientist at Department of Organic Chemistry, University of Barcelona-Spain. 2004-2005: contract Professor of General Chemistry at Science Faculty of MM. FF. NN-University of Naples Federico II. 2006-2008: Contract Professor of General Chemistry at Biotechnology Faculty of University of Naples Federico II. The scientific interests of Dr. Zaccaro concern both the development of new molecules with specific activities or able to interact with specific molecular targets, and the structure-activity relationship studies of bioactive systems to understand the molecular device for the biological activity. Dr. Zaccaro has experience in the field of rational design of peptide and peptido-mimetic systems, synthesis in solution and on solid phase, purification by chromatography techniques, structural characterisation by mass spectrometry and spectroscopic techniques and interaction studies by surface plasmon resonance.

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* High-Resolution Conformational Analysis of RGDechi-Derived Peptides Based on a Combination of NMR Spectroscopy and MD Simulations (30 views)
Acconcia C, Paladino A, Valle MD, Farina B, Del Gatto A, Gaetano SD, Capasso D, Gentile MT, Malgieri G, Isernia C, Saviano M, Fattorusso R, Zaccaro L, Russo L
Int J Mol Sci (ISSN: 1422-0067linking), 2022 Sep 20; 23 (19 ): N/D-N/D.
Impact Factor:
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* An Overview of Peptide-Based Molecules as Potential Drug Candidates for Multiple Sclerosis (100 views)
Del Gatto A, Saviano M, Zaccaro L
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Aug 28; 26(17): N/D-N/D.
Impact Factor: 4.411
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* A novel approach for studying receptor-ligand interactions on living cells surface by using NUS/T1ρ-NMR methodologies combined with computational techniques: The RGDechi15D-α(v)β(5) integrin complex (141 views)
Farina B, Andrea C, Del Gatto A, Comegna D, Di Gaetano S, Capasso D, Paladino A, Acconcia C, Teresa Gentile M, Saviano M, Fattorusso R, Zaccaro L, Russo L
Comput Struct Biotechnol J (ISSN: 2001-0370linking), 2021 May 29; 19: 3303-3318.
Impact Factor: 7.271
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* Selective Targeting of αvβ5 Integrin in HepG2 Cell Line by RGDechi15D Peptide (165 views)
Capasso D, Del Gatto A, Comegna D, Russo L, Fattorusso R, Saviano M, Di Gaetano S, Zaccaro L
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2020 Sep 19; 25(18): N/D-N/D.
Impact Factor: 3.267
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* Gold-Speckled SPION@SiO(2) Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications (134 views)
Siciliano G, Corricelli M, Iacobazzi RM, Canepa F, Comegna D, Fanizza E, Del Gatto A, Saviano M, Laquintana V, Comparelli R, Mascolo G, Murgolo S, Striccoli M, Agostiano A, Denora N, Zaccaro L, Curri ML, Depalo N
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 Aug 26; 26(48): 11048-11059.
Impact Factor: 4.857
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* A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment (701 views) (PDF 191 views)
Pirone L, Del Gatto A, Di Gaetano S, Saviano M, Capasso D, Zaccaro L, Pedone E
Front Mol Biosci (ISSN: 2296-889xlinking), 2020 Aug 3; 7: 186-186.
Impact Factor: 4.188
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* On-Bead Peptoid Dimerization Induced by Incorporation of Glycosylated Bridging Units in Submonomer Solid-Phase Approach to Glycopeptoids (268 views)
Comegna D, Del Gatto A, Saviano M, Zaccaro L
Org Lett (ISSN: 1523-7052linking, 1523-7052electronic, 1523-7060), 2019 Jun 21; 21(12): 4454-4458.
Impact Factor: 5.128
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* Conformational studies of RGDechi peptide by natural-abundance NMR spectroscopy (302 views)
Farina B, Del Gatto A, Comegna D, Di Gaetano S, Capasso D, Isernia C, Saviano M, Fattorusso R, Zaccaro L, Russo L
J Pept Sci (ISSN: 1075-2617linking, 1099-1387electronic), 2019 May; 25(5): e3166-e3166.
