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NameLuciano Pirone
AreaResearch&Development
PositionResearcher
Work siteNaples - Castellino
AddressVia Pietro Castellino 111, 80131 Naples - Italy
E-mailluciano.pironecnr.it
Skype IDlucianopirone@outlook.it
▼    Cancer Diseases
▼    Gadd45 beta and its implication in chronic inflammation
▼    Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
▼    Monoclonal Antibodies for therapeutic and diagnostic applications
▼    Targeted Drug Delivery by integrin avb3 antagonist
▼    Chemical protein synthesis and modification for biomedical applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Imaging Tumor Acidosis
▼    Bioactive peptide-membrane assemblies
No results.
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Clinical Oncology
▼    Translational Molecular Imaging in Cancer
▼    Molecular imaging for personalized therapy in oncology
▼    Modeling radiation induced normal tissue effects
▼    Evaluation of new molecular probes by preclinical imaging
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Brain segmentation for radiation oncology application
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Drug discovery by mirror-image phage display
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Macromolecules for biomedical and biotechnological applications
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    A multi-targeting approach to fight COVID-19
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Chemical protein synthesis and modification for biomedical applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Generation of innovative scaffolds by manipulating hyperstable proteins
▼    The fine structure of proteins as a new tool for protein structure validation, quality assessment, and prediction
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
▼    Plant polypeptides as natural enhancers of biostimulation
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Protein-based biotherapeutics
▼    Understanding SARS-CoV-2 interaction with its host of for therapeutic applications
▼    Structure and function of proteins involved in physio-pathologic processes
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    A multi-targeting approach to fight COVID-19
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Carbonic Anhydrase family as target for rational drug design
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Chemical protein synthesis and modification for biomedical applications
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Structural characterization of the porphyrins/proteasome interaction
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Drug discovery by mirror-image phage display
▼    Analysis of Sam domain druggability through computational and experimental studies
▼    Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
▼    Targeting Of Protein-Protein Interactions For Therapeutic Purposes
▼    Small molecules and peptides/modified peptides for diagnostic, therapeutic and biotechnological applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    New peptide–based molecules as NGF mimetics in the therapy of neurological dysfunctions
▼    Peptide-based molecules for αvβ3 integrin modulation in Th17 cells-dependent demyelinating diseases
▼    Development of integrin subtypes selective ligands: from a first rationally designed peptide to a wide range of molecules
▼    Design of New FSHR-Specific Peptides for therapeutic and diagnostic applications
▼    New synthetic molecules for active targeting of multifunctional theranostic nanosystems
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    A multi-targeting approach to fight COVID-19
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Drug discovery by mirror-image phage display
▼    Peptides of therapeutic interest with antimicrobial and/ or antitumoral activity
▼    Analysis of Sam domain druggability through computational and experimental studies
▼    Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Plant polypeptides as natural enhancers of biostimulation
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Design and screening of molecular repertoires as a source for new bioactive compounds
▼    Targeting Of Protein-Protein Interactions For Therapeutic Purposes
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    A multi-targeting approach to fight COVID-19
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors
▼    Analysis of Sam domain druggability through computational and experimental studies
▼    Peptides of therapeutic interest with antimicrobial and/ or antitumoral activity

IBB-CNR (Italy)

Institute of Biostructure and Bioimaging of the National Research Council, Naples

Duration

From 30/09/2019 

Position

Researcher

Principal activities

 

 

 

Interests

 

 

 

 

 

Ph.D.

Molecular Biotechnology

 

 

Master

 

 

 


Degree

Industrial Biotechnology

 

 

Identification and functional and structural characterization of a therapeutic target (gene/protein). The research activities include structural biology and molecular biology studies using biochemical and biophysical techniques.

 

Protein structure-function relationship, protein–protein interactions;; biophysical characterization; antimicrobial and antitumoral peptides; static and dynamic light scattering; thermophoresis; ITC.

 

 

                              EDUCATION

 

University of Naples Federico II, Faculty of Biotechnological Sciences.

Date: 11/01/2010

 

Thesis title: Medulloblastoma tumour suppressor factor RENKCTD11: structure and function based design and development of new compounds for therapeutic interest.

Institute of Biostructure and Bioimaging (CNR), Via Tommaso De Amicis,  95, 80145 Naples (Italy)

Date: 06/06/2005 - 05/06/2007


Program title: ▪        STRUIM - Training of specialists in the field of biostructures and bioimaging.

