View contact record, Full name: Lucia De Rosa
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NameLucia De Rosa
AreaResearch&Development
PositionResearcher
Work siteNaples - Castellino
AddressVia Pietro Castellino 111, 80131 Naples - Italy
E-maillucia.derosaunina.it
▼    Cancer Diseases
▼    Gadd45 beta and its implication in chronic inflammation
▼    Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
▼    Monoclonal Antibodies for therapeutic and diagnostic applications
▼    Targeted Drug Delivery by integrin avb3 antagonist
▼    Chemical protein synthesis and modification for biomedical applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Imaging Tumor Acidosis
▼    Bioactive peptide-membrane assemblies
No results.
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Clinical Oncology
▼    Translational Molecular Imaging in Cancer
▼    Molecular imaging for personalized therapy in oncology
▼    Modeling radiation induced normal tissue effects
▼    Evaluation of new molecular probes by preclinical imaging
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Brain segmentation for radiation oncology application
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Drug discovery by mirror-image phage display
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Other Diseases
▼    Structural characterization of proteins and enzymes isolated from organisms living under unusual conditions
▼    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
▼    Bioactive peptide-membrane assemblies
No results.
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Chemical protein synthesis and modification for biomedical applications
▼    Comparison of noninvasive cardiac imaging modalities in patients with myocardial infarction
▼    Structural and functional studies of virulence factors in Mycobacterium tuberculosis infection
▼    Assessment of the cardiac risk and its temporal variation
▼    Evaluation of new molecular probes by preclinical imaging
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Phenotyping of murine models by preclinical imaging
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Drug discovery by mirror-image phage display
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Macromolecules for biomedical and biotechnological applications
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    A multi-targeting approach to fight COVID-19
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Chemical protein synthesis and modification for biomedical applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Generation of innovative scaffolds by manipulating hyperstable proteins
▼    The fine structure of proteins as a new tool for protein structure validation, quality assessment, and prediction
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
▼    Plant polypeptides as natural enhancers of biostimulation
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Protein-based biotherapeutics
▼    Understanding SARS-CoV-2 interaction with its host of for therapeutic applications
▼    Structure and function of proteins involved in physio-pathologic processes
▼    Carbonic Anhydrase IX as target for the development of new anti-tumour drugs
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    A multi-targeting approach to fight COVID-19
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Carbonic Anhydrase family as target for rational drug design
▼    Characterization of the KCTD protein family: key factors in several biological processes
▼    Chemical protein synthesis and modification for biomedical applications
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Structural characterization of the porphyrins/proteasome interaction
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Drug discovery by mirror-image phage display
▼    Analysis of Sam domain druggability through computational and experimental studies
▼    Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Biochemical and functional characterization of intrinsically disordered proteins (IDPs) in human diseases
▼    Biochemical and functional characterization of Protein-Protein and DNA-protein Interaction networks in physio/pathological events
▼    Biochemical and structural insights on Chromatin Assembly Factor 1 in physio/pathological events
▼    Targeting Of Protein-Protein Interactions For Therapeutic Purposes
▼    Small molecules and peptides/modified peptides for diagnostic, therapeutic and biotechnological applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    New peptide–based molecules as NGF mimetics in the therapy of neurological dysfunctions
▼    Peptide-based molecules for αvβ3 integrin modulation in Th17 cells-dependent demyelinating diseases
▼    Development of integrin subtypes selective ligands: from a first rationally designed peptide to a wide range of molecules
▼    Design of New FSHR-Specific Peptides for therapeutic and diagnostic applications
▼    New synthetic molecules for active targeting of multifunctional theranostic nanosystems
▼    Biomolecular NMR: structural studies of proteins and peptides and drug discovery applications
▼    Galectins: Structure, function and therapeutic potential inhibitors
▼    Protein-Protein-Interaction network–disease relationship, pathogenicity and therapeutic perspectives
▼    A multi-targeting approach to fight COVID-19
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Drug discovery by mirror-image phage display
▼    Peptides of therapeutic interest with antimicrobial and/ or antitumoral activity
▼    Analysis of Sam domain druggability through computational and experimental studies
▼    Targeting Sam-Sam interactions mediated by EphA2 receptor: design and evaluation of peptide inhibitors
▼    Environmental chemistry & human health. Computational studies. Synthesis of small molecules, modified peptides and nucleobase-decorated peptides. Spectroscopic and computational investigation on the potential of natural products in biomedicine. Nucleic acid and protein binding studies
▼    Plant polypeptides as natural enhancers of biostimulation
▼    Chemical modification of natural molecules, such as peptides and polysaccharides, to be employed as therapeutic agents as well as sensor diagnostic tools
▼    Design and screening of molecular repertoires as a source for new bioactive compounds
▼    Targeting Of Protein-Protein Interactions For Therapeutic Purposes
▼    Chemical protein synthesis and modification for biomedical applications
▼    Biomolecules able to modulate the VEGF-dependent angiogenesis
▼    Axl and Gas6 targeting for therapeutic and diagnostic applications
▼    Drug discovery by mirror-image phage display

