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Anna Di Fiore
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Research&Development
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Researcher
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Naples - Castellino
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Via Pietro Castellino 111, 80131 Naples - Italy
E-mail
anna.difiore
cnr.it
▼
Structure and function of proteins involved in physio-pathologic processes
▼
Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
Buonanno Martina
Monti Simona Maria
Langella Emma
Di Fiore Anna
D'Ambrosio Katia
De Simone Giuseppina
Alterio Vincenzo
▼
Biomolecules able to modulate the VEGF-dependent angiogenesis
D'Andrea Luca Domenico
De Rosa Lucia
Di Stasi Rossella
Diana Donatella
Di Gaetano Sonia
▼
A multi-targeting approach to fight COVID-19
Zaccaro Laura
Del Gatto Annarita
Pedone EmiliaMaria
Pirone Luciano
Di Gaetano Sonia
▼
Galectins: Structure, function and therapeutic potential inhibitors
Pedone EmiliaMaria
Di Gaetano Sonia
Pirone Luciano
▼
Carbonic Anhydrase family as target for rational drug design
Monti Simona Maria
De Simone Giuseppina
Alterio Vincenzo
▼
Characterization of the KCTD protein family: key factors in several biological processes
Pedone EmiliaMaria
Vitagliano Luigi
Di Gaetano Sonia
Pirone Luciano
▼
Chemical protein synthesis and modification for biomedical applications
D'Andrea Luca Domenico
De Rosa Lucia
Di Stasi Rossella
▼
Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
Pedone EmiliaMaria
Di Gaetano Sonia
Diana Donatella
Pirone Luciano
▼
Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
Maglio Ornella
Diana Donatella
Leone Marilisa
▼
Structural characterization of the porphyrins/proteasome interaction
Diana Donatella
▼
Axl and Gas6 targeting for therapeutic and diagnostic applications
De Rosa Lucia
D'Andrea Luca Domenico
Di Stasi Rossella
▼
Drug discovery by mirror-image phage display
D'Andrea Luca Domenico
De Rosa Lucia
Di Stasi Rossella
▼
Analysis of Sam domain druggability through computational and experimental studies
Leone Marilisa
Palumbo Rosanna
Pedone EmiliaMaria
Pirone Luciano
▼
Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors
Leone Marilisa
Marasco Daniela
Palumbo Rosanna
Pedone EmiliaMaria
Pirone Luciano
▼
Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
Musumeci Domenica
Vicidomini Caterina
Palumbo Rosanna
Roviello Giovanni Nicola
▼
Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
De Simone Giuseppina
Alterio Vincenzo
D'Ambrosio Katia
Di Fiore Anna
Buonanno Martina
Langella Emma
Monti Simona Maria
▼
Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
De Simone Giuseppina
Alterio Vincenzo
D'Ambrosio Katia
Di Fiore Anna
Buonanno Martina
Langella Emma
Monti Simona Maria
▼
Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
De Simone Giuseppina
Alterio Vincenzo
Di Fiore Anna
D'Ambrosio Katia
Buonanno Martina
Langella Emma
Monti Simona Maria
▼
Targeting Of Protein-Protein Interactions For Therapeutic Purposes
Ruvo Menotti
Sandomenico Annamaria
Doti Nunzianna
▼
Cancer Diseases
▼
Gadd45 beta and its implication in chronic inflammation
Ruvo Menotti
Monti Simona Maria
▼
Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions
D'Ambrosio Katia
Vitagliano Luigi
Pedone EmiliaMaria
De Simone Giuseppina
Esposito Luciana
Alterio Vincenzo
▼
Characterization of the KCTD protein family: key factors in several biological processes
Pedone EmiliaMaria
Vitagliano Luigi
Di Gaetano Sonia
Pirone Luciano
▼
Characterization of neurotoxic and neuroprotective factors by using computational methodologies
Vitagliano Luigi
Esposito Luciana
▼
Monoclonal Antibodies for therapeutic and diagnostic applications
Ruvo Menotti
▼
Targeted Drug Delivery by integrin avb3 antagonist
Panico Mariarosaria
Zaccaro Laura
Zannetti Antonella
▼
Chemical protein synthesis and modification for biomedical applications
D'Andrea Luca Domenico
De Rosa Lucia
Di Stasi Rossella
▼
Biomolecules able to modulate the VEGF-dependent angiogenesis
D'Andrea Luca Domenico
De Rosa Lucia
Di Stasi Rossella
Diana Donatella
Di Gaetano Sonia
▼
Imaging Tumor Acidosis
Longo Dario Livio
▼
Bioactive peptide-membrane assemblies
No results.
