* In vitro and in vivo comparison of MRI chemical exchange saturation transfer (CEST) properties between native glucose and 3-O-Methyl-D-glucose in a murine tumor model (106 views)
Anemone A, Capozza M, Arena F, Zullino S, Bardini P, Terreno E, Longo DL, Aime S
Nmr Biomed (ISSN: 0952-3480linking, 1099-1492electronic), 2021 Aug 22; N/D: e4602-N/D.
Impact Factor: 3.221
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* GlucoCEST MRI for the Evaluation Response to Chemotherapeutic and Metabolic Treatments in a Murine Triple-Negative Breast Cancer: A Comparison with[(18)F]F-FDG-PET (64 views)
Capozza M, Anemone A, Dhakan C, Della Peruta M, Bracesco M, Zullino S, Villano D, Terreno E, Longo DL, Aime S
Mol Imaging Biol (ISSN: 1536-1632linking, 1860-2002), 2021 Aug 12; N/D: N/D-N/D.
Impact Factor: 3.844
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* A global view of standards for open image data formats and repositories (50 views)
Swedlow JR, Kankaanpää P, Sarkans U, Goscinski W, Galloway G, Malacrida L, Sullivan RP, Härtel S, Brown CM, Wood C, Keppler A, Paina F, Loos B, Zullino S, Longo DL, Aime S, Onami S
Nat Methods (ISSN: 1548-7091linking), 2021 May 4; N/D: N/D-N/D.
Impact Factor: 30.822
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* ParaHydrogen Polarized Ethyl-[1-(13) C]pyruvate in Water, a Key Substrate for Fostering the PHIP-SAH Approach to Metabolic Imaging (107 views)
Carrera C, Cavallari E, Digilio G, Bondar O, Aime S, Reineri F
Chemphyschem (ISSN: 1439-4235linking, 1439-7641), 2021 Mar 15; 22(11): 1042-1048.
Impact Factor: 3.144
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* Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism* (117 views)
Eills J, Cavallari E, Kircher R, Di Matteo G, Carrera C, Dagys L, Levitt MH, Ivanov KL, Aime S, Reineri F, Münnemann K, Budker D, Buntkowsky G, Knecht S
Angew Chem Int Ed (ISSN: 1433-7851linking, 1521-3773electronic), 2021 Mar 15; 60(12): 6791-6798.
Impact Factor: 15.336
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* A Novel Class of (1) H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by (14) N-Containing Imidazole Moieties (132 views)
Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
Angew Chem Int Ed (ISSN: 1433-7851linking, 1521-3773electronic), 2021 Feb 19; 60(8): 4208-4214.
Impact Factor: 12.959
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* Hydrogenative-PHIP polarized metabolites for biological studies (88 views)
Reineri F, Cavallari E, Carrera C, Aime S
Magma (ISSN: 0968-5243linking), 2021 Feb; 34(1): 25-47.
Impact Factor: 2.31
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* Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues (157 views)
Tear LR, Carrera C, Gianolio E, Aime S
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 May 12; 26(27): 6056-6063.
Impact Factor: 4.857
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* In-vitro NMR Studies of Prostate Tumor Cell Metabolism by Means of Hyperpolarized [1-(13)C]Pyruvate Obtained Using the PHIP-SAH Method (139 views)
Cavallari E, Carrera C, Di Matteo G, Bondar O, Aime S, Reineri F
Front Oncol (ISSN: 2234-943xlinking), 2020 Apr 17; 10: 497-497.
Impact Factor: 4.25
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* In vivo assessment of tumour associated macrophages in murine melanoma obtained by low-field relaxometry in the presence of iron oxide particles (249 views)
Baroni S, Ruggiero MR, Bitonto V, Broche LM, Lurie DJ, Aime S, Geninatti Crich S
Biomaterials (ISSN: 0142-9612linking, 1878-5905electronic), 2020 Jan 27; 236: 119805-119805.