Impact Factor: 1.807
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* Therapeutic Potential of a Novel alphavbeta(3) Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type (422 views) (PDF 118 views)
Hill BS, Sarnella A, Capasso D, Comegna D, Del Gatto A, Gramanzini M, Albanese S, Saviano M, Zaccaro L, Zannetti A
Cancers (ISSN: 2072-6694linking), 2019 Jan 24; 11(2): 139-139.
Impact Factor: 6.126
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* [(99m)Tc][Tc(N)PNP43]-Labeled RGD Peptides As New Probes for a Selective Detection of alphavbeta3 Integrin: Synthesis, Structure-Activity and Pharmacokinetic Studies (476 views)
Bolzati C, Salvarese N, Carpanese D, Seraglia R, Melendez-alafort L, Rosato A, Capasso D, Saviano M, Del Gatto A, Comegna D, Zaccaro L
J Med Chem (ISSN: 0022-2623linking, 0022-2623print, 1520-4804electronic), 2018 Nov 8; 61(21): 9596-9610.
Impact Factor: 6.253
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* A selective αvβ5 integrin antagonist hidden into the anophelin family protein cE5 from the malaria vector Anopheles gambiae (353 views)
Di Gaetano S, Del Gatto A, Pirone L, Comegna D, Zaccaro L, Saviano M, Arcà B, Capasso D, Pedone E
Peptide Science, 2018; N/D: N/D-N/D.
Impact Factor: 2.081
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* Deciphering RGDechi peptide‐α5β1 integrin interaction mode in isolated cell membranes (334 views)
Russo L, Farina B, Del Gatto A, Comegna D, Di Gaetano S, Capasso D, Liguoro D, Malgieri G, Saviano M, Fattorusso R, Zaccaro L
Peptide Science, 2018; N/D: N/D-N/D.
Impact Factor: 2.081
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* Chemical Modification for Proteolytic Stabilization of the Selective alphavbeta3 Integrin RGDechi Peptide: in Vitro and in Vivo Activities on Malignant Melanoma Cells (1016 views) (PDF 223 views)
Comegna D, Zannetti A, Del Gatto A, De Paola I, Russo L, Di Gaetano S, Liguoro A, Capasso D, Saviano M, Zaccaro L
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2017 Dec 14; 60(23): 9874-9884.
Impact Factor: 6.253
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* NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (497 views) (PDF 200 views)
Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.
Impact Factor: 8.097
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* Insights into the anticancer properties of the first antimicrobial peptide from Archaea (466 views)
Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0304-4165linking), 2017 Jun 15; 1861(9): 2155-2164.
Impact Factor: 4.28
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* A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 beta-like: from in silico identification to experimental evidence (441 views)
Bosso A, Pirone L, Gaglione R, Pane K, Del Gatto A, Zaccaro L, Di Gaetano S, Diana D, Fattorusso R, Pedone E, Cafaro V, Haagsman HP, Van Dijk A, Scheenstra MR, Zanfardino A, Crescenzi O, Arciello A, Varcamonti M, Veldhuizen EJA, Di Donato A, Notomista E, Pizzo E
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Apr 25; N/D: N/D-N/D.
Impact Factor: 4.28
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* The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism (318 views) (PDF 160 views)
Persico M, Fattorusso R, Taglialatela-scafati O, Chianese G, De Paola I, Zaccaro L, Rondinelli F, Lombardo M, Quintavalla A, Trombini C, Fattorusso E, Fattorusso C, Farina B
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Apr 6; 7: 45485-45485.
