View contact record, Full name: Vincenzo Alterio
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NameVincenzo Alterio
AreaResearch&Development
PositionResearcher
Work siteNaples - Castellino
AddressVia Pietro Castellino 111, 80131 Naples - Italy
E-mailvincenzo.alterio@ibb.cnr.it
▼    Cancer Diseases
▼    Gadd45 beta and its implication in chronic inflammation
▼    Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
▼    Monoclonal Antibodies for therapeutic and diagnostic applications
▼    Targeted Drug Delivery by integrin avb3 antagonist
▼    Chemical protein synthesis and modification for biomedical applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Imaging Tumor Acidosis
▼    Bioactive peptide-membrane assemblies
No results.
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Clinical Oncology
▼    Translational Molecular Imaging in Cancer
▼    Molecular imaging for personalized therapy in oncology
▼    Modeling radiation induced normal tissue effects
▼    Evaluation of new molecular probes by preclinical imaging
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Brain segmentation for radiation oncology application
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Drug discovery by mirror-image phage display
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Other Diseases
▼    Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions
▼    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
▼    Bioactive peptide-membrane assemblies
No results.
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Chemical protein synthesis and modification for biomedical applications
▼    Comparison of noninvasive cardiac imaging modalities in patients with myocardial infarction
▼    Structural and functional studies of virulence factors in Mycobacterium tuberculosis infection
▼    Assessment of the cardiac risk and its temporal variation
▼    Evaluation of new molecular probes by preclinical imaging
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Phenotyping of murine models by preclinical imaging
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Drug discovery by mirror-image phage display
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Structure and function of proteins involved in physio-pathologic processes
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    A multi-targeting approach to fight COVID-19
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Carbonic Anhydrase family as target for rational drug design
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Chemical protein synthesis and modification for biomedical applications
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Structural characterization of the porphyrins/proteasome interaction
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Drug discovery by mirror-image phage display
▼    Analysis of Sam domain druggability through computational and experimental studies
▼    Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
▼    Targeting Of Protein-Protein Interactions For Therapeutic Purposes
▼    Macromolecules for biomedical and biotechnological applications
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    A multi-targeting approach to fight COVID-19
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Chemical protein synthesis and modification for biomedical applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Generation of innovative scaffolds by manipulating hyperstable proteins
▼    The fine structure of proteins as a new tool for protein structure validation, quality assessment, and prediction
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
▼    Plant polypeptides as natural enhancers of biostimulation
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Protein-based biotherapeutics
▼    Understanding SARS-CoV-2 interaction with its host of for therapeutic applications
▼    Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions
▼    Carbonic Anhydrase family as target for rational drug design
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
Dr. Vincenzo Alterio was born in Naples on 16/06/1975. He graduated in Chemistry at the University of Naples “Federico II” in 2001 and received his Ph.D. in Chemical Sciences from the same University in 2004. In 2006 he has been visiting scientist at the Biochemistry Institute of the University of Luebeck (Germany). Since 2009, he is researcher at the Institute of Biostructures and Bioimaging. 
His main research activity is focused on the study of structure/function relationships in biological systems having medical and/or biotechnological interest. These studies are carried out by Dr. Alterio by means of several experimental methodologies, including X-ray crystallography, absorption and emission spectroscopy and molecular biology. In particular, Dr. Alterio has a high experience in the most powerful structural resolution techniques in the field of X-ray crystallography, for the determination of protein structures. In this field Dr. Alterio expertise covers all stages of a structural determination: crystallization, data collection by both conventional and synchrotron sources, structure resolution by means of different phasing methodologies, including molecular replacement, MAD and SAD, model refinement. 
Dr. Alterio is author of scientific publications on international journals among which PNAS, JACS, Chem. Rev. 
Currently He is member of the editorial board of various international journals.
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* 6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography (125 views)
Nocentini A, Bonardi A, Bazzicalupi C, Alterio V, Esposito D, Monti SM, Smietana M, De Simone G, Supuran CT, Gratteri P, Winum JY
J Med Chem (ISSN: 0022-2623linking), 2023 Jun 22; 66 (12 ): 8118-8129.
Impact Factor:
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* A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, a Still Poorly Investigated Class of CA Inhibitors (187 views)
Langella E, Esposito D, Monti SM, Supuran CT, De Simone G, Alterio V
Biology (ISSN: 2079-7737linking), 2023 Feb 10; 12 (2 ): N/D-N/D.