▼
Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
Buonanno Martina
Monti Simona Maria
Langella Emma
Di Fiore Anna
D'Ambrosio Katia
De Simone Giuseppina
Alterio Vincenzo
▼
Clinical Oncology
De Rosa Viviana
Iommelli Francesca
Salvatore Barbara
Del Vecchio Silvana
Fonti Rosa
▼
Translational Molecular Imaging in Cancer
Del Vecchio Silvana
Fonti Rosa
Panico Mariarosaria
De Rosa Viviana
Iommelli Francesca
▼
Molecular imaging for personalized therapy in oncology
Del Vecchio Silvana
Fonti Rosa
Iommelli Francesca
De Rosa Viviana
▼
Modeling radiation induced normal tissue effects
Pacelli Roberto
Conson Manuel
Palma Giuseppe
Liuzzi Raffaele
Cella Laura
▼
Evaluation of new molecular probes by preclinical imaging
Gargiulo Sara
▼
Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
Musumeci Domenica
Vicidomini Caterina
Palumbo Rosanna
Roviello Giovanni Nicola
▼
Brain segmentation for radiation oncology application
Quarantelli Mario
Comerci Marco
Pacelli Roberto
Conson Manuel
Liuzzi Raffaele
Cella Laura
▼
Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
De Luca Stefania
▼
Drug discovery by mirror-image phage display
D'Andrea Luca Domenico
De Rosa Lucia
Di Stasi Rossella
▼
Axl and Gas6 targeting for therapeutic and diagnostic applications
De Rosa Lucia
D'Andrea Luca Domenico
Di Stasi Rossella
▼
Macromolecules for biomedical and biotechnological applications
▼
Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
Pedone EmiliaMaria
Di Gaetano Sonia
Diana Donatella
Pirone Luciano
▼
A multi-targeting approach to fight COVID-19
Zaccaro Laura
Del Gatto Annarita
Pedone EmiliaMaria
Pirone Luciano
Di Gaetano Sonia
▼
Galectins: Structure, function and therapeutic potential inhibitors
Pedone EmiliaMaria
Di Gaetano Sonia
Pirone Luciano
▼
Characterization of the KCTD protein family: key factors in several biological processes
Pedone EmiliaMaria
Vitagliano Luigi
Di Gaetano Sonia
Pirone Luciano
▼
Chemical protein synthesis and modification for biomedical applications
D'Andrea Luca Domenico
De Rosa Lucia
Di Stasi Rossella
▼
Biomolecules able to modulate the VEGF-dependent angiogenesis
D'Andrea Luca Domenico
De Rosa Lucia
Di Stasi Rossella
Diana Donatella
Di Gaetano Sonia
▼
Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
Maglio Ornella
Diana Donatella
Leone Marilisa
▼
Axl and Gas6 targeting for therapeutic and diagnostic applications
De Rosa Lucia
D'Andrea Luca Domenico
Di Stasi Rossella
▼
Generation of innovative scaffolds by manipulating hyperstable proteins
Ruggiero Alessia
Berisio Rita
Vitagliano Luigi
▼
The fine structure of proteins as a new tool for protein structure validation, quality assessment, and prediction
Vitagliano Luigi
Esposito Luciana
▼
Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
Buonanno Martina
Monti Simona Maria
Langella Emma
Di Fiore Anna
D'Ambrosio Katia
De Simone Giuseppina
Alterio Vincenzo
▼
Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
De Simone Giuseppina
Alterio Vincenzo
D'Ambrosio Katia
Di Fiore Anna
Buonanno Martina
Langella Emma
Monti Simona Maria
▼
Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
De Simone Giuseppina
Alterio Vincenzo
D'Ambrosio Katia
Di Fiore Anna
Buonanno Martina
Langella Emma
Monti Simona Maria
▼
Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
De Simone Giuseppina
Alterio Vincenzo
Di Fiore Anna
D'Ambrosio Katia
Buonanno Martina
Langella Emma
Monti Simona Maria
▼
Plant polypeptides as natural enhancers of biostimulation
Buonanno Martina
Langella Emma
Monti Simona Maria
▼
Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
De Luca Stefania
▼
Protein-based biotherapeutics