Impact Factor: 7.883
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* Real-Time Nuclear Magnetic Resonance Detection of Fumarase Activity Using Parahydrogen-Hyperpolarized [1-(13)C]Fumarate (149 views)
Eills J, Cavallari E, Carrera C, Budker D, Aime S, Reineri F
J Am Chem Soc (ISSN: 0002-7863linking, 0002-7863print), 2019 Dec 26; 141(51): 20209-20214.
Impact Factor: 14.695
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* Synthesis and Relaxometric Characterization of New Poly[N, N-bis(3-aminopropyl)glycine] (PAPGly) Dendrons Gd-Based Contrast Agents and Their in Vivo Study by Using the Dynamic Contrast-Enhanced MRI Technique at Low Field (1 T) (179 views)
Granato L, Longo D, Boutry S, Vander Elst L, Henoumont C, Aime S, Muller RN, Laurent S
Chem Biodivers (ISSN: 1612-1872linking), 2019 Nov; 16(11): e1900322-e1900322.
Impact Factor: 1.449
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* Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9. 4 Tesla (239 views)
Zaiss M, Anemone A, Goerke S, Longo DL, Herz K, Pohmann R, Aime S, Rivlin M, Navon G, Golay X, Scheffler K
Nmr Biomed (ISSN: 0952-3480linking, 1099-1492electronic), 2019 Sep; 32(9): e4113-e4113.
Impact Factor: 2.983
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* Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent (308 views)
Baroni S, Ruggiero MR, Aime S, Geninatti Crich S
Magn Reson Chem (ISSN: 0749-1581linking), 2019 Jan 24; N/D: N/D-N/D.
Impact Factor: 1.601
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* An innovative therapeutic approach for malignant mesothelioma treatment based on the use of Gd/boron multimodal probes for MRI guided BNCT (251 views)
Alberti D, Deagostino A, Toppino A, Protti N, Bortolussi S, Altieri S, Aime S, Crich SG
Journal Of Controlled Release, 2018 Jun; N/D: N/D-N/D.
Impact Factor: 7.877
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* Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents (284 views)
Dastru W, Menchise V, Ferrauto G, Fabretto S, Carrera C, Terreno E, Aime S, Delli Castelli D
Chemistryselect (ISSN: 2365-6549), 2018 Jun; 3(22): 6035-6041.
Impact Factor: 1.505
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* The Issue of Gadolinium Retained in Tissues: Insights on the Role of Metal Complex Stability by Comparing Metal Uptake in Murine Tissues Upon the Concomitant Administration of Lanthanum- and Gadolinium-Diethylentriamminopentaacetate (250 views)
Di Gregorio E, Ferrauto G, Furlan C, Lanzardo S, Nuzzi R, Gianolio E, Aime S
Invest Radiol (ISSN: 1536-0210electronic, 0020-9996linking), 2018 Mar; 53(3): 167-172.
Impact Factor: 4.85
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* Cancer cell death induced by ferritins and the peculiar role of their labile iron pool (257 views)
Cutrin JC, Alberti D, Bernacchioni C, Ciambellotti S, Turano P, Luchinat C, Crich SG, Aime S
Oncotarget, 2018; N/D: N/D-N/D.
Impact Factor: 5.168
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* Early diagnosis of breast cancer by using Fast field cycling relaxometry (FFC-NMRD): investigations of ex-vivo murine breast tissue (295 views)
Di Gregorio E, Ferrauto G, Lanzardo S, Gianolio E, Aime S
Breast Cancer Radiology, 2018; N/D: N/D-N/D.
Impact Factor: 1.712
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* Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by In Vivo Field-Cycling Relaxometry (300 views)
Ruggiero MR, Baroni S, Pezzana S, Ferrante G, Geninatti Crich S, Aime S
Angewandte Chemie - International Edition, 2018; N/D: N/D-N/D.
Impact Factor: 11.994
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* Gadolinium deposition, MRI hyperintensities, and glucose uptake in the hypoperfused rat brain after repeated administrations of Gadodiamide (230 views)
Arena F, Bardini P, Blasi F, Gianolio E, Marini G, Aime S
Neuroradiolgy, 2018; N/D: N/D-N/D.