Impact Factor: 4.122
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* The (unusual) aspartic acid in the metal coordination sphere of the prokaryotic zinc finger domain (320 views)
D'Abrosca G, Russo L, Palmieri M, Baglivo I, Netti F, De Paola I, Zaccaro L, Farina B, Iacovino R, Pedone PV, Isernia C, Fattorusso R, Malgieri G
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2016 Aug; 161: 91-98.
Impact Factor: 3.348
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* A Combined NMR and Computational Approach to Determine the RGDechi-hCit-alphav beta3 Integrin Recognition Mode in Isolated Cell Membranes (807 views)
Farina B, De Paola I, Russo L, Capasso D, Liguoro A, Gatto AD, Saviano M, Pedone PV, Di Gaetano S, Malgieri G, Zaccaro L, Fattorusso R
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Jan 11; 22(2): 681-693.
Impact Factor: 5.317
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* Silver nanoparticles functionalized with a fluorescent cyclic RGD peptide: a versatile integrin targeting platform for cells and bacteria (370 views) (PDF 182 views)
Di Pietro P, Zaccaro L, Comegna D, Del Gatto A, Saviano M, Snyders R, Cossement D, Satriano C, Rizzarelli E
The Royal Society Of Chemistry, 2016 Jan 01; 6: N/D-N/D.
Impact Factor: 3.564
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* Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures (462 views)
Valente G, Depalo N, De Paola I, Iacobazzi RM, Denora N, Laquintana V, Comparelli R, Altamura E, Latronico T, Altomare M, Fanizza E, Striccoli M, Agostiano A, Saviano M, Del Gatto A, Zaccaro L, Curri ML
Nano Res (ISSN: 1998-0124), 2016; 9(3): 644-662.
Impact Factor: 7.354
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* Cullin3 - BTB interface: A novel target for stapled peptides (803 views) (PDF 61 views)
De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Apr 7; 10(4): e0121149-e0121149.
Impact Factor: 3.057
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* Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics (670 views)
Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015; 17(3): 640-643.
Impact Factor: 6.732
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* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (631 views)
Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
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* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (603 views)
Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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* Conformational features of human melanin-concentrating hormone: an NMR and computational analysis (574 views)
Vitale RM, Zaccaro L, Di Blasio B, Fattorusso R, Isernia C, Amodeo P, Pedone C, Saviano M
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2014 Sep 17; 4(1): 73-81.
Impact Factor: 3.088
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* Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutant (508 views)
Palmieri M, Russo L, Malgieri G, Esposito S, Baglivo I, Rivellino A, Farina B, de Paola I, Zaccaro L, Milardi D, Isernia C, Pedone PV, Fattorusso R
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 30-36.
Impact Factor: 3.444
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* Zinc To Cadmium Replacement In The Prokaryotic Zinc-Finger Domain (628 views)
Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, De Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C
Metallomics (ISSN: 1756-591x, 1756-5901, 1756-591xelectronic), 2013 Dec 18; 6(1): 96-104.
Impact Factor: 3.978
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* Selective alpha v beta 3 receptor peptide antagonist for therapeutic and diagnostic applications (1225 views)
Del Gatto A, Zaccaro L, Pedone C, Saviano M
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2013 Oct 1; N/D: N/D-N/D.
Impact Factor: 0
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* Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders (395 views)
Vitagliano L, Zaccaro L, Morelli G, Martegani E
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2013 Jun 11; N/D: N/D-N/D.
Impact Factor: 0
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* Structural Zn(II) Implies a Switch from Fully Cooperative to Partly Downhill Folding in Highly Homologous Proteins (468 views)
Palmieri M, Malgieri G, Russo L, Baglivo I, Esposito S, Netti F, Del Gatto A, De Paola I, Zaccaro L, Pedone PV, Isernia C, Milardi D, Fattorusso R
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2013 Apr 2; 135(13): 5220-5228.
Impact Factor: 11.444
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* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (635 views)
Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
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* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (726 views)
Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
Bioconjug Chem (ISSN: 1520-4812, 1043-1802, 1520-4812electronic), 2012 Mar 21; 23(3): 340-349.