Impact Factor:
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* Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion (132 views)
Sarnella A, Ferrara Y, Auletta L, Albanese S, Cerchia L, Alterio V, De Simone G, Supuran CT, Zannetti A
J Exp Clin Canc Res (ISSN: 0392-9078linking, 1756-9966, 1756-9966electronic), 2022 Apr 2; 41(1): 122-122.
Impact Factor: 12.658
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* Zeta-carbonic anhydrases show CS(2) hydrolase activity: A new metabolic carbon acquisition pathway in diatoms? (179 views)
Alterio V, Langella E, Buonanno M, Esposito D, Nocentini A, Berrino E, Bua S, Polentarutti M, Supuran CT, Monti SM, De Simone G
Comput Struct Biotechnol J (ISSN: 2001-0370linking), 2021 Jun 5; 19: 3427-3436.
Impact Factor: 7.271
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* Benzyl alcohol inhibits carbonic anhydrases by anchoring to the zinc coordinated water molecule (125 views)
De Simone G, Bua S, Supuran CT, Alterio V
Biochem Biophys Res Commun (ISSN: 0006-291xlinking), 2021 Apr 9; 548: 217-221.
Impact Factor: 3.575
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* A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity (190 views) (PDF 52 views)
Sarnella A, D'Avino G, Hill BS, Alterio V, Winum JY, Supuran CT, De Simone G, Zannetti A
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Nov 9; 21(21): N/D-N/D.
Impact Factor: 4.556
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* 2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site (170 views)
Bozdag M, Supuran CT, Esposito D, Angeli A, Carta F, Monti SM, De Simone G, Alterio V
Chem Commun (ISSN: 1359-7345linking, 1364-548xelectronic), 2020 Jul 23; 56(59): 8297-8300.
Impact Factor: 5.996
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* Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy (257 views)
Nocentini A, Alterio V, Bua S, Micheli L, Esposito D, Buonanno M, Bartolucci G, Osman SM, Alothman ZA, Cirilli R, Pierini M, Monti SM, Di Cesare Mannelli L, Gratteri P, Ghelardini C, De Simone G, Supuran CT
J Med Chem (ISSN: 0022-2623linking, 0022-2623print, 1520-4804), 2020 May 28; 63(10): 5185-5200.
Impact Factor: 6.205
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* Biochemical and structural insights into Carbonic Anhydrase XII/Fab6A10 complex (239 views)
Alterio V, Kellner M, Esposito D, Liesche-starnecker F, Bua S, Supuran CT, Monti SM, Zeidler R, De Simone G
J Mol Biol (ISSN: 0022-2836linking, 1089-8638), 2019 Dec 6; 431(24): 4910-4921.
Impact Factor: 5.067
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* Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity (347 views)
Langella E, Alterio V, D'Ambrosio K, Cadoni R, Winum JY, Supuran CT, Monti SM, De Simone G, Di Fiore A
J Enzym Inhib Med Ch (ISSN: 1475-6366linking, 1475-6374electronic), 2019 Dec; 34(1): 1498-1505.
Impact Factor: 4.027
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* Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2, 4, 6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor (638 views)
Alterio V, Esposito D, Monti SM, Supuran CT, De Simone G
J Enzym Inhib Med Ch (ISSN: 1475-6374electronic, 1475-6366linking), 2018 Dec; 33(1): 151-157.
Impact Factor: 4.293
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* Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding (322 views)
De Simone G, Angeli A, Bozdag M, Supuran CT, Winum JY, Monti SM, Alterio V
Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Sep 11; 54(73): 10312-10315.
Impact Factor: 6.169
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* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (809 views)
Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
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* Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations (336 views)
De Simone G, Langella E, Esposito D, Supuran CT, Monti SM, Winum JY, Alterio V
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2017 Dec; 32(1): 1002-1011.
Impact Factor: 3.638
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* Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides (541 views)
Brunò E, Buemi MR, Di Fiore A, De LucaL, Ferro S, Angeli A, Cirilli R, Sadutto D, Alterio V, Monti SM, Supuran CT, De Simone G, Gitto R
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2017 May 25; 60(10): 4316-4326.
Impact Factor: 6.253
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* Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements (488 views)
Buonanno M, Langella E, Zambrano N, Succoio M, Sasso E, Alterio V, Di Fiore A, Sandomenico A, Supuran CT, Scaloni A, Monti SM, De Simone G
Acs Chem Biol (ISSN: 1554-8929), 2017 Apr 19; N/D: N/D-N/D.