Sandomenico Annamaria
Doti Nunzianna
Ruvo Menotti
▼
Understanding SARS-CoV-2 interaction with its host of for therapeutic applications
Squeglia Flavia
Ruggiero Alessia
Romano Maria
Berisio Rita
▼
Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
Buonanno Martina
Monti Simona Maria
Langella Emma
Di Fiore Anna
D'Ambrosio Katia
De Simone Giuseppina
Alterio Vincenzo
▼
Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
De Simone Giuseppina
Alterio Vincenzo
D'Ambrosio Katia
Di Fiore Anna
Buonanno Martina
Langella Emma
Monti Simona Maria
▼
Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
De Simone Giuseppina
Alterio Vincenzo
D'Ambrosio Katia
Di Fiore Anna
Buonanno Martina
Langella Emma
Monti Simona Maria
▼
Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
De Simone Giuseppina
Alterio Vincenzo
Di Fiore Anna
D'Ambrosio Katia
Buonanno Martina
Langella Emma
Monti Simona Maria
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Biochemical, structural, and computational studies of a γ-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei
(
58 views
)
Di Fiore A
, De Luca V,
Langella E
, Nocentini A,
Buonanno M
,
Monti SM
, Supuran CT, Capasso C,
De Simone G
Comput Struct Biotechnol J (ISSN: 2001-0370linking)
,
2022 Jul 27;
20: 4185-4194.
Impact Factor:
6.155
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*
Post-translational modifications in tumor-associated carbonic anhydrases
(
88 views
)
Di Fiore A
, Supuran CT, Scaloni A,
De Simone G
Amino Acids (ISSN: 0939-4451linking, 1438-2199electronic)
,
2022 Apr;
54(4): 543-558.
Impact Factor:
3.46
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*
Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor
(
67 views
)
Ayoub J,
Buonanno M
,
Di Fiore A
,
De Simone G
,
Monti SM
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic)
,
2022 Feb 15;
23(4): 2160-2160.
Impact Factor:
6.208
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*
Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches
(
108 views
)
Pagnozzi D, Pala N, Biosa G, Dallocchio R, Dessì A, Singh PK, Rogolino D,
Di Fiore A
,
De Simone G
, Supuran CT, Sechi M
Acs Med Chem Lett
,
2022;
13: 271-277.
Impact Factor:
4.632
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*
Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides
(
206 views
)
Urbański LJ, Angeli A, Hytönen VP,
Di Fiore A
,
De Simone G
, Parkkila S, Supuran CT
J Enzym Inhib Med Ch (ISSN: 1475-6366linking, 1475-6374electronic)
,
2021 Dec;
36(1): 329-334.
Impact Factor:
4.673
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*
Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII
(
142 views
)
Mancuso F,
Di Fiore A
,
De Luca L
, Angeli A,
De Simone G
, Supuran CT, Gitto R
Bioorg Med Chem (ISSN: 0968-0896linking, 1464-3391)
,
2021 Aug 15;
44: 116279-116279.
Impact Factor:
3.641
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*
The crystal structures of 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II and VII provide insights into selective CA inhibitor development
(
152 views
)
D’ambrosio K,
Di Fiore A
,
Buonanno M
, Kumari S, Tiwari M, Supuran CT, Mishra CB,
Monti SM
,
De Simone G
New Journal Of Chemistry
,
2021;
45: 147-152.
Impact Factor:
3.288
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*
Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis
(
195 views
)
Urbański LJ,
Di Fiore A
, Azizi L, Hytönen VP, Kuuslahti M,
Buonanno M
,
Monti SM
, Angeli A, Zolfaghari Emameh R, Supuran CT,
De Simone G
, Parkkila S
J Enzym Inhib Med Ch (ISSN: 1475-6366linking, 1475-6374electronic)
,
2020 Dec;
35(1): 1292-1299.