Impact Factor: 4.58
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* Structure-based design of a potent artificial transactivation domain based on p53 (541 views)
Langlois C, Del Gatto A, Arseneault G, Lafrance-vanasse J, De Simone M, Morse T, De Paola I, Lussier-price M, Legault P, Pedone C, Zaccaro L, Omichinski JG
J Am Chem Soc (ISSN: 1520-5126, 0002-2786, 0002-7863), 2012 Jan 25; 134(3): 1715-1723.
Impact Factor: 5.65
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* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (466 views)
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (504 views)
Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011 Nov; 95(11): 801-810.
Impact Factor: 2.87
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* TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach (730 views)
Zaccaro L, Garcia-lopez Mt Gonzalez-muniz RG
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2011 Jun 15; 21(12): 3541-3545.
Impact Factor: 2.554
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* Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD - cullin 3 recognition (508 views)
Pirone L, Correale S, De Paola I, Zaccaro L, De Simone G, Vitagliano L, Pedone E, Di Gaetano S
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 373-376.
Impact Factor: 1.799
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* Investigation of the Best Conditions to Obtain c(RGDfK) Peptide on Solid Phase (607 views)
Saviano M, Del Gatto A, De Simone M, De Paola I, Saviano M, Zaccaro L
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2011 Mar; 17(1): 39-45.
Impact Factor: 0.986
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* Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor (562 views)
Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele DL, Zaccaro L, Alberghina L, Papa M
Neurobiology Of Disease (ISSN: 0969-9961), 2011 Mar; 41(3): 630-639.
Impact Factor: 5.403
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* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (595 views)
Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
J Transl Med (ISSN: 1479-5876electronic, 1479-5876linking), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
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* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (518 views)
Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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* Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers (649 views)
Pérez de Vega MJ, García-López MT, Zaccaro L, Royo M, Albericio F, Fernández-Carvajal A, Ferrer-Montiel A, González-Muñiz R
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2010 Jul 15; 15(7): 4924-4933.
Impact Factor: 1.988
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* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (549 views)
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A,  De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (1052 views)
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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* MicroPET/CT of mice bearing alpha(v)beta(3)-expressing tumors by a 18F-labeled bifunctional chimeric RGD peptide (469 views)
Zannetti A, Iommelli F, Panico M, Del Gatto A, Zaccaro L, Saviano M, Pedone C, Salvatore M, Del Vecchio S
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
Impact Factor: 4.531
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* New high yield HPLC purification with ethanol of 18F-RGDEchi and directly injection in mice (557 views)
Panico MM, Lang L, Greco A, Greco A, Gargiulo S, Larobina M, Del Vecchio S, Zannetti A, Zaccaro L, Zaccaro L, Del Gatto A, Saviano M, Alfano B, Salvatore M
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Sep; 36: N/D-N/D.
Impact Factor: 4.531
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* Peptides for tumour therapy and diagnosis: current status and future directions (1599 views)
Zaccaro L, Del Gatto A, Pedone C, Saviano M
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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* A new and selective radiolabeled alpha(V)beta(3) peptide antagonist as tracer in tumor diagnosis (546 views)
De Luca S, Del Gatto A, Ruvo M, Panico M, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M, Zaccaro L
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 439-440.
Impact Factor: 2.02
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* An Improved Radiolabeling Synthesis of RGDECHI with 18F-Fluoride (561 views)
Panico M, Lang L, Del Vecchio S, Nardelli A, Castaldi E, Zaccaro L, Del Gatto A, Saviano M, Zannetti A, Larobina M, Gargiulo S, Pedone C, Salvatore M
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Oct; 35: N/D-N/D.