Education

January 2011  PhD in Biotechnology

October 2007  Master’s Degree cum laude in Biotechnology

 

Professional Experience

July 2020- today Researcher at IBB-CNR

February 2019-July 2020 Post-Doctoral fellowships awarded from Fondazione Umberto Veronesi

October 2012-January 2019 Post-Doc associate at IBB-CNR

October 2011-September 2012 Post-Doctoral fellowship at the Dept. of Biological Science of the University Federico II

November-December 2010 Visiting student at the Dept. of Biophysics and Biochemistry of Yale University, New Haven (CT-USA)

 

Main research activities

1.             protein synthesis by chemical ligation;

2.             protein semi-synthesis by expressed protein ligation;

3.             development of peptide-based molecules for biomedical applications by mirror-image phage display and rational design;

4.             synthesis and characterization of bioactive peptides and peptidomimetics targeting protein

5.             protein interactions;

6.             protein/peptide bioconjugation;

7.             peptide/protein folding studies.

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* Pro-angiogenic peptides in biomedicine (565 views)
De Rosa L, Di Stasi R, D'Andrea LD
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
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* Labeling of VEGFR1D2 through oxime ligation (236 views)
De Rosa L, Di Stasi R, Longhitano L, D'Andrea LD
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2019 Jul 29; 91: 103160-103160.
Impact Factor: 3.926
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* Probing the helical stability in a VEGF-mimetic peptide (73 views)
De Rosa L, Diana D, Di Stasi R, Romanelli A, Sciacca MF, Milardi D, Isernia C, Fattorusso R, D'Andrea LD
Bioorganic Chemistry, 2021; 16: N/D-N/D.
Impact Factor: 5.307
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* beta-Hairpin stabilization through an interstrand triazole bridge (504 views)
Celentano V, Diana D, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012 Jan 18; 48(5): 762-764.
Impact Factor: 6.378
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* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (388 views)
Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(44): 11461-11466.
Impact Factor: 5.16
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* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (536 views)
Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Apr 11; 22(16): 5534-5537.
Impact Factor: 5.317
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* Functional Binding Surface Of A Beta-Hairpin Vegf Receptor Targeting Peptide Determined By Nmr Spectroscopy In Living Cells (526 views)
Diana D, Russomanno A, De Rosa L, Di Stasi R, Capasso D, Di Gaetano S, Romanelli A, Russo L, D'Andrea LD, Fattorusso R
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 2; 21(1): 91-95.
Impact Factor: 5.771
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* Peptides targeting angiogenesis related growth factor receptors (14800 views)
D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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* Therapeutic aspects of the Axl/Gas6 molecular system (65 views)
Di Stasi R, De Rosa L, D’andrea LD
Drug Discovery Today, 2020; 25: 2130-2148.
Impact Factor: 8.369
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* Design, Structural And Biological Characterization Of A Vegf Inhibitor Beta-Hairpin-Constrained Peptide (610 views)
De Rosa L, Diana D, Basile A, Russomanno A, Isernia C, Turco MC, Fattorusso R, D'Andrea LD
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014; 73: 210-216.
Impact Factor: 3.447
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* Metabolic and conformational stabilization of a VEGF-mimetic beta-hairpin peptide by click-chemistry (95 views)
De Rosa L, Capasso D, Diana D, Stefania R, Di Stasi R, Fattorusso R, D'Andrea LD
European Journal Of Medicinal Chemistry, 2021; 222: N/D-N/D.
Impact Factor: 7.088
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* Peptides Interacting with Growth Factor Receptors Regulating Angiogenesis (391 views)
Di Stasi R, De Rosa L, Romanelli A, D'Andrea LD
Frontiers In Medicinal Chemistry, 2016; 9: 103-160.
Impact Factor: 0
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* Probing the molecular origin of native-state flexibility in repeat proteins (460 views)
Cohen SS, Riven I, Cortajarena AL, De Rosa L, D'Andrea LD, Regan L, Haran G
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 0002-7863print), 2015; 137(32): 10367-10373.
Impact Factor: 13.038
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* Analysis of the haptoglobin binding region on the apolipoprotein A-I-derived P2a peptide (468 views)
Spagnuolo MS, Di Stasi R, De Rosa L, Maresca B, Cigliano L, D'Andrea LD
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 220-226.
Impact Factor: 1.862
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* Structural investigation of the VEGF receptor interaction with a helical antagonist peptide (483 views)