Impact Factor:
4.673
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*
Human carbonic anhydrases and post-translational modifications: a hidden world possibly affecting protein properties and functions
(
203 views
)
Di Fiore A
, Supuran CT, Scaloni A,
De Simone G
J Enzym Inhib Med Ch (ISSN: 1475-6366linking, 1475-6374electronic)
,
2020 Dec;
35(1): 1450-1461.
Impact Factor:
4.673
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*
Inhibition of the newly discovered β‑carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules
(
165 views
)
Urbański LJ, Angeli A, Hytönen VP,
Di Fiore A
, Parkkila S,
De Simone G
, Supuran CT
J Chem Res (ISSN: 0162-0134linking, 0162-0134print, 1873-3344)
,
2020 Dec;
213: 111274-111274.
Impact Factor:
3.212
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*
Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms
(
154 views
)
Mancuso F,
Di Fiore A
,
De Luca L
, Angeli A,
Monti SM
,
De Simone G
, Supuran CT, Gitto R
Acs Med Chem Lett (ISSN: 1948-5875linking)
,
2020 May 14;
11(5): 1000-1005.
Impact Factor:
3.975
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*
Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach
(
295 views
)
De Simone G
,
Di Fiore A
, Truppo E,
Langella E
, Vullo D, Supuran CT,
Monti SM
J Enzym Inhib Med Ch (ISSN: 1475-6366linking, 1475-6374electronic)
,
2019 Dec;
34(1): 1506-1510.
Impact Factor:
4.027
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*
Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity
(
308 views
)
Langella E
,
Alterio V
,
D'Ambrosio K
, Cadoni R, Winum JY, Supuran CT,
Monti SM
,
De Simone G
,
Di Fiore A
J Enzym Inhib Med Ch (ISSN: 1475-6366linking, 1475-6374electronic)
,
2019 Dec;
34(1): 1498-1505.
Impact Factor:
4.027
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*
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety
(
416 views
)
Buemi MR,
Di Fiore A
,
De Luca L
, Angeli A, Mancuso F, Ferro S,
Monti SM
,
Buonanno M
, Russo E, De Sarro G,
De Simone G
, Supuran CT, Gitto R
Eur J Med Chem (ISSN: 1768-3254electronic, 0223-5234linking)
,
2019 Feb 1;
163: 443-452.
Impact Factor:
4.833
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*
Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one
(
742 views
)
Supuran CT,
Alterio V
,
Di Fiore A
,
D'Ambrosio K
, Carta F,
Monti SM
,
De Simone G
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking)
,
2018 Sep;
38(6): 1799-1836.
Impact Factor:
8.29
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*
Protective Role of Carbonic Anhydrases III and VII in Cellular Defense Mechanisms upon Redox Unbalance
(
264 views
)
Di Fiore A
, Monti DM, Scaloni A,
De Simone G
,
Monti SM
Oxid Med Cell Longev (ISSN: 1942-0994linking)
,
2018 Aug 5;
2018:2018306: 2018306-2018306.
Impact Factor:
4.936
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*
The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior
(
394 views
)
Buonanno M
,
Di Fiore A
,
Langella E
, D’ambrosio K, Supuran CT,
Monti SM
,
De Simone G
Int J Mol Sc (ISSN: 1661-6596, 1422-0067, 1422-0067electronic)
,
2018 May;
19(6): 19-24.
Impact Factor:
3.687
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*
Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage
(
455 views
)
Monti DM,
De Simone G
,
Langella E
, Supuran CT,
Di Fiore A
,
Monti SM
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking)
,
2017 Dec;
32(1): 5-12.
Impact Factor:
3.638
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*
Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides
(
477 views
)
Brunò E, Buemi MR,
Di Fiore A
, De LucaL, Ferro S, Angeli A, Cirilli R, Sadutto D,
Alterio V
,
Monti SM
, Supuran CT,
De Simone G
, Gitto R
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print)
,
2017 May 25;
60(10): 4316-4326.