Impact Factor: 4.532
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* Development of new molecules that compete with p53 for Binding to TFIIH (440 views)
Zaccaro L, Del Gatto A, Saviano M, Langella E, Langlois C, Di Lello P, Baffreau J, Mas C, Legault P, Omichinski JG, Pedone C
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
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* A New Nerve Growth Factor (ngf)-Mimetic Peptide Active On Neuropathic Pain In Rats (758 views)
Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E
J Neurosci (ISSN: 0270-6474, 0270-0647, 1529-2401), 2008 Mar 12; 28(11): 2698-2709.
Impact Factor: 7.452
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* The Prokaryotic Cys2his2 Zinc Finger Domain Adopts A Novel Fold As Revealed By The Solution Structure Of Agrobacterium Tumefaciens Ros Dna Binding Domain (574 views)
Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2007 Oct 30; 104(44): 17341-17346.
Impact Factor: 9.598
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* In vivo imaging of alpha(v) beta(3) integrin expression with a radiolabeled chimeric RGD peptide (481 views)
Del Vecchio S, Zannetti A, Panico M, Speranza A, Iommelli F, Papaccioli A, Sommella J, Lettieri A, Saviano M, Zaccaro L, Del Gatto A, Lang L, Pedone C, Salvatore M
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: N/D-N/D.
Impact Factor: 4.101
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* A new and selective radiolabeled alpha(v)beta 3 peptide antagonist as tracer in tumor diagnosis (445 views)
Zaccaro L, Del Gatto A,  De Luca S, Ruvo M, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(4): N/D-N/D.
Impact Factor: 2.389
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* Integrin Receptor Family: Promising Target For Therapeutic And Diagnostic Applications (401 views)
Zaccaro L, Del Gatto A, Pedone C, Saviano M
Current Topics In Biochemical Research (ISSN: 0972-4583), 2007; 9(2): 45-56.
Impact Factor: 0
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* A novel type of zinc finger DNA binding domain in the Agrobacterium tumefaciens transcriptional regulator Ros (1076 views)
Esposito S, Baglivo I, Malgieri G, Russo L, Zaccaro L, D'Andrea LD, Mammucari M, Di Blasio B, Isernia C, Fattorusso R, Pedone PV
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Sep 29; 45(34): 10394-10405.
Impact Factor: 3.633
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* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (908 views)
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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* Antisense PNA and PNA-peptide conjugates for the modulation of beta-globin gene splicing (377 views)
Romanelli A, Pensato S, Di Niola E, Feriotto G, Salvatori F, Breveglieri G, Zaccaro L, Saviano M, Gambari R, Pedonel C, Benedetti E
Understanding Biology Using Peptides, 2006; N/D: N/D-N/D.
Impact Factor: 2.614
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* Engineering Peptides In Angiogenesis (486 views)
Del Gatto A, D'Andrea LD, Zaccaro L, Saviano M, Pedone C, Benedetti E
Biopolymers, 2006; 0: 215-216.
Impact Factor: 2.288
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* Novel and selective alpha v beta 3 receptor peptide antagonist: Design, synthesis and biological behaviour (484 views)
Del Gatto A, Zaccaro L, Zannetti A, Del Vecchio S, Benedetti E, Salvatore M, Pedone C, Saviano M
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006; 12: N/D-N/D.
Impact Factor: 1.801
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* Characterization of a novel RGD-containing peptide with improved selectivity for imaging alpha v beta 3 integrin expression (544 views)
Del Vecchio S, Zannetti A, Del Gatto A, Grieco P, Iommelli F, Zaccaro L, Panico M, Saviano M, Blystone SD, Pedone C, Salvatore M
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: N/D-N/D.
Impact Factor: 3.883
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* Erratum: A new class of foldamers based on cis-γ-amino-L-proline (Journal of the American Chemical Society (2004) 126 (6048-6057)) (392 views)
Farrera-Sinfreu J, Zaccaro L, Vidal D, Salvatella X, Giralt E, Pons M, Albericio F, Royo M
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2005; 127(1): 474-474.