Impact Factor: 2.346
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* Gd accumulation in tissues of healthy mice upon repeated administrations of Gadodiamide and Gadoteridol (249 views)
Di Gregorio E, Iani R, Ferrauto G, Nuzzi R, Aime S, Gianolio E
Journal Of Trace Elements In Medicine And Biology, 2018; N/D: N/D-N/D.
Impact Factor: 3.755
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* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (446 views)
Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
Radiology (ISSN: 0033-8419, 1527-1315), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
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* Eight-Coordinate, Stable Fe(II) Complex as a Dual (19)F and CEST Contrast Agent for Ratiometric pH Imaging (281 views)
Srivastava K, Ferrauto G, Young Vg J, Aime S, Pierre VC
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2017 Oct 16; 56(20): 12206-12213.
Impact Factor: 4.7
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* Nano-sized and other improved reporters for magnetic resonance imaging of angiogenesis (306 views)
Crich SG, Terreno E, Aime S
Adv Drug Deliver Rev (ISSN: 0169-409x), 2017 Sep 15; 119: 61-72.
Impact Factor: 13.66
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* Endogenous glutamine decrease is associated with pancreatic cancer progression (300 views)
Roux C, Riganti C, Borgogno SF, Curto R, Curcio C, Catanzaro V, Digilio G, Padovan S, Puccinelli MP, Isabello M, Aime S, Cappello P, Novelli F
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Aug 24; 8(56): 95361-95376.
Impact Factor: 5.008
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* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (706 views)
Longo DL, Stefania R, Aime S, Oraevsky A
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Aug 7; 18(8): N/D-N/D.
Impact Factor: 3.687
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* In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging (242 views)
Anemone A, Consolino L, Conti L, Reineri F, Cavallo F, Aime S, Longo DL
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic), 2017 Aug; 51(2): 498-506.
Impact Factor: 3.333
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* A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol (424 views)
Longo DL, Aime S
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 2017 Jul 07; 79(3): 1553-1558.
Impact Factor: 4.082
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* Unsaturated Long-Chain Fatty Acids Are Preferred Ferritin Ligands That Enhance Iron Biomineralization (260 views)
Zanzoni S, Pagano K, D'Onofrio M, Assfalg M, Ciambellotti S, Bernacchioni C, Turano P, Aime S, Ragona L, Molinari H
Chemistry, 2017 Jul; N/D: N/D-N/D.
Impact Factor: 5.16
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* (13) C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro (297 views)
Cavallari E, Carrera C, Aime S, Reineri F
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 Jan 23; 23(5): 1200-1204.
Impact Factor: 5.16
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* EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (830 views)
Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Impact Factor: 3.862
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* Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI (439 views)
Longo DL, Cutrin JC, Michelotti F, Irrera P, Aime S
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2017; 30(7): N/D-N/D.
Impact Factor: 3.031
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* The RNA-binding protein ESRP1 promotes human colorectal cancer progression (420 views)
Fagoonee S, Picco G, Orso F, Arrigoni A, Longo DL, Forni M, Scarfo I, Cassenti A, Piva R, Cassoni P, Silengo L, Tolosano E, Aime S, Taverna D, Pandolfi PP, Brancaccio M, Medico E, Altruda F
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2016 Dec 28; 8(6): 10007-10024.
Impact Factor: 5.168
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* Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging (321 views)
Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S
Gastric Cancer (ISSN: 1436-3291, 1436-3291linking), 2016 Dec 19; 20(4): 629-639.
Impact Factor: 5.454
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* In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging (329 views)
Longo DL, Bartoli A, Consolino L, Bardini P, Arena F, Schwaiger M, Aime S
Cancer Res (ISSN: 0008-5472, 1538-7445, 0008-5472linking), 2016 Nov 15; 76(22): 6463-6470.