University of Naples Federico II, Faculty of Biotechnological Sciences.

Date: 30/03/2004

Thesis title: Study of genetic systems for the expression of the putative cellulase SsCelS from Sulfolobus solfataricus.

 

 

                   RESEARCH ACTIVITIES

 

My research is strongly focused on the structure-activity-function relationship in proteins relevant to biomedicine and biotechnology, aiming at the understanding of the molecular determinants underlying their biological activities. We use methodologies of both structural and molecular biology; starting from genes, we are able to express and purify protein samples useful for the structural characterization. We can use several experimental techniques for the study of the macromolecular structures: Dynamic Light Scattering and circular dichroism. Structural studies are generally associated with a biophysical and functional characterization of the samples under study. In doing this we exploit techniques such as UV-VIS spectroscopy,  Fluorimetry, Isothermal Titration Calorimetry and Microscale Thermophoresis. Furthermore, we often use advanced methods in molecular biology in order to prepare ad-hoc point mutants to gain further insights into the proteins biological functions.

 

                  SCIENTIFIC PRODUCTION/MANAGERIAL

 

I am author and co-author of 55 international journals.  The h-index is 16 (Web of Science - Scopus). Total citation: more than 600

 

I am Guest Editor of International Journal of Molecular Science Special Issue “Structure–Function Relationship in Proteins Correlated with the Insurgence of Diseases" (Impact factor 4.556, 2019).

 

 

 

 

 

 

 

 

 

 

 

 