Impact Factor: 7.419
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* A New Class of Foldamers Based on cis-γ-Amino-L-proline (642 views)
Farrera-Sinfreu J, Zaccaro L, Vidal D, Salvatella X, Giralt E, Pons M, Albericio F, Royo M
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 May 19; 126(19): 6048-6057.
Impact Factor: 6.903
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* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (769 views)
De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (516 views)
Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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* NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein (570 views)
Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003 Mar 3; 4(2-3): 171-180.
Impact Factor: 3.992
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* Synthetic peptides mimicking the interleukin-6/gp130 interaction: a two-helix bundle system. Design and conformational studies (1144 views)
Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Feb; 9(2): 105-105.
Impact Factor: 1.377
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* Synthetic peptides mimicking the interleukin-6/gp130 interaction: A two-helix bundle system. Design and confirmational studies (577 views)
Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003; 9(2): 90-105.
Impact Factor: 1.377
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* The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys(2)-His(2) zinc finger motif (1144 views)
Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962, 1362-4962electronic), 2002 Nov 15; 30(22): 4945-4951.
Impact Factor: 7.051
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Fully automated synthesis of peptide-oligonucleotide conjugates (413 views)
Romanelli A, De Napoli L, Messere A, Montesarchio D, Piccialli G, Zaccaro L, Pedone C, Rossi F, Benedetti E
Peptides For The New Millennium, 2000; N/D: N/D-N/D.
Impact Factor: 2.614
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Conformational Behaviour Of C (alpha, Alpha)-Diphenylglycine: Folded Vs. Extended Structures In Dphig-Containing Tripeptides (556 views)
Pavone V, Lombardi A, Saviano M, Nastri F, Zaccaro L, Maglio O, Pedone C, Omote Y, Yamanaka Y, Yamada T
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 1998 Feb; 4(1): 21-32.
Impact Factor: 1.311
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Conformational Behaviour Of C-Alpha-Alpha-Diphenylglicine. Folded Versus Extended Structures In Dfg-Containing Tripeptides (443 views)
Pavone V, Lombardi A, Saviano M, Nastri F, Zaccaro L, Maglio O, Pedone C, Omote Y, Yamanaka Y, Yamada T
Journal Of Peptide Science, 1998; 4: 21-32.
Impact Factor: 0
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Experimental evidence at atomic resolution for intramolecular N- H···π (phenyl) interactions in a family of amino acid derivatives (549 views)
Crisma M, Formaggio F, Valle G, Toniolo C, Saviano M, Iacovino R, Zaccaro L, Benedetti E
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1997; 42(1): 1-6.
Impact Factor: 2.425
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Mixed conformation in C(α, α)-disubstituted tripeptides: X-ray crystal structures of Z-Aib-Dph-Gly-OMe and Bz-Dph-Dph-Gly-OMe (453 views)
Pavone V, Lombardi A, Saviano M, Di Blasio B, Nastri F, Fattorusso R, Zaccaro L, Maglio O, Yamada T, Omote Y
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Dec; 34(12): 1595-1604.
Impact Factor: 2.425
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A Structural Two-Rings In Crystals Of A Cyclo D, L-Hexapeptide (509 views)
Saviano M, Zaccaro L, Lombardi A, Pedone C, Di Blasio B
Journal Of Inclusion Phenomena And Molecular Recognition In Chemistry, 1994; 18: 27-36.
Impact Factor: 0
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beta-Cyclodextrins as potent bioactive delivery system (524 views)
Rossi F, Zaccaro L, Di Blasio B, Pavone V, Maglio O, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
Peptides, 1992; N/D: 577-578.
Impact Factor: 0
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77 Records (60 excluding Abstracts).
Total impact factor: 301.055 (248.482 excluding Abstracts).
Total 5 year impact factor: 297.827 (239.165 excluding Abstracts).

Last modified by Massimiliano Sorbillo on Monday 16 September 2024, 15:20:54
6215 views. Last view on Tuesday 08 October 2024, 19:45:45