Impact Factor:
6.253
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*
Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements
(
416 views
)
Buonanno M
,
Langella E
, Zambrano N, Succoio M, Sasso E,
Alterio V
,
Di Fiore A
,
Sandomenico A
, Supuran CT, Scaloni A,
Monti SM
,
De Simone G
Acs Chem Biol (ISSN: 1554-8929)
,
2017 Apr 19;
N/D: N/D-N/D.
Impact Factor:
4.592
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*
The anticonvulsant sulfamide JNJ-26990990 and its S, S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies
(
316 views
)
Di Fiore A
,
De Simone G
,
Alterio V
, Riccio V, Winum JY, Carta F, Supuran CT
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic)
,
2016 Jun 07;
14(21): 4853-4858.
Impact Factor:
3.564
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*
Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors
(
395 views
)
(PDF
243 views
)
Di Fiore A
,
Vergara A
, Caterino M,
Alterio V
,
Monti SM
, Ombouma J, Dumy P, Vullo D, Supuran CT, Winum JY,
De Simone G
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic)
,
2015 Jul 2;
51(57): 11519-11522.
Impact Factor:
6.567
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*
Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense
(
384 views
)
De Simone G
,
Monti SM
,
Alterio V
,
Buonanno M
, De Luca V, Rossi M, Carginale V, Supuran CT, Capasso C,
Di Fiore A
Bioorg Med Chem Lett (ISSN: 0960-894x)
,
2015 May 1;
25(9): 2002-2006.
Impact Factor:
2.486
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*
X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor
(
389 views
)
Alterio V
, Tanc M, Ivanova J, Zalubovskis R, Vozny I,
Monti SM
,
Di Fiore A
,
De Simone G
, Supuran CT
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic)
,
2015 Apr 7;
13(13): 4064-4069.
Impact Factor:
3.559
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*
The zinc coordination pattern in the eta-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families
(
554 views
)
De Simone G
,
Di Fiore A
, Capasso C, Supuran CT
Bioorg Med Chem Lett (ISSN: 0960-894x)
,
2015 Apr 1;
25(7): 1385-1389.
Impact Factor:
2.486
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*
Carbonic Anhydrase VII
(
285 views
)
Monti SM
, Supuran CT,
De Simone G
,
Di Fiore A
Carbonic Anhydrases As Biocatalysts
,
2015 Jan 08;
N/D: 151-168.
Impact Factor:
0
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*
Recent developments of carbonic anhydrase inhibitors as potential drugs
(
671 views
)
Iqbal J, Al-rashida M, Durdagi S,
Alterio V
,
Di Fiore A
Biomed Res Int (ISSN: 2314-6133, 2314-6141)
,
2015;
2015: 174178-174178.
Impact Factor:
2.134
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Thermostable carbonic anhydrases in biotechnological applications
(
595 views
)
Di Fiore A
,
Alterio V
,
Monti SM
,
De Simone G
, D’Ambrosio K
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking)
,
2015;
16(7): 15456-15480.
Impact Factor:
3.257
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Faox enzymes inhibited Maillard reaction development during storage both in protein glucose model system and low lactose UHT milk
(
297 views
)
Troise AD, Dathan NA, Fiore A, Roviello G,
Di Fiore A
, Caira S, Cuollo M,
De Simone G
, Fogliano V,
Monti SM
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic)
,
2014 Feb;
46(2): 279-288.
Impact Factor:
3.293
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Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors
(
376 views
)
De Simone G
, Pizika G,
Monti SM
,
Di Fiore A
, Ivanova J, Vozny I, Trapencieris P, Zalubovskis R, Supuran CT,
Alterio V
Biomed Res Int (ISSN: 2314-6133, 2314-6141)
,
2014;
2014: 523210-523210.
Impact Factor:
1.579
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X-ray structure of the first 'extremo-alpha-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1
(
822 views
)
Di Fiore A
, Capasso C, De Luca V,
Monti SM
, Carginale V, Supuran CT, Scozzafava A,
Pedone C
, Rossi M,
De Simone G
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking)
,
2013 Jun;
69(6): 1150-1159.
Impact Factor:
7.232
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Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms?