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* Insights into the anticancer properties of the first antimicrobial peptide from Archaea (466 views)
Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0304-4165linking), 2017 Jun 15; 1861(9): 2155-2164.
Impact Factor: 4.28
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* Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain? (499 views)
Mercurio FA, Costantini S, Di Natale C, Pirone L, Guariniello S, Scognamiglio PL, Marasco D, Pedone EM, Leone M
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639linking), 2017 Jun 06; 1865(9): 1095-1104.
Impact Factor: 4.28
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* A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 beta-like: from in silico identification to experimental evidence (439 views)
Bosso A, Pirone L, Gaglione R, Pane K, Del Gatto A, Zaccaro L, Di Gaetano S, Diana D, Fattorusso R, Pedone E, Cafaro V, Haagsman HP, Van Dijk A, Scheenstra MR, Zanfardino A, Crescenzi O, Arciello A, Varcamonti M, Veldhuizen EJA, Di Donato A, Notomista E, Pizzo E
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 1570-9639print), 2017 Apr 25; N/D: N/D-N/D.
Impact Factor: 4.28
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* Molecular recognition of Cullin3 by KCTDs: Insights from experimental and computational investigations (572 views)
Balasco N, Pirone L, Smaldone G, Di Gaetano S, Esposito L, Pedone E, Vitagliano L
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2014 Jul; 1844(7): 1289-1298.
Impact Factor: 4.882
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* Molecular basis of the PED/PEA15 interaction with the C-terminal fragment of phospholipase D1 revealed by NMR spectroscopy (640 views)
Farina B, Doti N, Pirone L, Malgieri G, Pedone E, Ruvo M, Fattorusso R
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2013 Sep; 1834(8): 1572-1580.
Impact Factor: 3.191
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* C68 from the Sulfolobus islandicus plasmid-virus pSSVx is a novel member of the AbrB-like transcription factor family (1160 views)
Contursi P, D'Ambrosio K, Pirone L, Pedone E, Aucelli T, She Q, De Simone G, Bartolucci S
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2011 Apr 1; 435(1): 157-166.
Impact Factor: 4.897
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* Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor (586 views)
Mercurio FA, Marasco D, Pirone L, Pedone E, Pellecchia M,  Leone M
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2012 Mar 13; 51(10): 2136-2145.
Impact Factor: 3.377
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* KCTD1: A novel modulator of adipogenesis through the interaction with the transcription factor AP2alpha (261 views)
Pirone L, Smaldone G, Spinelli R, Barberisi M, Beguinot F, Vitagliano L, Miele C, Di Gaetano S, Raciti GA, Pedone E
Biochim Biophys Acta Mol Cell Biol Lipids (ISSN: 1388-1981linking), 2019 Aug 26; 1864(12): 158514-158514.
Impact Factor: 4.402
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* Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners (428 views) (PDF 203 views)
Pirone L, Smaldone G, Esposito C, Balasco N, Petoukhov MV, Spilotros A, Svergun DI, Di Gaetano S, Vitagliano L, Pedone E
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2016 Sep 24; 131: 106-114.
Impact Factor: 3.112
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* Exploring the binding of d(GGGT)4 to the HIV-1 integrase: An approach to investigate G-quadruplex aptamer/target protein interactions (498 views)
Esposito V, Pirone L, Mayol L, Pedone E, Virgilio A, Galeone A
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2016; 127: 19-22.
Impact Factor: 3.112
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* Molecular organization of the cullin E3 ligase adaptor KCTD11 (705 views)
Correale S, Pirone L, Di Marcotullio L, De Smaele E, Greco A, Mazzà D, Moretti M, Alterio V, Vitagliano L, Di Gaetano S, Gulino A, Pedone E
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Apr; 93(4): 715-724.
Impact Factor: 3.022
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* Thermal and chemical stability of two homologous POZ/BTB domains of KCTD proteins characterized by a different oligomeric organization (598 views)
Pirone L, Esposito C, Correale S, Graziano G, Di Gaetano S, Vitagliano L, Pedone E
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2013; 2013: 162674-162674.
Impact Factor: 1.579
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* Design and analysis of EphA2-SAM peptide ligands: A multi-disciplinary screening approach (306 views)
Mercurio FA, Di Natale C, Pirone L, Marasco D, Calce E, Vincenzi M, Pedone EM, De Luca S, Leone M
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2019 Mar; 84: 434-443.
Impact Factor: 3.929
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* Sam domain-based stapled peptides: Structural analysis and interaction studies with the Sam domains from the EphA2 receptor and the lipid phosphatase Ship2 (437 views)
Mercurio FA, Pirone L, Di Natale C, Marasco D, Pedone EM, Leone M
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2018 Oct; 80: 602-610.
Impact Factor: 3.9