Diana D, Di Stasi R, De Rosa L, Isernia C, D'Andrea LD, Fattorusso R
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 214-219.
Impact Factor: 1.862
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* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (709 views)
Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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* Chemical ligation in Structural Biology in “Chemical Ligation: Tools for Biomolecules Synthesis and Modification” (393 views)
De Rosa L, Romanelli A, D'Andrea LD
John Wiley & Sons, 2017; N/D: N/D-N/D.
Impact Factor: 0
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* Introduction to chemical ligation reactions in Chemical Ligation: Tools for Biomolecules Synthesis and Modification (342 views)
De Rosa L, Romanelli A, D'Andrea LD
John Wiley & Sons, 2017; N/D: N/D-N/D.
Impact Factor: 0
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* Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein (832 views)
Capasso D, Di Gaetano S, Celentano V, Diana D, Festa L, Di Stasi R, De Rosa L, Fattorusso R, D'Andrea LD
Mol Biosyst (ISSN: 1742-206x), 2017 Jul 25; 13(8): 1619-1629.
Impact Factor: 2.759
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* Biochemical and Conformational Characterization of Recombinant VEGFR2 Domain "7" (284 views)
Di Stasi R, Diana D, De Rosa L, Fattorusso R, D'Andrea LD
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Nov; 61(11): 860-872.
Impact Factor: 2.275
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* Human Recombinant VEGFR2D4 Biochemical Characterization to Investigate Novel Anti-VEGFR2D4 Antibodies for Allosteric Targeting of VEGFR2 (352 views)
Di Stasi R, De Rosa L, Diana D, Fattorusso R, D'Andrea LD
Mol Biotechnol (ISSN: 1073-6085linking, 1559-0305electronic), 2019 Apr 26; 61(7): 513-520.
Impact Factor: 2.275
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* Exploiting Protein N-Terminus for Site-Specific Bioconjugation (26 views)
De Rosa L, Di Stasi R, Romanelli A, D’andrea LD
Molecules, 2021; 26: 3521-3521.
Impact Factor: 4.927
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* Semi-Synthesis of Labeled Proteins for Spectroscopic Applications (604 views)
De Rosa L, Russomanno A, Romanelli A, D'Andrea LD
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2013 Jan; 18(1): 440-465.
Impact Factor: 2.095
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* VEGF mimetic peptides: potential applications in central nervous system therapeutics (580 views)
D’andrea LD, De Rosa L, Vigliotti C, Cataldi M
New Horizons In Translational Medicine, 2017; 233: 225-225.
Impact Factor: 0
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* Site-specific protein double labeling by expressed protein ligation: applications to repeat proteins (506 views)
De Rosa L, Cortajarena AL, Romanelli A, Regan L, D'Andrea LD
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2012; 10(2): 273-280.
Impact Factor: 3.568
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* Conformational stabilization of a beta-hairpin through a triazole-tryptophan interaction (475 views)
Diana D, Di Salvo C, Celentano V, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2018 Jan 31; 16(5): 787-795.
Impact Factor: 3.451
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* Structure and biological activity of a conformational constrained apolipoprotein A-I-derived helical peptide targeting the protein haptoglobin (504 views)
Cigliano L, De Rosa L, Diana D, Di Stasi R, Spagnuolo MS, Maresca B, Fattorusso R, D'Andrea LD
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic), 2014; 4(93): 51353-51361.
Impact Factor: 3.84
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* Miniaturizing VEGF: Peptides mimicking the discontinuous VEGF receptor-binding site modulate the angiogenic response (449 views)
De Rosa L, Finetti F, Diana D, Di Stasi R, Auriemma S, Romanelli A, Fattorusso R, Ziche M, Morbidelli L, D'Andrea LD
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2016 Aug 08; 6: 31295-31295.
Impact Factor: 4.259
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* Long range Trp-Trp interaction initiates the folding pathway of a pro-angiogenic beta-hairpin peptide (569 views)
Diana D, De Rosa L, Palmieri M, Russomanno A, Russo L, La Rosa C, Milardi D, Colombo G, D'Andrea LD, Fattorusso R
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2015 Nov 25; 5: 16651-16651.
Impact Factor: 5.228
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* Total chemical synthesis by native chemical ligation of the all-D immunoglobulin-like domain 2 of Axl (261 views)
De Rosa L, Di Stasi R, D'Andrea LD
Tetrahedron, 2019; N/D: N/D-N/D.
Impact Factor: 2.377
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30 Records (29 excluding Abstracts).
Total impact factor: 116.884 (111.957 excluding Abstracts).
Total 5 year impact factor: 115.005 (109.895 excluding Abstracts).

Last modified by Massimiliano Sorbillo on Monday 16 September 2024, 15:22:36
1437 views. Last view on Wednesday 09 October 2024, 2:26:54