(
628 views
)
Alterio V
,
Di Fiore A
,
D'Ambrosio K
, Supuran CT,
De Simone G
Chem Rev (ISSN: 0009-2665)
,
2012 Sep;
112(8): 4421-4468.
Impact Factor:
41.298
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Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors
(
472 views
)
Truppo E, Supuran CT,
Sandomenico A
, Vullo D, Innocenti A,
Di Fiore A
,
Alterio V
,
De Simone G
,
Monti SM
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x)
,
2012 Feb 15;
22(4): 1560-1564.
Impact Factor:
2.338
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Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors
(
417 views
)
Di Fiore A
, Maresca A, Supuran CT,
De Simone G
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic)
,
2012;
48(70): 8838-8840.
Impact Factor:
6.378
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Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II
(
381 views
)
Di Fiore A
, Maresca A,
Alterio V
, Supuran CT,
De Simone G
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic)
,
2011;
47(42): 11636-11638.
Impact Factor:
6.169
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Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide
(
525 views
)
Di Fiore A
, Truppo E, Supuran CT,
Alterio V
, Dathan N, Bootorabi F, Parkkila S,
Monti SM
,
De Simone G
Bioorg Med Chem Lett (ISSN: 0960-894x)
,
2010 Sep 1;
20(17): 5023-5026.
Impact Factor:
2.661
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Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV
(
400 views
)
Di Fiore A
,
Monti SM
, Innocenti A, Winum J-Y,
De Simone G
, Supuran CT
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x)
,
2010 Jun 15;
20(12): 3601-3605.
Impact Factor:
2.661
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Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII
(
569 views
)
Supuran CT,
Di Fiore A
,
Alterio V
,
Monti SM
,
De Simone G
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286)
,
2010;
16(29): 3246-3254.
Impact Factor:
4.774
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Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
(
674 views
)
Alterio V
, Hilvo M,
Di Fiore A
, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S,
Pedone C
, Scozzafava A,
Monti SM
,
De Simone G
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print)
,
2009 Sep 22;
106(38): 16233-16238.
Impact Factor:
9.432
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Structural analysis of BldR from Sulfolobus solfataricus provides insights into the molecular basis of transcriptional activation in Archaea by MarR family proteins
(
509 views
)
Di Fiore A
, Fiorentino G, Vitale RM, Ronca R, Amodeo P,
Pedone C
, Bartolucci S,
De Simone G
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic)
,
2009 May 8;
388(3): 559-569.
Impact Factor:
3.871
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Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide
(
881 views
)
Di Fiore A
,
Monti SM
, Hilvo M, Parkkila S, Romano V, Scaloni A,
Pedone C
, Scozzafava A, Supuran CT,
De Simone G
Proteins (ISSN: 1097-0134, 0887-3585, 1097-0134electronic)
,
2009 Jan;
74(1): 164-175.
Impact Factor:
3.085
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X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design
(
490 views
)
Alterio V
,
Di Fiore A
,
D'Ambrosio K
, Supuran CT,
De Simone G
Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009)
,
2009;
N/D: 73-138.
Impact Factor:
1.156
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Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes
(
827 views
)
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A,
Monti SM
,
Di Fiore A
,
De Simone G
, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking)
,
2008 Oct 10;
283(41): 27799-27809.
Impact Factor:
5.52
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Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography
(
789 views
)
Woo LWL, Fischer DS, Sharland CM, Trusselle M, Foster PA, Chander SK,
Di Fiore A
, Supuran CT,
De Simone G
, Purohit A, Reed MJ, Potter BVL
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic)
,
2008 Sep;
7(8): 2435-2444.
Impact Factor:
5.003
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Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity
(
730 views
)
Supuran CT,
Di Fiore A
,
De Simone G
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214)
,
2008 Jun;
13(2): 383-392.
Impact Factor:
3.08
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Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors
(
502 views
)
Di Fiore A
,
Pedone C
, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT,
De Simone G
Bioorg Med Chem Lett (ISSN: 1464-3405, 0960-894x, 1464-3405electronic)
,
2008 Apr 15;
18(8): 2669-2674.
Impact Factor:
2.531
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Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents
(
585 views
)
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E,
Di Fiore A
,
De Simone G
, Supuran CT, Purohit A, Reed MJ, Potter BVL
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print)
,
2008 Mar 13;
51(5): 1295-1308.