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* Synthesis of diglycosylated (di)sulfides and comparative evaluation of their antiproliferative effect against tumor cell lines: A focus on the nature of sugar-recognizing mediators involved (234 views)
Di Gaetano S, Bedini E, Landolfi A, Pedone E, Pirone L, Saviano M, Traboni S, Capasso D, Iadonisi A
Carbohyd Res (ISSN: 0008-6215linking), 2019 Aug 1; 482: 107740-107740.
Impact Factor: 1.91
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* Ubiquitin binds the amyloid beta peptide and interferes with its clearance pathways (252 views) (PDF 57 views)
Bellia F, Lanza V, Garcia-vinuales S, Ahmed IMM, Pietropaolo A, Iacobucci C, Malgieri G, D'Abrosca G, Fattorusso R, Nicoletti VG, Sbardella D, Tundo GR, Coletta M, Pirone L, Pedone E, Calcagno D, Grasso G, Milardi D
Chem Sci (ISSN: 2041-6520linking, 2041-6520print), 2019 Jan 10; 10 (9 ): 2732-2742.
Impact Factor: 8.668
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* Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins (466 views) (PDF 109 views)
Malgieri G, D'Abrosca G, Pirone L, Toto A, Palmieri M, Russo L, Sciacca MFM, Tate R, Sivo V, Baglivo I, Majewska R, Coletta M, Pedone PV, Isernia C, De Stefano M, Gianni S, Pedone EM, Milardi D, Fattorusso R
Chem Sci (ISSN: 2041-6520linking, 2041-6520print, 2041-6539), 2018 Apr 7; 9(13): 3290-3298.
Impact Factor: 9.063
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* Targeting EphA2-Sam and Its Interactome: Design and Evaluation of Helical Peptides Enriched in Charged Residues (483 views)
Mercurio FA, Marasco D, Di Natale C, Pirone L, Costantini S, Pedone EM, Leone M
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2016 Nov 17; 17(22): 2179-2188.
Impact Factor: 2.847
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* Peptide Fragments of Odin-Sam1: Conformational Analysis and Interaction Studies with EphA2-Sam (645 views)
Mercurio FA, Di Natale C, Pirone L, Scognamiglio PL, Marasco D, Pedone EM, Saviano M, Leone M
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2015; 16(11): 1629-1636.
Impact Factor: 2.85
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* Heterotypic Sam-Sam Association Between Odin-Sam1 And Arap3-Sam: Binding Affinity And Structural Insights (507 views)
Mercurio FA, Marasco D, Pirone L, Scognamiglio PL, Pedone E, Pellecchia M, Leone M
Chembiochem (ISSN: 1439-4227, 1439-9422, 1439-7633), 2013 Jan 2; 14(1): 100-106.
Impact Factor: 2.92
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* Exploring the ability of cyclic peptides to target SAM domains: a computational and experimental study (333 views)
Mercurio FA, Di Natale C, Pirone L, Vincenzi M, Marasco D, De Luca S, Pedone EM, Leone M
Chembiochem (ISSN: 1439-4227linking, 1439-7633), 2020 Mar 2; 21(5): 702-711.
Impact Factor: 2.641
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* Mapping Functional Interaction Sites of Human Prune C-Terminal Domain by NMR Spectroscopy in Human Cell Lysates (482 views)
Diana D, Smaldone G, De Antonellis P, Pirone L, Carotenuto M, Alonzi A, Di Gaetano S, Zollo M, Pedone E, Fattorusso R
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2013 Sep 9; 19(37): 12217-12220.
Impact Factor: 5.696
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* The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation (118 views) (PDF 23 views)
Senatore E, Chiuso F, Rinaldi L, Intartaglia D, Donne RD, Pedone E, Catalanotti B, Pirone L, Fiorillo B, Moraca F, Giamundo G, Scala G, Raffeiner A, Torres-quesada O, Stefan E, Kwiatkowski M, Pijkeren A, Morleo M, Franco B, Garbi C, Conte I, Feliciello A
Embo J (ISSN: 0261-4189linking), 2021 May 17; 40(10): e106503-N/D.
Impact Factor: 9.96
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* Functional and structural characterization of protein disulfide oxidoreductase from Thermus thermophilus HB27 (445 views)
Pedone E, Fiorentino G, Pirone L, Contursi P, Bartolucci S, Limauro D
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2014 Jul; 18(4): 723-731.
Impact Factor: 2.306
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* Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase (594 views)
Limauro D, De Simone G, Pirone L, Bartolucci S, D'Ambrosio K, Pedone E
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2014 Mar; 18(2): 219-228.
Impact Factor: 2.306
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* Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction (386 views) (PDF 224 views)
Birolo L, Sacchi S, Smaldone G, Molla G, Leo G, Caldinelli L, Pirone L, Eliometri P, Di Gaetano S, Orefice I, Pedone E, Pucci P, Pollegioni L
Febs J (ISSN: 1742-464x), 2016 Sep; 283(18): 3353-3370.
Impact Factor: 3.902
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* Molecular insights into the role of the polyalanine region in mediating PHOX2B aggregation (407 views) (PDF 67 views)
Pirone L, Caldinelli L, Di Lascio S, Di Girolamo R, Di Gaetano S, Fornasari D, Pollegioni L, Benfante R, Pedone E
Febs J (ISSN: 1742-464xlinking), 2019 Apr 7; 286(13): 2505-2521.
Impact Factor: 3.129
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* NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites (846 views)
Farina B, Pirone L, Russo L, Viparelli F, Doti N, Pedone C, Pedone E, Fattorusso R