Impact Factor: 4.592
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* Benzoxaborole as a new chemotype for carbonic anhydrase inhibition (576 views)
Alterio V, Cadoni R, Esposito D, Vullo D, Fiore AD, Monti SM, Caporale A, Ruvo M, Sechi M, Dumy P, Supuran CT, De Simone G, Winum JY
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2016 Sep 29; 52(80): 11983-11986.
Impact Factor: 6.319
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* Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1, 6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors (372 views)
Vullo D, Supuran CT, Scozzafava A, De Simone G, Monti SM, Alterio V, Carta F
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2016 Aug 15; 24(16): 3643-3648.
Impact Factor: 2.93
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* The anticonvulsant sulfamide JNJ-26990990 and its S, S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies (341 views)
Di Fiore A, De Simone G, Alterio V, Riccio V, Winum JY, Carta F, Supuran CT
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2016 Jun 07; 14(21): 4853-4858.
Impact Factor: 3.564
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* Discovery of 1, 1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors (428 views)
La Regina G, Coluccia A, Famiglini V, Pelliccia S, Monti L, Vullo D, Nuti E, Alterio V, De Simone G, Monti SM, Pan P, Parkkila S, Supuran CT, Rossello A, Silvestri R
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2015 Nov 12; 58(21): 8564-8572.
Impact Factor: 5.589
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* Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors (434 views) (PDF 254 views)
Di Fiore A, Vergara A, Caterino M, Alterio V, Monti SM, Ombouma J, Dumy P, Vullo D, Supuran CT, Winum JY, De Simone G
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2015 Jul 2; 51(57): 11519-11522.
Impact Factor: 6.567
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* Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense (420 views)
De Simone G, Monti SM, Alterio V, Buonanno M, De Luca V, Rossi M, Carginale V, Supuran CT, Capasso C, Di Fiore A
Bioorg Med Chem Lett (ISSN: 0960-894x), 2015 May 1; 25(9): 2002-2006.
Impact Factor: 2.486
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* X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor (485 views)
Alterio V, Tanc M, Ivanova J, Zalubovskis R, Vozny I, Monti SM, Di Fiore A, De Simone G, Supuran CT
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2015 Apr 7; 13(13): 4064-4069.
Impact Factor: 3.559
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* Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii (876 views)
Alterio V, Langella E, De Simone G, Monti SM
Mar Drugs (ISSN: 1660-3397, 1660-3397linking), 2015 Mar 25; 13(4): 1688-1697.
Impact Factor: 3.345
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* CDCA1 From Thalassiosira weissflogii as Representative Member of ζ-Class CAs: General Features and Biotechnological Applications (347 views)
Monti SM, De Simone G, Supuran CT, Alterio V
Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 351-359.
Impact Factor: 0
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* Recent developments of carbonic anhydrase inhibitors as potential drugs (704 views)
Iqbal J, Al-rashida M, Durdagi S, Alterio V, Di Fiore A
Biomed Res Int (ISSN: 2314-6133, 2314-6141), 2015; 2015: 174178-174178.
Impact Factor: 2.134
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* Thermostable carbonic anhydrases in biotechnological applications (636 views)
Di Fiore A, Alterio V, Monti SM, De Simone G, D’Ambrosio K
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(7): 15456-15480.
Impact Factor: 3.257
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* Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (693 views)
Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
J Enzym Inhib Med Ch (ISSN: 1475-6366, 1475-6374electronic, 1475-6366linking), 2014; 29(4): 500-504.
Impact Factor: 2.332
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* Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors (420 views)
De Simone G, Pizika G, Monti SM, Di Fiore A, Ivanova J, Vozny I, Trapencieris P, Zalubovskis R, Supuran CT, Alterio V
Biomed Res Int (ISSN: 2314-6133, 2314-6141), 2014; 2014: 523210-523210.
Impact Factor: 1.579
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* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (562 views)
Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
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* Thermal-stable carbonic anhydrases: a structural overview (468 views)
Alterio V, Monti SM, De Simone G
Subcell Biochem (ISSN: 0306-0225), 2014; 75: 387-404.