Impact Factor:
4.898
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Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs?
(
581 views
)
De Simone G
,
Di Fiore A
, Supuran CT
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286)
,
2008 Mar;
14(7): 655-660.
Impact Factor:
4.399
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Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties
(
507 views
)
Di Fiore A
, Scozzafava A, Winum JY, Montero JL,
Pedone C
, Supuran CT,
De Simone G
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x)
,
2007 Mar 15;
17(6): 1726-1731.
Impact Factor:
2.604
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2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity
(
1047 views
)
Leese MP, Leblond B, Smith A, Newman SP,
Di Fiore A
,
De Simone G
, Supuran CT, Purohit A, Reed MJ, Potter BVL
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804)
,
2006 Dec 28;
49(26): 7683-7696.
Impact Factor:
5.115
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Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1, 3, 4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)1, 3, 4-thiadiazole-2-sulfon amide to human isoform II
(
355 views
)
Menchise V
,
De Simone G
,
Di Fiore A
, Scozzafava A, Supuran CT
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x)
,
2006 Dec 15;
16(24): 6204-6208.
Impact Factor:
2.538
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Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX
(
610 views
)
De Simone G
, Vitale RM,
Di Fiore A
,
Pedone C
, Scozzafava A, Montero JL, Winum JY, Supuran CT
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print)
,
2006 Sep 7;
49(18): 5544-5551.
Impact Factor:
5.115
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Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib
(
385 views
)
Di Fiore A
,
Pedone C
,
D'Ambrosio K
, Scozzafava A,
De Simone G
, Supuran CT
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x)
,
2006 Jan 15;
16(2): 437-442.
Impact Factor:
2.538
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Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II
(
577 views
)
Menchise V
,
De Simone G
,
Alterio V
,
Di Fiore A
,
Pedone C
, Scozzafava A, Supuran CT
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print)
,
2005 Sep 8;
48(18): 5721-5727.
Impact Factor:
4.926
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The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants
(
625 views
)
Merlino A
,
Mazzarella L
, Carannante A,
Di Fiore A
, Di Donato A, Notomista E,
Sica F
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking)
,
2005 May 6;
280(18): 17953-17960.
Impact Factor:
5.854
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Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies
(
904 views
)
De Simone G
,
Di Fiore A
,
Menchise V
,
Pedone C
, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x)
,
2005 May 2;
15(9): 2315-2320.
Impact Factor:
2.478
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The role of the hinge loop in domain swapping - The special case of bovine seminal ribonuclease
(
578 views
)
Picone D,
Di Fiore A
, Ercole C, Franzese M,
Sica F
, Tomaselli S,
Mazzarella L
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking)
,
2005 Apr 8;
280(14): 13771-13778.
Impact Factor:
5.854
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Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II
(
571 views
)
Di Fiore A
,
De Simone G
,
Menchise V
,
Pedone C
, Casini A, Scozzafava A, Supuran CT
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x)
,
2005 Apr 1;
15(7): 1937-1942.
Impact Factor:
2.478
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Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease - An enzyme tailored to evade ribonuclease protein inhibitor
(
582 views
)
Sica F
,
Di Fiore A
,
Merlino A
,
Mazzarella L
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking)
,
2004 Sep 27;
279(35): 36753-36760.
Impact Factor:
6.355
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Crystal Structure Of The Dimeric Un-Swapped Form Of Bovine Seminal Ribonuclease
(
444 views
)
Berisio R
,
Sica F
, De Lorenzo C,
Di Fiore A
, Piccoli R, Zagari A,
Mazzarella L
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic)
,
2003 Nov 6;
554(1-2): 105-110.
Impact Factor:
3.609
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The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative
(
420 views
)
Sica F
,
Di Fiore A
, Zagari A,
Mazzarella L
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic)
,
2003 Sep 1;
52(2): 263-271.
Impact Factor:
4.313
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61
Records (
60
excluding Abstracts).
Total impact factor:
292.061
(
286.946
excluding Abstracts).
Total 5 year impact factor:
246.858
(
241.354
excluding Abstracts).
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