Febs J (ISSN: 1742-4658, 1742-464x, 1742-4658electronic), 2010 Oct; 277(20): 4229-4240.
Impact Factor: 3.129
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* Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress (497 views)
Limauro D, Pedone E, Pirone L, Bartolucci S
Febs Journal (ISSN: 1742-464x), 2006 Feb; 273(4): 721-731.
Impact Factor: 3.033
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* The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states (383 views) (PDF 61 views)
Smaldone G, Pirone L, Pedone E, Marlovits T, Vitagliano L, Ciccarelli L
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468), 2016 Jun; 590(11): 1663-1671.
Impact Factor: 3.623
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* Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility (506 views)
Sacchi S, Cappelletti P, Pirone L, Smaldone G, Pedone E, Pollegioni L
Febs Lett (ISSN: 1873-3468, 0014-5793, 0014-5793print), 2017 Feb; 591(4): 646-655.
Impact Factor: 2.999
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* MucR binds multiple target sites in the promoter of its own gene and is a heat-stable protein: Is MucR a H-NS-like protein? (258 views)
Baglivo I, Pirone L, Malgieri G, Fattorusso R, Roop Ii RM, Pedone EM, Pedone PV
Febs Open Bio (ISSN: 2211-5463print, 2211-5463linking), 2018 Mar 31; 8(4): 711-718.
Impact Factor: 2.999
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* Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs (212 views) (PDF 35 views)
Tito A, Colantuono C, Pirone L, Pedone E, Intartaglia D, Giamundo G, Conte I, Vitaglione P, Apone F
Front Chem (ISSN: 2296-2646linking), 2021 Apr 28; 9: 638187-638187.
Impact Factor: 3.693
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* A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment (701 views) (PDF 187 views)
Pirone L, Del Gatto A, Di Gaetano S, Saviano M, Capasso D, Zaccaro L, Pedone E
Front Mol Biosci (ISSN: 2296-889xlinking), 2020 Aug 3; 7: 186-186.
Impact Factor: 4.188
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* A physicochemical investigation on the metal binding properties of TtSmtB, a thermophilic member of the ArsR/SmtB transcription factor family (344 views)
Gallo G, Antonucci I, Pirone L, Amoresano A, Contursi P, Limauro D, Pedone E, Bartolucci S, Fiorentino G
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jul 26; 138: 1056-1063.
Impact Factor: 4.784
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* Focusing on the functional characterization of the anserinase from Oreochromis niloticus (250 views)
Pirone L, Di Gaetano S, Rizzarelli E, Bellia F, Pedone E
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Feb 22; 130: 158-165.
Impact Factor: 4.784
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* The essential player in adipogenesis GRP78 is a novel KCTD15 interactor (300 views)
Smaldone G, Pirone L, Capolupo A, Vitagliano L, Monti MC, Di Gaetano S, Pedone E
Int J Biol Macromol (ISSN: 1879-0003electronic, 0141-8130linking), 2018 Aug; 115: 469-475.
Impact Factor: 4.784
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* More Is Always Better Than One: The N-Terminal Domain of the Spike Protein as Another Emerging Target for Hampering the SARS-CoV-2 Attachment to Host Cells (167 views)
Di Gaetano S, Capasso D, Delre P, Pirone L, Saviano M, Pedone E, Mangiatordi GF
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic), 2021 Jun 16; 22 (12 ): N/D-N/D.
Impact Factor: 2.598
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* Insights into PPARγ Phosphorylation and Its Inhibition Mechanism (287 views)
Montanari R, Capelli D, Yamamoto K, Awaishima H, Nishikata K, Barendregt A, Heck AJR, Loiodice F, Altieri F, Paiardini A, Grottesi A, Pirone L, Pedone E, Peiretti F, Brunel JM, Itoh T, Pochetti G
J Med Chem (ISSN: 0022-2623linking, 0022-2623print, 1520-4804), 2020 May 14; 63(9): 4811-4823.
Impact Factor: 6.205
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* Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD - cullin 3 recognition (504 views)
Pirone L, Correale S, De Paola I, Zaccaro L, De Simone G, Vitagliano L, Pedone E, Di Gaetano S
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 May; 17(5): 373-376.
Impact Factor: 1.799
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* Functional analyses yield detailedinsight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae (441 views) (PDF 200 views)
Pirone L, Ripoll-rozada J, Leone M, Ronca R, Lombardo F, Fiorentino G, Andersen JF, Pereira PJB, Arcà B, Pedone E
Jbc Papers (ISSN: 0021-9258linking, 1083-351x), 2017 Jul 28; 292(30): 12632-12642.
Impact Factor: 4.125
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* A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABA(B2) receptor (496 views)
Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E
Journal Of Molecular Recognition (ISSN: 0952-3499, 0952-2349), 2013 Oct; 26(10): 488-495.
Impact Factor: 2.337
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* The identification of a novel Sulfolobus islandicus CAMP-like peptide points to archaeal microorganisms as cell factories for the production of antimicrobial molecules (1202 views)
Notomista E, Falanga A, Fusco S, Pirone L, Zanfardino A, Galdiero S, Varcamonti M, Pedone E, Contursi P
Microb Cell Fact (ISSN: 1475-2859), 2015; 14(1): N/D-N/D.