Impact Factor: 33.116
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* Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates (669 views)
Rami M, Dubois L, Parvathaneni NK, Alterio V, van Kuijk SJ, Monti SM, Lambin P, De Simone G, Supuran CT, Winum JY
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2013 Nov 14; 56(21): 8512-8520.
Impact Factor: 5.48
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* Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors (650 views)
De Simone G, Alterio V, Supuran CT
Expert Opin Drug Discov (ISSN: 1746-0441), 2013 Jul; 8(7): 793-810.
Impact Factor: 3.467
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* Multiple binding modes of inhibitors to carbonic anhydrases: How to design specific drugs targeting 15 different isoforms? (666 views)
Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
Chem Rev (ISSN: 0009-2665), 2012 Sep; 112(8): 4421-4468.
Impact Factor: 41.298
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* Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii (635 views)
Alterio V, Langella E, Viparelli F, Vullo D, Ascione G, Dathan NA, Morel FM, Supuran CT, De Simone G, Monti SM
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2012 May; 94(5): 1232-1241.
Impact Factor: 3.142
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* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (497 views)
Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
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* Molecular organization of the cullin E3 ligase adaptor KCTD11 (789 views)
Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
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* Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II (406 views)
Di Fiore A, Maresca A, Alterio V, Supuran CT, De Simone G
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011; 47(42): 11636-11638.
Impact Factor: 6.169
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* The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: The carbonic anhydrase I-topiramate complex (639 views)
Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2010 Sep 7; 8(15): 3528-3533.
Impact Factor: 3.451
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* Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide (565 views)
Di Fiore A, Truppo E, Supuran CT, Alterio V, Dathan N, Bootorabi F, Parkkila S, Monti SM, De Simone G
Bioorg Med Chem Lett (ISSN: 0960-894x), 2010 Sep 1; 20(17): 5023-5026.
Impact Factor: 2.661
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* Crystal structure of an S-formylglutathione hydrolase from pseudoalteromonas haloplanktis TAC125 (523 views)
Alterio V, Aurilia V, Romanelli A, Parracino A, Saviano M, D'Auria S, De Simone G
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2010 Sep; 93(8): 669-677.
Impact Factor: 2.572
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* Recent advances in structural studies of the carbonic anhydrase family: The crystal structure of human CA IX and CA XIII (609 views)
Supuran CT, Di Fiore A, Alterio V, Monti SM, De Simone G
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2010; 16(29): 3246-3254.
Impact Factor: 4.774
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* Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis- sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors (563 views)
Vitale RM, Alterio V, Innocenti A, Winum JY, Monti SM, De Simone G, Supuran CT
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2009 Oct 8; 52(19): 5990-5998.
Impact Factor: 4.802
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* Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX (723 views)
Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2009 Sep 22; 106(38): 16233-16238.
Impact Factor: 9.432
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* X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design (529 views)
Alterio V, Di Fiore A, D'Ambrosio K, Supuran CT, De Simone G
Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; N/D: 73-138.
Impact Factor: 1.156
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* Functional and structural features of the oxyanion hole in a thermophilic esterase from Alicyclobacillus acidocaldarius (490 views)
Mandrich L, Menchise V, Alterio V, De Simone G, Pedone C, Rossi M, Manco G
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2008 Jun; 71(4): 1721-1731.
Impact Factor: 3.419
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* Carbonic anhydrase inhibitors: Inhibition of human, bacterial, and archaeal isozymes with benzene-1, 3-disulfonamides-Solution and crystallographic studies (456 views)
Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Sep 1; 17(15): 4201-4207.
Impact Factor: 2.604
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* Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX (867 views)
Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jun 28; 128(25): 8329-8335.
Impact Factor: 7.696
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* Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase (1267 views)
Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2006 Mar 14; 45(10): 3226-3234.
Impact Factor: 3.633
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* Carbonic anhydrase inhibitors: Stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II (601 views)
Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2005 Sep 8; 48(18): 5721-5727.
Impact Factor: 4.926
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* The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family (1131 views)
De Simone G, Menchise V, Alterio V, Mandrich L, Rossi M, Manco G, Pedone C
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2004 Oct 8; 343(1): 137-146.
Impact Factor: 5.542
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51 Records (51 excluding Abstracts).
Total impact factor: 283.336 (283.336 excluding Abstracts).
Total 5 year impact factor: 260.5 (260.5 excluding Abstracts).

Last modified by Vincenzo Alterio on Saturday 28 January 2023, 11:22:35
7513 views. Last view on Monday 02 December 2024, 22:05:44