Impact Factor: 9.122
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* Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy (324 views)
Longo DL, Stefania R, Callari C, De Rose F, Rolle R, Conti L, Consolino L, Arena F, Aime S
Adv Healthc Mater (ISSN: 2192-2640, 2192-2640linking), 2016 Oct 26; N/D: N/D-N/D.
Impact Factor: 5.11
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* LipoCEST and cellCEST imaging agents: opportunities and challenges (425 views)
Ferrauto G, Delli Castelli D, Di Gregorio E, Terreno E, Aime S
Wires Nanomed Nanobi (ISSN: 1939-5116), 2016 Jul; 8(4): 602-618.
Impact Factor: 4.761
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* Diolein based nanostructures as targeted theranostics (584 views)
Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (348 views)
Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
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* The Role of the Amino Protecting Group during Parahydrogenation of Protected Dehydroamino Acids (278 views)
Cerutti E, Viale A, Nervi C, Gobetto R, Aime S
J Phys Chem A (ISSN: 1089-5639, 1520-5215electronic, 1089-5639linking), 2015 Nov 19; 119(46): 11271-11279.
Impact Factor: 2.883
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* Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners (706 views)
Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-crich S, Giovenzana GB, Aime S
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2015 Oct 16; 75: 47-57.
Impact Factor: 8.387
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* Sensitive MRI detection of internalized T contrast agents using magnetization transfer contrast (295 views)
Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2015 Oct 16; N/D: N/D-N/D.
Impact Factor: 2.983
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* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (472 views)
Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
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* Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound (571 views)
Rizzitelli S, Giustetto P, Cutrin JC, Delli Castelli D, Boffa C, Ruzza M, Menchise V, Molinari F, Aime S, Terreno E
J Control Release (ISSN: 0168-3659), 2015 Jan 24; 202: 21-30.
Impact Factor: 7.441
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* Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment (569 views)
Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Impact Factor: 1.98
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* A general MRI-CEST ratiometric approach for pH imaging: demonstration of in vivo pH mapping with iobitridol (626 views)
Longo DL, Sun PZ, Consolino L, Michelotti FC, Uggeri F, Aime S
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2014 Oct 15; 136(41): 14333-14336.
Impact Factor: 12.113
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* A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging (519 views)
Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2013 Apr 2; 52(14): 3926-3930.
Impact Factor: 11.336
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* Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases (611 views)
Gringeri CV, Menchise V, Rizzitelli S, Cittadino E, Catanzaro V, Dati G, Chaabane L, Digilio G, Aime S
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2012 Mar; 7(2): 175-184.
Impact Factor: 2.872
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* MR Contrast Agents (388 views)
Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
Mol Pharm (ISSN: 1543-8384), 2011 Sep; 8(5): 1750-1756.
Impact Factor: 4.782
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* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (560 views)
Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
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* In vivo labeling of B16 melanoma tumor xenograft with a thiol-reactive gadolinium based MRI contrast agent (897 views)
Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
Mol Pharm (ISSN: 1543-8384), 2011; 8(5): 1750-1756.
Impact Factor: 4.782
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* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (506 views)
Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
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* Targeting exofacial protein thiols with Gd-III complexes. An efficient procedure for MRI cell labelling (397 views)
Digilio G, Catanzaro V, Fedeli F, Gianolio E, Menchise V, Napolitano R, Gringeri C, Aime S
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2009 Feb 28; (8): 893-895.
Impact Factor: 5.504
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* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (716 views)
Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (589 views)
Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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* Characterization of 111In labeled CCK8 peptide coupled to a novel DTPA-like derivative in CCK-B receptor overexpressing cells (497 views)
Aloj L, Zannetti A, Caraco C, Del Vecchio S, Tasauro D,  De Luca S, Brunetti A, Aime S, Morelli G, Pedone C
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2001 Sep; 28(8): N/D-N/D.
Impact Factor: 3.464
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An NMR study of H(μ-H)Os3(CO)11 (463 views)
Aime S, Dastrù W, Gobetto R, Viale A
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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