Impact Factor: 3.744
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* Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor family (477 views)
Contursi P, Farina B, Pirone L, Fusco S, Russo L, Bartolucci S, Fattorusso R, Pedone E
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962), 2014; 42(9): 5993-6011.
Impact Factor: 9.112
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* Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis (496 views)
Ruggiero A, Squeglia F, Pirone L, Correale S, Berisio R
Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309), 2011 Jan 1; 67(1): 164-168.
Impact Factor: 0.506
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* A selective αvβ5 integrin antagonist hidden into the anophelin family protein cE5 from the malaria vector Anopheles gambiae (350 views)
Di Gaetano S, Del Gatto A, Pirone L, Comegna D, Zaccaro L, Saviano M, Arcà B, Capasso D, Pedone E
Peptide Science, 2018; N/D: N/D-N/D.
Impact Factor: 2.081
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* Selective Photo-Assisted Eradication of Triple-Negative Breast Cancer Cells through Aptamer Decoration of Doped Conjugated Polymer Nanoparticles (78 views)
Ibarra LE, Camorani S, Agnello L, Pedone E, Pirone L, Chesta CA, Palacios RE, Fedele M, Cerchia L
Pharmaceutics (ISSN: 1999-4923linking, 1999-4923electronic), 2022 Mar 12; 14(3): N/D-N/D.
Impact Factor: 6.321
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* Cullin 3 recognition is not a universal property among KCTD proteins (986 views)
Smaldone G, Pirone L, Balasco N, Di Gaetano S, Pedone E, Vitagliano L
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 May 14; 10(5): e0126808-e0126808.
Impact Factor: 3.057
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* Cullin3 - BTB interface: A novel target for stapled peptides (803 views) (PDF 60 views)
De Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazza D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Apr 7; 10(4): e0121149-e0121149.
Impact Factor: 3.057
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* The Sam-Sam interaction between Ship2 and the EphA2 receptor: design and analysis of peptide inhibitors (340 views)
Mercurio FA, Di Natale C, Pirone L, Iannitti R, Marasco D, Pedone EM, Palumbo R, Leone M
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Dec 12; 7(1): 17474-17474.
Impact Factor: 4.122
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* Ml proteins from Mesorhizobium loti and MucR from Brucella abortus: an AT-rich core DNA-target site and oligomerization ability (327 views)
Baglivo I, Pirone L, Pedone E, Pitzer JE, Muscariello L, Marino MM, Malgieri G, Freschi A, Chambery A, Roop Ii RM, Pedone PV
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Nov 17; 7(1): 15805-15805.
Impact Factor: 4.122
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* Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (632 views)
Carotenuto M, Pedone E, Diana D, de Antonellis P, Džeroski S, Marino N, Navas L, Di Dato V, Scoppettuolo MN, Cimmino F, Correale S, Pirone L, Monti SM, Bruder E, Zenko B, Slavkov I, Pastorino F, Ponzoni M, Schulte JH, Schramm A, Eggert A, Westermann F, Arrigoni G, Accordi B, Basso G, Saviano M, Fattorusso R, Zollo M
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2013 Mar 1; 3: 1351-1351.
Impact Factor: 5.078
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* Structural Insight of the Full-Length Ros Protein: A Prototype of the Prokaryotic Zinc-Finger Family (285 views) (PDF 14 views)
D'Abrosca G, Paladino A, Baglivo I, Russo L, Sassano M, Grazioso R, Iacovino R, Pirone L, Pedone E, Pedone P, Isernia C, Fattorusso R, Malgieri G
Sci Rep (ISSN: 2045-2322, 2045-2322linking, 2045-2322electronic), 2020 Jun 9; 10(1): 9283-9283.
Impact Factor: 4.011
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* Identifying the region responsible for Brucella abortus MucR higher-order oligomer formation and examining its role in gene regulation (240 views)
Pirone L, Pitzer JE, D'Abrosca G, Fattorusso R, Malgieri G, Pedone EM, Pedone PV, Roop RM, Baglivo I
Sci Rep (ISSN: 2045-2322electronic, 2045-2322linking), 2018 Nov 22; 8(1): 17238-17238.
Impact Factor: 5.078
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* Molecular basis of the scalp-ear-nipple syndrome unraveled by the characterization of disease-causing KCTD1 mutants (227 views)
Smaldone G, Balasco N, Pirone L, Caruso D, Di Gaetano S, Pedone EM, Vitagliano L
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2019 Jul 19; 9(1): 10519-10519.
Impact Factor: 5.078
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* Investigating the properties of TBA variants with twin thrombin binding domains (239 views)
Amato T, Virgilio A, Pirone L, Vellecco V, Bucci M, Pedone E, Esposito V, Galeone A
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2019 Jun 24; 9(1): 9184-9184.
Impact Factor: 5.078
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56 Records (54 excluding Abstracts).
Total impact factor: 225.966 (217.195 excluding Abstracts).
Total 5 year impact factor: 216.019 (207.102 excluding Abstracts).

Last modified by Massimiliano Sorbillo on Monday 16 September 2024, 15:24:45
1924 views. Last view on Thursday 03 October 2024, 12:56:55