Biografia
Interessi di ricerca
Pubblicazioni scelte
Progetti in evidenza
Biografia
The Dr. Autiero research area lies in between computational methods applied to biologically relevant systems and structural investigations of small molecules, proteins, nucleic acids and drug/target complexes. Her main areas of interest are: systems biology, molecular modeling, docking, molecular dynamics studies, structures and molecules interactions.
Ida Autiero received a master degree in Pharmaceutical Chemistry at the University of Napoli,
“Federico II” in a molecular modeling project to design of new antimalarial agents. Dr. Ida Autiero kept studying modeling and theoretical chemistry at the Second University of Naples earing a PhD in ‘Computational Biology’ in the 2011, during these years she improved expertises in theoretical studies of biochemical relevant entities, including proteins, nucleic acids, artificial nucleic acids and small molecules applying several computational approaches through a collaboration with the Oncology Research Center (CROM) of Mercogliano (AV) and a fellowship at the School of Pharmacy of London in the group of Prof. Stephen Neidle. From 2011 to 2016 Dr. Ida Autiero did post-doctoral works at the Italian National Council of Research (CNR). From the 2016 to 2017, she worked at the King Abdullah University of Science & Technology in Saudi Arabia. Form 08/2017 to 01/2022 Ida worked for Molecular Horizon srl as computational chemist senior scientist and as consultant in computational biochemistry for Molecular Discovery and other companies. From 02/2022 Ida got a permanent position as Scientist at The Institute of Biostructures and Bioimaging (IBB) of the National Research Council (CNR), in Napoli (Italy). In the 2023, Ida Autiero got a Short Term Mobility as visiting scientist in Annalisa Di Ruscio’s laboratory, for a collaboration aimed at studying the role of non-coding RNAs in epigenetic mechanisms at the Harvard School of Medicine.
Interessi di ricerca
molecular modelling. theoretical chemistry, simulations and molecular interaction prediction. rational drug design and discovery. epigenetic. RNA, nucleic acid, proteins and small molecules. RNA aptamers for neuropathic pain treatments.
Pubblicazioni scelte
1. RNAs anchoring replication complex control initiation and firing of DNA replication.
Ummarino S, Poluben L, Ebralidze AK, Autiero I, Rinaldi L, Paniza T, Deshpande M, Mandel NH, Lee JD, Zhang Y, Bassal MA, Budnik B, Trinh BQ, Balk SP, Flaumenhaft R, Gerhardt J, Mirkin SM, Tenen DG, Di Ruscio A.
Nat Commun. 2026 May 27;17(1):8830. doi: 10.1038/s41467-026-73478-2.
PMID: 42203769
2. Assessing Computational Strategies for the Evaluation of Antibody Binding Affinities.
Autiero I, Buratto D, Guo F, Wang W, Biswal MR, Chan KC, Zhou R, Zonta F.
J Chem Theory Comput. 2025 Nov 11;21(21):11271-11281. doi: 10.1021/acs.jctc.5c01231. Epub 2025 Oct 23.
PMID: 41129205
3. Enhanced molecular dynamic simulation studies unravel long-range effects caused by sequence variations and partner binding in RNA aptamers.
Autiero I, Vitagliano L.
Mol Ther Nucleic Acids. 2023 Sep 29;34:102039. doi: 10.1016/j.omtn.2023.102039. eCollection 2023 Dec 12.
PMID: 37869259
4. Exosite binding in thrombin: a global structural/dynamic overview of complexes with aptamers and other ligands
R Troisi, N Balasco, I Autiero, L Vitagliano, F Sica
International journal of molecular sciences 22 (19), 10803
5. Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation.
Esposito CL, Autiero I, Sandomenico A, Li H, Bassal MA, Ibba ML, Wang D, Rinaldi L, Ummarino S, Gaggi G, Borchiellini M, Swiderski P, Ruvo M, Catuogno S, Ebralidze AK, Kortylewski M, de Franciscis V, Di Ruscio A.
Nat Commun. 2023 Jan 6;14(1):99. doi: 10.1038/s41467-022-35222-4.
PMID: 36609400
Progetti in evidenza
PRIN 2022 PNRR - Progetti di Rilevante Interesse Nazionale
Titolo del progetto: RNA Aptamer development for epigenetic control in neuropathic pain with specific delivery system: from theoretical to in vivo studies.
Codice del progetto: P202299RFC
RNA nei meccanismi epigenetici, approcci teorici e sperimentali. in collaboration with the Annalisa Di Ruscio Lab, at the Center for Life Sciences Boston, Harvard medical school
Settore ERC: LS1
Principal Investigator: Ida AUTIERO
Ente di afferenza: Consiglio Nazionale delle Ricerche
Canali social